1. Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients
- Author
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Mayumi Yamato, Koichi Okita, Arata Fukushima, Hiroyuki Tsutsui, Kagami Hirabayashi, Takashi Yokota, Shingo Takada, Shouji Matsushima, Shintaro Kinugawa, Ippei Nakano, and Tadashi Suga
- Subjects
Male ,medicine.medical_specialty ,Science ,Cardiology ,030209 endocrinology & metabolism ,Diseases ,Exercise intolerance ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Article ,Phosphocreatine ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Medical research ,Internal medicine ,medicine ,TBARS ,Humans ,Muscle, Skeletal ,Exercise ,Aerobic capacity ,Heart Failure ,Multidisciplinary ,business.industry ,Health care ,Skeletal muscle ,Middle Aged ,medicine.disease ,Oxidative Stress ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Heart failure ,Medicine ,medicine.symptom ,business ,Energy Metabolism ,Anaerobic exercise ,Oxidative stress - Abstract
Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood testing, cardiopulmonary exercise testing, and magnetic resonance spectroscopy (MRS). The serum thiobarbituric acid reactive substances (TBARS; lipid peroxides) were significantly higher (5.1 ± 1.1 vs. 3.4 ± 0.7 μmol/L, p p 2) at both peak exercise and anaerobic threshold was significantly depressed in the CHF patients; the parameters of aerobic capacity were inversely correlated with serum TBARS and positively correlated with serum SOD activity. The phosphocreatine loss during plantar-flexion exercise and intramyocellular lipid content in the participants' leg muscle measured by 31phosphorus- and 1proton-MRS, respectively, were significantly elevated in the CHF patients, indicating abnormal intramuscular energy metabolism. Notably, the skeletal muscle abnormalities were related to the enhanced systemic oxidative stress. Our analyses revealed that systemic oxidative stress is related to lowered whole-body aerobic capacity and skeletal muscle dysfunction in CHF patients. more...
- Published
- 2021