10 results on '"Quinn Brian"'
Search Results
2. Identification of milk from different animal and plant sources by desorption electrospray ionisation high-resolution mass spectrometry (DESI-MS).
- Author
-
Hong, Yunhe, Birse, Nicholas, Quinn, Brian, Montgomery, Holly, Wu, Di, Rosas da Silva, Gonçalo, van Ruth, Saskia M., and Elliott, Christopher T.
- Subjects
GOAT milk ,CAMEL milk ,MATRIX-assisted laser desorption-ionization ,MASS spectrometry ,MILK - Abstract
This study used desorption electrospray ionisation mass spectrometry (DESI-MS) to analyse and detect and classify biomarkers in five different animal and plant sources of milk for the first time. A range of differences in terms of features was observed in the spectra of cow milk, goat milk, camel milk, soya milk, and oat milk. Chemometric modelling was then used to classify the mass spectra data, enabling unique or significant markers for each milk source to be identified. The classification of different milk sources was achieved with a cross-validation percentage rate of 100% through linear discriminate analysis (LDA) with high sensitivity to adulteration (0.1–5% v/v). The DESI-MS results from the milk samples analysed show the methodology to have high classification accuracy, and in the absence of complex sample clean-up which is often associated with authenticity testing, to be a rapid and efficient approach for milk fraud control. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
3. Bioaccumulation of metals in juvenile rainbow trout (oncorhynchus mykiss) via dietary exposure to blue mussels.
- Author
-
McEneff, Gillian, Quinn, Brian, Bennion, Matthew, Dolan, Sorcha, Morrison, Liam, and O'Rourke, Kathleen
- Subjects
- *
RAINBOW trout , *BIOACCUMULATION in fishes , *FOOD chains , *FISH feeds , *EFFECT of heavy metals on fishes , *EFFECT of pollution on fishes - Abstract
The potential for metals to bioaccumulate in aquatic species, such as fish, via trophic level transfer was investigated. An in vivo experiment was set up in a flow-through system in which juvenile rainbow trout were fed blue mussels collected from a Class A pristine site and an effluent-impacted river estuary, over a period of 28 days. Selected elements (As, Cd, Cr, Co, Cu, Fe, Pb, Mn, Mo, Ni, Se, Sn, V, Zn) were determined in the mussels and fish tissues (muscle and skin) collected at 0, 14 and 28 days. This study reveals the occurrence of metals in mussels sampled in the Irish marine environment and highlights the bioaccumulation potential of metals in fish tissues via trophic transfer. All 14 monitored metals were determined in the mussels collected from both sites and mussels collected from the effluent-impacted site contained three times more Co, Mo, Sn and V than the mussels collected from the Class A site. Following a 28-day dietary exposure, concentrations of As and Se (fish muscle), and Pb, Se and Zn (fish skin), were significantly greater in fish feeding on contaminated mussels compared to those with a regular fish feed diet. The significance of metal detection and bioaccumulation in the mussel and fish tissues, highlights the potential for metal exposure to humans through the food chain. As fish are recommended as a healthy and nutritious food source, it is important to fully understand metal bioaccumulation in commercially important aquatic species and ensure the safety of human consumers. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
4. Feasibility of a Breath Test for Monitoring Adherence to Vaginal Administration of Antiretroviral Microbicide Gels.
- Author
-
Morey, Timothy E., Wasdo, Scott, Wishin, Judith, Quinn, Brian, van der Straten, Ariane, Booth, Matthew, Gonzalez, Daniel, Derendorf, Hartmut, Melker, Richard J., and Dennis, Donn M.
- Subjects
HIV prevention ,ANTI-infective agents ,BREATH tests ,CHI-squared test ,DRUGS ,GAS chromatography ,MASS spectrometry ,PATIENT compliance ,RESEARCH funding ,STATISTICAL sampling ,T-test (Statistics) ,VAGINAL medication ,ANTIRETROVIRAL agents ,RANDOMIZED controlled trials ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Adherence to microbicide gel use is critical to optimizing effectiveness in preventing human immunodeficiency virus transmission. The authors hypothesized that ester taggants added to vaginal gels would generate exhaled alcohol and ketone metabolites and provide a 'breath test' for vaginal gel use. This 2-arm (vaginal and dermal), randomized, participant-blinded, pilot study tested this hypothesis. On 8 visits, healthy women (n = 8) received intravaginal taggant (2-butyl acetate, 2-pentyl acetate, isopropyl butyrate, or 2-pentyl butyrate; 30 mg) formulated in hydroxyethylcellulose or tenofovir placebo gel. A second group (n = 4) of women received the same formulations administered dermally on the forearm to determine if skin administration might confound the system. Breath samples were collected using bags before and after taggant administration for 1 hour. Samples were measured using a miniature gas chromatograph and/or gas chromatography-mass spectroscopy for ester taggant, alcohol, and ketone concentrations. After vaginal administration, 2-butyl acetate, 2-pentyl acetate, and metabolites were observed in breath, whereas isopropyl butyrate, 2-pentyl butyrate, and metabolites were not. Some women reported self-resolving, mild burning (24/64 visits) with vaginal administration or a 'bubblegum' taste (7/64 visits). No taggants or metabolites were detected following dermal application. A 'breath test' for adherence to antiretroviral vaginal gel application appears physiologically and technically feasible. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
5. Oral Adherence Monitoring Using a Breath Test to Supplement Highly Active Antiretroviral Therapy.
- Author
-
Morey, Timothy, Booth, Matthew, Wasdo, Scott, Wishin, Judith, Quinn, Brian, Gonzalez, Daniel, Derendorf, Hartmut, Mcgorray, Susan, Simoni, Jane, Melker, Richard, and Dennis, Donn
- Subjects
ANALYSIS of variance ,BREATH tests ,CONFIDENCE intervals ,CROSSOVER trials ,DRUGS ,FOOD ,GAS chromatography ,HIV infections ,LONGITUDINAL method ,MASS spectrometry ,MOLECULAR structure ,PATIENT compliance ,RESEARCH funding ,STATISTICS ,PILOT projects ,DATA analysis ,RANDOMIZED controlled trials ,HIGHLY active antiretroviral therapy ,REPEATED measures design ,BLIND experiment ,RECEIVER operating characteristic curves ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Copyright of AIDS & Behavior is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2013
- Full Text
- View/download PDF
6. SELECTED RESIN ACIDS IN EFFLUENT AND RECEIVING WATERS DERIVED FROM A BLEACHED AND UNBLEACHED KRAFT PULP AND PAPER MILL.
- Author
-
Quinn, Brian P., Booth, Matthew M., Delfino, Joseph J., Holm, Stewart E., and Gross, Timothy S.
- Subjects
- *
PULP mills , *PAPER mills , *MILLS & mill-work , *PONDS , *GAS chromatography , *MASS spectrometry , *ACIDS - Abstract
Water samples were collected on three dates at 24 sites influenced by effluent from Georgia-Pacific's Palatka Pulp and Paper Mill Operation, a bleached and unbleached kraft mill near Palatka, Florida, USA. The sampling sites were located within the mill retention ponds, Rice Creek, and the St. John's River. Samples were analyzed by gas chromatography--mass spectrometry for abietic, dehydroabietic, and isopimaric acids, all of which are potentially toxic by-products of pulp production. Isopimaric acid concentrations greater than 12 mg/L were measured at the mill's effluent outfall but were less than 20 µg/L at the end of Rice Creek. This result indicates that the waters of Rice Creek provide dilution or conditions conducive for degradation or sorption of these compounds. Large differences in resin acid concentrations were observed between sampling events. In two sampling events, the maximum observed concentrations were less than 2 mg/L for each analyte. In a third sampling event, all of the compounds were detected at concentrations greater than 10 mg/L. Data from the three sample dates showed that resin acid concentrations were below 20 µg/L before the confluence of Rice Creek and the St. John's River in all cases. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
- View/download PDF
7. MALDI-ToF MS and chemometric analysis as a tool for identifying wild and farmed salmon.
- Author
-
Hong, Yunhe, Birse, Nicholas, Quinn, Brian, Li, Yicong, Jia, Wenyang, van Ruth, Saskia, and Elliott, Christopher T.
- Subjects
- *
MATRIX-assisted laser desorption-ionization , *SOCKEYE salmon , *SALMON , *CHEMOMETRICS , *ATLANTIC salmon , *PRINCIPAL components analysis , *HUMAN fingerprints - Abstract
• Demonstrating the novel application of MALDI-ToF for food authenticity analysis. • Developing a software pipeline capable to enable MALDI-ToF food authenticity workflows. • Identification of wild and farmed salmon through MALDI-ToF fingerprinting profile. • Achieving 100% accuracy in distinguishing wild and farmed salmon. In this study, the difference between wild and farmed salmon production was successfully profiled and differentiated by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-ToF MS) combined with chemometric analysis. The established method based on multivariate analysis mainly involved principal component analysis (PCA), partial least squares-discriminant analysis (PLS-DA), and orthogonal partial least squares-discriminant analysis (OPLS-DA) as the screening and verifying tools to provide insights into the distinctive features found in wild and farmed salmon products, respectively. The discrimination between farmed and wild salmon was accomplished with 100% classification accuracy using chemometric models, 100% identification accuracy was also achieved in distinguishing wild Salmo salar and Oncorhynchus nerka samples. The results of the present work suggest that the proposed method could serve as a reference for detecting salmon fraud relating to wild or farmed production and expand the application of MALDI-ToF technology further into food authenticity applications. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
8. Authentication of organically grown vegetables by the application of ambient mass spectrometry and inductively coupled plasma (ICP) mass spectrometry; The leek case study.
- Author
-
Birse, Nicholas, McCarron, Philip, Quinn, Brian, Fox, Kimberly, Chevallier, Olivier, Hong, Yunhe, Ch, Ratnasekhar, and Elliott, Christopher
- Subjects
- *
INDUCTIVELY coupled plasma mass spectrometry , *MASS spectrometry , *EDIBLE greens , *VEGETABLE farming , *MASS spectrometers , *LEEK - Abstract
Health conscious and environmentally aware consumers are purchasing more organically produced foods. They prefer organic fruits and leafy vegetables as these are much less likely to have been exposed to contaminants such as pesticides. The detection of fraudulent activity in this area is difficult to undertake, because many chemical plant protection treatments degrade very quickly or can be washed off to remove evidence of their existence. It was found that when combining DART-MS with a compact, inexpensive and robust single quadrupole mass spectrometer, it was possible to differentiate organic from conventional leeks with 93.8% to 100% accuracy. ICP-MS results showed similar performance, with an ability to differentiate conventional from organic leeks with 92.5% to 98.1% accuracy. This study has paved the way for the certification of vegetables as being organically produced. The next step is to create data libraries to support the roll out of the methodologies described. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
9. Redefining dilute and shoot: The evolution of the technique and its application in the analysis of foods and biological matrices by liquid chromatography mass spectrometry.
- Author
-
Greer, Brett, Chevallier, Olivier, Quinn, Brian, Botana, Luis M., and Elliott, Christopher T.
- Subjects
- *
LIQUID chromatography , *ANALYTICAL chemistry techniques , *FOOD chemistry , *SHOOTING techniques , *MATRIX effect , *LIQUID chromatography-mass spectrometry , *MASS spectrometry - Abstract
With laboratories seeking to expand analytical capabilities and create multi-class, multi-analyte methods, there has been a shift toward generic sample clean-up techniques such as "dilute-and-shoot". Advantages of this methodology include its simplicity, minimal analyte losses, high sample throughput and number of analyte classes included. The evolution of dilute-and-shoot has permitted its use across a variety of matrices including food and biological and in various scientific fields such as food, forensics and environmental. The versatility of the technique permits the expansion of current fields of research without the usual laborious method development. There can be issues with matrix effects and robust quantitation as analyte number increases. This review provides an overview of the technique combined with liquid chromatography mass spectrometry, highlighting its power in facilitating multi-class analysis. Coupled with increases in instrument performance there is potential to employ this methodology in expanding analytical capabilities in many areas of life science research. • Evolution of the dilute-and-shoot technique applied to analytical chemistry. • Application to food, biological and environmental matrices. • Implementation of the methodology in forensic and clinical toxicology. • Creation of multi-class, multis-analyte methodologies using LC-MS. • Enhanced sample throughput and screening capabilities. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
10. A year-long study of the spatial occurrence and relative distribution of pharmaceutical residues in sewage effluent, receiving marine waters and marine bivalves.
- Author
-
McEneff, Gillian, Barron, Leon, Kelleher, Brian, Paull, Brett, and Quinn, Brian
- Subjects
- *
SEWAGE purification , *DRUG residues , *MARINE pollution , *BIVALVES , *QUANTITATIVE research , *SPECIES diversity , *AQUATIC organisms - Abstract
Reports concerning the quantitative analysis of pharmaceuticals in marine ecosystems are somewhat limited. It is necessary to determine pharmaceutical fate and assess any potential risk of exposure to aquatic species and ultimately, seafood consumers. In the work presented herein, analytical methods were optimised and validated for the quantification of pharmaceutical residues in wastewater effluent, receiving marine waters and marine mussels (Mytilus spp.). Selected pharmaceuticals included two non-steroidal anti-inflammatory drugs (NSAIDs) (diclofenac and mefenamic acid), an antibiotic (trimethoprim), an antiepileptic (carbamazepine) and a lipid regulator (gemfibrozil). This paper also presents the results of an in situ study in which caged Mytilus spp. were deployed at three sites on the Irish coastline over a 1-year period. In water samples, pharmaceutical residues were determined using solid phase extraction (SPE) and liquid chromatography–tandem mass spectrometry (LC–MS/MS). The extraction of pharmaceuticals from mussel tissues used an additional pressurised liquid extraction (PLE) step prior to SPE and LC–MS/MS. Limits of quantification between 15 and 225ng·L−1 were achieved in wastewater effluent, between 3 and 38ng·L−1 in marine surface water and between 4 and 29ng·g−1 dry weight in marine mussels. Method linearity was achieved for pharmaceuticals in each matrix with correlation coefficients of R2 ≥0.976. All five selected pharmaceuticals were quantified in wastewater effluent and marine surface waters. This work has demonstrated the susceptibility of the Mytilus spp. to pharmaceutical exposure following the detection of pharmaceutical residues in the tissues of this mussel species at measurable concentrations. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.