1. Novel diagnostic approaches in Bing-Neel syndrome.
- Author
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Ly KI, Fintelmann F, Forghani R, Schaefer PW, Hochberg EP, and Hochberg FH
- Subjects
- Aged, Biopsy, Brain pathology, Female, Humans, Male, Middle Aged, Spinal Cord pathology, Waldenstrom Macroglobulinemia cerebrospinal fluid, Waldenstrom Macroglobulinemia pathology, Magnetic Resonance Imaging, Waldenstrom Macroglobulinemia diagnosis
- Abstract
The central nervous system (CNS) manifestations of Waldenström's macroglobulinemia (WM) are known as the Bing-Neel syndrome (BNS). Patients with BNS can be classified into Group A and Group B based on the presence of lymphoplasmacytoid (LMP) cells within the brain parenchyma, leptomeninges, dura, and/or cerebrospinal fluid (CSF). To identify characteristic imaging findings for both Group A and Group B patients, we reviewed all 36 cases (26 referenced, 10 unreported) of proven WM with CNS symptoms, CSF analysis and/or biopsy, and magnetic resonance imaging (MRI) of the brain and/or spinal cord. Enhancement on MRI suggests invasion of the central neuraxis by LMP cells, and can help distinguish between Group A and Group B patients. In addition to differentiating true WM lesions in the CNS from ischemia, hyperviscosity events, and demyelinating lesions, evaluation of brain and spinal cord with gadolinium-enhanced MRI has the potential to guide management., (Copyright © 2010 Elsevier Inc. All rights reserved.)
- Published
- 2011
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