1. Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract.
- Author
-
Martinez GV, Navath S, Sewda K, Rao V, Foroutan P, Alleti R, Moberg VE, Ahad AM, Coppola D, Lloyd MC, Gillies RJ, Morse DL, and Mash EA
- Subjects
- Animals, Linear Models, Mice, Mice, Inbred C3H, Molecular Structure, Contrast Media administration & dosage, Contrast Media chemistry, Gastrointestinal Tract metabolism, Heterocyclic Compounds administration & dosage, Heterocyclic Compounds chemistry, Magnetic Resonance Imaging, Organometallic Compounds administration & dosage, Organometallic Compounds chemistry, Sucrose administration & dosage, Sucrose chemistry
- Abstract
A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated., (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Published
- 2013
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