156 results on '"Boffetta, Paolo"'
Search Results
2. Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study
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Brenner, Darren R, Fehringer, Gord, Zhang, Zuo-Feng, Lee, Yuan-Chin Amy, Meyers, Travis, Matsuo, Keitaro, Ito, Hidemi, Vineis, Paolo, Stucker, Isabelle, Boffetta, Paolo, Brennan, Paul, Christiani, David C, Diao, Nancy, Hong, Yun-Chul, Landi, Maria T, Morgenstern, Hal, Schwartz, Ann G, Rennert, Gad, Saliba, Walid, McLaughlin, John R, Harris, Curtis C, Orlow, Irene, Dios, Juan M Barros, Raviña, Alberto Ruano, Siemiatycki, Jack, Koushik, Anita, Cote, Michele, Lazarus, Philip, Fernandez-Tardon, Guillermo, Tardon, Adonina, Le Marchand, Loïc, Brenner, Hermann, Saum, Kai-Uwe, Duell, Eric J, Andrew, Angeline S, Consonni, Dario, Olsson, Ann, Hung, Rayjean J, and Straif, Kurt
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Biomedical and Clinical Sciences ,Epidemiology ,Health Sciences ,Public Health ,Oncology and Carcinogenesis ,Cancer ,Alcoholism ,Alcohol Use and Health ,Lung Cancer ,Lung ,Prevention ,Substance Misuse ,2.2 Factors relating to the physical environment ,Aetiology ,Stroke ,Good Health and Well Being ,Adenocarcinoma ,Aged ,Alcohol Drinking ,Alcoholic Beverages ,Carcinoma ,Squamous Cell ,Case-Control Studies ,Cohort Studies ,Female ,Humans ,Lung Neoplasms ,Male ,Middle Aged ,Odds Ratio ,Risk Factors ,Surveys and Questionnaires ,Alcohol ,Lung cancer ,Pooled analysis ,Public Health and Health Services ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
BackgroundThere is inadequate evidence to determine whether there is an effect of alcohol consumption on lung cancer risk. We conducted a pooled analysis of data from the International Lung Cancer Consortium and the SYNERGY study to investigate this possible association by type of beverage with adjustment for other potential confounders.MethodsTwenty one case-control studies and one cohort study with alcohol-intake data obtained from questionnaires were included in this pooled analysis (19,149 cases and 362,340 controls). Adjusted odds ratios (OR) or hazard ratios (HR) with corresponding 95% confidence intervals (CI) were estimated for each measure of alcohol consumption. Effect estimates were combined using random or fixed-effects models where appropriate. Associations were examined for overall lung cancer and by histological type.ResultsWe observed an inverse association between overall risk of lung cancer and consumption of alcoholic beverages compared to non-drinkers, but the association was not monotonic. The lowest risk was observed for persons who consumed 10-19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95% CI: 0.67, 0.91), where 1 drink is approximately 12-15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). The association with all lung cancer varied little by type of alcoholic beverage, but there were notable differences for SCC. We observed an association with beer intake (OR for ≥20 g/day vs nondrinker = 1.42; 95% CI: 1.06, 1.90).ConclusionsWhether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms.
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- 2019
3. Epidemiology of Occupational Lung Cancer
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Malhotra, Jyoti, Boffetta, Paolo, Anttila, Sisko, editor, and Boffetta, Paolo, editor
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- 2020
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4. Exposure to second-hand smoke and risk of lung cancer among Iranian population: A multicenter case-control study.
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Lotfi, Fereshte, Rashidian, Hamideh, Hadji, Maryam, Mohebbi, Elham, Marzban, Maryam, Naghibzadeh-Tahami, Ahmad, Pukkala, Eero, Boffetta, Paolo, Etemadi, Arash, and Zendehdel, Kazem
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LUNG cancer ,IRANIANS ,DISEASE risk factors ,PASSIVE smoking ,TOBACCO smoke ,SMOKING statistics - Abstract
Objective: Despite the implementation of the WHO Framework Convention on Tobacco Control (FCTC) program in Iran, the regulation of second-hand smoke (SHS) exposure—an often-overlooked hazard—, still requires improvement. We employed a multi-center case-control study to investigate the association between exposure to secondhand smoke (SHS) from various tobacco products (cigarettes, water-pipes, pipes, and chopogh), opium use, and the risk of lung cancer. Method: We included 627 lung cancer cases and 3477 controls. Exposure to SHS tobacco and SHS opium was collected through a questionnaire. We used mixed-model logistic regressions to estimate odds ratios (ORs) and 95% confidence intervals (CI). Result: Among the overall population exposed to second-hand tobacco smoke (SHTS), the odds ratio (OR) compared to those never exposed was 1.35 (95% CI: 1.08–1.71). Never smokers who were ever exposed to second-hand tobacco smoke (SHTS) had 1.69-fold risk of lung cancer compared to those who were never exposed (95% CI: 1.13–2.52). Exposure to SHTS between 2–3 per day (OR = 2.27, 95% CI: 1.13–4.53) and more than three hours per day (OR = 2.29, 95% CI: 1.20–4.37) can increase the risk of lung cancer compared with the no exposure group (P-trend <0.01). We did not observe any association between exposure to second-hand opium smoke (SHOS) and the risk of lung cancer, either in the overall population or among never-smokers. Conclusion: Our study estimates the impact of second-hand tobacco smoke (SHTS) on lung cancer risk in both the overall population and never-smokers. Additional studies are required to evaluate the association between exposure to second-hand smoke from opium and other type of tobacco, including water-pipe and the risk of lung cancer. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study
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Fehringer, Gordon, Brenner, Darren R, Zhang, Zuo‐Feng, Lee, Yuan‐Chin Amy, Matsuo, Keitaro, Ito, Hidemi, Lan, Qing, Vineis, Paolo, Johansson, Mattias, Overvad, Kim, Riboli, Elio, Trichopoulou, Antonia, Sacerdote, Carlotta, Stucker, Isabelle, Boffetta, Paolo, Brennan, Paul, Christiani, David C, Hong, Yun‐Chul, Landi, Maria Teresa, Morgenstern, Hal, Schwartz, Ann G, Wenzlaff, Angela S, Rennert, Gad, McLaughlin, John R, Harris, Curtis C, Olivo‐Marston, Susan, Orlow, Irene, Park, Bernard J, Zauderer, Marjorie, Dios, Juan M Barros, Raviña, Alberto Ruano, Siemiatycki, Jack, Koushik, Anita, Lazarus, Philip, Fernández‐Somoano, Ana, Tardon, Adonina, Le Marchand, Loic, Brenner, Hermann, Saum, Kai‐Uwe, Duell, Eric J, Andrew, Angeline S, Szeszenia‐Dabrowska, Neonila, Lissowska, Jolanta, Zaridze, David, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Foretova, Lenka, Janout, Vladimir, Bencko, Vladimir, Holcatova, Ivana, Pesatori, Angela Cecilia, Consonni, Dario, Olsson, Ann, Straif, Kurt, and Hung, Rayjean J
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Lung ,Cancer ,Substance Misuse ,Tobacco ,Alcoholism ,Alcohol Use and Health ,Tobacco Smoke and Health ,Prevention ,Lung Cancer ,Cardiovascular ,Stroke ,Respiratory ,Good Health and Well Being ,Aged ,Alcohol Drinking ,Alcoholic Beverages ,Asia ,Case-Control Studies ,Cohort Studies ,Europe ,Female ,Humans ,Lung Neoplasms ,Male ,Middle Aged ,North America ,Risk Factors ,Smoking ,alcohol ,lung cancer ,wine ,beer ,liquor ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
It is not clear whether alcohol consumption is associated with lung cancer risk. The relationship is likely confounded by smoking, complicating the interpretation of previous studies. We examined the association of alcohol consumption and lung cancer risk in a large pooled international sample, minimizing potential confounding of tobacco consumption by restricting analyses to never smokers. Our study included 22 case-control and cohort studies with a total of 2548 never-smoking lung cancer patients and 9362 never-smoking controls from North America, Europe and Asia within the International Lung Cancer Consortium (ILCCO) and SYNERGY Consortium. Alcohol consumption was categorized into amounts consumed (grams per day) and also modelled as a continuous variable using restricted cubic splines for potential non-linearity. Analyses by histologic sub-type were included. Associations by type of alcohol consumed (wine, beer and liquor) were also investigated. Alcohol consumption was inversely associated with lung cancer risk with evidence most strongly supporting lower risk for light and moderate drinkers relative to non-drinkers (>0-4.9 g per day: OR = 0.80, 95% CI = 0.70-0.90; 5-9.9 g per day: OR = 0.82, 95% CI = 0.69-0.99; 10-19.9 g per day: OR = 0.79, 95% CI = 0.65-0.96). Inverse associations were found for consumption of wine and liquor, but not beer. The results indicate that alcohol consumption is inversely associated with lung cancer risk, particularly among subjects with low to moderate consumption levels, and among wine and liquor drinkers, but not beer drinkers. Although our results should have no relevant bias from the confounding effect of smoking we cannot preclude that confounding by other factors contributed to the observed associations. Confounding in relation to the non-drinker reference category may be of particular importance.
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- 2017
6. Dietary quality using four dietary indices and lung cancer risk: the Golestan Cohort Study (GCS)
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Wang, Qian, Hashemian, Maryam, Sepanlou, Sadaf G., Sharafkhah, Maryam, Poustchi, Hossein, Khoshnia, Masoud, Gharavi, Abdolsamad, Pourshams, Akram, Malekshah, Akbar Fazeltabar, Kamangar, Farin, Etemadi, Arash, Abnet, Christian C., Dawsey, Sanford M., Malekzadeh, Reza, and Boffetta, Paolo
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- 2021
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7. Secondhand Tobacco Smoke Exposure and Lung Adenocarcinoma In Situ/Minimally Invasive Adenocarcinoma (AIS/MIA)
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Kim, Claire H, Lee, Yuan-Chin Amy, Hung, Rayjean J, Boffetta, Paolo, Xie, Dong, Wampfler, Jason A, Cote, Michele L, Chang, Shen-Chih, Ugolini, Donatella, Neri, Monica, Le Marchand, Loic, Schwartz, Ann G, Morgenstern, Hal, Christiani, David C, Yang, Ping, and Zhang, Zuo-Feng
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Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Lung ,Clinical Research ,Tobacco Smoke and Health ,Lung Cancer ,Cancer ,Tobacco ,Prevention ,Respiratory ,Good Health and Well Being ,Adenocarcinoma ,Adenocarcinoma of Lung ,Aged ,Aged ,80 and over ,Case-Control Studies ,Female ,Humans ,Lung Neoplasms ,Male ,Middle Aged ,Risk Factors ,Tobacco Smoke Pollution ,Medical and Health Sciences ,Epidemiology ,Biomedical and clinical sciences ,Health sciences - Abstract
The aim of this study was to estimate the effect of exposure to secondhand tobacco smoke on the incidence of lung adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA). Data from seven case-control studies participating in the International Lung Cancer Consortium (ILCCO) were pooled, resulting in 625 cases of AIS/MIA and 7,403 controls, of whom 170 cases and 3,035 controls were never smokers. Unconditional logistic regression was used to estimate adjusted ORs (ORadj) and 95% confidence intervals (CI), controlling for age, sex, race, smoking status (ever/never), and pack-years of smoking. Study center was included in the models as a random-effects intercept term. Ever versus never exposure to secondhand tobacco smoke was positively associated with AIS/MIA incidence in all subjects (ORadj = 1.48; 95% CI, 1.14-1.93) and in never smokers (ORadj = 1.45; 95% CI, 1.00-2.12). There was, however, appreciable heterogeneity of ORadj across studies (P = 0.01), and the pooled estimates were largely influenced by one large study (40% of all cases and 30% of all controls). These findings provide weak evidence for an effect of secondhand tobacco smoke exposure on AIS/MIA incidence. Further studies are needed to assess the impact of secondhand tobacco smoke exposure using the newly recommended classification of subtypes of lung adenocarcinoma.
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- 2015
8. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
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Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, De Vivo, Immaculata, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John KC, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, and Davis, Faith G
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Tobacco ,Clinical Research ,Urologic Diseases ,Lung ,Genetics ,Rare Diseases ,Lung Cancer ,Human Genome ,Hematology ,Cancer ,Tobacco Smoke and Health ,Prevention ,Lymphoma ,Adult ,Aged ,Asian People ,Bone Neoplasms ,Female ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Kidney Neoplasms ,Leukemia ,Lymphocytic ,Chronic ,B-Cell ,Lung Neoplasms ,Lymphoma ,Large B-Cell ,Diffuse ,Male ,Middle Aged ,Neoplasms ,Osteosarcoma ,Polymorphism ,Single Nucleotide ,Smoking ,Testicular Neoplasms ,Tissue Array Analysis ,Urinary Bladder Neoplasms ,White People ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundStudies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.MethodsBetween 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.ResultsGWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.ConclusionOur results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
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- 2015
9. Occupational exposure to diesel exhausts and liver and pancreatic cancers: a systematic review and meta-analysis.
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Sassano, Michele, Collatuzzo, Giulia, Teglia, Federica, and Boffetta, Paolo
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LIVER cancer ,OCCUPATIONAL exposure ,PANCREATIC cancer ,LUNG cancer ,LUNGS ,RANDOM effects model ,CARCINOGENS - Abstract
Background: Diesel exhaust (DE) is human carcinogen with sufficient evidence only for lung cancer. Systematic evidence on other cancer types is scarce, thus we aimed to systematically review current literature on the association between occupational DE exposure and risk of liver and pancreatic cancers. Methods: We performed a systematic literature review to identify cohort studies on occupational DE exposure and risk of cancers other than lung. We computed pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) for liver and pancreatic cancers using DerSimonian and Laird random-effects model. Results: Fifteen studies reporting results on pancreatic cancer and fourteen on liver cancer were included. We found a weakly increased risk of pancreatic cancer in workers exposed to DE (RR: 1.07, 95% CI: 1.00, 1.14), mainly driven by results on incidence (RR: 1.11, 95% CI: 1.02, 1.22). As for liver cancer, results were suggestive of a positive association (RR: 1.09; 95% CI: 0.99, 1.19), although a significant estimate was present in studies published before 2000 (RR: 1.41; 95% CI: 1.09, 1.82). We found no compelling evidence of publication bias. Conclusions: Our findings suggest an association between occupational DE exposure and liver and pancreatic cancer. Further studies with detailed exposure assessment, environmental monitoring data, and appropriate control for confounders are warranted. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies.
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Wan, Wenxin, Peters, Susan, Portengen, Lützen, Olsson, Ann, Schüz, Joachim, Ahrens, Wolfgang, Schejbalova, Miriam, Boffetta, Paolo, Behrens, Thomas, Brüning, Thomas, Kendzia, Benjamin, Consonni, Dario, Demers, Paul A., Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John K., Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, and Gustavsson, Per
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OCCUPATIONAL exposure ,LUNG cancer ,DISEASE risk factors ,RISK assessment ,CASE-control method - Abstract
Rationale: Benzene has been classified as carcinogenic to humans, but there is limited evidence linking benzene exposure to lung cancer. Objectives: We aimed to examine the relationship between occupational benzene exposure and lung cancer. Methods: Subjects from 14 case-control studies across Europe and Canada were pooled. We used a quantitative job-exposure matrix to estimate benzene exposure. Logistic regression models assessed lung cancer risk across different exposure indices. We adjusted for smoking and five main occupational lung carcinogens and stratified analyses by smoking status and lung cancer subtypes. Measurements and Main Results: Analyses included 28,048 subjects (12,329 cases, 15,719 control subjects). Lung cancer odds ratios ranged from 1.12 (95% confidence interval, 1.03–1.22) to 1.32 (95% confidence interval, 1.18–1.48) (P
trend = 0.002) for groups with the lowest and highest cumulative occupational exposures, respectively, compared with unexposed subjects. We observed an increasing trend of lung cancer with longer duration of exposure (Ptrend < 0.001) and a decreasing trend with longer time since last exposure (Ptrend = 0.02). These effects were seen for all lung cancer subtypes, regardless of smoking status, and were not influenced by specific occupational groups, exposures, or studies. Conclusions: We found consistent and robust associations between different dimensions of occupational benzene exposure and lung cancer after adjusting for smoking and main occupational lung carcinogens. These associations were observed across different subgroups, including nonsmokers. Our findings support the hypothesis that occupational benzene exposure increases the risk of developing lung cancer. Consequently, there is a need to revisit published epidemiological and molecular data on the pulmonary carcinogenicity of benzene. [ABSTRACT FROM AUTHOR]- Published
- 2024
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11. Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls
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Brenner, Darren R, Brennan, Paul, Boffetta, Paolo, Amos, Christopher I, Spitz, Margaret R, Chen, Chu, Goodman, Gary, Heinrich, Joachim, Bickeböller, Heike, Rosenberger, Albert, Risch, Angela, Muley, Thomas, McLaughlin, John R, Benhamou, Simone, Bouchardy, Christine, Lewinger, Juan Pablo, Witte, John S, Chen, Gary, Bull, Shelley, and Hung, Rayjean J
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Biological Sciences ,Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Genetics ,Prevention ,Lung Cancer ,Human Genome ,Lung ,Cancer ,Aetiology ,2.1 Biological and endogenous factors ,Alleles ,Canada ,Case-Control Studies ,Europe ,Female ,Gene Frequency ,Genetic Predisposition to Disease ,Genetic Variation ,Genome-Wide Association Study ,Genotype ,Humans ,Inflammation ,Likelihood Functions ,Lung Neoplasms ,Male ,Middle Aged ,Models ,Statistical ,Polymorphism ,Single Nucleotide ,Risk ,United States ,White People ,Complementary and Alternative Medicine ,Paediatrics and Reproductive Medicine ,Genetics & Heredity ,Reproductive medicine - Abstract
Recent evidence suggests that inflammation plays a pivotal role in the development of lung cancer. In this study, we used a two-stage approach to investigate associations between genetic variants in inflammation pathways and lung cancer risk based on genome-wide association study (GWAS) data. A total of 7,650 sequence variants from 720 genes relevant to inflammation pathways were identified using keyword and pathway searches from Gene Cards and Gene Ontology databases. In Stage 1, six GWAS datasets from the International Lung Cancer Consortium were pooled (4,441 cases and 5,094 controls of European ancestry), and a hierarchical modeling (HM) approach was used to incorporate prior information for each of the variants into the analysis. The prior matrix was constructed using (1) role of genes in the inflammation and immune pathways; (2) physical properties of the variants including the location of the variants, their conservation scores and amino acid coding; (3) LD with other functional variants and (4) measures of heterogeneity across the studies. HM affected the priority ranking of variants particularly among those having low prior weights, imprecise estimates and/or heterogeneity across studies. In Stage 2, we used an independent NCI lung cancer GWAS study (5,699 cases and 5,818 controls) for in silico replication. We identified one novel variant at the level corrected for multiple comparisons (rs2741354 in EPHX2 at 8p21.1 with p value = 7.4 × 10(-6)), and confirmed the associations between TERT (rs2736100) and the HLA region and lung cancer risk. HM allows for prior knowledge such as from bioinformatic sources to be incorporated into the analysis systematically, and it represents a complementary analytical approach to the conventional GWAS analysis.
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- 2013
12. Previous Lung Diseases and Lung Cancer Risk: A Pooled Analysis From the International Lung Cancer Consortium
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Brenner, Darren R, Boffetta, Paolo, Duell, Eric J, Bickeböller, Heike, Rosenberger, Albert, McCormack, Valerie, Muscat, Joshua E, Yang, Ping, Wichmann, H-Erich, Brueske-Hohlfeld, Irene, Schwartz, Ann G, Cote, Michele L, Tjønneland, Anne, Friis, Søren, Le Marchand, Loic, Zhang, Zuo-Feng, Morgenstern, Hal, Szeszenia-Dabrowska, Neonila, Lissowska, Jolanta, Zaridze, David, Rudnai, Peter, Fabianova, Eleonora, Foretova, Lenka, Janout, Vladimir, Bencko, Vladimir, Schejbalova, Miriam, Brennan, Paul, Mates, Ioan N, Lazarus, Philip, Field, John K, Raji, Olaide, McLaughlin, John R, Liu, Geoffrey, Wiencke, John, Neri, Monica, Ugolini, Donatella, Andrew, Angeline S, Lan, Qing, Hu, Wei, Orlow, Irene, Park, Bernard J, and Hung, Rayjean J
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Epidemiology ,Health Services and Systems ,Health Sciences ,Chronic Obstructive Pulmonary Disease ,Pneumonia ,Prevention ,Lung ,Tobacco Smoke and Health ,Cancer ,Tobacco ,Rare Diseases ,Pneumonia & Influenza ,Lung Cancer ,Infectious Diseases ,Respiratory ,Good Health and Well Being ,Bronchitis ,Chronic ,Humans ,Logistic Models ,Lung Neoplasms ,Proportional Hazards Models ,Pulmonary Emphysema ,Risk ,Risk Factors ,Self Report ,Tuberculosis ,Pulmonary ,bronchitis ,chronic ,emphysema ,lung diseases ,lung neoplasms ,meta-analysis ,pneumonia ,pulmonary disease ,chronic obstructive ,tuberculosis ,Mathematical Sciences ,Medical and Health Sciences - Abstract
To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, the authors conducted a pooled analysis of studies in the International Lung Cancer Consortium. Seventeen studies including 24,607 cases and 81,829 controls (noncases), mainly conducted in Europe and North America, were included (1984-2011). Using self-reported data on previous diagnoses of lung diseases, the authors derived study-specific effect estimates by means of logistic regression models or Cox proportional hazards models adjusted for age, sex, and cumulative tobacco smoking. Estimates were pooled using random-effects models. Analyses stratified by smoking status and histology were also conducted. A history of emphysema conferred a 2.44-fold increased risk of lung cancer (95% confidence interval (CI): 1.64, 3.62 (16 studies)). A history of chronic bronchitis conferred a relative risk of 1.47 (95% CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk = 1.48, 95% CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk = 1.57, 95% CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk. Among never smokers, elevated risks were observed for emphysema, pneumonia, and tuberculosis. These results suggest that previous lung diseases influence lung cancer risk independently of tobacco use and that these diseases are important for assessing individual risk.
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- 2012
13. Tobacco smoking as a risk factor of bronchioloalveolar carcinoma of the lung: pooled analysis of seven case–control studies in the International Lung Cancer Consortium (ILCCO)
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Boffetta, Paolo, Jayaprakash, Vijayvel, Yang, Ping, Asomaning, Kofi, Muscat, Joshua E, Schwartz, Ann G, Zhang, Zuo-Feng, Le Marchand, Loic, Cote, Michele L, Stoddard, Shawn M, Morgenstern, Hal, Hung, Rayjean J, and Christiani, David C
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Epidemiology ,Health Sciences ,Cancer ,Lung Cancer ,Tobacco ,Tobacco Smoke and Health ,Lung ,Prevention ,Respiratory ,Good Health and Well Being ,Adenocarcinoma ,Bronchiolo-Alveolar ,Aged ,Case-Control Studies ,Female ,Humans ,Lung Neoplasms ,Male ,Middle Aged ,Odds Ratio ,Risk Factors ,Smoking ,Lung cancer ,Bronchioloalveolar carcinoma ,Tobacco smoking ,Oncology and Carcinogenesis ,Public Health and Health Services ,Oncology and carcinogenesis - Abstract
BackgroundThe International Lung Cancer Consortium (ILCCO) was established in 2004, based on the collaboration of research groups leading large molecular epidemiology studies of lung cancer that are ongoing or have been recently completed. This framework offered the opportunity to investigate the role of tobacco smoking in the development of bronchioloalveolar carcinoma (BAC), a rare form of lung cancer.MethodsOur pooled data comprised seven case-control studies from the United States, with detailed information on tobacco smoking and histology, which contributed 799 cases of BAC and 15,859 controls. We estimated the odds ratio of BAC for tobacco smoking, using never smokers as a referent category, after adjustment for age, sex, race, and study center.ResultsThe odds ratio of BAC for ever smoking was 2.47 (95% confidence interval [CI] 2.08, 2.93); the risk increased linearly with duration, amount, and cumulative cigarette smoking and persisted long after smoking cessation. The proportion of BAC cases attributable to smoking was 0.47 (95% CI 0.39, 0.54).ConclusionsThis analysis provides a precise estimate of the risk of BAC for tobacco smoking.
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- 2011
14. In-Home Coal and Wood Use and Lung Cancer Risk: A Pooled Analysis of the International Lung Cancer Consortium
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Hosgood, H Dean, Boffetta, Paolo, Greenland, Sander, Lee, Yuan-Chin Amy, McLaughlin, John, Seow, Adeline, Duell, Eric J, Andrew, Angeline S, Zaridze, David, Szeszenia-Dabrowska, Neonila, Rudnai, Peter, Lissowska, Jolanta, Fabiánová, Eleonóra, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Morgenstern, Hal, Rothman, Nathaniel, Hung, Rayjean J, Brennan, Paul, and Lan, Qing
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Lung ,Clinical Research ,Prevention ,Cancer ,Lung Cancer ,2.2 Factors relating to the physical environment ,Aetiology ,Respiratory ,Aged ,Air Pollution ,Indoor ,Coal ,Cooking ,Female ,Heating ,Humans ,International Agencies ,Lung Neoplasms ,Male ,Middle Aged ,Risk Factors ,Wood ,coal ,lung cancer ,pooled ,risk factor ,wood ,Environmental Sciences ,Medical and Health Sciences ,Toxicology - Abstract
BackgroundDomestic fuel combustion from cooking and heating is an important public health issue because roughly 3 billion people are exposed worldwide. Recently, the International Agency for Research on Cancer classified indoor emissions from household coal combustion as a human carcinogen (group 1) and from biomass fuel (primarily wood) as a probable human carcinogen (group 2A).ObjectivesWe pooled seven studies from the International Lung Cancer Consortium (5,105 cases and 6,535 controls) to provide further epidemiological evaluation of the association between in-home solid-fuel use, particularly wood, and lung cancer risk.MethodsUsing questionnaire data, we classified subjects as predominant solid-fuel users (e.g., coal, wood) or nonsolid-fuel users (e.g., oil, gas, electricity). Unconditional logistic regression was used to estimate the odds ratios (ORs) and to compute 95% confidence intervals (CIs), adjusting for age, sex, education, smoking status, race/ethnicity, and study center.ResultsCompared with nonsolid-fuel users, predominant coal users (OR = 1.64; 95% CI, 1.49-1.81), particularly coal users in Asia (OR = 4.93; 95% CI, 3.73-6.52), and predominant wood users in North American and European countries (OR = 1.21; 95% CI, 1.06-1.38) experienced higher risk of lung cancer. The results were similar in never-smoking women and other subgroups.ConclusionsOur results are consistent with previous observations pertaining to in-home coal use and lung cancer risk, support the hypothesis of a carcinogenic potential of in-home wood use, and point to the need for more detailed study of factors affecting these associations.
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- 2010
15. Mortality among Workers Employed in the Titanium Dioxide Production Industry in Europe
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Boffetta, Paolo, Soutar, Anne, Cherrie, John W., Granath, Fredrik, Andersen, Aage, Anttila, Ahti, Blettner, Maria, Gaborieau, Valerie, Klug, Stefanie J., Langard, Sverre, Luce, Daniele, Merletti, Franco, Miller, Brian, Mirabelli, Dario, Pukkala, Eero, Adami, Hans-Olov, and Weiderpass, Elisabete
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- 2004
16. Occupational Risk Factors for Lung Cancer in Men and Women: A Population-Based Case-Control Study in Italy
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Richiardi, Lorenzo, Boffetta, Paolo, Simonato, Lorenzo, Forastiere, Francesco, Zambon, Paola, Fortes, Cristina, Gaborieau, Valerie, and Merletti, Franco
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- 2004
17. Pooled Exposure-Response Analyses and Risk Assessment for Lung Cancer in 10 Cohorts of Silica-Exposed Workers: An IARC Multicentre Study
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Steenland, Kyle, Mannetje, Andrea, Boffetta, Paolo, Stayner, Leslie, Attfield, Michael, Chen, Jingqiong, Dosemeci, Mustafa, DeKlerk, Nicholas, Hnizdo, Eva, Koskela, Riitta, and Checkoway, Harvey
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- 2001
18. Risk of Childhood Cancer and Adult Lung Cancer after Childhood Exposure to Passive Smoke: A Meta-Analysis
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Boffetta, Paolo, Trédaniel, Jean, and Greco, Antonia
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- 2000
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19. A Multicenter Case-Control Study of Diet and Lung Cancer among Non-Smokers
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Brennan, Paul, Fortes, Cristina, Butler, Joel, Agudo, Antonio, Benhamou, Simone, Darby, Sarah, Gerken, Michael, Jöckel, Karl-Heinz, Kreuzer, Michaela, Mallone, Sandra, Nyberg, Fredrik, Pohlabeln, Hermann, Ferro, Gilles, and Boffetta, Paolo
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- 2000
20. Epidemiology of Cancer and Principles of Prevention
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Boccia, Stefania, La Vecchia, Carlo, Boffetta, Paolo, Boccia, Stefania, editor, Villari, Paolo, editor, and Ricciardi, Walter, editor
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- 2015
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21. Lung Cancer Mortality among European Rock/Slag Wool Workers: Exposure-Response Analysis
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Consonni, Dario, Boffetta, Paolo, Andersen, Aage, Chang-Claude, Jenny, Cherrie, John W., Ferro, Gilles, Frentzel-Beyme, Rainer, Hansen, Johnni, Olsen, Jørgen, Plato, Nils, Westerholm, Peter, and Saracci, Rodolfo
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- 1998
22. A European Validation Study of Smoking and Environmental Tobacco Smoke Exposure in Nonsmoking Lung Cancer Cases and Controls
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Nyberg, Fredrik, Agudo, Antonio, Boffetta, Paolo, Fortes, Cristina, González, Carlos A., and Pershagen, Göran
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- 1998
23. Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Lung Cancer Risk: Results from a Pooled Analysis of Case–Control Studies (SYNERGY)
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Olsson, Ann, Guha, Neela, Bouaoun, Liacine, Kromhout, Hans, Peters, Susan, Siemiatycki, Jack, Ho, Vikki, Gustavsson, Per, Boffetta, Paolo, Vermeulen, Roel, Behrens, Thomas, Bruning, Thomas, Kendzia, Benjamin, Guénel, Pascal, Luce, Danièle, Karrasch, Stefan, Wichmann, Heinz-Erich, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Merletti, Franco, Mirabelli, Dario, Richiardi, Lorenzo, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Tardon, Adonina, Zaridze, David, Field, John K, Lissowska, Jolanta, Świątkowska, Beata, McLaughlin, John R, Demers, Paul A, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Pandics, Tamas, Fabianova, Eleonora, Mates, Dana, Forastiere, Francesco, Bueno-de-Mesquita, Bas, Schüz, Joachim, Straif, Kurt, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Utrecht University [Utrecht], Université de Montréal (UdeM), Karolinska Institutet [Stockholm], University of Bologna/Università di Bologna, Stony Brook University [SUNY] (SBU), State University of New York (SUNY), Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Ludwig Maximilian University [Munich] (LMU), Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Department of Medical Sciences [Turin, Italy] (DMS), Università degli studi di Torino = University of Turin (UNITO), Universitätsklinikum Essen [Universität Duisburg-Essen] (Uniklinik Essen), Universität Bremen, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, University of Oviedo, N.N. Blokhin National Medical Research Center of Oncology, University of Liverpool, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (MCMCC), Nofer Institute of Occupational Medicine (NIOM), University of Toronto, Occupational Cancer Research Centre, First Faculty of Medicine, Charles University [Prague] (CU), Masaryk Memorial Cancer Institute (MMCI), Faculty of Health Sciences [UEF, Kuopio, Finland], University of Eastern Finland, National Public Health Center, National Institute of Public Health [Romania] (INSP), Azienda Sanitaria Locale [ROMA] (ASL), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Boston College (BC), and Chard-Hutchinson, Xavier
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Male ,Lung Neoplasms ,Epidemiology ,Medizin ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Oncology ,polycyclic aromatic hydrocarbons ,benzo[a]pyrene ,lung cancer ,occupational exposures ,case-control study ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Case-Control Studies ,Occupational Exposure ,Carcinogens ,Humans ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Polycyclic Aromatic Hydrocarbons ,Lung - Abstract
German Social Accident Insurance (DGUV) between 2007 and 2011, Olsson A, Guha N, Bouaoun L, Kromhout H, Peters S, Siemiatycki J, Ho V, Gustavsson P, Boffetta P, Vermeulen R, Behrens T, Brüning T, Kendzia B, Guénel P, Luce D, Karrasch S, Wichmann HE, Consonni D, Landi MT, Caporaso NE, Merletti F, Mirabelli D, Richiardi L, Jöckel KH, Ahrens W, Pohlabeln H, Tardón A, Zaridze D, Field JK, Lissowska J, Świątkowska B, McLaughlin JR, Demers PA, Bencko V, Foretova L, Janout V, Pándics T, Fabianova E, Mates D, Forastiere F, Bueno-de-Mesquita B, Schüz J, Straif K
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- 2022
24. Cancer Mortality among Man-Made Vitreous Fiber Production Workers
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Boffetta, Paolo, Saracci, Rodolfo, Andersen, Aage, Bertazzi, Pier A., Chang-Claude, Jenny, Cherrie, John, Ferro, Gilles, Frentzel-Beyme, Reiner, Hansen, Johnni, Olsen, Jørgen, Plato, Nils, Teppo, Lyly, Westerholm, Peter, Winter, Paul D., and Zocchetti, Carlo
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- 1997
25. Cancer Risk from Occupational and Environmental Exposure to Polycyclic Aromatic Hydrocarbons
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Boffetta, Paolo, Jourenkova, Nadia, and Gustavsson, Per
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- 1997
26. Meat Intake, Meat Mutagens and Risk of Lung Cancer in Uruguayan Men
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De Stefani, Eduardo, Boffetta, Paolo, Deneo-Pellegrini, Hugo, Ronco, Alvaro L., Aune, Dagfinn, Acosta, Gisele, Brennan, Paul, Mendilaharsu, María, and Ferro, Gilles
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- 2009
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27. Occupation and Risk of Lung Cancer in Central and Eastern Europe: The IARC Multi-Center Case-Control Study
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Bardin-Mikolajczak, Alicja, Lissowska, Jolanta, Zaridze, David, Szeszenia-Dabrowska, Neonila, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Navratilova, Marie, Bencko, Vladimir, Janout, Vladimir, Fevotte, Joelle, Fletcher, Tony, Mannetje, Andrea't, Brennan, Paul, and Boffetta, Paolo
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- 2007
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28. Role of Occupation in Shaping Cancer Disparities.
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Collatuzzo, Giulia, Teglia, Federica, and Boffetta, Paolo
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PUBLIC health ,RACE ,OCCUPATIONS ,HEALTH literacy ,HEALTH insurance ,EMPLOYMENT ,HEALTH equity ,ETHNIC groups - Abstract
Simple Summary: The investigation of cancer disparities is of major importance. In this paper, we address this issue through the occupational point of view, trying to capture how work and its related factors impact on cancer inequalities. The data we provide may increase awareness relevant to cancer control, and stimulate further studies aimed at the identification of the occupational determinants of cancer disparities and the quantification of their role. Cancer occurrence is characterized globally by profound socioeconomic differences. Occupation is a fundamental component of socioeconomic status. In this review, we discuss the role of occupation as a determinant of cancer disparities. First, we address the issue of participation in cancer screening programs based on income, health insurance, occupational status and job title. Second, we review the role of occupation in contributing to disparities by acting as a mediator between cancer and (i) education and (ii) race/ethnicity. Lastly, we analyze data from a multicenter case−control study of lung cancer to calculate the mediating role of occupational exposure to diesel exhaust, silica and welding fumes in the association between education and lung cancer. By addressing the complex paths from occupation to cancer inequalities from multiple points of view, we provide evidence that occupational-related characteristics, such as income, health insurance, unemployment and hazardous exposures impinge on cancer control and outcomes. The increasing awareness of these aspects is fundamental and should lead to public health interventions to avoid inequalities rising from occupational factors. [ABSTRACT FROM AUTHOR]
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- 2022
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29. Aspirin and NSAID use and lung cancer risk: a pooled analysis in the International Lung Cancer Consortium (ILCCO)
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McCormack, Valerie A., Hung, Rayjean J., Brenner, Darren R., Bickeböller, Heike, Rosenberger, Albert, Muscat, Joshua E., Lazarus, Philip, Tjønneland, Anne, Friis, Søren, Christiani, David C., Chun, Eun-mi, Le Marchand, Loic, Rennert, Gad, Rennert, Hedy S., Andrew, Angeline S., Orlow, Irene, Park, Bernard, Boffetta, Paolo, and Duell, Eric J.
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- 2011
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30. Family history and lung cancer risk: international multicentre case–control study in Eastern and Central Europe and meta-analyses
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Lissowska, Jolanta, Foretova, Lenka, Dąbek, Joanna, Zaridze, David, Szeszenia-Dabrowska, Neonila, Rudnai, Peter, Fabianova, Eleonora, Cassidy, Adrian, Mates, Dana, Bencko, Vladimir, Janout, Vladimir, Hung, Rayjean J., Brennan, Paul, and Boffetta, Paolo
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- 2010
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31. Endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers
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Lenters, Virissa, Basinas, Ioannis, Beane-Freeman, Laura, Boffetta, Paolo, Checkoway, Harvey, Coggon, David, Portengen, Lützen, Sim, Malcolm, Wouters, Inge M., Heederik, Dick, and Vermeulen, Roel
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- 2010
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32. Diesel Engine Exhaust Exposure, Smoking, and Lung Cancer Subtype Risks. A Pooled Exposure-Response Analysis of 14 Case-Control Studies
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Ge, Calvin, Peters, Susan, Olsson, Ann, Portengen, Lützen, Schüz, Joachim, Almansa, Josué, Ahrens, Wolfgang, Bencko, Vladimir, Benhamou, Simone, Boffetta, Paolo, Bueno-de-Mesquita, Bas, Caporaso, Neil, Consonni, Dario, Demers, Paul, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Janout, Vladimir, Jöckel, Karl Heinz, Karrasch, Stefan, Teresa Landi, Maria, Lissowska, Jolanta, Luce, Danièle, Mates, Dana, McLaughlin, John, Merletti, Franco, Mirabelli, Dario, Pándics, Tamás, Parent, Marie Élise, Plato, Nils, Pohlabeln, Hermann, Richiardi, Lorenzo, Siemiatycki, Jack, Świątkowska, Beata, Tardón, Adonina, Wichmann, Heinz Erich, Zaridze, David, Straif, Kurt, Kromhout, Hans, Vermeulen, Roel, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Division of Environmental Epidemiology, Utrecht University [Utrecht]-Institute of Risk Assessment Sciences, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institute for Risk Assessment Sciences, Utrecht University [Utrecht], Bremen Institute for Prevention Research and Social Medicine (BIPS), Division of Epidemiological Methods and Etiologic Research, University of Bremen, Institute of Hygiene and Epidemiology, Charles University [Prague] (CU)-1st Faculty of Medicine, Variabilité Génétique et Maladies Humaines, Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment [Bilthoven] (RIVM), National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Unit of Epidemiology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University of Toronto, Regional Authority of Public Health [Slovaquia] (RAPH), Ministry of Health of the Slovak Republic [Slovaquia], Azienda Sanitaria Locale [ROMA] (ASL), Masaryk Memorial Cancer Institute, Masaryk Memorial Cancer Institute (RECAMO), Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Faculty of Medicine, Palacky University Olomouc, Institute for Medical Informatics, Biometry, and Epidemiology, Universität Duisburg-Essen [Essen], Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institute of Public Health, Cancer Care Ontario, Occupational Cancer Research Centre, Cancer Epidemiology Unit, Université de Turin, Institut Armand Frappier (INRS-IAF), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), Bremen Institute for Prevention Research and Social Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Molecular Epidemiology of Cancer Unit, CIBER de Epidemiología y Salud Pública (CIBERESP), King‘s College London, Institute of Carcinogenesis, Russian Academy of Medical Sciences, Masaryk Memorial Cancer Institute (MMCI), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP)
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Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,[SDV]Life Sciences [q-bio] ,Medizin ,Cumulative Exposure ,lung neoplasms ,Critical Care and Intensive Care Medicine ,complex mixtures ,03 medical and health sciences ,0302 clinical medicine ,Occupational Exposure ,Diesel Exhaust ,Lung Neoplasms ,Epidemiology ,Internal medicine ,medicine ,030212 general & internal medicine ,Lung cancer ,Exposure assessment ,business.industry ,Case-control study ,diesel exhaust ,Odds ratio ,occupational exposure ,respiratory system ,medicine.disease ,Confidence interval ,3. Good health ,respiratory tract diseases ,030228 respiratory system ,Adenocarcinoma ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,epidemiology ,business ,human activities - Abstract
Rationale: Although the carcinogenicity of diesel engine exhaust has been demonstrated in multiple studies, little is known regarding exposure-response relationships associated with different exposure subgroups and different lung cancer subtypes.Objectives: We expanded on a previous pooled case-control analysis on diesel engine exhaust and lung cancer by including three additional studies and quantitative exposure assessment to evaluate lung cancer and subtype risks associated with occupational exposure to diesel exhaust characterized by elemental carbon (EC) concentrations.Methods: We used a quantitative EC job-exposure matrix for exposure assessment. Unconditional logistic regression models were used to calculate lung cancer odds ratios and 95% confidence intervals (CIs) associated with various metrics of EC exposure. Lung cancer excess lifetime risks (ELR) were calculated using life tables accounting for all-cause mortality. Additional stratified analyses by smoking history and lung cancer subtypes were performed in men.Measurements and Main Results: Our study included 16,901 lung cancer cases and 20,965 control subjects. In men, exposure response between EC and lung cancer was observed: odds ratios ranged from 1.09 (95% CI, 1.00-1.18) to 1.41 (95% CI, 1.30-1.52) for the lowest and highest cumulative exposure groups, respectively. EC-exposed men had elevated risks in all lung cancer subtypes investigated; associations were strongest for squamous and small cell carcinomas and weaker for adenocarcinoma. EC lung cancer exposure response was observed in men regardless of smoking history, including in never-smokers. ELR associated with 45 years of EC exposure at 50, 20, and 1 mu g/m(3) were 3.0%, 0.99%, and 0.04%, respectively, for both sexes combined.Conclusions: We observed a consistent exposure-response relationship betweenECexposure and lung cancer in men. Reduction of workplace EC levels to background environmental levels will further reduce lung cancer ELR in exposed workers.
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- 2020
33. Dietary phytoestrogen intake and lung cancer risk: an analysis of the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial.
- Author
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Wang, Qian, Ru, Meng, Zhang, Yaning, Kurbanova, Tamara, and Boffetta, Paolo
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DISEASE risk factors ,FOOD consumption ,LUNG cancer ,EARLY detection of cancer ,PROPORTIONAL hazards models - Abstract
Phytoestrogens (PEs) have estrogen-like activity and were found to lower incidences of several hormone-dependent cancers. Emerging evidence suggests that estrogen may play a role in lung cancer carcinogenesis. We aim to evaluate dietary PE intake and lung cancer risk using data from the Prostate, Lung, Colorectal and Ovarian cancer screening trial. A total of 1706 lung cancer cases were identified. The association between lung cancer risk and PE intake (in quartiles) was calculated using the Cox proportional hazard models adjusting for potential confounders. Stratified analyses by smoking status, sex and histology were also performed. The highest quartile of total PE intake was associated with a reduced risk of lung cancer compared with the lowest quartile [hazard ratio (HR) = 0.85, 95% confidence interval (CI): 0.73–0.99 for >1030 μg/day versus <290 μg/day] (P trend = 0.56). Similar patterns were observed among ever smokers (HR = 0.84, 95% CI: 0.71–0.98), non-small cell histology (HR = 0.84, 95% CI: 0.72–0.99), male (HR = 0.84, 95% CI: 0.69–1.03) and female (HR = 0.80, 95% CI: 0.64–0.99 for 510–1030 μg/day, HR = 0.84, 95% CI: 0.67–1.06 for >1030 μg/day versus <290 μg/day) subjects with no significant linear trend observed. Despite a lower consumption compared with the Asian population, increased PE intake still appears to decrease lung cancer risk in a Caucasian-dominant population. Future studies are needed to replicate these results in independent cohorts and shed a light on the potential mechanism of the protective effect of PEs on lung carcinogenesis and the interaction between PEs, smoking and endogenous estrogens. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
- View/download PDF
34. The Establishment of the Household Air Pollution Consortium (HAPCO)
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Hosgood, H. Dean, Klugman, Madelyn, Matsuo, Keitaro, White, Alexandra J., Sadakane, Atsuko, Shu, Xiao-Ou, Lopez-Ridaura, Ruy, Shin, Aesun, Tsuji, Ichiro, Malekzadeh, Reza, Noisel, Nolwenn, Bhatti, Parveen, Yang, Gong, Saito, Eiko, Rahman, Shafiur, Hu, Wei, Bassig, Bryan, Downward, George, Vermeulen, Roel, Xue, Xiaonan, Rohan, Thomas, Abe, Sarah K., Broët, Philippe, Grant, Eric J., Dummer, Trevor J. B., Rothman, Nat, Inoue, Manami, Lajous, Martin, Yoo, Keun-Young, Ito, Hidemi, Sandler, Dale P., Ashan, Habib, Zheng, Wei, Boffetta, Paolo, Lan, Qing, One Health Chemisch, dIRAS RA-2, One Health Chemisch, dIRAS RA-2, Hosgood H.D., Klugman M., Matsuo K., White A.J., Sadakane A., Shu X.-O., Lopez-Ridaura R., Shin A., Tsuji I., Malekzadeh R., Noisel N., Bhatti P., Yang G., Saito E., Rahman S., Hu W., Bassig B., Downward G., Vermeulen R., Xue X., Rohan T., Abe S.K., Broet P., Grant E.J., Dummer T.J.B., Rothman N., Inoue M., Lajous M., Yoo K.-Y., Ito H., Sandler D.P., Ashan H., Zheng W., Boffetta P., and Lan Q.
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Pollution ,Atmospheric Science ,medicine.medical_specialty ,media_common.quotation_subject ,Air pollution ,consortium ,Environmental Science (miscellaneous) ,lcsh:QC851-999 ,medicine.disease_cause ,Article ,Human lung ,03 medical and health sciences ,Bioma ,0302 clinical medicine ,stomatognathic system ,cohort studies ,Environmental health ,Epidemiology ,medicine ,pollution ,cancer ,030212 general & internal medicine ,Prospective cohort study ,Lung cancer ,media_common ,0303 health sciences ,biomass ,business.industry ,Public health ,030311 toxicology ,Environmental exposure ,medicine.disease ,3. Good health ,medicine.anatomical_structure ,13. Climate action ,lcsh:Meteorology. Climatology ,environmental exposures ,business ,Cohort studie ,Cohort study - Abstract
Household air pollution (HAP) is of public health concern, with ~3 billion people worldwide (including >15 million in the US) exposed. HAP from coal use is a human lung carcinogen, yet the epidemiological evidence on carcinogenicity of HAP from biomass use, primarily wood, is not conclusive. To robustly assess biomass’s carcinogenic potential, prospective studies of individuals experiencing a variety of HAP exposures are needed. We have built a global consortium of 13 prospective cohorts (HAPCO: Household Air Pollution Consortium) that have site- and disease-specific mortality and solid fuel use data, for a combined sample size of 587,257 participants and 57,483 deaths. HAPCO provides a novel opportunity to assess the association of HAP with lung cancer death while controlling for important confounders such as tobacco and outdoor air pollution exposures. HAPCO is also uniquely positioned to determine the risks associated with cancers other than lung as well as nonmalignant respiratory and cardiometabolic outcomes, for which prospective epidemiologic research is limited. HAPCO will facilitate research to address public health concerns associated with HAP-attributed exposures by enabling investigators to evaluate sex-specific and smoking status-specific effects under various exposure scenarios.
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- 2019
35. Mortality of Talc Miners and Millers from Val Chisone, Northern Italy
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Pira, Enrico, Coggiola, Maurizio, Ciocan, Catalina, Romano, Canzio, La Vecchia, Carlo, Pelucchi, Claudio, Boffetta, Paolo, and Pira, E. and Coggiola, M. and Ciocan, C. and Romano, C. and La Vecchia, C. and Pelucchi, C. and Boffetta, P.
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Male ,Mesothelioma ,peritoneum cancer ,pharynx cancer ,nonmedical occupation ,talc miner ,mining ,lung tumor ,asbesto ,cause of death ,cardiovascular disease ,cardiovascular mortality ,cancer mortality ,bladder tumor ,talc, Article ,Pleural Neoplasm ,Silicosi ,central nervous system cancer ,asbestos free talc ,stomach cancer ,talc ,leukemia ,kidney cancer ,pneumoconiosi ,prostate cancer ,unclassified drug ,cerebrovascular disease ,esophagus cancer ,Italy ,Gastrointestinal Neoplasm ,employment ,bladder cancer ,epidemiology ,Public Health ,milller ,Human ,standardized mortality ratio ,cohort analysi ,colorectal cancer ,lymphoma ,miner ,pleura tumor ,respiratory tract disease ,liver cancer ,pancreas cancer ,Occupational Exposure ,mouth tumor ,gastrointestinal tumor ,brain cancer ,silicosis, Cause of Death ,liver cirrhosi ,Environmental and Occupational Health ,Public Health, Environmental and Occupational Health ,pleura cancer ,larynx cancer ,mouth cancer ,ischemic heart disease ,major clinical study ,mortality ,Mouth Neoplasm ,dust exposure ,Lung Neoplasm ,lung cancer ,Urinary Bladder Neoplasms ,hematopoietic system tumor ,Neoplasm ,Cohort Studie ,chronic obstructive lung disease - Abstract
Objective: The aim of this study was to update the analysis of mortality of a cohort of talc miners and millers in Northern Italy. Methods: We analyzed the mortality during 1946 to 2013 of 1722 male workers in an asbestos-free talc mine (1166 miners and 556 millers) employed during 1946 to 1995. Results: The overall standardized mortality ratio (SMR) was 1.24 [95% confidence interval (95% CI) 1.17 to 1.32]; no deaths were observed from pleural cancer; mortality from lung cancer was not increased. Mortality from pneumoconiosis was increased (SMR 26.62; 95% CI 20.71 to 33.69), in particular among miners, and was associated with duration of employment and time since first employment. Conclusions: We confirmed the lack of association between exposure to asbestos-free talc, lung cancer, and mesothelioma. Increased mortality from pneumoconiosis among miners is attributable to past exposure to silica. © Copyright 2017 American College of Occupational and Environmental Medicine.
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- 2017
36. Systematic review of the potential respiratory carcinogenicity of metallic nickel in humans.
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Prueitt, Robyn L., Li, Wenchao, Chang, Yu-Chi, Boffetta, Paolo, and Goodman, Julie E.
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CARCINOGENICITY ,META-analysis ,NICKEL ,NICKEL compounds ,NICKEL ores ,LUNG cancer - Abstract
The inhalation of dust containing certain nickel compounds has been associated with an increased risk of lung and nasal cancers in occupational studies of workers who process or refine sulfidic nickel ores and are exposed to relatively high levels of mixtures of water-soluble, sulfidic, oxidic, and/or metallic forms of nickel. We conducted a systematic review of the potential carcinogenicity of metallic nickel, focusing on cancers of the respiratory tract. We evaluated the quality and risk of bias (RoB) of the relevant epidemiology, experimental animal, and in vitro mechanistic studies using the National Toxicology Program's Office of Health Assessment and Translation (OHAT) RoB Rating Tool. We then used a systematic review protocol based on the OHAT approach to critically assess whether metallic nickel should be considered a human respiratory carcinogen. Our evaluation of the epidemiology studies indicates that there is no substantive evidence of increased respiratory cancer risk in workers exposed predominantly to metallic nickel. Animal evidence indicates that metallic nickel does not increase the incidence of respiratory tumors in rodents exposed by inhalation. The in vitro studies are limited in value, as they bypass normal clearance mechanisms. Nevertheless, the mechanistic evidence indicates that metallic nickel is not mutagenic but can induce DNA strand breaks under certain conditions. Based on a standard framework for assessing causality, we conclude that the evidence does not support a causal relationship between metallic nickel exposure and respiratory cancer in humans. [ABSTRACT FROM AUTHOR]
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- 2020
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37. Cancer mortality predictions for 2019 in Latin America.
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Carioli, Greta, Bertuccio, Paola, Malvezzi, Matteo, Rodriguez, Teresa, Levi, Fabio, Boffetta, Paolo, La Vecchia, Carlo, and Negri, Eva
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CANCER-related mortality ,DEATH rate ,FORECASTING ,LUNG cancer ,BREAST cancer - Abstract
We estimated mortality figures for 2019 in seven Latin American countries, with focus on breast cancer. We retrieved cancer death certification and population data from the WHO and PAHO databases. We obtained mortality statistics for Argentina, Brazil, Chile, Colombia, Cuba, Mexico and Venezuela for 1970–2015. We predicted current death numbers and age‐standardised (world population) mortality rates using joinpoint regression models. Total cancer mortality is predicted to decline in all countries and both sexes, except Argentinian women. Cuba had the highest all cancer rates for 2019, 136.9/100,000 men and 90.4 women, while Mexico showed the lowest ones, 63.8/100,000 men and 61.9 women. Stomach cancer showed favourable trends over the whole period, while colorectal cancer only recently. Lung cancer rates declined in men, while in women they decreased slightly over the most recent years, only. In Cuban women, lung cancer rates overtook breast cancer ones. Breast cancer showed overall favourable trends, but rates are rising in young women. Prostate and uterine cancer had favourable trends. Pancreas, ovary, bladder and leukaemias showed slightly decreasing trends. Between 1990 and 2019, mortality from all neoplasms is predicted to fall by about 18% in Argentina, 26% in Chile, 14% in Colombia, 17% in Mexico and 13% in Venezuela, corresponding to almost 0.5 million avoided cancer deaths. No decline was observed in Brazil and Cuba. Of concern, the persisting high rates of (cervix) uterus cancer, the high lung cancer rates in Cuba, the possible increases in breast cancer in young women, and the lack of overall declines in Brazil, Cuba and Venezuelan men. What's new? In Latin American countries, overall cancer mortality has declined over the last 3 decades. Still, unfavorable trends continue in certain populations and certain neoplasms. Here, the authors update their earlier work on cancer mortality, looking at trends for several cancer types across 7 Latin American countries. Their analysis predicted a continued decline in total cancer mortality rates among both men and women, with the exception of Argentinian women. Stomach cancer deaths in Chile and Colombia remain particularly high among both sexes, as does lung cancer in Cuba. Breast cancer mortality showed favorable trends overall, but rates are rising among young women. Cervical cancer remains exceedingly high. [ABSTRACT FROM AUTHOR]
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- 2020
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38. Risk of mesothelioma after cessation of asbestos exposure: a systematic review and meta-regression.
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Boffetta, Paolo, Donato, Francesca, Pira, Enrico, Luu, Hung N., and La Vecchia, Carlo
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ASBESTOS , *META-analysis , *RANDOM effects model , *LUNG cancer - Abstract
Purpose: A 'risk reversal' has been observed for several human carcinogens following cessation of exposure, but it is unclear whether it also exists for asbestos-related mesothelioma. Methods: We conducted a systematic review of the literature and identified nine studies that reported information on risk of mesothelioma after cessation of asbestos exposure, and performed a meta-regression based on random effects models. As comparison we analyzed results on lung cancer risk from four of these studies. Results: A total of six risk estimates from five studies were included in the meta-analysis. The summary relative risk (RR) of mesothelioma for 10-year interval since cessation of exposure was 1.02 [95% confidence interval (CI) 0.87–1.19; p-heterogeneity 0.01]. The corresponding RR of lung cancer was 0.91 (95% CI 0.84–0.98). Conclusions: This analysis provides evidence that the risk of mesothelioma does not decrease after cessation of asbestos exposure, while lung cancer risk does. [ABSTRACT FROM AUTHOR]
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- 2019
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39. Lung cancer risk among cooks when accounting for tobacco smoking: a pooled analysis of case-control studies from Europe, Canada, New Zealand, and China
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Bigert, Carolina, Gustavsson, Per, Straif, Kurt, Pesch, Beate, Brüning, Thomas, Kendzia, Benjamin, Schüz, Joachim, Stücker, Isabelle, Guida, Florence, Brüske, Irene, Wichmann, Heinz-Erich, Pesatori, Angela C, Landi, Maria Teresa, Caporaso, Neil, Tse, Lap Ah, Yu, Ignatius Tak-sun, Siemiatycki, Jack, Pintos, Javier, Merletti, Franco, Mirabelli, Dario, Simonato, Lorenzo, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Tardón, Adonina, Zaridze, David, Field, John, 't Mannetje, Andrea, Pearce, Neil, McLaughlin, John, Demers, Paul, Szeszenia-Dabrowska, Neonila, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Dumitru, Rodica Stanescu, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Boffetta, Paolo, Forastiere, Francesco, Bueno-de-Mesquita, Bas, Peters, Susan, Vermeulen, Roel, Kromhout, Hans, Olsson, Ann C, Risk Assessment, Infection & Immunity, dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), Bigert, C., Gustavsson, P., Straif, K., Pesch, B., Brüning, T., Kendzia, B., Schüz, J., Stücker, I., Guida, F., Brüske, I., Wichmann, H.-E., Pesatori, A.C., Landi, M.T., Caporaso, N., Tse, L.A., Yu, I.T.-S., Siemiatycki, J., Pintos, J., Merletti, F., Mirabelli, D., Simonato, L., Jöckel, K.-H., Ahrens, W., Pohlabeln, H., Tardón, A., Zaridze, D., Field, J., 'T Mannetje, A., Pearce, N., McLaughlin, J., Demers, P., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Stanescu Dumitru, R., Bencko, V., Foretova, L., Janout, V., Boffetta, P., Forastiere, F., Bueno-De-Mesquita, B., Peters, S., Vermeulen, R., Kromhout, H., Olsson, A.C., Risk Assessment, Infection & Immunity, dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), and LS IRAS EEPI GRA (Gezh.risico-analyse)
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Male ,Canada ,China ,Lung Neoplasms ,Medizin ,Small-cell carcinoma ,Article ,Sex Factors ,Risk Factors ,Environmental health ,Occupational Exposure ,medicine ,otorhinolaryngologic diseases ,Odds Ratio ,Humans ,Basal cell ,Cooking ,Lung cancer ,Aged ,business.industry ,Medicine (all) ,Environmental and Occupational Health ,Carcinoma ,Smoking ,Public Health, Environmental and Occupational Health ,Case-control study ,technology, industry, and agriculture ,food and beverages ,Odds ratio ,Middle Aged ,medicine.disease ,Europe ,Occupational Diseases ,Increased risk ,Pooled analysis ,Lung cancer - cooks - smoking habits ,Case-Control Studies ,Female ,New Zealand ,Public Health ,business - Abstract
OBJECTIVES: To investigate the risk of lung cancer among cooks, while controlling for smoking habits. METHODS: We used data from the SYNERGY project including pooled information on lifetime work histories and smoking habits from 16 case-control studies conducted in Europe, Canada, New Zealand, and China. RESULTS: Before adjustment for smoking, we observed an increased risk of lung cancer in male cooks, but not in female cooks. After adjusting, there was no increased risk and no significant exposure-response relationship. Nevertheless, subgroup analyses highlighted some possible excess risks of squamous cell carcinoma and small cell carcinoma in female cooks. CONCLUSIONS: There is evidence that lung cancer risks among cooks may be confounded by smoking. After adjustment, cooks did not experience an increased risk of lung cancer overall. The subgroup analyses showing some excess risks among female cooks require cautious interpretation. Copyright © 2015 by the American College of Occupational and Environmental Medicine.
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- 2015
40. Lung cancer risk among bricklayers in a pooled analysis of case-control studies
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Consonni, Dario, De Matteis, Sara, Pesatori, Angela C, Bertazzi, Pier Alberto, Olsson, Ann C, Kromhout, Hans, Peters, Susan, Vermeulen, Roel Ch, Pesch, Beate, Brüning, Thomas, Kendzia, Benjamin, Behrens, Thomas, Stücker, Isabelle, Guida, Florence, Wichmann, Heinz-Erich, Brüske, Irene, Landi, Maria Teresa, Caporaso, Neil E, Gustavsson, Per, Plato, Nils, Tse, Lap Ah, Yu, Ignatius Tak-Sun, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Merletti, Franco, Richiardi, Lorenzo, Simonato, Lorenzo, Forastiere, Francesco, Siemiatycki, Jack, Parent, Marie-Élise, Tardón, Adonina, Boffetta, Paolo, Zaridze, David, Chen, Ying, Field, John K, 't Mannetje, Andrea, Pearce, Neil, McLaughlin, John, Demers, Paul, Lissowska, Jolanta, Szeszenia-Dabrowska, Neonila, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Rudnai, Peter, Fabiánová, Eleonóra, Stanescu Dumitru, Rodica, Bueno-de-Mesquita, Bas, Schüz, Joachim, Straif, Kurt, Risk Assessment, Infection & Immunity, dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), Consonni, D. and De Matteis, S. and Pesatori, A.C. and Bertazzi, P.A. and Olsson, A.C. and Kromhout, H. and Peters, S. and Vermeulen, R.C.H. and Pesch, B. and Brüning, T. and Kendzia, B. and Behrens, T. and Stücker, I. and Guida, F. and Wichmann, H.-E. and Brüske, I. and Landi, M.T. and Caporaso, N.E. and Gustavsson, P. and Plato, N. and Tse, L.A. and Yu, I.T.-S. and Jöckel, K.-H. and Ahrens, W. and Pohlabeln, H. and Merletti, F. and Richiardi, L. and Simonato, L. and Forastiere, F. and Siemiatycki, J. and Parent, M.-É. and Tardón, A. and Boffetta, P. and Zaridze, D. and Chen, Y. and Field, J.K. and Mannetje, A. and Pearce, N. and McLaughlin, J. and Demers, P. and Lissowska, J. and Szeszenia-Dabrowska, N. and Bencko, V. and Foretova, L. and Janout, V. and Rudnai, P. and Fabiánová, E. and Dumitru, R.S. and Bueno-De-Mesquita, H.B. and Schüz, J. and Straif, K., Courcelles, Michel, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Università degli Studi di Milano = University of Milan (UNIMI), Imperial College London, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Institute for Risk Assessment Sciences, Utrecht University [Utrecht], The University of Western Australia (UWA), Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), The Chinese University of Hong Kong [Hong Kong], University Hospital Essen, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, University of Bremen, Unit of Cancer Epidemiology, Université de Turin-CERMS and Centre for Oncologic Prevention, Università degli Studi di Padova = University of Padua (Unipd), Azienda Sanitaria Locale [ROMA] (ASL), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), CIBER de Epidemiología y Salud Pública (CIBERESP), International Prevention Research Institute (IPRI), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Institute of Carcinogenesis, Russian Cancer Research Centre, Keele University [Keele], University of Liverpool, London School of Hygiene and Tropical Medicine (LSHTM), Samuel Lunenfeld Research Institute, Mount Sinai Hospital [Toronto, Canada] (MSH), Cancer Care Ontario, The M Sklodowska-Curie Cancer Center and Institute of Oncology, The Nofer Institute of Occupational Medicine, Institute of Hygiene and Epidemiology, Charles University [Prague] (CU)-First Faculty of Medicine, Masaryk University [Brno] (MUNI), Department of Optics [Univ Palacký], Faculty of Science [Univ Palacký], Palacky University Olomouc-Palacky University Olomouc, National Institutes of Environmental Health Sciences, Regional Authority of Public Health [Slovaquia] (RAPH), Ministry of Health of the Slovak Republic [Slovaquia], Institute of Public Health, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Grant sponsor: German Social Accident Insurance (DGUV), Grant number: FP 271, Grant sponsors: Canadian Institutes for Health Researchand Guzzo-SRC Chair in Environm ent and Cancer, National Cancer Institute of Canada, Canadian Cancer Society, Occupational Cancer ResearchCentre, Workplace Safety and Insuranc e Boar d, Canadian Cancer Society, and Cancer Care Ontario, Grant sponsor: European Commission’s INCO Copernicus program, Grant number: IC15-CT96-0313, Grant sponsor: European Union Nuclear Fission Safety Program, Grant number:F14P-CT96-0055, Grant sponsors: French Agency of Health Security (ANSES), Fondation de France, French National Research Agency (ANR),National Institute of Cancer (INCA), Fondation pour la Recherche Medicale, French Institute for Public Health Surveillance (InVS), Health Ministry (DGS), Organization for the Research on Cancer (ARC), and French Ministry of work, solidarity, and public function (DGT), Grant sponsor: Federal Ministry of Education, Science, Research, and Technology, Grant number: 01 HK 173/0), Grant sponsor: Federal Ministry of Science, Grant number:01 HK 546/8, Grant sponsor: Ministry of Labour and Social Affairs, Grant number: IIIb7-27/13, Grant sponsor: Research Grants Council of the Hong Kong Special Administrative Region, China, Grant number: CUHK4460/03M, Grant sponsors: Environmental Epidemiology Program of the Lombardy Region, INAIL, Italian Association for Cancer Research, Region Piedmont, Compagnia di San Paolo, Lazio Region, Health Research Council of New Zealand, New Zealand Department of Labour, Lottery Health Research, Cancer Society of New Zealand, Grant sponsor: Polish State Committee for Scientific Research, Grant number: SPUB-M-COPERNICUS/P-05/DZ-30/99/2000, Grant sponsors: Instituto Universitario de Oncologia, Universidad de Oviedo, Asturias, Fondo de Investigacion Sanitaria (FIS) and Ciber de Epidemiologia y Salud Publica (CIBERESP), Swedish Council for Work Life Research and Swedish Environmental Protection Agency, Dutch Ministry of Health, Welfare and Sports, National Institute of Public Health and the Environment, and Europe Against Cancer Program, Roy Castle Foundation, and Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland, Risk Assessment, Infection & Immunity, dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), Università degli Studi di Milano [Milano] (UNIMI), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Universita degli Studi di Padova, Charles University and General University Hospital-First Faculty of Medicine, and Masaryk Memorial Cancer Institute and Medical Faculty of Masaryk University
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Male ,Epidemiology ,control studies ,cancer risk ,bricklayer ,middle aged ,occupation ,CARCINOGENS ,blue collar worker ,POPULATION ,comparative study ,education.field_of_study ,MESH: Middle Aged ,risk assessment ,WORKERS ,MEN ,MESH: Carcinoma, Squamous Cell ,clinical trial ,MESH: Follow-Up Studies ,Prognosis ,MESH: Case-Control Studies ,3. Good health ,Occupational Diseases ,[SDV] Life Sciences [q-bio] ,OCCUPATIONAL-EXPOSURE ,hospital based case control study ,Oncology ,priority journal ,risk factor, Adenocarcinoma ,Carcinoma, Squamous Cell ,case ,Human ,MESH: Occupational Diseases ,medicine.medical_specialty ,national cancer institute of ,additional supporting information may ,case–control studies ,employment statu ,MESH: Prognosis ,Article ,Follow-Up Studie ,MESH: International Agencies ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,carcinogen, adult ,Humans ,[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health ,research and guzzo-src chair ,education ,CRYSTALLINE SILICA DUST ,fp 271 ,Science & Technology ,MESH: Humans ,Occupational health ,MORTALITY ,health care facility ,Construction Industry ,Case-control study ,bricklayers ,Odds ratio ,case control study ,medicine.disease ,dguv ,lung adenocarcinoma ,major clinical study ,Lung neoplasm ,occupational hazard ,MESH: Lung Neoplasms ,Occupational Disease ,occupational cancer ,multicenter study ,age ,Relative risk ,small cell lung cancer ,Occupational medicine ,MESH: Female ,population research ,Cancer Research ,online version of this ,[SDV]Life Sciences [q-bio] ,canada ,Medizin ,medicine.disease_cause ,MESH: Occupational Exposure ,grant number ,Risk Factors ,MESH: Risk Factors ,Carcinoma, Small Cell ,Medicine (all) ,international cooperation ,grant sponsor ,article ,canadian institutes for health ,MESH: Carcinoma, Small Cell ,be found in the ,MESH: Construction Industry ,female ,NORDIC COUNTRIES ,International Agencie ,canadian cancer society ,epidemiology ,grant sponsors ,Gustavsson ,in environment and cancer ,Case-Control Studie ,Life Sciences & Biomedicine ,lifespan ,prognosi ,Population ,UNITED-STATES ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,lung neoplasms ,Asbestos ,smoking ,building industry ,occupational health ,Internal medicine ,Occupational Exposure ,medicine ,follow up ,controlled study ,occupational ,Lung cancer ,population based case control study ,Plato ,[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health ,adenocarcinoma ,business.industry ,case-control studies ,Risk Factor ,Carcinoma ,MESH: Adenocarcinoma ,International Agencies ,Small Cell ,Confidence interval ,MESH: Male ,human tissue ,Surgery ,lung cancer ,german social accident insurance ,Squamous Cell ,Bricklayers ,Case-control studies ,Lung neoplasms ,Adenocarcinoma ,Case-Control Studies ,Female ,Follow-Up Studies ,Lung Neoplasms ,Middle Aged ,business ,CONSTRUCTION-INDUSTRY ,squamous cell lung carcinoma - Abstract
Bricklayers may be exposed to several lung carcinogens, including crystalline silica and asbestos. Previous studies that analyzed lung cancer risk among these workers had several study design limitations. We examined lung cancer risk among bricklayers within SYNERGY, a large international pooled analysis of case–control studies on lung cancer and the joint effects of occupational carcinogens. For men ever employed as bricklayers we estimated odds ratios (OR) and 95% confidence intervals (CI) adjusted for study center, age, lifetime smoking history and employment in occupations with exposures to known or suspected lung carcinogens. Among 15,608 cases and 18,531 controls, there were 695 cases and 469 controls who had ever worked as bricklayers (OR: 1.47; 95% CI: 1.28–1.68). In studies using population controls the OR was 1.55 (95% CI: 1.32–1.81, 540/349 cases/controls), while it was 1.24 (95% CI: 0.93–1.64, 155/120 cases/controls) in hospital-based studies. There was a clear positive trend with length of employment (p < 0.001). The relative risk was higher for squamous (OR: 1.68, 95% CI: 1.42–1.98, 309 cases) and small cell carcinomas (OR: 1.78, 95% CI: 1.44–2.20, 140 cases), than for adenocarcinoma (OR: 1.17, 95% CI: 0.95–1.43, 150 cases) (p-homogeneity: 0.0007). ORs were still elevated after additional adjustment for education and in analyses using blue collar workers as referents. This study provided robust evidence of increased lung cancer risk in bricklayers. Although non-causal explanations cannot be completely ruled out, the association is plausible in view of the potential for exposure to several carcinogens, notably crystalline silica and to a lesser extent asbestos. WHAT'S NEW?: In their work, bricklayers can be exposed to various airborne carcinogens, including crystalline silica and asbestos. Previous studies of cancer risk have not accounted for full employment history or smoking status, and failed to establish a firm relationship between bricklaying and lung cancer. In this study, the authors used data from the largest collection of case-control studies on lung cancer with complete occupational and smoking history existing today, the SYNERGY project. They found clear evidence that lung cancer risk increases in proportion to the length of time spent working as a bricklayer, paving the way for better protection and compensation for those in this occupation.
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- 2015
41. Idiopathic Pulmonary Fibrosis and Lung Cancer. A Systematic Review and Meta-analysis.
- Author
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Brown, Stacey-Ann Whittaker, Dobelle, Molly, Padilla, Maria, Agovino, Mariangela, Wisnivesky, Juan P., Hashim, Dana, Boffetta, Paolo, and Whittaker Brown, Stacey-Ann
- Abstract
Rationale: The association between idiopathic pulmonary fibrosis (IPF) and lung cancer has been previously reported. However, there is the potential for significant confounding by age and smoking, and an accurate summary risk estimate has not been previously ascertained.Objectives: To determine the risk and burden of lung cancer in patients with IPF, accounting for known confounders.Methods: We conducted a comprehensive literature search of MEDLINE, EMBASE, and SCOPUS databases and used the Newcastle Ottawa criteria to assess study quality. We then assessed the quality of ascertainment of IPF cases based on modern consensus criteria. Data that relied on administrative claims or autopsies were excluded. We calculated summary risk estimates using a random effects model.Results: Twenty-five cohort studies were included in the final analysis. The estimated adjusted incidence rate ratio from two studies was 6.42 (95% confidence interval [CI], 3.21-9.62) and accounted for age, sex, and smoking. The summary incidence rate from 11 studies was 2.07 per 100 person-years (95% CI, 1.46-2.67), and the summary mortality rate was 1.06 per 100 person-years (95% CI, 0.62-1.51) obtained from three studies. The summary prevalence from 11 studies was 13.74% (95% CI, 10.17-17.30), and the proportion of deaths attributable to lung cancer was 10.20 (95% CI, 8.52-11.87) and was obtained from nine studies.Conclusions: IPF is an increased independent risk factor for lung cancer, even after accounting for smoking. Further well-designed studies using modern consensus criteria are needed to explore mechanisms of this association. [ABSTRACT FROM AUTHOR]
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- 2019
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42. Exposure-Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case-Control Studies
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Olsson, Ann C, Vermeulen, Roel, Schüz, Joachim, Kromhout, Hans, Pesch, Beate, Peters, Susan, Behrens, Thomas, Portengen, Lützen, Mirabelli, Dario, Gustavsson, Per, Kendzia, Benjamin, Almansa, Josue, Luzon, Veronique, Vlaanderen, Jelle, Stücker, Isabelle, Guida, Florence, Consonni, Dario, Caporaso, Neil, Landi, Maria Teresa, Field, John, Brüske, Irene, Wichmann, Heinz-Erich, Siemiatycki, Jack, Parent, Marie-Elise, Richiardi, Lorenzo, Merletti, Franco, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Plato, Nils, Tardón, Adonina, Zaridze, David, McLaughlin, John, Demers, Paul, Szeszenia-Dabrowska, Neonila, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Stanescu Dumitru, Rodica, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Boffetta, Paolo, Bueno-de-Mesquita, Bas, Forastiere, Francesco, Brüning, Thomas, Straif, Kurt, LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), Sub IRAS EEPI Algemeen, dIRAS RA-2, Nofer Institute of Occupational Medicine, Łódź, Poland, Olsson, A.C., Vermeulen, R., Schüz, J., Kromhout, H., Pesch, B., Peters, S., Behrens, T., Portengen, L., Mirabelli, D., Gustavsson, P., Kendzia, B., Almansa, J., Luzon, V., Vlaanderen, J., Stücker, I., Guida, F., Consonni, D., Caporaso, N., Landi, M.T., Field, J., Brüske, I., Wichmann, H.-E., Siemiatycki, J., Parent, M.-E., Richiardi, L., Merletti, F., Jöckel, K.-H., Ahrens, W., Pohlabeln, H., Plato, N., Tardon, A., Zaridze, D., McLaughlin, J., Demers, P., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Stanescu Dumitru, R., Bencko, V., Foretova, L., Janout, V., Boffetta, P., Bueno-De-Mesquita, B., Forastiere, F., Brüning, T., Straif, K., LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), Sub IRAS EEPI Algemeen, dIRAS RA-2, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Karolinska Institutet [Stockholm], Institute for Risk Assessment Sciences, Utrecht University [Utrecht], Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), The University of Western Australia (UWA), University of Turin, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Paris-Sud - Paris 11 (UP11), Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Institute of Translational Medicine, University of Liverpool, Helmholtz-Zentrum München (HZM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Institut Armand Frappier (INRS-IAF), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), Universität Duisburg-Essen [Essen], Bremen Institute for Prevention Research and Social Medicine (BIPS), CIBER de Epidemiología y Salud Pública (CIBERESP), Russian Cancer Research Centre, Public Health Ontario - Santé publique Ontario, Cancer Care Ontario, Nofer Institute of Occupational Medicine (NIOM), Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (MCMCC), National center for public health [Hungary], Regional Authority of Public Health [Slovaquia] (RAPH), Ministry of Health of the Slovak Republic [Slovaquia], National Institute of Public Health [Romania] (INSP), Charles University [Prague] (CU), Masaryk University [Brno] (MUNI), Palacky University Olomouc, Icahn School of Medicine at Mount Sinai [New York] (MSSM), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Azienda Sanitaria Locale [ROMA] (ASL), The SYNERGY project is funded by the German Social Accident Insurance (DGUV), Grant FP 271. The original studies were funded as follows: in Canada by Canadian Institutes for Health Research and Guzzo-SRC Chair in Environment and Cancer, National Cancer Institute of Canada, Canadian Cancer Society, Occupational Cancer Research Centre, Workplace Safety and Insurance Board, Canadian Cancer Society, and Cancer Care Ontario, in France by the French Agency of Health Security (ANSES), Fondation de France, French National Research Agency (ANR), National Institute of Cancer (INCA), Fondation pour la Recherche Médicale, French Institute for Public Health Surveillance (InVS), Health Ministry (DGS), Organization for the Research on Cancer (ARC), and French Ministry of work, solidarity, and public function (DGT), in Germany by Federal Ministry of Education, Science, Research, and Technology (Grant 01 HK 173/0), Federal Ministry of Science (Grant 01 HK 546/8), and the Ministry of Labour and Social Affairs (Grant IIIb7-27/13), in Italy by Environmental Epidemiology Program of the Lombardy Region, INAIL, Italian Association for Cancer Research, Region Piedmont, Compagnia di San Paolo, and Lazio Region, in Poland by Polish State Committee for Scientific Research (Grant SPUB-M-COPERNICUS/P-05/ DZ-30/99/2000), in Czech Republic by MH CZ - DRO (MMCI, 00209805), in Spain by Instituto Universitario de Oncologia, Universidad de Oviedo, Asturias, Fondo de Investigacion Sanitaria (FIS) and Ciber de Epidemiologia y Salud Publica (CIBERESP), in Sweden by Swedish Council for Work Life Research and Swedish Environmental Protection Agency, in the Netherlands by Dutch Ministry of Health, Welfare and Sports, National Institute of Public Health and the Environment, and Europe Against Cancer Program, in the UK by Roy Castle Foundation, in the USA by Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, the IARC multicenter study in Central and Eastern Europe was funded by the European Commission’s INCO Copernicus program (Contract IC15-CT96-0313)., and Joachim Schüz and Kurt Straif are part of a collaborative study with the State Russian Institute of Occupational Health (SRIOH) on asbestos and cancer risk, which includes financial support from SRIOH to IARC. Paolo Boffetta acted as expert witness for Edison SpA in asbestos-related litigation, outside the submitted work. Beate Pesch, Thomas Behrens, Benjamin Kendzia, and Thomas Brüning, as staff of the Institute for Prevention and Occupational Medicine (IPA), are employed at the 'Berufsgenossenschaft Rohstoffe und chemische Industrie' (BG RCI), a public body, which is a member of the study’s main sponsor, the German Social Accident Insurance (DGUV). IPA is an independent research institute of the Ruhr-Universität Bochum. The authors are independent from the German Social Accident Insurance in study design, access to the collected data, responsibility for data analysis and interpretation, and the right to publish
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Adult ,Male ,Canada ,Pathology ,medicine.medical_specialty ,Lung Neoplasms ,Epidemiology ,[SDV]Life Sciences [q-bio] ,Population ,Medizin ,Cumulative Exposure ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,medicine.disease_cause ,Asbestos ,03 medical and health sciences ,asbestos exposure ,0302 clinical medicine ,Occupational Exposure ,Odds Ratio ,medicine ,Humans ,030212 general & internal medicine ,Lung cancer ,education ,Aged ,education.field_of_study ,business.industry ,Occupational asbestos exposure, lung cancer ,Smoking ,Case-control study ,Absolute risk reduction ,Odds ratio ,Middle Aged ,Occupational Epidemiology ,medicine.disease ,Small Cell Lung Carcinoma ,030210 environmental & occupational health ,Confidence interval ,3. Good health ,Europe ,lung cancer ,Logistic Models ,Case-Control Studies ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Carcinoma, Squamous Cell ,Female ,business ,Demography - Abstract
Supplemental Digital Content is available in the text., Background: Evidence is limited regarding risk and the shape of the exposure–response curve at low asbestos exposure levels. We estimated the exposure–response for occupational asbestos exposure and assessed the joint effect of asbestos exposure and smoking by sex and lung cancer subtype in general population studies. Methods: We pooled 14 case–control studies conducted in 1985–2010 in Europe and Canada, including 17,705 lung cancer cases and 21,813 controls with detailed information on tobacco habits and lifetime occupations. We developed a quantitative job-exposure-matrix to estimate job-, time period-, and region-specific exposure levels. Fiber-years (ff/ml-years) were calculated for each subject by linking the matrix with individual occupational histories. We fit unconditional logistic regression models to estimate odds ratios (ORs), 95% confidence intervals (CIs), and trends. Results: The fully adjusted OR for ever-exposure to asbestos was 1.24 (95% CI, 1.18, 1.31) in men and 1.12 (95% CI, 0.95, 1.31) in women. In men, increasing lung cancer risk was observed with increasing exposure in all smoking categories and for all three major lung cancer subtypes. In women, lung cancer risk for all subtypes was increased in current smokers (ORs ~two-fold). The joint effect of asbestos exposure and smoking did not deviate from multiplicativity among men, and was more than additive among women. Conclusions: Our results in men showed an excess risk of lung cancer and its subtypes at low cumulative exposure levels, with a steeper exposure–response slope in this exposure range than at higher, previously studied levels. (See video abstract at, http://links.lww.com/EDE/B161.)
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- 2017
43. Is previous respiratory disease a risk factor for lung cancer?
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Denholm, Rachel, Schüz, Joachim, Straif, Kurt, Stücker, Isabelle, Jöckel, Karl-Heinz, Brenner, Darren R, De Matteis, Sara, Boffetta, Paolo, Guida, Florence, Brüske, Irene, Wichmann, Heinz-Erich, Landi, Maria Teresa, Caporaso, Neil, Siemiatycki, Jack, Ahrens, Wolfgang, Pohlabeln, Hermann, Zaridze, David, Field, John K, McLaughlin, John, Demers, Paul, Szeszenia-Dabrowska, Neonila, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Dumitru, Rodica Stanescu, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Kendzia, Benjamin, Peters, Susan, Behrens, Thomas, Vermeulen, Roel, Brüning, Thomas, Kromhout, Hans, Olsson, Ann, Risk Assessment of Toxic and Immunomodulatory Agents, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), IRAS RATIA2, IRAS RATIA-SIB, Risk Assessment of Toxic and Immunomodulatory Agents, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), IRAS RATIA2, IRAS RATIA-SIB, Coppens, Kim, Denholm, R., Schüz, J., Straif, K., Stücker, I., Jöckel, K.-H., Brenner, D.R., De Matteis, S., Boffetta, P., Guida, F., Brüske, I., Wichmann, H.-E., Landi, M.T., Caporaso, N., Siemiatycki, J., Ahrens, W., Pohlabeln, H., Zaridze, D., Field, J.K., McLaughlin, J., Demers, P., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Dumitru, R.S., Bencko, V., Foretova, L., Janout, V., Kendzia, B., Peters, S., Behrens, T., Vermeulen, R., Brüning, T., Kromhout, H., and Olsson, A.C.
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Male ,Chronic bronchitis ,Lung Neoplasms ,Medizin ,Critical Care and Intensive Care Medicine ,Case–control Study ,Data Pooling ,Epidemiologic Study ,Lung Neoplasm ,Pulmonary Disease ,Risk Factors ,Odds Ratio ,Prevalence ,Epidemiologic study ,ComputingMilieux_MISCELLANEOUS ,pulmonary disease ,Respiratory disease ,respiratory system ,Middle Aged ,Bronchitis, Chronic ,Europe ,Pulmonary Emphysema ,Female ,Original Article ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Canada ,Case–control study ,Data pooling ,Internal medicine ,medicine ,Humans ,Risk factor ,Intensive care medicine ,Lung cancer ,Asthma ,business.industry ,Case-control study ,case–control study ,Odds ratio ,Pneumonia ,medicine.disease ,Lung neoplasm ,lung neoplasm ,respiratory tract diseases ,Logistic Models ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,data pooling ,Case-Control Studies ,epidemiologic study ,Multivariate Analysis ,Pulmonary disease ,business - Abstract
Rationale: Previous respiratory diseases have been associated with increased risk of lung cancer. Respiratory conditions often co-occur and few studies have investigated multiple conditions simultaneously. Objectives: Investigate lung cancer risk associated with chronic bronchitis, emphysema, tuberculosis, pneumonia, and asthma. Methods: The SYNERGY project pooled information on previous respiratory diseases from 12,739 case subjects and 14,945 control subjects from 7 case-control studies conducted in Europe and Canada. Multivariate logistic regression models were used to investigate the relationship between individual diseases adjusting for co-occurring conditions, and patterns of respiratory disease diagnoses and lung cancer. Analyses were stratified by sex, and adjusted for age, center, ever-employed in a high-risk occupation, education, smoking status, cigarette pack-years, and time since quitting smoking. Measurements and Main Results: Chronic bronchitis and emphysema were positively associated with lung cancer, after accounting for other respiratory diseases and smoking (e.g., in men: odds ratio [OR], 1.33; 95% confidence interval [CI], 1.20-1.48 and OR, 1.50; 95% CI, 1.21-1.87, respectively). A positive relationship was observed between lung cancer and pneumonia diagnosed 2 years or less before lung cancer (OR, 3.31; 95% CI, 2.33-4.70 for men), but not longer. Co-occurrence of chronic bronchitis and emphysema and/or pneumonia had a stronger positive association with lung cancer than chronic bronchitis "only." Asthma had an inverse association with lung cancer, the association being stronger with an asthma diagnosis 5 years or more before lung cancer compared with shorter. Conclusions: Findings from this large international case-control consortium indicate that after accounting for co-occurring respiratory diseases, chronic bronchitis and emphysema continue to have a positive association with lung cancer. Copyright © 2014 by the American Thoracic Society.
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- 2014
44. Differences in education and premature mortality: a record linkage study of over 35 million Italians.
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Alicandro, Gianfranco, Frova, Luisa, Sebastiani, Gabriella, Boffetta, Paolo, and La Vecchia, Carlo
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ITALIANS ,CENSUS ,CONFIDENCE intervals ,MORTALITY ,DISEASES in men ,RETROSPECTIVE studies ,LUNG tumors ,MEDICAL record linkage ,SOCIOECONOMIC factors ,SEX distribution ,COMPARATIVE studies ,LIVER diseases ,GENITOURINARY diseases ,MARITAL status ,EDUCATIONAL attainment ,LONGITUDINAL method ,DEATH certificates ,BREAST tumors - Abstract
Background: Large, representative studies are needed to evaluate cause-specific aspects of socio-economic inequalities in mortality. Methods: We conducted a census-based retrospective cohort study to quantify differences in cause-specific premature mortality by educational level in Italy. We linked the 2011 Italian census with 2012 and 2013 death registries. We used the mortality rate ratio (MRR) as a measure of relative inequality. Results: Overall, 305043 deaths (190061 men-114982 women) were registered from a population of 35 708 445 subjects aged 30-74. The age-standardized mortality rate for all educational levels was 57.68 deaths per 10 000 person-years among men and 31.41 among women. MRR from all causes was 0.51 (95% CI: 0.49; 0.52) in men and 0.63 (95% CI: 0.61; 0.65) in women for the highest (university) compared to the lowest level of education (none or primary school). The association was stronger in single than in married individuals: MRRs were 0.36 (95% CI: 0.34; 0.39) in single men, 0.57 (95% CI: 0.55; 0.59) in married men, 0.44 (95% CI: 0.40; 0.47) in single women and 0.69 (95% CI: 0.66; 0.72) in married women. High education was associated with lower mortality from liver, circulatory, chronic respiratory and genitourinary diseases in both sexes. Highly educated men had a lower mortality from lung cancer than less educated men, whereas highly educated women did not have a reduced mortality from lung and breast cancers. Conclusion: Level of education is a strong indicator of premature mortality. The magnitude of the association between educational level and mortality differs across sexes, marital status and causes of death. [ABSTRACT FROM AUTHOR]
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- 2018
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45. Mortality from respiratory diseases associated with opium use: a population-based cohort study.
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Rahmati, Atieh, Shakeri, Ramin, Khademi, Hooman, Poutschi, Hossein, Pourshams, Akram, Etemadi, Arash, Khoshnia, Masoud, Sohrabpour, Amir Ali, Aliasgari, Ali, Jafari, Elham, Islami, Farhad, Semnani, Shahryar, Gharravi, Abdolsamad, Abnet, Christian C., Pharoah, Paul D. P., Brennan, Paul, Boffetta, Paolo, Dawsey, Sanford M., Malekzadeh, Reza, and Kamangar, Farin
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RESPIRATORY diseases ,EPIDEMIOLOGY ,OPIUM ,ETIOLOGY of diseases ,MORTALITY ,ANALGESICS ,LONGITUDINAL method ,LUNG tumors ,NARCOTICS ,SURVIVAL ,DRUG abusers - Abstract
Background: Recent studies have suggested that opium use may increase mortality from cancer and cardiovascular diseases. However, no comprehensive study of opium use and mortality from respiratory diseases has been published. We aimed to study the association between opium use and mortality from respiratory disease using prospectively collected data.Methods: We used data from the Golestan Cohort Study, a prospective cohort study in northeastern Iran, with detailed, validated data on opium use and several other exposures. A total of 50 045 adults were enrolled from 2004 to 2008, and followed annually until June 2015, with a follow-up success rate of 99%. We used Cox proportional hazard regression models to evaluate the association between opium use and outcomes of interest.Results: During the follow-up period, 331 deaths from respiratory disease were reported (85 due to respiratory malignancies and 246 due to non-malignant aetiologies). Opium use was associated with an increased risk of death from any respiratory disease (adjusted HR 95% CI 3.13 (2.42 to 4.04)). The association was dose-dependent with a HR of 3.84 (2.61 to 5.67) for the highest quintile of cumulative opium use versus never use (Ptrend<0.001). The HRs (95% CI) for the associations between opium use and malignant and non-malignant causes of respiratory mortality were 1.96 (1.18 to 3.25) and 3.71 (2.76 to 4.96), respectively.Conclusions: Long-term opium use is associated with increased mortality from both malignant and non-malignant respiratory diseases. [ABSTRACT FROM AUTHOR]- Published
- 2017
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46. Occupational exposures contribute to educational inequalities in lung cancer incidence among men: evidence from the EPIC prospective cohort study
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Menvielle, Gwenn, Boshuizen, Hendriek, Kunst, Anton E., Vineis, Paolo, Dalton, Susanne O., Bergmann, Manuela M., Hermann, Silke, Veglia, Fabrizio, Ferrari, Pietro, Overvad, Kim, Raaschou-Nielsen, Ole, Tjønneland, Anne, Kaaks, Rudolf, Linseisen, Jakob, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Rodriguez, Laudina, Agudo, Antonio, Sánchez, Maria-José, Arozena, Jone Miren Altzibar, Cirera, Lluis, Ardanaz, Eva, Bingham, Sheila, Khaw, Kay-Tee, Boffetta, Paolo, Duell, Eric, Slimani, Nadia, Gallo, Valentina, Riboli, Elio, Bueno-de-Mesquita, H. Bas, Menvielle, G., Boshuizen, H., Kunst, A.E., Vineis, P., Dalton, S.O., Bergmann, M.M., Hermann, S., Veglia, F., Ferrari, P., Overvad, K., Raaschou-Nielsen, O., Tjønneland, A., Kaaks, R., Linseisen, J., Palli, D., Krogh, V., Tumino, R., Rodriguez, L., Agudo, A., Sánchez, M.-J., Arozena, J.M.A., Cirera, L., Ardanaz, E., Bingham, S., Khaw, K.-T., Boffetta, P., Duell, E., Slimani, N., Gallo, V., Riboli, E., Bas Bueno-de-Mesquita, H., Public Health, Amsterdam Public Health, and Public and occupational health
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Male ,prospective cohort study ,Lung Neoplasms ,Incidence ,men ,educational ,Article ,Occupational ,Cohort Studies ,lung cancer ,SDG 3 - Good Health and Well-being ,Socioeconomic Factors ,exposure ,inequalitie ,Occupational Exposure ,incidence ,Educational Status ,Humans ,Prospective Studies ,ddc:610 ,EPIC ,Proportional Hazards Models - Abstract
The aim of this study is to investigate to what extent occupational exposures may explain socioeconomic inequalities in lung cancer incidence after adjusting for smoking and dietary factors. Analyses were based on a subsample of the European Prospective Investigation into Cancer and Nutrition (EPIC study), a prospective cohort. The analyses included 703 incident lung cancer cases among men in Denmark, the United Kingdom, Germany, Italy, Spain and Greece. The socioeconomic position was measured using the highest level of education. The estimates of relative indices of inequality (RII) were computed with Cox regression models. We first adjusted for smoking (with detailed information on duration and quantity) and dietary factors (fruits and vegetables consumption) and then for occupational exposures. The exposure to three carcinogens [asbestos, heavy metals and polycyclic aromatic hydrocarbons (PAH)] was analyzed. The occupational exposures explained 14% of the socioeconomic inequalities remaining after adjustment for smoking and fruits and vegetables consumption. The inequalities remained nevertheless statistically significant. The RII decreased from 1.87 (95% CI: 1.36-2.56) to 1.75 (1.27-2.41). The decrease was more pronounced when adjusting for asbestos than for heavy metals or PAH. Analyses by birth cohort suggested an effect of occupational exposures among older men, while due to small number of endpoints, no conclusion could be drawn about the role of occupational exposures in educational inequalities among younger men. Our study revealed that the impact of occupational exposures on socioeconomic inequalities in cancer incidence, rarely studied until now, exists while of modest magnitude. Some authors are partners of Environmental Cancer Risk, Nutrition and Individual Susceptibility, a network of excellence of the European Commission (6FP contract 513943). Antonio Agudo and Paolo Vineis were supported by ECNIS.
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- 2009
47. A mortality study of beryllium workers.
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Boffetta, Paolo, Fordyce, Tiffani A., and Mandel, Jack S.
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LUNG cancer risk factors , *BERYLLIUM industry , *CANCER-related mortality , *OCCUPATIONAL diseases , *FOLLOW-up studies (Medicine) - Abstract
We aimed at investigating mortality among beryllium-exposed workers, according to solubility of beryllium and beryllium compounds. We conducted an historical cohort study of 16,115 workers employed during 1925-2008 in 15 facilities, including eight entailing exposure to insoluble beryllium and seven entailing exposure to soluble/mixed beryllium compounds, who were followed up for mortality until 2011. Data were analyzed using indirect standardization and Cox regression modeling. Lung cancer standardized mortality ratio ( SMR, national reference rates) was 1.02 (95% confidence interval [ CI]: 0.94-1.10) in the whole cohort, 0.88 (95% CI: 0.75-1.03) in the insoluble beryllium subcohort, and 1.09 (95% CI: 0.99-1.09) in the soluble/mixed beryllium subcohort. For lung cancer, there was an association with period of hire in soluble/mixed beryllium plants but not in insoluble plants, and, conversely, employment in soluble/mixed plants was associated with increased mortality only among workers hired before 1955. There was no trend with duration of employment. Mortality from chronic beryllium disease increased, in particular, among workers hired before 1955 in soluble/mixed beryllium facilities. There was no increase in lung cancer mortality in the entire cohort and lung cancer mortality was not increased among beryllium workers hired in 1955 or later in soluble/mixed beryllium facilities, or at any time among those employed in insoluble beryllium facilities. [ABSTRACT FROM AUTHOR]
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- 2016
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48. Updated mortality study of a cohort of asbestos textile workers.
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Pira, Enrico, Romano, Canzio, Violante, Francesco S., Farioli, Andrea, Spatari, Giovanna, La Vecchia, Carlo, and Boffetta, Paolo
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PERITONEUM ,MESOTHELIOMA ,ASBESTOS ,OVARIAN cancer ,LUNG cancer - Abstract
Limited information is available on risk of peritoneal mesothelioma after asbestos exposure, and in general on the risk of cancer after cessation of asbestos exposure. We updated to 2013 the follow-up of a cohort of 1083 female and 894 male textile workers with heavy asbestos exposure (up to 100 fb/ mL), often for short periods. A total of 1019 deaths were observed, corresponding to a standardized mortality ratio ( SMR) of 1.68 (95% confidence interval [ CI]: 1.57-1.78). SMRs were 29.1 (95% CI: 21.5-38.6) for peritoneal cancer, 2.96 (95% CI: 2.50-3.49) for lung cancer, 33.7 (95% CI: 25.7-43.4) for pleural cancer, and 3.03 (95% CI: 1.69-4.99) for ovarian cancer. For pleural and peritoneal cancer, there was no consistent pattern of risk in relation to time since last exposure, whereas for lung cancer there was an indication of a decline in risk after 25 years since last exposure. The findings of this unique cohort provide novel data for peritoneal cancer, indicating that - as for pleural cancer - the excess risk does not decline up to several decades after cessation of exposure. [ABSTRACT FROM AUTHOR]
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- 2016
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49. Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia.
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Brenner, Darren R., Amos, Christopher I., Brhane, Yonathan, Timofeeva, Maria N., Caporaso, Neil, Yufei Wang, Christiani, David C., ller, Heike Bickebö, Ping Yang, Albanes, Demetrius, Stevens, Victoria L., Gapstur, Susan, McKay, James, Boffetta, Paolo, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, and Mates, Dana
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LUNG cancer ,LUNG histology ,SQUAMOUS cell carcinoma ,BAYESIAN analysis ,PROBABILITY theory ,FALSE discovery rate - Abstract
Large-scale genome-wide association studies (GWAS) have likely uncovered all common variants at the GWAS significance level. Additional variants within the suggestive range (0.0001> P > 5Ã--10
â'8 ) are, however, still of interest for identifying causal associations. This analysis aimed to apply novel variant prioritization approaches to identify additional lung cancer variants that may not reach the GWAS level. Effects were combined across studies with a total of 33456 controls and 6756 adenocarcinoma (AC; 13 studies), 5061 squamous cell carcinoma (SCC; 12 studies) and 2216 small cell lung cancer cases (9 studies). Based on prior information such as variant physical properties and functional significance, we applied stratified false discovery rates, hierarchical modeling and Bayesian false discovery probabilities for variant prioritization. We conducted a fine mapping analysis as validation of our methods by examining top-ranking novel variants in six independent populations with a total of 3128 cases and 2966 controls. Three novel loci in the suggestive range were identified based on our Bayesian framework analyses: KCNIP4 at 4p15.2 (rs6448050, P = 4.6Ã--10â'7 ) and MTMR2 at 11q21 (rs10501831, P = 3.1Ã--10â'6 ) with SCC, as well as GAREM at 18q12.1 (rs11662168, P = 3.4Ã--10â'7 ) with AC. Use of our prioritization methods validated two of the top three loci associated with SCC (P = 1.05Ã--10â'4 for KCNIP4, represented by rs9799795) and AC (P = 2.16Ã--10â'4 for GAREM, represented by rs3786309) in the independent fine mapping populations. This study highlights the utility of using prior functional data for sequence variants in prioritization analyses to search for robust signals in the suggestive range. [ABSTRACT FROM AUTHOR]- Published
- 2015
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50. Diesel Engine Exhaust and Lung Cancer Mortality: Time-Related Factors in Exposure and Risk.
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Moolgavkar, Suresh H., Chang, Ellen T., Luebeck, Georg, Lau, Edmund C., Watson, Heather N., Crump, Kenny S., Boffetta, Paolo, and McClellan, Roger
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DIESEL motor exhaust gas ,ENVIRONMENTAL exposure ,LUNG cancer risk factors ,CARCINOGENESIS ,HEALTH of miners ,PHYSIOLOGY - Abstract
To develop a quantitative exposure-response relationship between concentrations and durations of inhaled diesel engine exhaust (DEE) and increases in lung cancer risks, we examined the role of temporal factors in modifying the estimated effects of exposure to DEE on lung cancer mortality and characterized risk by mine type in the Diesel Exhaust in Miners Study (DEMS) cohort, which followed 12,315 workers through December 1997. We analyzed the data using parametric functions based on concepts of multistage carcinogenesis to directly estimate the hazard functions associated with estimated exposure to a surrogate marker of DEE, respirable elemental carbon (REC). The REC-associated risk of lung cancer mortality in DEMS is driven by increased risk in only one of four mine types (limestone), with statistically significant heterogeneity by mine type and no significant exposure-response relationship after removal of the limestone mine workers. Temporal factors, such as duration of exposure, play an important role in determining the risk of lung cancer mortality following exposure to REC, and the relative risk declines after exposure to REC stops. There is evidence of effect modification of risk by attained age. The modifying impact of temporal factors and effect modification by age should be addressed in any quantitative risk assessment (QRA) of DEE. Until there is a better understanding of why the risk appears to be confined to a single mine type, data from DEMS cannot reliably be used for QRA. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
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