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A 67-year-old male diagnosed as having inoperable advanced hepatocellular carcinoma with portal invasion was able to undergo resection after continuous intra-arterial chemotherapy with 5-fluorouracil (5-FU) and cisplatin (CDDP). These were continuously administered for 24 hours at doses of 5-FU of 250 mg and CDDP of 5 mg/day, from day 1 to day 5 in a week, repeated 6 times. In additions to the reductions of the levels of AFP and PIVKA-II from 212.6 ng/ml and 16,100 mAU/ml to 11.8 ng/ml and 12 mAU/ml, respectively, the volume of the tumor and the portal invasion were diminished remarkably. As a result, a left extended hepatectomy could be performed. No sign of recurrence was seen during 16 months of follow-up after the operation. Given the above results, continuous intra-arterial chemotherapy with 5-FU and CDDP therapy may be effective for patients with hepatocellular carcinoma.

The effect of moxisylyte hydrochloride, a new type alpha 1-blocking vasodilator, on the retinal circulation was investigated in 14 diabetics, using the video-densitometric image analysis of fluorescein angiography. The build-up time (BT) and the mean circulation time (MCT) were compared before and after oral administration of moxisylyte. The BT one hour after oral administration of 30 mg moxisylyte was significantly shorter than that before therapy (artery; before 5.2 +/- 1.5 vs after 4.6 +/- 1.0 sec; p = 0.0001, vein; before 6.9 +/- 1.3 vs 6.3 +/- 1.1 sec; p = 0.0005). The MCT two weeks after oral administration of 90 mg per day moxisylyte was significantly shortened (before 3.6 +/- 2.3 vs after 2.6 +/- 1.4 sec; p = 0.0180). These results suggested that oral moxisylyte improved the retinal circulation and might support the concept that moxisylyte hydrochloride has clinical usefulness in patients with diabetes mellitus.