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A new xanthone derivative, 3,5,8-trihydroxy-2,2-dimethyl-3,4,4-trihydro-2 H,6 H-pyrano[3,2- b]-xanthen-6one ( 1), together with three known compounds, 5,8-dihydroxy-2,2-dimethyl-2 H,6 H-pyrano[3,2- b]xanthen6-one ( 2), cyclo-( N- O-methyl-L-Trp-L-Ile-D-Pip-L-2-amino-8-oxo-decanoyl) ( 3), and cyclo-(Phe-Tyr) ( 4), was isolated from the mangrove endophytic fungus No. ZSU-H16 obtained from the South China Sea coast. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopic techniques. Compound 1 exhibited cytotoxicity against KB and KBV 200 cells with IC50 values greater than 50 μg/mL, respectively. [ABSTRACT FROM AUTHOR]

A new naphtho- γ-pyrone, 5-hydroxy-6,8-dimethoxy-2-benzyl-4H-naphtho[2,3-b]-pyran-4-one ( 1), together with three known compounds 5,7-dihydroxy-2-methylbenzopyran-4-one ( 2), 3,5-dihydroxy-2,7dimethylbenzopyran-4-one ( 3) and cyclo(Tyr-Tyr) ( 4) were isolated from the mangrove endophytic fungus Phomopsis sp. ZSU-H26 obtained from the South China Sea. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopic techniques. Primary bioassays showed that 1 exhibited cytotoxicity against HEp-2 and HepG2 cells with IC50 values of 10 and 8 μg/mL, respectively. [ABSTRACT FROM AUTHOR]

A new polyketide, 2-(7′-hydroxyoxooctyl)-3-hydroxy-5-methoxybenzeneacetic acid ethyl ester ( 1), together with three known compounds dothiorelone A ( 2), B ( 3), and C ( 4) were isolated from the mangrove endophytic fungus Phomopsis sp. ZSU-H76 obtained from the South China Sea. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopic techniques. Primary bioassays showed that 1 exhibited cytotoxicity against HEp-2 and HepG2 cells with IC50 values of 25 and 30 μg/mL, respectively. [ABSTRACT FROM AUTHOR]

A new isoprenyl phenyl ether, 3-hydroxy-4-(3-methylbut-2-enyloxy)benzoic acid methyl ester ( 1), together with 4-hydroxybenzoic acid ( 2), 2-hydroxy-6-methylbenzoic acid ( 3), and 4-hydroxy-3-methoxybenzoic acid ( 4) were isolated from Mangrove fungus (No. B60) from the South China Sea. The structures of the compounds were established on the basis of NMR spectroscopic and mass spectrometric data. In the preliminary bioassay, compound 1 exhibited antibacterial and antifungal activities. Compound 1 also inhibited cytotoxicity to the hepG2 cell line with an IC50 value of 10.0 µg/mL. [ABSTRACT FROM AUTHOR]

A new griseofulvin derivative, 7-chloro-2',5,6-trimethoxy-6'-methylspiro(benzofuran-2(3H),1'-(2) cyclohexene)3,4'-dione (1), together with the known 2-acetyl-7-methoxybenzofuran (2), was isolated from the marine-derived mangrove endophytic fungus Sporothrix sp. (No. 4335). The structure of new compound 1 was elucidated by analysis of spectroscopic data. [ABSTRACT FROM AUTHOR]