1. Survival benefit of conversion surgery after intensive chemotherapy for unresectable metastatic gastric cancer: a propensity score-matching analysis
- Author
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Hiroyuki Ohnuma, Koji Miyanishi, Naoki Onoyama, Naotaka Hayasaka, Kazuyuki Murase, Ichiro Takemasa, Kota Hamaguchi, Yasushi Sato, Takayuki Nobuoka, Takeshi Murakami, Junji Kato, Kohichi Takada, Tatsuya Ito, and Masanori Sato
- Subjects
0301 basic medicine ,Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Multivariate analysis ,medicine.medical_treatment ,Subgroup analysis ,Adenocarcinoma ,Risk Assessment ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Gastrectomy ,Stomach Neoplasms ,Antineoplastic Combined Chemotherapy Protocols ,Medicine ,Humans ,Neoplasm Metastasis ,Propensity Score ,Aged ,Retrospective Studies ,Chemotherapy ,business.industry ,Confounding ,Cancer ,Combination chemotherapy ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Survival Analysis ,Surgery ,030104 developmental biology ,Treatment Outcome ,Oncology ,Chemotherapy, Adjuvant ,030220 oncology & carcinogenesis ,Propensity score matching ,Female ,business - Abstract
The clinical benefit of conversion surgery (CS) for unresectable gastric cancer (GC), whereby unresectable GC responds to chemotherapy and subsequently receives curative-intent surgery, remains unclear. Here, we aimed to clarify the clinical value of CS. In this retrospective cohort study, we analyzed 175 unresectable GC, who received triple combined chemotherapy between 2004 and 2019. We divided patients into two groups: those who underwent CS and those receiving chemotherapy only (CS and C groups, respectively). Propensity score matching was used to minimize confounding bias. Of 175 cases, 61 (34.9%) underwent CS. R0 resection was obtained in 85.2%. After matching, 44 pairs were selected; there were no significant differences in baseline covariants. Group CS had a significantly better median overall survival (OS) (18.8 vs. 46.0 months, p
- Published
- 2020