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2. Comparison between selective and nonselective nitric oxide synthase inhibition and phenylephrine in normal and endotoxic swine

Author

Rubin I. Cohen, Steven M. Scharf, Avi Davis, Yehuda Shapir, and Rishi Loona

Subjects
Lipopolysaccharides, Cardiac function curve, medicine.medical_specialty, Cardiac output, Mean arterial pressure, Cardiotonic Agents, Swine, medicine.medical_treatment, Critical Care and Intensive Care Medicine, Phenylephrine, Internal medicine, medicine, Animals, Enzyme Inhibitors, Pulmonary wedge pressure, Saline, Acidosis, business.industry, Hemodynamics, Shock, Septic, NG-Nitroarginine Methyl Ester, medicine.anatomical_structure, Anesthesia, Circulatory system, Cardiology, Vascular resistance, Female, Nitric Oxide Synthase, medicine.symptom, business, Isothiuronium
Abstract

OBJECTIVE To compare the cardiopulmonary and peripheral circulatory effects of the nonselective nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester (L-NAME) to the more selective inducible NOS inhibitor S-methylisothiourea (SMT) and to phenylephrine (PE) in endotoxic and normal swine. DESIGN Prospective, randomized, unblinded study. SETTING Research laboratory of academic medical center. SUBJECTS Nonanesthetized, sedated, mechanically ventilated, minimally invasive swine model. INTERVENTIONS Animals received either lipopolysaccharide (LPS, LPS groups) or equivalent volume of saline (normal groups). LPS animals were further randomized into four groups when mean arterial pressure (MAP) had dropped to

Published
2000
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