1. Exposure to growth hormone is associated with hepatic up-regulation of cPLA2α and COX.
- Author
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Piazza VG, Matzkin ME, Cicconi NS, Muia NV, Valquinta S, Mccallum GJ, Micucci GP, Freund T, Zotta E, González L, Frungieri MB, Fang Y, Bartke A, Sotelo AI, and Miquet JG
- Subjects
- Alanine Transaminase blood, Animals, Body Weight, Cattle, Cell Proliferation, Female, Group IV Phospholipases A2 metabolism, Hepatocytes cytology, Liver anatomy & histology, Male, Mice, Transgenic, Organ Size, Phosphorylation, Prostaglandin-Endoperoxide Synthases metabolism, Rats, Receptor, IGF Type 1 metabolism, Receptors, Somatotropin metabolism, Group IV Phospholipases A2 genetics, Growth Hormone metabolism, Liver metabolism, Prostaglandin-Endoperoxide Synthases genetics, Up-Regulation genetics
- Abstract
Continuously elevated levels of growth hormone (GH) during life in mice are associated with hepatomegaly due to hepatocytes hypertrophy and hyperplasia, chronic liver inflammation, elevated levels of arachidonic acid (AA) at young ages and liver tumors development at old ages. In this work, the hepatic expression of enzymes involved in AA metabolism, cPLA2α, COX1 and COX2 enzymes, was evaluated in young and old GH-transgenic mice. Mice overexpressing GH exhibited higher hepatic expression of cPLA2α, COX1 and COX2 in comparison to controls at young and old ages and in both sexes. In old mice, when tumoral and non-tumoral tissue were compared, elevated expression of COX2 was observed in tumors. In contrast, exposure to continuous lower levels of hormone for a short period affected COX1 expression only in males. Considering the role of inflammation during liver tumorigenesis, these findings support a role of alterations in AA metabolism in GH-driven liver tumorigenesis., Competing Interests: Declaration of competing interest All the authors declare no conflict of interest., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
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