Liver plays an important role in maintaining the biological equilibrium of vertebrates. Liver diseases are a major worldwide health problem with high endemicity in developing countries. They are mainly caused by chemicals and some drugs when taken in very high doses. Despite advances in modern r, medicine, there is no effective drug available that stimulates liver function, offer protection to the liver from damage, help to regenerate hepatic cells. There is urgent need, therefore, for effective drugs to replace/supplement those in current use. The plant kingdom is undoubtedly valuable as a source of new medicinal agents. The main aim of any medication in the treatment of liver disorders is to prevent degeneration of hepatocytes and associated metabolic abnormalities and promote regeneration of hepatic cells. In the present study, hepatoprotective activity of Cynodon dactylon ethanolic extract was evaluated in paracetamol induced liver toxicity by biochemical parameters like SGPT, SGOT, ALP and BIT and histopathology. Acute administration of paracetamol produced marked elevation of the serum levels of the above parameters compared to that of the control group. Treatment with ethanolic of Cynodon dactylon leaves at doses of200 i and 400 mg/kg produces significant prevention in paracetamol induced rise of the parameters. Silymarin at 100 mg/kg body weight significantly prevented such rise in study. The effect of Cynodon dactylon leaves ethanolic extracts was found possess promising hepatoprotective activity. [ABSTRACT FROM AUTHOR]