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Your search keyword '"Baker, Stephen R."' showing total 10 results
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10 results on '"Baker, Stephen R."'

4. Palladium catalysis in cephalosporin chemistry: general methodology for the synthesis of cephem side chains

Author

Sheila I. Hauck, Daniel A. Benigni, Baker Stephen R, Chester Sapino, and Vittorio Farina

Subjects
Cephem, Bicyclic molecule, medicine.drug_class, Chemistry, Organic Chemistry, Cephalosporin, chemistry.chemical_element, Combinatorial chemistry, Catalysis, chemistry.chemical_compound, Chemical coupling, medicine, Side chain, Lactam, Palladium
Abstract

We describe in full the palladium-catalyzed coupling of 3-(triflyloxy) cephems with organotin compounds, leading to the synthesis of 3-alkenyl-, 3-alkynyl-, and 3-arylcephems under exceptionally mild conditions

Published
1990

5. Palladium in Cephalosporin Chemistry: Mild Triflate Couplings in the Absence of Phosphines and Halide Donors

Author

Chester Sapino, Gregory Roth, and Baker Stephen R

Subjects
medicine.drug_class, Organic Chemistry, Cephalosporin, Halide, chemistry.chemical_element, Catalysis, chemistry.chemical_compound, chemistry, Reagent, Polymer chemistry, medicine, Organic chemistry, Trifluoromethanesulfonate, Phosphine, Palladium
Abstract

Palladium catalyzed triflate-organostannane couplings are shown to proceed in a very mild manner in the absence of added phosphine and halide reagents. This protocol has been demonstrated for 3-trifloxycephems and vinyl triflates.

Published
1990

6. Reactions of organocuprates with vinyl-triflates and related cephems: A novel approach to 3-substituted cephalosporins

Author

Joydeep Kant, Baker Stephen R, and Chester Sapino

Subjects
chemistry.chemical_classification, Addition reaction, Bicyclic molecule, medicine.drug_class, Organic Chemistry, Cephalosporin, Carboxamide, Sulfonic acid, Biochemistry, Combinatorial chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Lactam, medicine
Abstract

Vinyl-triflates and related 3-substituted cephems readily undergo addition-elimination reactions with a variety of organocuprates to form new carbon-carbon bonds. This chemistry presents a novel approach to the synthesis of 3-alkyl, 3-aryl, and 3-alkenylcephalosporins.

Published
1990

7. Disodium D-6-[.ALPHA.-(1,2,4-triazine-3,5-dione-6-carboxamido)-4-hydroxyphenylacetamido]penicillanate, BL-P1908

Author

Baker Stephen R, Charles Truman Holdrege, and Mcgregor Donald N

Subjects
Chemical Phenomena, Stereochemistry, Penicillin Resistance, Alpha (ethology), Penicillins, medicine.disease_cause, Mice, chemistry.chemical_compound, Drug Discovery, polycyclic compounds, medicine, Animals, heterocyclic compounds, Triazine, Pharmacology, Chemistry, Physical, Chemistry, Pseudomonas aeruginosa, biochemical phenomena, metabolism, and nutrition, Carbenicillin, In vitro, Penicillin, Ticarcillin, bacteria, medicine.drug
Abstract

The synthesis of a new penicillin, disodium D-6-[alpha-(1,2,4-triazine-3,5-dione-6-carboxyamido)-4-hydroxyphenylacetamido]penicillanate (BL-P1908), is described. The compound shows superior in vitro activity against Pseudomonas aeruginosa compared to carbenicillin and ticarcillin and produces higher intramuscular serum levels in mice than does carbenicillin.

Published
1979

8. Palladium catalysis in cephalosporin chemistry: A versatile new approach to 3-substituted cephems

Author

Baker Stephen R, Vittorio Farina, and Chester Sapino

Subjects
Bicyclic molecule, medicine.drug_class, Chemistry, Ligand, Organic Chemistry, Cephalosporin, chemistry.chemical_element, Carboxamide, Biochemistry, Catalysis, chemistry.chemical_compound, Drug Discovery, medicine, Lactam, Organic chemistry, Phosphine, Palladium
Abstract

The coupling of 3-triflyloxycephems with unsaturated stannanes proceeds under mild conditions with the use of a palladium (O) catalyst based on the new ligand tri(2-furyl)phosphine.

Published
1988

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