1. An unusual quinolinone alkaloid from Waltheria douradinha.
- Author
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Hoelzel SC, Vieira ER, Giacomelli SR, Dalcol II, Zanatta N, and Morel AF
- Subjects
- Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Molecular Structure, Plant Bark chemistry, Plant Roots chemistry, Quinolines pharmacology, Malvaceae chemistry, Quinolines chemistry
- Abstract
The chemical investigation of the methanolic extract of the root bark of Waltheria douradinha (Sterculiaceae) afforded an unusual quinolinone alkaloid named waltherione-A (1). Its structure was determined mainly by NMR spectroscopic methods. The antibacterial activity of waltherione-A (1) and the corresponding O-methylated derivative (2) was tested against three gram-negative and three gram-positive bacteria, with only (2) having moderate activity.
- Published
- 2005
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