1. An intelligent responsive macrophage cell membrane-camouflaged mesoporous silicon nanorod drug delivery system for precise targeted therapy of tumors.
- Author
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Li M, Gao X, Lin C, Shen A, Luo J, Ji Q, Wu J, and Wang P
- Subjects
- Cell Line, Tumor, Cell Survival drug effects, Doxorubicin chemistry, Doxorubicin pharmacokinetics, Doxorubicin pharmacology, Humans, Indocyanine Green chemistry, Infrared Rays, Neoplasms metabolism, Photochemotherapy, Photothermal Therapy, Silicon chemistry, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacokinetics, Antineoplastic Agents pharmacology, Cell Membrane chemistry, Cell Membrane metabolism, Drug Delivery Systems methods, Macrophages cytology, Nanotubes chemistry
- Abstract
Macrophage cell membrane-camouflaged nanocarriers can effectively reduce immune cell clearance and actively target tumors. In this study, a macrophage cell membrane-camouflaged mesoporous silica nanorod (MSNR)-based antitumor drug carrier equipped with a cationic polymer layer was developed. As drug carriers, these MSNRs were loaded with the thermosensitive phase change material L-menthol (LM), the chemotherapy drug doxorubicin (DOX) and the fluorescent molecule indocyanine green (ICG). The rod-like shape of the MSNRs was shown to enhance the penetration of the drug carriers to tumors. In the weakly acidic tumor microenvironment, the cationic polymer exhibited a proton sponge effect to trigger macrophage cell membrane coating detachment, promoting tumor cell uptake. Following nanocarrier uptake, ICG is heated by near-infrared (NIR) irradiation to make LM undergo a phase transition to release DOX and generate a synergistic effect of thermochemotherapy which kills tumor cells and inhibits tumor growth together with reactive oxygen species (ROS) produced by ICG. Overall, this nanohybrid drug delivery system demonstrates an intelligent cascade response, leads to tissue-cell specific targeting and improves drug release accuracy, thus proving to be an effective cancer therapy., (© 2021. The Author(s).)
- Published
- 2021
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