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Landslides are recognized as high-impact natural hazards in different regions around the world; therefore, they are extensively researched by experts. Landslide inventories are essential to identify areas that are likely to be affected in the future, thereby enabling interventions to prevent loss of life. Today, through combined approaches, such as remote sensing and machine learning techniques, it is possible to apply algorithms that use data derived from satellite images to produce landslide inventories. This work presents the performance of five machine learning methods—k-nearest neighbor (KNN), stochastic gradient descendent (SGD), support vector machine radial basis function (SVM RBF Kernel), support vector machine (SVM linear kernel), and AdaBoost—in landslide detection in a zone of the state of Guerrero in southern Mexico, using continuous change maps and primary landslide factors, such as slope angle, terrain orientation (aspect), and lithology, as inputs. The models were trained with 2/3 of ground truth samples of 671 slidden/non-slidden polygons. The obtained inventory maps were evaluated with the remaining 1/3 of ground truth samples by generating a confusion matrix and applying the Kappa concordance coefficient, accuracy, precision, recall, and F1 score as evaluation metrics, as well as omission and commission errors. According to the results, the AdaBoost classifier reached greater spatial and statistical coherence than the other implemented methods. The best input layer combination for detection was the continuous change maps obtained by the linear regression and image differencing detection methods, together with the slope angle, aspect, and lithology conditioning factors. [ABSTRACT FROM AUTHOR]