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Your search keyword '"Olha V. Hordiyenko"' showing total 2 results
Start Over Author "Olha V. Hordiyenko" Topic medicinal chemistry
2 results on '"Olha V. Hordiyenko"'

1. ChemInform Abstract: Regioselective Synthesis of 4-Aryl-3,4-dihydro-1,3,5-triazino[2,1-a]isoindol-2-ones

Author

Olha V. Hordiyenko, M. V. Vovk, Konstantin A. Pichugin, Oleg V. Shishkin, Volodymyr A. Sukach, Irina S. Konovalova, and Angelina V. Biitseva

Subjects
chemistry.chemical_compound, chemistry, Aryl, Condensation, Regioselectivity, General Medicine, Bifunctional, Medicinal chemistry
Abstract

The condensation of binucleophilic 3-amino-1-arylimino-1H-isoindoles with bifunctional 1-chloro-benzylisocyanates occurs regioselectively resulting in 3,4-dihydro-1,3,5-triazino[2,1-a]isoindol-2-one derivatives. The structures of the synthesized compounds were unambiguously established by NOE experiments.

Published
2008
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2. N′-(3-Amino-1H-isoindol-1-ylidene)-R-carbohydrazides and Their Amide-Type Isomerism

Author

Oleg V. Shishkin, Nicolas Brosse, Brigitte Jamart-Grégoire, Olha V. Hordiyenko, Roman I. Zubatyuk, Mikhail Yu. Kornilov, Angelina V. Biitseva, Alexandre Hocquet, Laboratoire de Chimie Physique Macromoléculaire (LCPM), and Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)

Subjects
chemistry.chemical_classification, Steric effects, 010405 organic chemistry, Chemistry, Stereochemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Aryl, Organic Chemistry, Nuclear magnetic resonance crystallography, Nuclear magnetic resonance spectroscopy, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, 0104 chemical sciences, [SPI.MAT]Engineering Sciences [physics]/Materials, chemistry.chemical_compound, [CHIM.POLY]Chemical Sciences/Polymers, Amide, Proton NMR, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, Physical and Theoretical Chemistry, Isomerization, Alkyl, ComputingMilieux_MISCELLANEOUS
Abstract

A series of N′-(3-amino-1H-isoindol-1-ylidene)alkyl(aryl,heteroaryl)carbohydrazides have been synthesized in good yields and their structure and conformational behavior in the solid state and in solution have been studied by X-ray crystallography, NMR spectroscopy, and quantum calculations. (E)/(Z) amide-type isomerism and the dependence of the isomeric ratio upon steric effects and solvent polarity are discussed. The thermodynamic parameters of (E) (Z) isomerization were determined by 1H NMR dynamic spectroscopy. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

Published
2006
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