1. Transarterial chemoembolization combined with Jie-du granule preparation improves the survival outcomes of patients with unresectable hepatocellular carcinoma
- Author
-
Zhe Chen, Lanyu Chen, Xuying Wan, Changquan Ling, Hetong Zhao, Feng Shen, and Xiao-feng Zhai
- Subjects
Male ,0301 basic medicine ,Sorafenib ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,transarterial chemoembolization ,Gastroenterology ,Jie-du granule ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,Combined Modality Therapy ,Chemoembolization, Therapeutic ,Survival rate ,retrospective cohort study ,Survival analysis ,Retrospective Studies ,business.industry ,Liver Neoplasms ,Retrospective cohort study ,Patient survival ,hepatocellular carcinoma ,Middle Aged ,medicine.disease ,Survival Analysis ,Surgery ,Survival Rate ,Treatment Outcome ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Hepatic surgery ,Female ,business ,Research Paper ,Drugs, Chinese Herbal ,medicine.drug - Abstract
The aim of the present study was to compare the effectiveness of transarterial chemoembolization (TACE), TACE combined with Jie-du granules (JD), and TACE combined with sorafenib (SOR) for treating patients with unresectable hepatocellular carcinoma (HCC). For this purpose, we conducted a retrospective analysis of data from 266 consecutive patients with unresectable HCC who underwent TACE treatment at the Shanghai Hospital and Eastern Hepatic Surgery Hospital between Jan 2009 and Dec 2010. We prospectively analyzed patient survival and progression times as well as independent predictors, within a follow-up period of 86 months. Patients were divided into TACE-JD (n = 75), TACE-SOR (n = 124) and TACE (n = 67) groups. Median overall survival (OS) times being: TACE-JD, 21.43 months; TACE-SOR, 23.23 months; TACE, 13.97 months (TACE-SOR vs TACE, P < 0.001; TACE-SOR vs TACE-JD, P = 0.852; TACE-JD vs TACE, P < 0.001). The median times to progression (TTP) were as follows: TACE-JD, 8.67 months; TACE-SOR, 5.37 months; TACE, 4.57 months (TACE-SOR vs TACE, P = 0.479; TACE-SOR vs TACE-JD, P < 0.001; TACE-JD vs TACE, P < 0.001). Independent predictors of OS were treatment allocation, Child-Pugh class large tumor, albumin and extrahepatic metastasis. These findings show that patients with unresectable HCC who were administered TACE-JD survived significantly longer compared with those administered TACE or TACE-SOR.
- Published
- 2017