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Solid-state radiation detectors based on the visible photoluminescence of radiation-induced F2 and F3+ color centers in lithium fluoride crystals have been used for advanced diagnostics of 18 and 27 MeV proton beams, produced by the TOP-IMPLART linear accelerator, which is under development for protontherapy applications at ENEA C.R. Frascati, Italy. Visible fluorescence microscopy was successfully used to read the latent proton beam images stored in the lithium fluoride crystals, thanks to high emission efficiency of the F2 and F3+ color centers obtained by simultaneous optical excitation in the blue spectral range. High intrinsic spatial resolution and wide dynamic range of these novel LiF detectors allow obtaining two-dimensional images of both the beam transverse intensity distribution and of the Bragg curve. By using a simple defect formation model that takes into account the energy released in the material and the saturation of defect concentration, not only the two-dimensional dose map was obtained from the beam transverse intensity distribution image, but also the full Bragg curve was reconstructed, allowing the thorough characterization of proton beams produced by the accelerator.

An analytical model that approximates Bragg curves due to protons in water is extended to lithium fluoride (LiF), both in bulk and lower-density homogeneous thin film form. To that purpose, Monte Carlo simulations of proton range for energies from 5 to 65 MeV are best fitted so that optimal values of the model parameters are deduced for LiF. Tests are performed by comparing analytically computed Bragg curves with corresponding ones simulated by Monte Carlo software in LiF, bulk and lower density, at two example proton energies and energy-straggling widths. The model is then applied to the reconstruction of the energy spectra of proton beams by best fitting experimental Bragg profiles due to visible photoluminescence of optically-active F2 and F 3 + color centers created in LiF crystals by the ionizing interaction of protons with the material.

Lithium fluoride (LiF) crystals were irradiated with a proton beam. With nominal beam energies of 3 and 7 MeV, several irradiations were performed which delivered doses ranging from 103 to 107 Gy. The ionisation produced by the protons in the LiF samples induced the stable formation in the crystalline lattice of colour centres, two types of which, the F2 and F 3 + ones, possess broad photoluminescence bands in the red and green, respectively, when optically pumped in the blue at wavelengths close to 450 nm. At both proton energies, measurements of the distinct F2 and F 3 + contributions to the emission spectra showed a decrease of the F 3 + integrated photoluminescence intensity at large doses, say from ∼106−107 Gy on. We try to explain such a behaviour by assuming the formation of absorption and/or quenching centres, and compare the predictions of an ad hoc developed model with experimental data.

In recent years, lithium fluoride (LiF) detectors based on the optical reading of photoluminescence emitted by radiation-induced F2 and F3+ colour centres have been successfully used for advanced diagnostics of proton beams. In this work, the visible photoluminescence response of LiF film-based radiation detectors of three different thicknesses, grown by thermal evaporation on glass and Si(100) substrates and irradiated with 27 MeV proton beams at doses in the range between 4.2 × 103 and 1.7 × 105 Gy, was carefully investigated by fluorescence optical microscopy. Before irradiation, the structural and morphological properties of LiF films were investigated by atomic force microscopy and X-ray diffraction techniques. Substrate-enhanced photoluminescence response up to 48% was observed in LiF film-based detectors grown on Si(100) substrates with respect to those deposited on glass in the same deposition run and irradiated in the same conditions. This photoluminescence enhancement can be mainly ascribed to the reflective properties of the Si substrate in the visible spectral range, where the emission bands of F2 and F3+ colour centres are located, combined with the proper choice of the film thickness. Other complex effects related to the polycrystalline nature of the LiF films cannot be excluded.

This contribution describes the methods developed for the characterization in air of the proton beam at the TOP-IMPLART linear accelerator of ENEA Frascati Research Centre. Beam energy and spectrum, transverse homogeneity, fluence and flux are assessed both experimentally and by numerical calculations. Here we present an application of these methods for the characterization of set-ups relevant for electronic and space components testing.

To demonstrate the large potential of proton minibeam radiotherapy (pMBRT) as a new method to treat tumor diseases, a preclinical proton minibeam radiation facility was designed. It is based on a tandem Van-de-Graaff accelerator providing a 16 MeV proton beam and a 3 GHz linac post-accelerator (designs: AVO-ADAM S.A, Geneva, Switzerland and ENEA, Frascati, Italy). To enhance the transmission of the tandem beam through the post-accelerator by a factor of 3, two drift tube buncher units were designed and constructed: A brazed 5-gap structure (adapted SCDTL tank of the TOP-IMPLART project (ENEA)) and a non-brazed low budget 4-gap structure. Both are made of copper. The performance of the two differently manufactured units was evaluated using a 16 MeV tandem accelerator beam and a Q3D magnetic spectrograph. Both buncher units achieve the required summed voltage amplitude of 42 kV and amplitude stability at a power feed of less than 800 W.

In the framework of the COBRA project, elemental analyses of cultural heritage objects based on the particle induced X-ray emission (PIXE) are planned in a collaboration between the APAM laboratory of ENEA-Frascati and the LABEC laboratory of INFN in Florence. With this aim a 3–7 MeV pulsed proton beam, driven by the injector of the protontherapy accelerator under construction for the TOP-IMPLART project, will be used to demonstrate the feasibility of the technique with a small-footprint pulsed accelerator to Italian small and medium enterprises interested in the composition analysis of ancient artifacts. The experimental set-up for PIXE analysis on the TOP-IMPLART machine consists of a modified assembly of the vertical beam line usually dedicated to radiobiology experiments: the beam produced by the injector (RFQ + DTL, a PL7 ACCSYSHITACHI model) is bent to 90° by a magnet, is collimated by a 300 μm aperture inserted in the end nozzle and extracted into ambient pressure by an exit window consisting of a Upilex foil 7.5 μm thick. The beam is pulsed with a variable pulse duration of 20–100 μs and a repetition rate variable from 10 to 100 Hz. The X-ray detection system is based on a Ketek Silicon Drift Detector (SDD) with 7 mm2 active area and 450 μm thickness, with a thin Beryllium entrance window (8 μm). The results of the calibration of this new PIXE set-up using thick target standards and of the analysis of the preliminary measurements on pigments are presented.

The Intensity Modulated Proton Linear Accelerator for Cancer Therapy (TOP-IMPLART) is under development and construction by ENEA in collaboration with the Italian Institute of Health (ISS) and the Oncological Hospital Regina Elena-IFO with financial support of Regione Lazio. Its peculiar time structure (few microseconds pulse width) and very high peak intensity (≍ 109 proton/pulse) demand for ad hoc dose delivery monitors (DDM). The TOP-IMPLART DDM is based on ionization gas chambers. One segmented chamber prototype uses Micro Pattern Gaseous Detector technology for the 2-dimensional simultaneous x/y readout; the charge collected from each active segment (strips with pad-like shape) is readout by a dedicated gain-adaptable electronics. Two small, highly sensitive, integral ionization chambers, using the same electronics, complement the 2D chamber for the monitor of the single pulse beam charge, down to 1 pC/pulse. While under development and deployment of its accelerating modular cavities, the linear TOP-IMPLART beam is improved thanks also to the continuous monitoring and characterization by these devices, whose responses are periodically compared to calibrated dosimetric detectors such as real-time active microDiamond sensor, passive Alanine pellets, intrinsically stable integral Faraday Cup. Different calibration campaigns have been recently conducted to measure the recombination and dose-rate effects on the above ionization chambers. The outcome of these measurements shows clear electron-ion recombination in the chamber active volume, largely related to the high beam intensity and its small transverse cross section. Those effects can be taken into account and used to correct the actual measurement of the DDM. In this paper, the TOP-IMPLART project and the DDM devices are shortly presented and details of the above experimental studies are discussed.

Passive solid-state radiation detectors, based on the radiophotoluminescence of stable color centers in nominally pure lithium fluoride (LiF) crystals, have been used for advanced diagnostics of the segment up to 35 MeV of the TOP-IMPLART proton linear accelerator for protontherapy applications, under development at ENEA Frascati. In LiF, proton beams generate a spatial distribution of F2 and F3+ aggregate color centers, which efficiently emit radiophotoluminescence in the red-green spectral range under optical pumping around 450 nm. LiF crystals were irradiated with 35 MeV nominal energy protons at several doses of interest for protontherapy (from 0.5 to 50 Gy). For the first time is shown here the possibility of measuring the radiophotoluminescence spectra of proton irradiated LiF even at such low doses and how the signal showed a linear behavior with dose with a good signal-to-noise ratio. A Bragg-curve image, stored as color-center distribution in a LiF crystal after a 50 Gy-dose irradiation in a particular geometry, was acquired in a conventional fluorescence microscope. After appropriate image processing, the signal intensity resulted to be proportional to the linear energy transfer along the whole Bragg curve. By best-fitting it with an ad-hoc analytical formula, the depth-dose distribution was reconstructed and the proton beam energy and energy spread were estimated.

Proton beams of 7 MeV energy, produced by a linear accelerator, were used to irradiate LiF crystals and thin films thermally evaporated on glass substrates in the dose range from 10 3 to 4 × 10 6 Gy, inducing the formation of stable photoluminescent colour centres (mainly F 2 and F 3 + ), emitting in the visible spectral range. Using a conventional fluorescence microscope, the transversal proton beam intensity was mapped by acquiring the photoluminescence image of the irradiated spots. Image analysis allowed measuring the integrated photoluminescence intensity as a function of the irradiation dose: a linear optical response was obtained up to different maximum dose values, after which a quenching was observed, depending on the nature of the samples (crystals or films). The colour centres formation was investigated by optical absorption spectroscopy at room temperature and the Principal Component Analysis was applied to the absorption spectra of irradiated LiF crystals. In samples irradiated at highest doses, it allowed clearly identifying the formation of more complex aggregate defects, which appears strictly related to the observed photoluminescence quenching effect.

In the last few years, the peculiar photoluminescence properties of radiation-induced color centers in lithium fluoride (LiF) films have been successfully used for advanced diagnostics of low-energy proton beams produced by the TOP-IMPLART linear accelerator for protontheraphy under development at ENEA C.R. Frascati. The two-dimensional spatial dose map of the transversal section of proton beams was fully reconstructed in a wide interval of doses. In this work the optical emission properties of LiF thin films, grown by thermal evaporation on glass and Si(100) substrates and subsequently irradiated by proton beams of nominal energy 3 MeV at doses higher than 105 Gy, were carefully investigated. Their structural and morphological analyses were performed by X-ray diffraction and atomic force microscopy. A careful comparison of the photoluminescence and photoluminescence-excitation spectra of F2 and F3+ electronic defects was performed. Substrate-enhanced photoluminescence intensity increase up to 100% was observed in colored LiF films grown on Si substrates with respect to glass ones. This behavior can be substantially ascribed to the reflective properties of the Si substrate at the emission wavelengths of F2 and F3+ CCs, although other complex effects due to the polycrystalline nature of the films cannot be excluded.

In a recent paper, an analytical expression for proton Bragg curves was introduced and utilized to best fit photoluminescent depth distributions of optically active F 2 and F 3 + color centers in lithium fluoride, with the purpose of evaluating the energy spectrum of a proton beam, assumed to consist of the superposition of Gaussian components. Here, an original alternative method is introduced by means of which the same energy spectrum analysis can be performed by iteratively applying a suitable mathematical operator to the photoluminescent depth distribution, no best fitting operation being needed.

In the framework of the Italian TOP-IMPLART project (Regione Lazio), ENEA-Frascati, ISS and IFO are developing and constructing the first proton linear accelerator based on an actively scanned beam for tumor radiotherapy with final energy of 150 MeV. An important feature of this accelerator is modularity: an exploitable beam can be delivered at any stage of its construction, which allows for immediate characterization and virtually continuous improvement of its performance. Currently, a sequence of 3 GHz accelerating modules combined with a commercial injector operating at 425 MHz delivers protons up to 35 MeV. Several dosimetry systems were used to obtain preliminary characteristics of the 35-MeV beam in terms of stability and homogeneity. Short-term stability and homogeneity better than 3% and 2.6%, respectively, were demonstrated; for stability an improvement with respect to the respective value obtained for the previous 27 MeV beam.

The first proton linear accelerator for tumor therapy based on an actively scanned beam up to the energy of 150 MeV, is under development and construction by ENEA-Frascati, ISS and IFO, under the Italian TOP-IMPLART project. Protons up to the energy of 7 MeV are generated by a customized commercial injector operating at 425 MHz; currently three accelerating modules allow proton delivery with energy up to 27 MeV. Beam homogeneity and reproducibility were studied using a 2D ionizing chamber, EBT3 films, a silicon diode, MOSFETs, LiF crystals and alanine dosimetry systems. Measurements were taken in air with the detectors at ~1 m from the beam line exit window. The maximum energy impinging on the detectors surface was 24.1 MeV, an energy suitable for radiobiological studies. Results showed beam reproducibility within 5% and homogeneity within 4%, on a circular surface of 16mm in diameter. © The Author(s) 2018.

Colour centres (CCs) in lithium fluoride (LiF) are well known for application in tuneable lasers and dosimeters. The visible photoluminescence (PL) of radiation-induced, broad-band light-emitting aggregate CCs in LiF crystals and films has been proposed for high spatial resolution X-ray imaging; use of LiF-based detectors has been recently successfully extended to advanced diagnostics of low-energy proton beams. After exposure, transversal dose mapping was obtained on LiF films by acquiring the visible PL image of the irradiated spots in a fluorescence microscope under blue-light pumping. Irradiation of thermally evaporated LiF thin films with a proton beam of 3 MeV nominal energy, produced by a linear accelerator, in the fluence range of 1011–1015 protons/cm2, induces the formation of stable CCs, mainly the primary F centre and the aggregate F2 and F3 + defects. A comparison with irradiations performed at 7 MeV shows that the spectrally integrated PL as a function of the absorbed dose is independent on the selected beam energy, at least as far as typical LiF film thicknesses are concerned. The PL behaviour vs. dose can be described by a linear growth which covers up to three order of magnitude, followed by saturation at high values (> ≈105 Gy). The spectral contributions of F2 and F3 + CCs to the detected PL, in the red and in the green respectively, under laser pumping were carefully analysed in order to investigate behaviour differences of these defects at high doses. © 2018 Elsevier B.V.

Proton beams of 3 and 7 MeV energies, produced by a linear accelerator, were used to irradiate lithium fluoride crystals and thermally evaporated LiF thin films in the fluence range of 1011-1015 protons/cm2. The irradiation induces the formation of stable colour centres, mainly the primary F centre and the aggregate F2 and F 3 + defects. By optical pumping in the blue spectral region, the F2 and F3 + centres emit broad photoluminescence bands in the visible spectral range. By conventional fluorescence microscopy, the integrated photoluminescence intensity was carefully measured in LiF crystals and thin films as a function of the irradiation fluence: a linear optical response was obtained in a large range of fluence, which is dependent on the used LiF samples and the selected beam energy. It was possible to record the transversal proton beam intensity profile by acquiring the photoluminescence image of the irradiated spots on LiF films by a standard optical microscope. Using LiF films grown on silicon substrates irradiated in a particular geometry, the same optical reading microscopy technique allowed one to measure the distribution of colour centres photoluminescence along the depth and direct imaging the Bragg peak position, which gives a rough estimation of the initial proton beam energy.© 2014 Published by Elsevier B.V.

In the last few years, the visible photoluminescence (PL) of radiation-induced laser-active F2 and F3+ aggregate color centers (CCs) in lithium fluoride, LiF, has been successfully used for advanced diagnostics of low-energy proton beams. A systematic study of the optical properties of LiF crystals and thin films exposed in different irradiation geometries to a proton beam of nominal energy 7 MeV is under way. The ionization induces the stable formation of primary and aggregate CCs in the crystalline lattice, among which the F2 and F3+ defects possess broad emission bands in the red and green spectral ranges, respectively, when optically pumped at wavelengths close to 450 nm. Their PL intensity has been found to be linearly proportional to the dose absorbed by the host material over at least three orders of magnitude, so that LiF solid-state dosimeters based on spectrally-integrated PL reading can be envisaged. A simple defect formation model that takes into account the energy released in the material, crystals and films, together with the saturation of CC concentration at high doses, allows obtaining both the full Bragg curve reconstruction with its dose distribution with depth and the accumulated bi-dimensional transversal dose-mapping from the visible fluorescence images latently stored in LiF crystals and thin films, respectively. Results obtained by using a fluorescence microscope are presented and discussed with the aim of highlighting some quantitative aspects of the PL behavior of CCs both in LiF crystals and films, which are relevant for low-energy proton-beam Bragg curve imaging and dose mapping in a wide interval of doses up to the ones at which strong CC saturation occurs.

Lithium fluoride (LiF) is a well-known dosimeter material and is sensitive to any kind of ionizing radiation. A linear accelerator for protontherapy under development at ENEA C.R. Frascati was used to irradiate LiF crystals and thin films at room temperature with proton beams of 3 and 7 MeV energy in a dose range from 103 to 107 Gy. The irradiation of LiF induced the formation of stable F2 and F3+ color centers (CCs), which emit with broad photoluminescence (PL) bands under optical pumping at wavelengths close to 450 nm. By acquiring the PL image of the irradiated spots with a conventional fluorescence microscope, the transversal proton beam intensity was mapped with a high spatial resolution. The integrated PL intensity was also measured as a function of the irradiation dose: LiF films showed a linear PL response extending over three orders of magnitude of dose range, independently on the beam energy. It was also possible to measure the CCs PL distribution with proton penetration depth and direct imaging the Bragg peak, which gives an estimation of the proton beam energy. The sensitivity of the optical reading techniques and the high emission efficiency of CCs provided encouraging results to use photoluminescent color-center LiF-based radiation detectors for proton beam dosimetry and imaging applications.

LiF films grown on glass and Si(100) substrates by thermal evaporation were used as radiation imaging detectors to evaluate the Bragg peak position of a 3 MeV proton beam produced by a linear accelerator. The proton irradiation of LiF films induces the formation of stable color centers, mainly the primary F centers and the aggregate F2 and F3 + defects, whose local concentrations are proportional to the deposited energy. Under optical pumping in the blue spectral region, F2 and F3 + color centers emit broad photoluminescence bands located at 678 and 541 nm, respectively, which can be detected by conventional fluorescence microscopy. Photoluminescence images of the top surface of the exposed LiF films allowed obtaining the Bragg peak position of the proton beam, whose evaluation is in satisfactory agreement with software simulations.

A lithium fluoride crystal slab was irradiated in air with a proton beam of nominal 7 MeV energy at a linear accelerator that is under development at ENEA C.R. Frascati. The irradiation generated a spatial distribution of stable colour centres in the crystal that could be detected as a luminescent image under blue-light excitation in a fluorescence microscope. The reconstruction of the whole Bragg curve from the luminescent image is here demonstrated for the first time by taking into account finite proton-energy bandwidth and saturation of defect concentration due to high absorbed dose. The obtained results confirm lithium fluoride detectors based on visible photoluminescence of radiation-induced aggregate colour centres as reliable candidate devices for advanced proton-beam diagnostics. © CopyrightEPLA, 2018.

Proton beams of energy 3 and 7 MeV, produced by a linear accelerator for protontherapy under development at ENEA Frascati, were used to irradiate lithium fluoride (LiF) crystals and 1 μm thick LiF films grown by thermal evaporation on glass substrates, in a fluence range from 10 11 to 10 15 protons/cm 2 . The irradiation of LiF induced the stable formation of aggregate visible-emitting F 2 and F 3 + color centers, which possess almost overlapping absorption bands around 450 nm and, under optical pumping in this spectral region, they simultaneously emit broad photoluminescence bands, peaked at 678 nm and 541 nm, respectively. Their laser excited emission spectra were acquired and the integrated photoluminescence signal was measured using a fluorescence optical microscope equipped with a cooled s-CMOS camera. The photoluminescence of proton irradiated LiF crystals and films shows an interesting linear response as a function of the irradiation fluence. By optical fluorescence microscopy, it was possible to record the transversal proton beam intensity profile by acquiring the photoluminescence image of irradiated LiF. Moreover, using cleaved LiF films grown on silicon substrates irradiated in a particular geometry allowed one to measure the colour centres photoluminescence distribution with proton penetration depth and provided a direct imaging of the Bragg peak.

Lithium fluoride is a well-known dosimeter material and it is currently under investigation also for high-resolution radiation imaging detectors based on colour centre photoluminescence. In order to extend their applications, proton beams of 3 MeV energy, produced by a linear accelerator, were used to irradiate LiF crystals and thin films in the fluence range of 1010–1015 protons/cm2. The irradiation induces the formation of colour centres, mainly the primary F centre and the aggregate F2 and F 3 + defects, which are stable at room temperature. By optical pumping in the blue spectral region, the F2 and F 3 + centres emit broad photoluminescence bands in the visible spectral range. By conventional fluorescence microscopy, the integrated photoluminescence intensity was carefully measured in LiF crystals and thin films as a function of the irradiation fluence: a linear optical response was obtained in a large range of fluence, which is dependent on the used LiF samples. Colour centres concentrations were estimated in LiF crystals by optical absorption spectroscopy. It was possible to record the transversal proton beam intensity profile by acquiring the photoluminescence image of the irradiated spots on LiF films.

Proton beams of 3 MeV energy, produced by the injector of a linear accelerator for proton therapy, were used to irradiate at room temperature lithium fluoride crystals and polycrystalline thin films grown by thermal evaporation. The irradiation fluence range was 1011-1015 protons/cm2. The proton irradiation induced the stable formation of primary and aggregate color centers. Their formation was investigated by optical absorption and photoluminescence spectroscopy. The F2 and F3 + photoluminescence intensities, carefully measured in LiF crystals and thin films, show linear behaviours up to different maximum values of the irradiation fluence, after which a quenching is observed, depending on the nature of the samples (crystals and films). The Principal Component Analysis, applied to the absorption spectra of colored crystals, allowed to clearly identify the formation of more complex aggregate defects in samples irradiated at highest fluences. © Published under licence by IOP Publishing Ltd.

Optically transparent LiF thin films thermally evaporated on glass and Si(100) substrates were used for advanced diagnostics of proton beams of energies from 1.4 to 7 MeV produced by a linear accelerator for protontheraphy under development at ENEA C.R. Frascati. The proton irradiation induces the formation of stable colour centres, among them the aggregate F2 and F3 + optically active defects. After exposure of LiF films grown on glass perpendicularly to the proton beams, their accumulated transversal spatial distributions were carefully measured by reading the latent two-dimensional (2-D) fluorescence images stored in the LiF thin layers by local formation of these broad-band visible light-emitting defects with an optical microscope under blue lamp excitation. Taking advantage from the low thickness of LiF thin films and from the linear behaviour of the integrated F2 and F3 + photoluminescence intensities up to the irradiation fluence of ∼5x1015 p/cm2, placing a cleaved LiF film grown on Si substrate with the cutted edge perpendicular to the proton beam, the 2-D fluorescence image of the film surface could allow to obtain the depth profile of the energy released by protons, which mainly lose their energy at the end of the path. © Published under licence by IOP Publishing Ltd.

Systematic irradiation of thermally evaporated 0.8 μm thick polycrystalline lithium fluoride films on glass was performed by proton beams of 3 and 7 MeV energies, produced by a linear accelerator, in a fluence range from 1011to1015protonscm2. The visible photoluminescence spectra of radiation-induced F2 and F3+laser active color centers, which possess almost overlapping absorption bands at about 450 nm, were measured under laser pumping at 458 nm. On the basis of simulations of the linear energy transfer with proton penetration depth in LiF, it was possible to obtain the behavior of the measured integrated photoluminescence intensity of proton irradiated LiF films as a function of the deposited dose. The photoluminescence signal is linearly dependent on the deposited dose in the interval from 103 to about 106Gy, independently from the used proton energies. This behavior is very encouraging for the development of advanced solid state radiation detectors based on optically transparent LiF thin films for proton beam diagnostics and two-dimensional dose mapping. © 2015 AIP Publishing LLC.