1. Influence of spatial resolution and contrast agent dosage on myocardial T1 relaxation times
- Author
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Jeanette Schulz-Menger, Edyta Blaszczyk, Felix Wanke, Luisa Schmacht, Florian von Knobelsdorff-Brenkenhoff, Andreas Greiser, and Agnieszka Töpper
- Subjects
Gadolinium DTPA ,Male ,media_common.quotation_subject ,Biophysics ,Contrast Media ,Inversion recovery ,Signal-To-Noise Ratio ,030204 cardiovascular system & hematology ,computer.software_genre ,030218 nuclear medicine & medical imaging ,Gadobutrol ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Nuclear magnetic resonance ,Voxel ,Image Interpretation, Computer-Assisted ,Organometallic Compounds ,medicine ,Humans ,Contrast (vision) ,Radiology, Nuclear Medicine and imaging ,Image resolution ,Voxel size ,Aged ,media_common ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Chemistry ,Myocardium ,Spin–lattice relaxation ,Reproducibility of Results ,Heart ,Magnetic resonance imaging ,Middle Aged ,Magnetic Resonance Imaging ,Healthy Volunteers ,Female ,Nuclear medicine ,business ,computer ,medicine.drug - Abstract
Our aim was to study the influence of small variations in spatial resolution and contrast agent dosage on myocardial T1 relaxation time. Twenty-nine healthy volunteers underwent cardiovascular magnetic resonance at 3T twice, including a modified look-locker inversion recovery (MOLLI) technique—3(3)3(3)5—for T1 mapping. Native T1 was assessed in three spatial resolutions (voxel size 1.4 × 1.4 × 6, 1.6 × 1.6 × 6, 1.7 × 1.7 × 6 mm3), and postcontrast T1 after 0.1 and 0.2 mmol/kg gadobutrol. Partition coefficient was calculated based on myocardial and blood T1. T1 analysis was done per segment, per slice, and for the whole heart. Native T1 values did not differ with varying spatial resolution per segment (p = 0.116–0.980), per slice (basal: p = 0.772; middle: p = 0.639; apex: p = 0.276), and globally (p = 0.191). Postcontrast T1 values were significantly lower with higher contrast agent dosage (p
- Published
- 2016