1. [Research progress of miRNAs targeting GSK-3β in regulation of hepatocellular carcinoma invasion and metastasis].
- Author
-
He SQ, Wen B, Chen GX, Sun HT, Sun JL, and Yang XM
- Subjects
- Carcinoma, Hepatocellular blood supply, Cell Differentiation genetics, Cell Line, Tumor, Cell Movement, Cell Proliferation genetics, Gene Expression Regulation, Neoplastic, Glycogen Synthase Kinase 3 beta, Humans, Liver Neoplasms blood supply, MicroRNAs genetics, Neoplasm Invasiveness, Neovascularization, Pathologic genetics, Carcinoma, Hepatocellular pathology, Carcinoma, Hepatocellular secondary, Liver Neoplasms pathology, MicroRNAs physiology, Neovascularization, Pathologic metabolism
- Abstract
Invasion and metastasis are key factors contributing to the high mortality rate of patients with hepatocellular carcinoma (HCC) involving a complex mechanism. In the invasion and metastasis of HCC, miRNAs can serve as either oncogenes or tumor suppressor genes to regulate the differentiation and proliferation of tumor cells being and play important roles in tumorigenesis, angiogenesis, invasion and metastasis. This review summarizes the recent progress in research of the molecular mechanisms by which miRNAs targeting GSK-3β regulate HCC invasion and metastasis and examines the roles of miRNAs in hepatocellular carcinoma cell proliferation, apoptosis, invasion, metastasis, and GSK-3β regulation.
- Published
- 2017