1. Clinical and Quantitative MRI Perfusion Analysis of Osteoid Osteomas Before and After Microwave Ablation.
- Author
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Kostrzewa M, Henzler T, Schoenberg SO, Diehl SJ, and Rathmann N
- Subjects
- Adolescent, Adult, Bone Neoplasms blood supply, Bone Neoplasms pathology, Child, Computed Tomography Angiography, Female, Humans, Male, Microwaves adverse effects, Middle Aged, Osteoma, Osteoid blood supply, Osteoma, Osteoid pathology, Predictive Value of Tests, Prospective Studies, Time Factors, Treatment Outcome, Young Adult, Ablation Techniques adverse effects, Bone Neoplasms diagnostic imaging, Bone Neoplasms surgery, Magnetic Resonance Angiography, Microwaves therapeutic use, Osteoma, Osteoid diagnostic imaging, Osteoma, Osteoid surgery, Perfusion Imaging methods
- Abstract
Aim: Evaluation of osteoid osteoma (OO) perfusion characteristics pre and post microwave ablation (MWA) using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with clinical follow-up., Materials and Methods: Patients with OO underwent T1-weighted 3D DCE-MRI at 3.0T pre and post MWA. Signal intensity (SI) and perfusion of lesions was measured. Patients answered a questionnaire for clinical follow-up., Results: A total of 24 patients were included (mean age of 28 years; nine females); 21 DCE-MRI datasets were of sufficient quality for analysis. The mean SI of lesions, plasma flow, volume of distribution and pain level all decreased statistically significantly after ablation., Conclusion: Quantitative MRI-perfusion analysis allows for objective treatment evaluation after MWA of OO, plasma flow and volume of distribution seem to be reliable indicators for successful thermoablation. MWA is an effective treatment option for OO with a low risk profile and significant pain reduction after treatment., (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2019
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