1. Risk factors associated with bacteremia in COVID-19 patients admitted to intensive care unit: a retrospective multicenter cohort study.
- Author
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Bonazzetti, Cecilia, Rinaldi, Matteo, Giacomelli, Andrea, Colombo, Riccardo, Ottolina, Davide, Rimoldi, Sara Giordana, Pagani, Cristina, Morena, Valentina, Ridolfo, Anna Lisa, Vatamanu, Oana, Giacomini, Maria Eugenia, Campoli, Caterina, Oreni, Letizia, Rizzardini, Giuliano, Viale, Pierluigi, Antinori, Spinello, and Giannella, Maddalena
- Subjects
BACTEREMIA ,INTENSIVE care units ,RESEARCH ,LENGTH of stay in hospitals ,COVID-19 ,SCIENTIFIC observation ,CONFIDENCE intervals ,STEROIDS ,TOCILIZUMAB ,SUPERINFECTION ,CROSS infection ,RETROSPECTIVE studies ,TREATMENT duration ,RISK assessment ,HOSPITAL mortality ,HOSPITAL care ,QUESTIONNAIRES ,RESEARCH funding ,DESCRIPTIVE statistics ,IMMUNOSUPPRESSIVE agents ,LONGITUDINAL method ,DISEASE risk factors - Abstract
Purpose: This multicenter observational study was done to evaluate risk factors related to the development of BSI in patients admitted to ICU for COVID-19. Methods: All patients with COVID-19 admitted in two COVID-19 dedicated ICUs in two different hospital between 02–2020 and 02–2021 were recruited. Result: 537 patients were included of whom 265 (49.3%) experienced at least one BSI. Patients who developed bacteremia had a higher SOFA score [10 (8–12) vs 9 (7–10), p < 0.001], had been intubated more frequently [95.8% vs 75%, p < 0.001] and for a median longer time [16 days (9–25) vs 8 days (5–14), p < 0.001]. Patients with BSI had a median longer ICU stay [18 days (12–31.5) vs 9 days (5–15), p < 0.001] and higher mortality [54% vs 42.3%, p < 0.001] than those who did not develop it. Development of BSI resulted in a higher SOFA score [aHR 1.08 (95% CI 1.03–1.12)] and a higher Charlson score [csAHR 1.15 (95% CI 1.05–1.25)]. Conclusion: A high SOFA score and a high Charlson score resulted associated with BSI's development. Conversely, immunosuppressive therapy like steroids and tocilizumab, has no role in increasing the risk of bacteremia. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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