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Oral cancer is the most common form of carcinoma of oral cavity and ranks as the 12th most common cancer in the world. Oral cancer is one of the major social & health problems in India and Indian subcontinent countries. Tobacco use in different forms is the main etiological factor for oral carcinoma. (i) To define relations of oral cancer with respect to gender, age group, socioeconomic status and risk habits; (ii) To observe the distribution of affected oral cavity sites and observe the clinical profile in oral cancer patients. A cross-sectional study of 340 oral cancer patients from January 2019 to December 2019 was carried out in Department of oncology & radiotherapy, JA Group of hospital, G. R. Medical Gwalior, Madhya Pradesh India. Details of patient's sex, age, tobacco habit and site of cancer and status were noted. Data were analyzed by probability of patient with risk factors and chi-squire (χ) test. The prevalence of oral cancer was significantly (p < 0.001) higher in males (91.5.9%) than females (8.5%). In both the sexes, most affected sites were the buccal mucosa and gingivo-buccal sulcus. However, the consuming form of tobacco was found to be significantly associated with oral cancer, in both sex. The study revealed that oral cancer is more common in men, probably due to habit of large tobacco consumption.

Globally, Breast Cancer is mostly detecting in women’s due to family history, obesity, irregular menstruation, intake of alcohol/tobacco, etc. When uncontrollable grow of cells in breast which turns into cancer, occur at lobules or duct of breast. Various indications are seen like – appearance of lumps, swelling, size & color of breast is change, unusual discharge, etc. Breast cancer can be diagnosis by oneself by doing some physical activity and by advance modern technology can help to detect the cancerous cells. Mammography and Sonography is the initial diagnosing method to detect the cancer cells without any incision or inserting tools into the breast. Doctors or trained healthcare observe the tumor i.e. it’s benign or malignant after that screening model is use to confirmation of the tumor.

Type II Diabetes mellitus (NIDDM) is a complex and metabolic disease that affects and presents a serious health problem for more than 100 million people around the world. Genetics and the environment are the variables which affect NIDDM. Reasonable screening models of animals will easily understand the pharmacological screening of different therapeutic agents. NIDDM animal models are acquired either naturally or caused by chemical reagents or by dietary, surgical or combination manipulation. A significant number of new genetically engineered animal models, including knock-out, transgenic, and tissue-specific knockout mice, have been designed for the Diabetes mellitus (D.M.) research in the past year. With regard to their characteristic characteristics and processes by which they arise, this analysis focuses on the animal models of NIDDM. In addition, this analysis explicitly discusses the optimal selection and use of various animal screening models for the treatment of NIDDM in preclinical research.

Floating drug delivery system was to organize the recent journalism with unique focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single unit and multiple unit floating systems. In the recent decades, there have been numerous attempts to overcome the barrier like short gastric residence times and unpredictable gastric emptying times. This review also summarizes the in –vitro technique of evaluation, all the pre-formulation and post formulation evaluations criteria. These systems are useful to several problems encountered during the development of pharmaceutical dosage form. In this review, the technologies of formulation and mechanism of drug release, advantage, application in drug delivery of floating systems are discussed.

Oral sub-mucous fibrosis (OSF) is a chronic, insidious disease which might affect the oral cavity (oral mucosa) including pharynx and larynx. Numerous approaches and anticancer molecules have been explored in the literature to treat OSF with different modes of action. However, complete cure for OSF is limited due to the lack of an ideal carrier for safe and effective delivery of potent drug moieties. There are several challenges such as anatomical or histological barriers and appropriate animal model need to be explored and optimized to develop the efficient treatment for oral sub-mucous fibrosis. Constant progression in the development of new formulations has led to the effective management of the disease associated with the mucosa using mucosal or muco-adhesive drug delivery systems. Muco-adhesive drug delivery systems (such as gel and patches) have gained unique position as drug cargoes. Therefore, present review is an attempt to contemplate on OSF in terms of pathogenesis, currently available treatment shaving their mode of action, major challenges encountered during treatment, usefulness/feasibility of muco-adhesive dosage forms, opportunities/future scope of muco-adhesive drug delivery in OSF and recent developments in the delivery of various anti-cancer drugs in the treatment of OSF.

Wound is known as disruption in the integrity of a tissue. The mechanisms of regeneration and tissue repair consist of a series of molecular and cellular events that occur after the onset of a tissue lesion to rebuild the damaged tissue. The remodelling phases of the exudative, proliferative, and extracellular matrix are concurrent events that occur through the interaction of complex processes involving soluble mediators, blood cells and parenchymal cells. Exudative phenomena that occur after injury, lead to tissue edema growth. The proliferative stage aims to minimize the area of tissue damage by myofibroblasts and fibroplasia contracting. Angiogenesis and reepithelialisation processes can still be observed at this point. Endothelial cells are capable of differentiating into mesenchymal components and this distinction seems to be finely coordinated by a series of signalling proteins. Many of the medicines available today is derived from natural sources. Flavonoids are essential components of the human diet apart from their physiological functions in plants, even though they are not considered as nutrients. In this review, naturally occurring flavonoid is discussed which occur in citrus fruits, vegetables, nuts, and beverages like coffee, tea, and red wine, and also in medical herbs. They exhibit different pharmacological actions, like antioxidant, anti-allergic, anti-bacterial, anti-inflammatory, anti-mutagenic and anti-cancer activity. One of the flavanones is Naringenin which is the ordinary dietary poly-phenolic constituent of the citrus fruits (grapefruit and oranges) and vegetables. It is beneficial in various neurological, cardiovascular, gastrointestinal, rheumatological, metabolic, malignant disorders, and functionally, this ameliorative effect of naringenin is primarily attributed to its anti-inflammatory (via inhibiting staffing of cytokines and inflammatory transcription factors) and anti-oxidant (via scavenging of free radicals, bolstering of endogenous antioxidant defence system and metal ion chelation) effects

Background: Under five children constitute the most vulnerable segment and their nutritional status and mortality rate is a sensitive indicator of the community’s health and nutrition. Health indices of slum children are worst among all urban groups and are even poorer than rural average.Methods: A community based cross-sectional study was conducted from October 2019 to January 2020 in urban slum area of Gwalior city. Data were collected from 550 mothers of children aged 6-60 months using pre-tested semi structured questionnaires and measuring weight, height and mid upper arm circumference of the children.Results: 68.36% of 550 children were having under nutrition in the form of underweight (53.09%), wasting (22.18%) and stunting (59.45%). Maximum number of underweight children belongs to age group 24-60 months (64.54%) followed by

Extensive use of hexavalent chromium [Cr(VI)] in leather tanning, stainless-steel production, wood preservatives and electroplating industries has resulted in widespread environmental pollution and poses a serious threat to human health. A plant's response to Cr(VI) stress results in growth inhibition and toxicity leading to changes in components of antioxidant systems. In a previous study, we observed that a large number of glutathione S-transferase (GST) genes were up-regulated under Cr(VI) stress in rice. In this study, two rice root-specific Tau class GST genes (OsGSTU30 and OsGSTU41) were introduced into yeast (Schizosaccharomyces pombe). Transformed yeast cells overexpressing OsGSTU30 and OsGSTU41 had normal growth, but had much higher levels of GST activities and showed enhanced resistance to Cr(VI) as compared to control cells (transformed with empty vector). Also, a higher accumulation of chromium was found in the transformed yeast cells as compared to the control cells. Manipulation of glutathione biosynthesis by exogenous application of buthionine sulfoximine abolishes the protective effect of OsGSTs against Cr(VI) stress. These results suggest that Tau class OsGSTs play a significant role in detoxification of Cr(VI), probably by chelating and sequestrating glutathione-Cr(VI) complexes into vacuoles.

BACKGROUND: Pancytopenia is an important clinicohematological entity having varying presentations and underlying cause ranging from megaloblastic anemia to fatal bone marrow aplasia and leukemias. Underlying pathology determines the treatment and prognosis.In majority of cases it is megaloblastic anemia which is readily treatable. OBJECTIVE: In our country causes of pancytopenia are not very well defined especially in Central India, so the present study has been undertaken to evaluate various causes and to correlate the peripheral blood finding with bone marrow. MATERIAL AND METHOD: It was a retrospective study of 155 cases presented with pancytopenia and evaluated clinically with hematological parameters and bone marrow aspiration in Department of Pathology, Gandhi Medical College, Bhopal during the period 2009-2012. RESULTS: Among 155 cases studied, age ranged from 2-80 years with mean age of 28 years with preponderance in male under 14 years age and female in 20-40 years age group. Generalised weakness and pallor were noted in all cases. Other common presentations were fever followed by bleeding manifestations. Splenomegaly was more common followed by hepatomegaly. Majority of patients had severe anemia, haemoglobin