1. Peptic Ulcer Disease in Living Liver Donors: A Longitudinal Population-Based Study.
- Author
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Lin SY, Lin CL, Liu YL, Hsu WH, Lin CC, Wang IK, Jeng LB, and Kao CH
- Subjects
- Adult, Comorbidity, Female, Follow-Up Studies, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Peptic Ulcer etiology, Prognosis, Taiwan epidemiology, Hepatectomy adverse effects, Liver Transplantation, Living Donors statistics & numerical data, Peptic Ulcer epidemiology
- Abstract
The objective of this nationwide cohort study was to investigate the risk of peptic ulcer disease (PUD) in living liver donors (LDs). A total of 1333 LDs and 5332 matched nondonors were identified during 2003-2011. Hospitalized patients identified as LDs were assigned to the LD cohort, and the non-LD comparison cohort comprised age- and sex-matched nondonors. Cumulative incidences and hazard ratios (HRs) were calculated. The overall incidence of PUD was 1.74-fold higher in the LD cohort than in the non-LD cohort (2.14 vs. 1.48 per 1000 person-years). After adjustment for age, sex, monthly income and comorbidities, we determined that the LD cohort exhibited a higher risk of PUD than did the non-LD cohort (adjusted HR 1.74, 95% confidence interval [CI] 1.45-2.09). The incidence of PUD increased with age; the risk of PUD was 2.53-fold higher in patients aged ≥35 years (95% CI 2.14-2.99) than in those aged ≤34 years. LDs with comorbidities of osteopathies, chondropathies and acquired musculoskeletal deformities exhibited a higher risk of PUD (adjusted HR 3.93, 95% CI 2.64-5.86) compared with those without these comorbidities. LDs are associated with an increased risk of PUD after hepatectomy., (© Copyright 2016 The American Society of Transplantation and the American Society of Transplant Surgeons.)
- Published
- 2016
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