In previous scholarly studies, the water and ethylene glycol mixtures as base liquids have been considered in the ratio of 40:60 (60EGW), with specific investigations focusing on a nanofluid in the form of Silicon dioxide (SiO2) in relation to its thermo-physical properties, besides its nature of the heat transfer coefficients (HTC). In this study, the main aim lies in SiO2 heat transfer coefficient prediction. With the approach of computational fluid dynamics (CFD) considered, the experimental conditions constitute 40EGW. For SiO2 nanoparticles, their viscosity and thermal conductivity are experimentally assessed, having been dispersed in 60EGW and 40EGW. Also, the existing literature and experimental values are used to conduct regression analysis. With thermal features on the focus, there is also the formulation of correlations. Furthermore, there is the invocation of correlations in heat transfer coefficients and CFD simulations that target Al2O 3 and SiO 2 nanoparticles, with predictions entailing their dispersion in 40EGW and 60EGW base fluids. The inlet temperature is set at 60 to 80 °C, and it is at this stage that there is CFD simulation implementation. For the volume concentration, the ranges include 0.0 percent to 1.5 percent. The existing literature is relied upon relative to the validation of the coefficients of heat transfer, besides previously predicted nanofluids. From the results, compared to the case of 40EGW base fluid, there is 51 percent and 53 percent enhancement when the experimental conditions are set at 1.0 percent volume concentration, with temperatures being 80 °C. From the computational outcomes, Al2O3/40EGW nanofluids tend to be associated with significant heat transfer coefficients. Specifically, the enhancement of heat transfer for these materials stands at 52.9%. On the other hand, the enhancement of heat transfer when the base fluid of SiO2/40EGW is considered stands at 51.0%. These values are obtained when the experimental conditions are considered at 80 °C, as well as a volume concentration of 1.0%. Therefore, when aspects of heat transfer coefficients and thermal conductivity are considered, the superiority of 40EGW is confirmed. As such, the study confirms the impact of the base nanofluids set at 40EGW relative to the coefficients of heat transfer and also the thermal properties of materials.