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Your search keyword '"Arthur W. E. Lieveld"' showing total 3 results
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3 results on '"Arthur W. E. Lieveld"'

1. Correlation between Serum Biomarkers and Lung Ultrasound in COVID-19: An Observational Study

Author

Amne Mousa, Siebe G. Blok, Dian Karssen, Jurjan Aman, Jouke T. Annema, Harm Jan Bogaard, Peter I. Bonta, Mark E. Haaksma, Micah L. A. Heldeweg, Arthur W. E. Lieveld, Prabath Nanayakkara, Esther J. Nossent, Jasper M. Smit, Marry R. Smit, Alexander P. J. Vlaar, Marcus J. Schultz, Lieuwe D. J. Bos, Frederique Paulus, Pieter R. Tuinman, and Amsterdam UMC COVID-19 Biobank Investigators

Subjects
lung, ultrasonography, epithelial injury, endothelial dysfunction, immune activation, respiratory failure, Medicine (General), R5-920
Abstract

Serum biomarkers and lung ultrasound are important measures for prognostication and treatment allocation in patients with COVID-19. Currently, there is a paucity of studies investigating relationships between serum biomarkers and ultrasonographic biomarkers derived from lung ultrasound. This study aims to assess correlations between serum biomarkers and lung ultrasound findings. This study is a secondary analysis of four prospective observational studies in adult patients with COVID-19. Serum biomarkers included markers of epithelial injury, endothelial dysfunction and immune activation. The primary outcome was the correlation between biomarker concentrations and lung ultrasound score assessed with Pearson’s (r) or Spearman’s (rs) correlations. Forty-four patients (67 [41–88] years old, 25% female, 52% ICU patients) were included. GAS6 (rs = 0.39), CRP (rs = 0.42) and SP-D (rs = 0.36) were correlated with lung ultrasound scores. ANG-1 (rs = −0.39) was inversely correlated with lung ultrasound scores. No correlations were found between lung ultrasound score and several other serum biomarkers. In patients with COVID-19, several serum biomarkers of epithelial injury, endothelial dysfunction and immune activation correlated with lung ultrasound findings. The lack of correlations with certain biomarkers could offer opportunities for precise prognostication and targeted therapeutic interventions by integrating these unlinked biomarkers.

Published
2024
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2. Comparing lung ultrasound: Extensive versus short in COVID-19 (CLUES): A multicentre, observational study at the emergency department

Author

Prabath W. B. Nanayakkara, Kaoutar Azijli, Arthur W E Lieveld, Frank H. Bosch, Bram Kok, Frederik H Schuit, VU University medical center, Surgery, Internal medicine, APH - Quality of Care, APH - Digital Health, and ACS - Diabetes & metabolism

Subjects
Adult, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), thoracic medicine, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Internal medicine, medicine, Humans, Prospective Studies, Prospective cohort study, Trial registration, Lung, Ultrasonography, ultrasound, SARS-CoV-2, business.industry, Radiology and Imaging, COVID-19, General Medicine, Emergency department, medicine.disease, Lung ultrasound, Pneumonia, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Medicine, Observational study, Emergency Service, Hospital, business
Abstract

BackgroundBedside lung ultrasound (LUS) is an affordable diagnostic tool that could contribute to identifying COVID-19 pneumonia. Different LUS protocols are currently used at the emergency department (ED) and there is a need to know their diagnostic accuracy.DesignA multicentre, prospective, observational study, to compare the diagnostic accuracy of three commonly used LUS protocols in identifying COVID-19 pneumonia at the ED.Setting/patientsAdult patients with suspected COVID-19 at the ED, in whom we prospectively performed 12-zone LUS and SARS-CoV-2 reverse transcription PCR.MeasurementsWe assessed diagnostic accuracy for three different ultrasound protocols using both PCR and final diagnosis as a reference standard.ResultsBetween 19 March 2020 and 4 May 2020, 202 patients were included. Sensitivity, specificity and negative predictive value compared with PCR for 12-zone LUS were 91.4% (95% CI 84.4 to 96.0), 83.5% (95% CI 74.6 to 90.3) and 90.0% (95% CI 82.7 to 94.4). For 8-zone and 6-zone protocols, these results were 79.7 (95% CI 69.9 to 87.6), 69.0% (95% CI 59.6 to 77.4) and 81.3% (95% CI 73.8 to 87.0) versus 89.9% (95% CI 81.7 to 95.3), 57.5% (95% CI 47.9 to 66.8) and 87.8% (95% CI 79.2 to 93.2). Negative likelihood ratios for 12, 8 and 6 zones were 0.1, 0.3 and 0.2, respectively. Compared with the final diagnosis specificity increased to 83.5% (95% CI 74.6 to 90.3), 78.4% (95% CI 68.8 to 86.1) and 65.0% (95% CI 54.6 to 74.4), respectively, while the negative likelihood ratios were 0.1, 0.2 and 0.16.ConclusionIdentifying COVID-19 pneumonia at the ED can be aided by bedside LUS. The more efficient 6-zone protocol is an excellent screening tool, while the 12-zone protocol is more specific and gives a general impression on lung involvement.Trial registration numberNL8497.

Published
2021
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3. [Lung ultrasound in patients with symptoms of covid-19]

Author

Natascha L, Assman, Bram, Kok, Arjan, van Laarhoven, Arthur W E, Lieveld, Frederik H, Schuit, and Frank H, Bosch

Subjects
SARS-CoV-2, COVID-19, Humans, Lung, Pandemics, Ultrasonography
Abstract

The SARS-CoV-2 pandemic presents a challenge for healthcare worldwide. In this context, rapid, correct diagnosis and early isolation of infected persons is of great importance. Pneumonia as an expression of COVID-19 is responsible for the most part of morbidity and mortality. Lung ultrasound can provide valuable information about the diagnosis of a COVID-19 pneumonia in daily practice. A normal ultrasound excludes COVID-19 pneumonia. Conversely, finding abnormalities matching with a COVID-19 pneumonia can be useful for isolation policy. Follow up lung ultrasound visualizes the development of the pneumonia and a possible alternative diagnosis can thereby be determined in the event of a deviating clinical course.

Published
2021

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