1. Pathophysiological mechanisms of liver injury in COVID-19.
- Author
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Nardo AD, Schneeweiss-Gleixner M, Bakail M, Dixon ED, Lax SF, and Trauner M
- Subjects
- Angiotensin-Converting Enzyme 2 physiology, Cholestasis etiology, Humans, Non-alcoholic Fatty Liver Disease etiology, COVID-19 complications, Liver virology, Liver Diseases etiology, SARS-CoV-2, Viral Tropism
- Abstract
The recent outbreak of coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has resulted in a world-wide pandemic. Disseminated lung injury with the development of acute respiratory distress syndrome (ARDS) is the main cause of mortality in COVID-19. Although liver failure does not seem to occur in the absence of pre-existing liver disease, hepatic involvement in COVID-19 may correlate with overall disease severity and serve as a prognostic factor for the development of ARDS. The spectrum of liver injury in COVID-19 may range from direct infection by SARS-CoV-2, indirect involvement by systemic inflammation, hypoxic changes, iatrogenic causes such as drugs and ventilation to exacerbation of underlying liver disease. This concise review discusses the potential pathophysiological mechanisms for SARS-CoV-2 hepatic tropism as well as acute and possibly long-term liver injury in COVID-19., (© 2020 The Authors. Liver International published by John Wiley & Sons Ltd.)
- Published
- 2021
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