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7 results on '"Uhač, Ivone"'

1. The role of P2X3 receptors in bilateral masseter muscle allodynia in rats.

Author

Tariba Knežević P, Vukman R, Antonić R, Kovač Z, Uhač I, and Simonić-Kocijan S

Subjects
Animals, Dose-Response Relationship, Drug, Freund's Adjuvant, Inflammation metabolism, Male, Neurons metabolism, Pain physiopathology, Rats, Rats, Wistar, Hyperalgesia metabolism, Masseter Muscle metabolism, Phenols pharmacology, Polycyclic Compounds pharmacology, Receptors, Purinergic P2X3 biosynthesis, Trigeminal Ganglion physiopathology
Abstract

Aim: To determine the relationship between bilateral allodynia induced by masseter inflammation and P2X3 receptor expression changes in trigeminal ganglia (TRG) and the influence of intramasseteric P2X3 antagonist administration on bilateral masseter allodynia., Methods: To induce bilateral allodynia, rats received a unilateral injection of complete Freund's adjuvant (CFA) into the masseter muscle. Bilateral head withdrawal threshold (HWT) was measured 4 days later. Behavioral measurements were followed by bilateral masseter muscle and TRG dissection. Masseter tissue was evaluated histopathologically and TRG tissue was analyzed for P2X3 receptor mRNA expression by using quantitative real-time polymerase chain reaction (PCR) analysis. To assess the P2X3 receptor involvement in nocifensive behavior, two doses (6 and 60 μg/50 μL) of selective P2X3 antagonist A-317491 were administrated into the inflamed masseter muscle 4 days after the CFA injection. Bilateral HWT was measured at 15-, 30-, 60-, and 120-minute time points., Results: HWT was bilaterally reduced after the CFA injection (P<0.001). Intramasseteric inflammation was confirmed ipsilaterally to the CFA injection. Quantitative real-time PCR analysis demonstrated enhanced P2X3 expression in TRG ipsilaterally to CFA administration (P<0.01). In comparison with controls, the dose of 6 μg of A-317491 significantly increased bilateral HWT at 15-, 30-, and 60-minute time points after the A-317491 administration (P<0.001), whereas the dose of 60 μg of A-317491 was efficient at all time points ipsilaterally (P=0.004) and at 15-, 30-, and 60-minute time points contralaterally (P<0.001)., Conclusion: Unilateral masseter inflammation can induce bilateral allodynia in rats. The study provided evidence that P2X3 receptors can functionally influence masseter muscle allodynia and suggested that P2X3 receptors expressed in TRG neurons are involved in masseter inflammatory pain conditions.

Published
2016
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2. Masseter muscle inflammation induces changes in expression of IL-1ß and KCNQ2 ion channels in ipsilateral TRG

Author

Simonic-Kocijan, Sunčana, Uhač, Ivone, Tariba, Petra, Vukman, Robert, and Wang K.W.

Subjects
sense organs, KCNQ2 ion channels, masseter muscle, pain
Abstract

Voltage gated ion channels regulate membrane potential in sensory neurons, and voltage gated potassium channels play important part in various pain conditions. The aim of this study was to investigate changes in expression level of KCNQ2 ion channel and interleukin-1β (IL-1β) in trigeminal ganglion (TRG) neurons after bilateral masseter muscle allodynia induced by unilateral masseter inflammation. he significant changes in KCNQ2 and IL-1β mRNA levels in ipsilateral TRG but not in contralateral suggest that changes at level of primary neurons are specific to inflammatory pain condition.

Published
2015

4. Alterations in the Masseter Muscle and Plasma IL-6 Level Following Experimentally Induced Occlusal Interference and Chronic Stress -A Study in Rats.

Author

Simonić-Kocijan, Sunčana, Uhač, Ivone, Tariba, Petra, Fugošić, Vesna, Pavičić, Daniela Kovačević, Lajnert, Vlatka, and Braut, Vedrana

Subjects
MASSETER muscle, BLOOD plasma, INTERLEUKIN-6, CHRONIC diseases, PSYCHOLOGICAL stress, PAIN management, LABORATORY rats
Abstract

Copyright of Collegium Antropologicum is the property of Croatian Anthropological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2012

5. Influence of Chronic Stress and Oclusal Interference on Masseter Muscle Pain in Rat.

Author

Simonić-Kocijan, Sunčana, Uhač, Ivone, Braut, Vedrana, Kovač, Zoran, Fugošić, Daniela Kovačević PaviČić Vesna, and Urek, Miranda Muhvić

Subjects
PHYSIOLOGICAL stress, DENTAL occlusion, MYALGIA, MASSETER muscle, PHYSIOLOGICAL aspects of pain, ANIMAL models in research, PAIN
Abstract

Copyright of Collegium Antropologicum is the property of Croatian Anthropological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2009

6. Influence of chronic stress and occlusal interference on masseter muscle pain

Author

Simonić-Kocijan, Sunčana, Uhač, Ivone, Pezelj-Ribarić, Sonja, Valentić-Peruzović, Melita, and Kučić, Natalia

Subjects
Orofacial pain, psychological, Stress, Dental occlusion, Masseter muscle, Rats
Abstract

Uvod: Temporomandibularni poremećaj (TMP) je muskoloskeletalni poremećaj koji obuhvaća niz kliničkih stanja karakteriziranih promjenama žvačne muskulature, temporomandibularnih zglobova (TMZ) i pridruženih struktura. Najčešći prisutan simptom je bol lokalizirana u žvačnim mišićima. Etiologija mišićne boli nije u potpunosti razjašnjena. Cilj istraživanja bio je ispitati utjecaj kroničnog stresa, okluzijske interferencije te njihovog zajedničkog djelovanja na bol maseteričnog mišića. Također, cilj je bio utvrditi utjecaj ispitivanih čimbenika na sistemsku i lokalnu razinu interleukina-6 (IL-6) te utvrditi moguću povezanost razine IL-6 s mišićnom boli. Cilj je bio utvrditi doprinos kroničnog stresa, okluzijske interferencije, razine IL-6 u tkivu i plazmi na bol maseteričnog mišića te utvrditi doprinos kroničnog stresa i okluzijske interferencije na razinu IL-6 u plazmi i tkivu maseteričnog mišića. Materijali i metode: U eksperimentalnom radu korišteno je 50 muških Wistar štakora. Životinje su podijeljene u pet skupina od 10 štakora. Skupine sačinjavaju: skupina izložena kroničnom stresu; skupina izložena okluzijskoj interferenciji; skupina izložena kroničnom stresu i okluzijskoj interferenciji; kontrolna skupina slobodna od kroničnog stresa i okluzijske interferencije i apsolutna kontrola koju formiraju životinje slobodne od bilo kakve procedure ili dobivanja ikakve tvari. Životinje su bile podvrgnute eksperimentu 56 dana. Zadnjeg eksperimentalnog dana životinjama se procjenjivala mišićna bol nakon čega su žrtvovane, te su sakupljeni uzorci krvi i masetera, iz kojih su enzimskim imunotestom određivane vrijednosti IL-6. Rezultati: Životinje izložene zajedničkom učinku okluzijske interferencije i kroničnog stresa pokazuju statistički značajno veću reakciju na bolni podražaj u usporedbi s kontrolnom skupinom (p=0,023). Također, utvrđena je značajno viša razina IL-6 maseteričnog mišića u skupini izloženoj zajedničkom učinku okluzijske interferencije i kroničnog stresa u usporedbi s kontrolnom skupinom (p=0,012). Utvrđena je pozitivna korelacija između razine IL-6 maseteričnog mišića i boli (r = 0,62; p, Introduction: Temporomandibular disorder (TMD) is a musculoskeletal disorder that involves various clinical conditions of masticatory muscles, temporomandibular joints and accompanied tissues. The most prominent symptom is pain in masticatory muscles. The etiology of TMD is poorly understood. Objectives of this study were to examine the individual effect of chronic stress and occlusal interference, as well as their combined influence on masseter muscle pain. The study also aimed to investigate influence of proposed etiological factors on systemic and local level of interleukine-6 (IL-6) and to find possible correlation between IL-6 and muscle pain. The aim was to estimate the contribution of chronic stress, occlusal interference and IL-6 levels on masseter muscle pain and to estimate contribution of chronic stress and occlusal interference on IL-6 levels. Material and methods: Experiments were performed on 50 male Wistar rats. Animals were divided in five groups of 10 rats. Groups were as follow: chronic stressed group, group with occlusal interference, group with both chronic stress and occlusal interference, control group free of chronic stress and occlusal interference and absolute control group free of experimental procedures and formalin injection. Experimental procedure, for all animals, lasted 56 days. On last experimental day muscle pain was evaluated. Animals were decapitated and blood and tissue samples were collected to determine IL-6 levels. Results: Animals submitted to combination of occlusal interference and chronic stress showed statistically significant difference of nociceptive behavioral response comparing to the control group (p=0,023). Also, tissue level of IL-6 in group of animals submitted to both occlusal interference and chronic stress were significantly higher than in the control group (p=0,012). A positive correlation between the tissue IL-6 level and the masseter muscle pain was established (r=0,62; p

Published
2017

7. Influence of chronic stress and occlusal interference on masseter muscle pain

Author

Simonić-Kocijan, Sunčana and Uhač, Ivone

Subjects
Stres, Orofacial pain, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, Štakori, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, Maseterični mišić, psihološki, Stress, Dental occlusion, udc:616(043.3), Dentalna okluzija, Masseter muscle, Rats, Orofacijalna bol, psychological, Pathology. Clinical medicine, Patologija. Klinička medicina
Abstract

Uvod: Temporomandibularni poremećaj (TMP) je muskoloskeletalni poremećaj koji obuhvaća niz kliničkih stanja karakteriziranih promjenama žvačne muskulature, temporomandibularnih zglobova (TMZ) i pridruženih struktura. Najčešći prisutan simptom je bol lokalizirana u žvačnim mišićima. Etiologija mišićne boli nije u potpunosti razjašnjena. Cilj istraživanja bio je ispitati utjecaj kroničnog stresa, okluzijske interferencije te njihovog zajedničkog djelovanja na bol maseteričnog mišića. Također, cilj je bio utvrditi utjecaj ispitivanih čimbenika na sistemsku i lokalnu razinu interleukina-6 (IL-6) te utvrditi moguću povezanost razine IL-6 s mišićnom boli. Cilj je bio utvrditi doprinos kroničnog stresa, okluzijske interferencije, razine IL-6 u tkivu i plazmi na bol maseteričnog mišića te utvrditi doprinos kroničnog stresa i okluzijske interferencije na razinu IL-6 u plazmi i tkivu maseteričnog mišića. Materijali i metode: U eksperimentalnom radu korišteno je 50 muških Wistar štakora. Životinje su podijeljene u pet skupina od 10 štakora. Skupine sačinjavaju: skupina izložena kroničnom stresu; skupina izložena okluzijskoj interferenciji; skupina izložena kroničnom stresu i okluzijskoj interferenciji; kontrolna skupina slobodna od kroničnog stresa i okluzijske interferencije i apsolutna kontrola koju formiraju životinje slobodne od bilo kakve procedure ili dobivanja ikakve tvari. Životinje su bile podvrgnute eksperimentu 56 dana. Zadnjeg eksperimentalnog dana životinjama se procjenjivala mišićna bol nakon čega su žrtvovane, te su sakupljeni uzorci krvi i masetera, iz kojih su enzimskim imunotestom određivane vrijednosti IL-6. Rezultati: Životinje izložene zajedničkom učinku okluzijske interferencije i kroničnog stresa pokazuju statistički značajno veću reakciju na bolni podražaj u usporedbi s kontrolnom skupinom (p=0,023). Također, utvrđena je značajno viša razina IL-6 maseteričnog mišića u skupini izloženoj zajedničkom učinku okluzijske interferencije i kroničnog stresa u usporedbi s kontrolnom skupinom (p=0,012). Utvrđena je pozitivna korelacija između razine IL-6 maseteričnog mišića i boli (r = 0,62; p

Published
2010

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