1. The effect of IL-6 on the des-gamma-carboxy prothrombin synthesis in human hepatoma cells.
- Author
-
Ono M, Kohda H, Naraki T, Ohta H, Ohhira M, Sekiya C, and Namiki M
- Subjects
- Carcinoma, Hepatocellular pathology, Humans, Interferon-gamma pharmacology, Interleukin-1 pharmacology, Interleukin-6 immunology, Liver Neoplasms pathology, Recombinant Proteins, Tumor Cells, Cultured metabolism, Tumor Necrosis Factor-alpha pharmacology, Biomarkers, Carcinoma, Hepatocellular metabolism, Interleukin-6 pharmacology, Liver Neoplasms metabolism, Protein Precursors biosynthesis, Prothrombin biosynthesis
- Abstract
Effects of several cytokines on des-gamma-carboxy prothrombin (PIVKA II) synthesis in human hepatoma cells were investigated to know the process of PIVKA II production during a liver allograft rejection. Human recombinant interleukin-6 (IL-6) significantly stimulated the PIVKA II synthesis without any influence on the cell proliferation. The effect was almost completely neutralized by the specific anti-IL-6 antibody. Neither tumor necrosis factor (TNF), interleukin-1 (IL-1) nor interferon-gamma (IFN-gamma) had such a stimulative effect. IL-6 appears to stimulate PIVKA II production, and would be a candidate of factors that enhance the production of PIVKA II during a liver allograft rejection.
- Published
- 1992
- Full Text
- View/download PDF