4 results on '"tumor-educated platelet"'
Search Results
2. Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer.
- Author
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Sheng, Meiling, Dong, Zhaohui, and Xie, Yanping
- Subjects
- *
RIBOSOMAL proteins , *CANCER patients , *LUNG cancer - Abstract
Background: Lung cancer is a severe cancer with a high death rate. The 5-year survival rate for stage III lung cancer is much lower than stage I. Early detection and intervention of lung cancer patients can significantly increase their survival time. However, conventional lung cancer-screening methods, such as chest X-rays, sputum cytology, positron-emission tomography (PET), low-dose computed tomography (CT), magnetic resonance imaging, and gene-mutation, -methylation, and -expression biomarkers of lung tissue, are invasive, radiational, or expensive. Liquid biopsy is non-invasive and does little harm to the body. It can reflect early-stage dysfunctions of tumorigenesis and enable early detection and intervention. Methods: In this study, we analyzed RNA-sequencing data of tumor-educated platelets (TEPs) in 402 non-small-cell lung cancer (NSCLC) patients and 231 healthy controls. A total of 48 biomarker genes were selected with advanced minimal-redundancy, maximal-relevance, and incremental feature-selection (IFS) methods. Results: A support vector-machine (SVM) classifier based on the 48 biomarker genes accurately predicted NSCLC with leave-one-out cross-validation (LOOCV) sensitivity, specificity, accuracy, and Matthews correlation coefficients of 0.925, 0.827, 0.889, and 0.760, respectively. Network analysis of the 48 genes revealed that the WASF1 actin cytoskeleton module, PRKAB2 kinase module, RSRC1 ribosomal protein module, PDHB carbohydrate-metabolism module, and three intermodule hubs (TPM2, MYL9, and PPP1R12C) may play important roles in NSCLC tumorigenesis and progression. Conclusion: The 48-gene TEP liquid-biopsy biomarkers will facilitate early screening of NSCLC and prolong the survival of cancer patients. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
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3. Tumor-Educated Platelets: A Review of Current and Potential Applications in Solid Tumors
- Author
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Theodore Nicolaides and Joyce Varkey
- Subjects
lung cancer ,Oncology ,liquid biopsy ,business.industry ,General Engineering ,Cancer research ,Medicine ,Platelet ,solid tumor ,Current (fluid) ,business ,tumor-educated platelet - Abstract
In this current era of precision medicine, liquid biopsy poses a unique opportunity for an easily accessible, comprehensive molecular profile that would allow for the identification of therapeutic targets and sequential monitoring. Solid tumors are definitively diagnosed by analyzing primary tumor tissue, but surgical sampling is not always sufficient to generate a comprehensive genetic fingerprint at the time of diagnosis, or an appropriate means for continued monitoring. Platelets are known to have a dynamic, bidirectional relationship with tumors, acting beyond their role of hemostasis. Tumor-educated platelets (TEP) are modified by the tumor in multiple ways and act as a carrier and protector of metastasis. Data so far have shown that the mRNA in TEP can be harnessed for cancer diagnostics, with many potential applications.
- Published
- 2021
4. Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer
- Author
-
Zhaohui Dong, Yanping Xie, and Meiling Sheng
- Subjects
0301 basic medicine ,Oncology ,Sputum Cytology ,medicine.medical_specialty ,IFS ,medicine.disease_cause ,tumor-educated platelet ,NSCLC ,OncoTargets and Therapy ,maximal relevance ,03 medical and health sciences ,Internal medicine ,minimal redundancy ,medicine ,Pharmacology (medical) ,Liquid biopsy ,Lung cancer ,Survival rate ,Original Research ,Lung ,liquid biopsy ,business.industry ,MRMR ,incremental feature selection ,medicine.disease ,Actin cytoskeleton ,030104 developmental biology ,medicine.anatomical_structure ,TEP ,non-small-cell lung cancer ,Biomarker (medicine) ,Carcinogenesis ,business - Abstract
Meiling Sheng,1,* Zhaohui Dong,2,* Yanping Xie3 1Department of Respiration, Jinhua People’s Hospital, Jinhua, Zhejiang 321000, China; 2Department of Intensive Care Unit, First Hospital of Huzhou, First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang 313000, China; 3Department of Respiratory Medicine, First Hospital of Huzhou, First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang 313000, China *These authors contributed equally tothis work Background: Lung cancer is a severe cancer with a high death rate. The 5-year survival rate for stage III lung cancer is much lower than stage I. Early detection and intervention of lung cancer patients can significantly increase their survival time. However, conventional lung cancer-screening methods, such as chest X-rays, sputum cytology, positron-emission tomography (PET), low-dose computed tomography (CT), magnetic resonance imaging, and gene-mutation, -methylation, and -expression biomarkers of lung tissue, are invasive, radiational, or expensive. Liquid biopsy is non-invasive and does little harm to the body. It can reflect early-stage dysfunctions of tumorigenesis and enable early detection and intervention. Methods: In this study, we analyzed RNA-sequencing data of tumor-educated platelets (TEPs) in 402 non-small-cell lung cancer (NSCLC) patients and 231 healthy controls. A total of 48 biomarker genes were selected with advanced minimal-redundancy, maximal-relevance, and incremental feature-selection (IFS) methods. Results: A support vector-machine (SVM) classifier based on the 48 biomarker genes accurately predicted NSCLC with leave-one-out cross-validation (LOOCV) sensitivity, specificity, accuracy, and Matthews correlation coefficients of 0.925, 0.827, 0.889, and 0.760, respectively. Network analysis of the 48 genes revealed that the WASF1 actin cytoskeleton module, PRKAB2 kinase module, RSRC1 ribosomal protein module, PDHB carbohydrate-metabolism module, and three intermodule hubs (TPM2, MYL9, and PPP1R12C) may play important roles in NSCLC tumorigenesis and progression. Conclusion: The 48-gene TEP liquid-biopsy biomarkers will facilitate early screening of NSCLC and prolong the survival of cancer patients. Keywords: tumor-educated platelet, TEP, liquid biopsy, minimal redundancy, maximal relevance, MRMR, incremental feature selection, IFS, non-small-cell lung cancer, NSCLC
- Published
- 2018
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