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A low-noise and -power readout integrated circuit (IC) for two-electrode electrocardiogram (ECG) recording is developed in this study using a common-mode charge pump (CMCP) for a robust 20-VPP common-mode interference (CMI). Two-electrode ECG recording offers more comfort than three-electrode ECG recording. Contrasting to the three-electrode ECG recording, the two-electrode ECG recording is affected by CMI during measurements; the intervention of a large CMI will distort the ECG signal measurement. To achieve robustness for the CMI, the proposed ECG readout IC adopts CMCP—it uses switched capacitors that store and subtract CMI by control logic. In this paper, a window comparator structure is applied to CMCP to obtain a signal with less distortion. The window voltage ranges were set between the input common-mode ranges in which IA can operate. Therefore, a signal with less distortion was obtained by stopping the operation of CMCP between the window voltage ranges. It also reduced additional current consumption. To achieve this, the proposed circuit is implemented using a chopper stabilization technique. The chopper implemented in the amplifier can reduce low-frequency noise components, such as 1/f noise, and it comprises a CMCP, current feedback instrumentation amplifier, QRS peak detector, relaxation oscillator, voltage reference, timing generator, and serial peripheral interface on a single chip. The proposed circuit was designed using a standard 0.18 μm CMOS process with an active area of 0.54 mm2. The proposed CMCP achieves a CMI robustness of 20 VPP at 60 Hz. The measured input-referred noise level was 119 nV/√Hz at 1 Hz, and the power consumption was 23.83 μW with a 1.8 V power supply. [ABSTRACT FROM AUTHOR]

This paper presents a potentiostat readout circuit with low-noise and mismatch-tolerant current mirror using chopper stabilization and dynamic element matching (DEM) for electrochemical sensors. Current-mode electrochemical sensors are widely used to detect the blood glucose and viruses in the diagnosis of various diseases such as diabetes, hyperlipidemia, and the H5N1 avian influenza virus (AIV). Low-noise and mismatch-tolerant characteristics are essential for sensing applications that require high reliability and high sensitivity. To achieve these characteristics, a proposed potentiostat readout circuit is implemented using the chopper stabilization scheme and the DEM technique. The proposed potentiostat readout circuit consists of a chopper-stabilized programmable gain transimpedance amplifier (TIA), gain-boosted cascode current mirror, and a control amplifier (CA). The chopper scheme, which is implemented in the TIA and CA, can reduce low frequency noise components, such as 1/f noise, and can obtain low-noise levels. The mismatch offsets of the cascode current mirror can be reduced by the DEM operation. The proposed current-mirror-based potentiostat readout circuit is designed using a standard 0.18 μm CMOS process and can measure the sensor current from 350 nA to 2.8 μA. The input-referred noise integrated from 0.1 Hz to 1 kHz is 21.7 pARMS, and the power consumption was 287.9 μW with a 1.8 V power supply. [ABSTRACT FROM AUTHOR]

In this paper, a low-power and low-noise readout circuit for resistive-bridge microsensors is presented. The chopper-stabilized, recycling folded cascode current-feedback instrumentation amplifier (IA) is proposed to achieve the low-power, low-noise, and high-input impedance. The chopper-stabilized, recycling folded cascode topology (with a Monticelli-style, class-AB output stage) can enhance the overall noise characteristic, gain, and slew rate. The readout circuit consists of a chopper-stabilized, recycling folded cascode IA, low-pass filter (LPF), ADC driving buffer, and 12-bit successive-approximation-register (SAR) analog-to-digital converter (ADC). The prototype readout circuit is implemented in a standard 0.18 µm CMOS process, with an active area of 12.5 mm2. The measured input-referred noise at 1 Hz is 86.6 nV/√Hz and the noise efficiency factor (NEF) is 4.94, respectively. The total current consumption is 2.23 μA, with a 1.8 V power supply. [ABSTRACT FROM AUTHOR]