Anthony Kafatos, Cristina Molina-Hidalgo, Idoia Labayen, Eva Karaglani, Eva Gesteiro, Marcela González-Gross, Luis M. Esteban, Pilar De Miguel-Etayo, Stefaan De Henauw, Sergio Sabroso-Lasa, Diego F Salazar-Tortosa, Jonatan R. Ruiz, Aline Meirhaeghe, Yannis Manios, Miguel Seral-Cortes, Laura Censi, Éva Erhardt, Laurent Béghin, Luis A. Moreno, Kurt Widhalm, Universidad Pública de Navarra. Departamento de Ciencias de la Salud, Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila, CHU Lille, Inserm, Institut Pasteur de Lille, Université de Lille, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286, University of Zaragoza - Universidad de Zaragoza [Zaragoza], Centro Nacional de Investigaciones Oncologicas / Spanish National Cancer Research Centre [Madrid, Espagne] [CNIO], Instituto de Salud Carlos III [Madrid] [ISC], Universität Bonn = University of Bonn, Universidad Politécnica de Madrid [UPM], Universiteit Gent = Ghent University [UGENT], University of Pecs, Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics [CREA], Harokopio University of Athens, Medizinische Universität Wien = Medical University of Vienna, University of Crete [Heraklion] [UOC], Lille Inflammation Research International Center - U 995 [LIRIC], Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE], University of Arizona, Universidad Pública de Navarra [Espagne] = Public University of Navarra [UPNA], Centro Nacional de Investigaciones Oncologicas / Spanish National Cancer Research Centre [Madrid, Espagne] (CNIO), Instituto de Salud Carlos III [Madrid] (ISC), Universidad Politécnica de Madrid (UPM), Universidad de Granada = University of Granada (UGR), Universiteit Gent = Ghent University (UGENT), Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics (CREA), University of Crete [Heraklion] (UOC), Lille Inflammation Research International Center - U 995 (LIRIC), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), and Universidad Pública de Navarra [Espagne] = Public University of Navarra (UPNA)
Obesity and metabolic syndrome (MetS) are worldwide major health challenges. The Mediterranean diet (MD) is associated with a better cardiometabolic profile, but these beneficial e ects may be influenced by genetic variations, modulating the predisposition to obesity or MetS. The aim was to assess whether interaction e ects occur between an obesity genetic risk score (obesity-GRS) and the MD on adiposity and MetS in European adolescents. Multiple linear regression models were used to assess the interaction e ects of an obesity-GRS and the MD on adiposity and MetS and its components. Interaction e ects between theMDon adiposity and MetS were observed in both sex groups (p < 0.05). However, those interaction e ects were only expressed in a certain number of adolescents, when a limited number of risk alleles were present. Regarding adiposity, a total of 51.1% males and 98.7% females had lower body mass index (BMI) as a result of higher MD adherence. Concerning MetS, only 9.9% of males with higher MD adherence had lower MetS scores. However, the same e ect was observed in 95.2% of females. In conclusion, obesity-related genotypes could modulate the relationship between MD adherence and adiposity and MetS in European adolescents; the interaction e ect was higher in females than in males., Iberus Talent Pre-doctoral fellowships 2018, under the European Union's H2020 research and innovation programme under Marie Sklodowska-Curie grant 801586, Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, CIBERObn ISCIII-CB15/00043, European Union (EU) FOOD-CT-2005-007034, HELENA project, Spanish Ministry of Economy and Competitiveness RYC-2010-05957 RYC-2011-09011, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn)