1. Predicting β-turns in protein using kernel logistic regression.
- Author
-
Elbashir MK, Sheng Y, Wang J, Wu F, and Li M
- Subjects
- Computational Biology methods, Databases, Protein, Neural Networks, Computer, Probability, Reproducibility of Results, Software, Support Vector Machine, Logistic Models, Protein Structure, Secondary, Proteins chemistry
- Abstract
A β-turn is a secondary protein structure type that plays a significant role in protein configuration and function. On average 25% of amino acids in protein structures are located in β-turns. It is very important to develope an accurate and efficient method for β-turns prediction. Most of the current successful β-turns prediction methods use support vector machines (SVMs) or neural networks (NNs). The kernel logistic regression (KLR) is a powerful classification technique that has been applied successfully in many classification problems. However, it is often not found in β-turns classification, mainly because it is computationally expensive. In this paper, we used KLR to obtain sparse β-turns prediction in short evolution time. Secondary structure information and position-specific scoring matrices (PSSMs) are utilized as input features. We achieved Q total of 80.7% and MCC of 50% on BT426 dataset. These results show that KLR method with the right algorithm can yield performance equivalent to or even better than NNs and SVMs in β-turns prediction. In addition, KLR yields probabilistic outcome and has a well-defined extension to multiclass case.
- Published
- 2013
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