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Start Over Author "Bruna Soley" Topic loxosceles
2 results on '"Bruna Soley"'

1. TCTP from Loxosceles Intermedia (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism

Author

Marianna Boia-Ferreira, Kamila G. Moreno, Alana B. C. Basílio, Lucas P. da Silva, Larissa Vuitika, Bruna Soley, Ana Carolina M. Wille, Lucélia Donatti, Katia C. Barbaro, Olga M. Chaim, Luiza Helena Gremski, Silvio S. Veiga, and Andrea Senff-Ribeiro

Subjects
loxosceles, brown spider, tctp, venom, toxin, hrf, Cytology, QH573-671
Abstract

LiTCTP is a toxin from the Translationally Controlled Tumor Protein (TCTP) family identified in Loxosceles brown spider venoms. These proteins are known as histamine-releasing factors (HRF). TCTPs participate in allergic and anaphylactic reactions, which suggest their potential role as therapeutic targets. The histaminergic effect of TCTP is related to its pro-inflammatory functions. An initial characterization of LiTCTP in animal models showed that this toxin can increase the microvascular permeability of skin vessels and induce paw edema in a dose-dependent manner. We evaluated the role of LiTCTP in vitro and in vivo in the inflammatory and allergic aspects that undergo the biological responses observed in Loxoscelism, the clinical condition after an accident with Loxosceles spiders. Our results showed LiTCTP recombinant toxin (LiRecTCTP) as an essential synergistic factor for the dermonecrotic toxin actions (LiRecDT1, known as the main toxin in the pathophysiology of Loxoscelism), revealing its contribution to the exacerbated inflammatory response clinically observed in envenomated patients.

Published
2019
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2. TCTP from

Author

Marianna, Boia-Ferreira, Kamila G, Moreno, Alana B C, Basílio, Lucas P, da Silva, Larissa, Vuitika, Bruna, Soley, Ana Carolina M, Wille, Lucélia, Donatti, Katia C, Barbaro, Olga M, Chaim, Luiza Helena, Gremski, Silvio S, Veiga, and Andrea, Senff-Ribeiro

Subjects
Spider Venoms, venom, Promethazine, Skin Diseases, TCTP, Article, Mice, Piperidines, Cromolyn Sodium, Biomarkers, Tumor, Hypersensitivity, Tumor Cells, Cultured, Animals, Mast Cells, toxin, Inflammation, Dose-Response Relationship, Drug, Phosphoric Diester Hydrolases, Tumor Protein, Translationally-Controlled 1, brown spider, Rats, Injections, Intravenous, HRF, Rabbits, Cimetidine, Loxosceles, Injections, Intraperitoneal
Abstract

LiTCTP is a toxin from the Translationally Controlled Tumor Protein (TCTP) family identified in Loxosceles brown spider venoms. These proteins are known as histamine-releasing factors (HRF). TCTPs participate in allergic and anaphylactic reactions, which suggest their potential role as therapeutic targets. The histaminergic effect of TCTP is related to its pro-inflammatory functions. An initial characterization of LiTCTP in animal models showed that this toxin can increase the microvascular permeability of skin vessels and induce paw edema in a dose-dependent manner. We evaluated the role of LiTCTP in vitro and in vivo in the inflammatory and allergic aspects that undergo the biological responses observed in Loxoscelism, the clinical condition after an accident with Loxosceles spiders. Our results showed LiTCTP recombinant toxin (LiRecTCTP) as an essential synergistic factor for the dermonecrotic toxin actions (LiRecDT1, known as the main toxin in the pathophysiology of Loxoscelism), revealing its contribution to the exacerbated inflammatory response clinically observed in envenomated patients.

Published
2019

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