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The aim of this study was to evaluate how referrals from Norwegian general practitioners for plain radiography of the lumbosacral spine conform to clinical recommendations. The clinical information given in 274 referral letters was compared with Norwegian and British recommendations. We also interviewed 99 of the patients about symptoms and prior radiographs, and performed a new comparison using all available information. Only 27% (43%) of the 274 referrals conformed to the Norwegian (British) recommendations, 36% (41%) did not conform, and 37% (16%) were considered uncertain, mainly because of lack of pertinent information in the referral letters. Of 143 referrals which were in disagreement with the Norwegian and/or the British recommendations, only four resulted in "important" findings (osteoporotic fractures in two patients, uncertain sacroiliac joint arthritis in one patient, and probably benign bony sclerosis in one patient). In the interview group, the proportion of non-conforming referrals decreased from 40% (47%) to 31% (29%) when the additional clinical information was considered. Nevertheless, we conclude that a substantial proportion of referrals for plain radiography of the lumbosacral spine do not conform to clinical recommendations. Referrals outside the advised criteria yield few relevant findings and could probably be cancelled.

Purpose: To evaluate how referrals from Norwegian general practitioners for plain radiography of the lumbosacral spine conform to clinical recommendations, and whether non-conforming referrals yield important findings., Material and Methods: The clinical information reported in referral letters of 323 patients was compared with recommendations given in a Norwegian and in a British "guide". Additional clinical data were obtained by interviewing 100 of the patients. Using all available information, a new comparison was performed. Radiological findings were obtained from the routine reports., Results: Of the 323 referrals, 24% (37%) conformed to the Norwegian (British) "guide", 34% (46%) did not conform, and 42% (18%) were considered uncertain, mainly because of lack of pertinent information in the referral letters. A total of 182 examinations were in disagreement with one or both "guides". Only 4 of these examinations revealed potentially important findings (osteoporotic fractures in 2 patients, uncertain sacroiliac joint arthritis in 1 patient, and "probably benign" sclerotic densities in 1 patient). In the interview group, the proportion of non-conforming referrals was 40% (48%) based on the referral letters, and 31% (30%) when the interview data were taken into account., Conclusion: A great proportion of referrals for plain radiography of the lumbosacral spine do not conform to recent clinical recommendations. Referrals outside the advised criteria yield few relevant findings and could probably be cancelled. They require at least supplementary information to justify radiography.

In this study, interobserver and intraobserver variations in the interpretation of plain radiographs of the lumbosacral spine were evaluated. Three radiologists independently interpreted the radiographs from 200 consecutive outpatients, aged 13-93 years, mostly referred from general practitioners. Interobserver agreement was best for vertebral fractures, osteopenia, spondylolisthesis at L5-S1, lumbosacral junctional vertebra, reduced disc height at L4-S1 and osteophytes at L2-S1 (kappa 0.61-0.95), and poorest for spina bifida of S1, degenerative spondylolisthesis and facet joint arthrosis at T12-L4, sacroiliac joint arthrosis, narrow central spinal canal, film quality, and for decisions concerning evaluation of facet joints and spinal canal (kappa < 0.34). For several diagnoses, the number of abnormal findings differed significantly between observers (p < 0.05, McNemar's test), indicating different diagnostic thresholds. Intraobserver agreement in 36 reevaluated patients was fair to excellent for almost all variables (kappa > 0.46). Although some diagnoses related to low back pain were quite consistently evaluated, the substantial disagreement on many findings should alert clinicians and radiologists against overestimating the validity and usefulness of the examinations. To improve diagnostic consistency, it is important to reduce variation caused by different thresholds for abnormality.

We studied 180 adult patients admitted to the Neurological Department, Haukeland Hospital in Bergen, Norway, for a period of 5 years from 1984 to 1988. One hundred fifty-seven patients were followed up 3.9-9.0 years after admittance to the Neurological Department. The purpose of this study was to find out if the total cerebrospinal fluid (CSF) protein concentration could predict the outcome of lumbar disc surgery or conservative treatment in patients with sciatica. Neurologic and radiologic parameters were also included in the investigation. The increase of the CSF total protein concentration in sciatica without spinal block is assumed to be due to leak of plasma proteins into the CSF from the nerve root. A relationship between CSF protein concentrations and certain clinical parameters has been found. At myelography, 10 ml of CSF was collected for analysis. The patients were evaluated for involvement of the nerve root and/or the dural sac, respectively. The neurologic parameters investigated were: straight leg raising tests, paresis, disturbances of sensibility, and altered reflexes. At follow-up, the patients were asked to fill in questionnaires concerning job function, sick leave or disability pension, subjective physical disability and pain perception, and a clinical examination with the same neurologic parameters was performed. Elevated CSF total protein concentration was related to chronic leg pain, leg pain, and subjective physical disability at follow-up. Nonoperated women reported higher subjective physical disability scores and were more often on sick-leave or disability pension than were men at follow-up. Lateral prolapses were associated with good job function outcome and less risk for sick-leave or disability pension. Reduced lower extremity reflexes, laterally located disc herniation and elevated CSF total protein concentration were associated with a favorable long-term outcome in patients with sciatica. CSF proteins as objective measures on nerve root injury are discussed. CSF total protein concentration can be regarded as an indicator of the functional status of the nerve root and a prognostic factor in patients with sciatica.

The protein concentration in the cerebrospinal fluid (CSF) is often increased in patients with sciatica, probably due to leaking of plasma proteins through the blood-nerve root barrier into CSF. Positive straight leg raising test, paresis, altered sensibility, reduced reflexes, and type of treatment were related to the CSF protein concentrations in 180 patients with sciatica caused by verified lumbar disk herniation. Significantly higher values of the CSF/serum albumin ratio and the CSF/serum immunoglobulin G ratio were found both in patients with positive straight leg raising test results and paresis compared with patients with no clinical findings. In the patients who had undergone emergency surgery, the same ratio parameters were significantly higher when compared with those who had undergone routine surgery and those had not undergone surgery. Elevated CSF proteins seem to be important indicators of the functional status of the nerve root and a measure of the degree of seriousness of sciatica. The interaction of smoking on CSF proteins was also studied.

We carried out a study of cerebrospinal fluid (CSF) proteins in 180 patients with sciatica caused by lumbar disc herniation to elucidate further the degree and mechanisms of protein elevations. The 63 controls were patients with tension headache or migraine without aura. The CSF/serum albumin ratios were higher in the patients (mean 8.84, SD 5.16) than in the controls (mean 5.60, SD 2.33). Similar differences were found for the CSF/serum IgG ratios and the CSF-total proteins. The CSF/serum albumin ratios, CSF/serum IgG ratios and the CSF-total protein concentrations were higher in men than in women among the patients. We suggest that the significant difference in ratio parameters between patients and controls indicates a leak of plasma albumin, most likely IgG, into the CSF in patients with sciatica. The leak was more pronounced in men. Also in the control group the CSF/serum albumin and CSF/serum IgG ratios were higher in men.

The transverse and sagittal diameters of the lumbar vertebral bodies have been compared in patients with symptoms and myelographic findings consistent with stenosis of the lumbar canal, in patients with some narrowing of the lumbar canal, and in patients without clinical or myelographic indication of stenosis. No significant difference in the measured diameters was found.

The degree of concavity (ie, the scalloping) on the posterior surface of the lumbar vertebral bodies has been evaluated quantitatively by means of a simple measuring device. The scalloping in the median sagittal plane was found to differ from that in the lateral plane, near the pedicular attachments. In the medial plane, an increase in scalloping from L1-L4 was noted, with a subsequent decrease at L5. Laterally, the concavity deepened from L1-L5, the values here being larger than those medially at all levels. The results are discussed with respect to the anatomy of the dural sac and its contents, and the spinal nerves. Scalloping in the lateral sagittal plane is, especially at the fourth and the fifth lumbar levels, presumed to be caused mainly by pressure exerted by the spinal nerves. The medial scalloping is presumed to be partially due to hydrostatic pressure of the cerebrospinal fluid in the dural sac. This pressure will, at the edges of the superior and inferior end-plates, be counteracted by the tractional stresses of the fibers of the discal annulus fibrosus that are inserted at the vertebral margins. This effect contributes to the final shape of the vertebral bodies. The posterior vertebral surface constitutes part of the anterior wall of spinal canal. Therefore its shape has relevance in cases of spinal stenosis, and some aspects of this relationship are discussed.