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Mandibular reconstruction with double vascularized free flap in the reconstruction of head and neck is unusual. This article describes the case of a female patient 24 years old with a high-grade chondroblastic osteosarcoma of the floor of the mouth and of the left hemimandible. Hemimandibulectomy was performed with a wide resection of submandibular skin, leaving a complex defect which included bone, mucosa and skin. Tumor resection and reconstruction of the defect was performed in a single surgical procedure through 2 free flaps: a free osteocutaneous fibula flap and radial forearm flap. The reconstruction allowed to achieve an adequate chewing function, aesthetic mandibular contour and normal phonation. [ABSTRACT FROM AUTHOR]