1. Frequency-specific changes in the default mode network in patients with cingulate gyrus epilepsy.
- Author
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Leng X, Xiang J, Yang Y, Yu T, Qi X, Zhang X, Wu S, and Wang Y
- Subjects
- Adolescent, Adult, Female, Gyrus Cinguli physiopathology, Humans, Male, Young Adult, Brain Waves physiology, Cerebral Cortex physiopathology, Connectome, Default Mode Network physiopathology, Epilepsy physiopathology, Magnetoencephalography
- Abstract
To identify abnormal functional connectivity of the default mode network in cingulate gyrus epilepsy, which may yield new information about the default mode network and suggest a new cingulate gyrus epilepsy biomarker. Fifteen patients with cingulate gyrus epilepsy (mean age = 21 years) and 15 healthy controls (mean age = 24 years) were studied in the resting state using magnetoencephalography. Twelve brain areas of interest in the default mode network were extracted and investigated with multifrequency signals that included alpha (α, 8-13 Hz), beta (β, 14-30 Hz), and gamma (γ, 31-80 Hz) band oscillations. Patients with cingulate gyrus epilepsy had significantly greater connectivity in all three frequency bands (α, β, γ). A frequency-specific elevation of functional connectivity was found in patients compared to controls. The greater functional connectivity in the γ band was significantly more prominent than that of the α and β bands. Patients with cingulate gyrus epilepsy and controls differed significantly in functional connectivity between the left angular gyrus and left posterior cingulate cortex in the α, β, and γ bands. The results of the node degree analysis were similar to those of the functional connectivity analysis. Our findings reveal for the first time that brain activity in the γ band may play a key role in the default mode network in cingulate gyrus epilepsy. Altered functional connectivity of the left angular gyrus and left posterior cingulate cortex may be a new biomarker for cingulate gyrus epilepsy., (© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.)
- Published
- 2020
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