1. Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease.
- Author
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Nasri A, Foisset F, Ahmed E, Lahmar Z, Vachier I, Jorgensen C, Assou S, Bourdin A, and De Vos J
- Subjects
- Airway Remodeling genetics, Cell Differentiation genetics, Epithelial-Mesenchymal Transition genetics, Epithelium growth & development, Epithelium metabolism, Epithelium pathology, Humans, Lung metabolism, Lung pathology, Mesenchymal Stem Cells cytology, Pulmonary Disease, Chronic Obstructive pathology, Respiratory Mucosa growth & development, Respiratory Mucosa metabolism, Lung growth & development, Mesenchymal Stem Cells metabolism, Organogenesis genetics, Pulmonary Disease, Chronic Obstructive genetics
- Abstract
Mesenchymal cells are an essential cell type because of their role in tissue support, their multilineage differentiation capacities and their potential clinical applications. They play a crucial role during lung development by interacting with airway epithelium, and also during lung regeneration and remodeling after injury. However, much less is known about their function in lung disease. In this review, we discuss the origins of mesenchymal cells during lung development, their crosstalk with the epithelium, and their role in lung diseases, particularly in chronic obstructive pulmonary disease.
- Published
- 2021
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