18 results on '"Baoxin Zhao"'
Search Results
2. Association between long-term exposure to Sulfur dioxide pollution and hypertension incidence in northern China: a 12-year cohort study
- Author
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Mengfan Yan, Pengyi Guo, Xuejun Li, Liwen Zhang, Yamin Liu, Xi Chen, Guang-Hui Dong, Naijun Tang, Chaokang Li, Tong Wang, Jie Chen, Zhao Ma, Hui Wu, Anqi Shan, Yu Zhang, Xueli Yang, and Baoxin Zhao
- Subjects
Adult ,Pollution ,China ,Health, Toxicology and Mutagenesis ,media_common.quotation_subject ,Nitrogen Dioxide ,010501 environmental sciences ,complex mixtures ,01 natural sciences ,Cohort Studies ,chemistry.chemical_compound ,Air Pollution ,Environmental health ,Humans ,Sulfur Dioxide ,Environmental Chemistry ,Medicine ,Sulfur dioxide ,Retrospective Studies ,0105 earth and related environmental sciences ,media_common ,Air Pollutants ,business.industry ,Incidence ,Incidence (epidemiology) ,Hazard ratio ,Retrospective cohort study ,Environmental Exposure ,General Medicine ,Middle Aged ,Confidence interval ,chemistry ,Hypertension ,Cohort ,Particulate Matter ,business ,Cohort study - Abstract
Several studies have researched the short-term effect of sulfur dioxide (SO2) exposure on hypertension. However, no evidence has provided the relationship between long-term high pollution exposure of SO2 and morbidity of hypertension in cohort studies in China. This retrospective cohort study aimed to evaluate this association. We used Cox proportional hazards regression models to examine the hazard ratios (HR) for hypertension risks from 1998 to 2009 associated with accumulative exposure of air SO2 among adults in northern China. Annual average concentrations of sulfur dioxide (SO2) were obtained from 15 local environmental monitoring centers. Hypertension was identified according to self-reported diagnostic time and treatment for hypertension with anti-hypertensive medication. Among 37,386 participants, 2619 new cases of hypertension were identified during 426,334 person-years. In the fully adjusted model, HR and 95% confidence interval (CI) of hypertension incidence for each 10 μg/m3 increase in SO2 were 1.176 (1.163 and 1.189). Results from stratified analyses suggested that effects of SO2 on hypertension morbidity were more pronounced in participants
- Published
- 2020
3. Long-term exposure to ambient PM2.5 and stroke mortality among urban residents in northern China
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Baoxin Zhao, Xuejun Li, Fangchao Liu, Yamin Liu, Zhao Ma, Anqi Shan, Jie Chen, Mengfan Yan, Dongfeng Gu, Tong Wang, Guang-Hui Dong, Fengchao Liang, Liwen Zhang, Xi Chen, Naijun Tang, Yang Liu, Hui Wu, and Xueli Yang
- Subjects
Adult ,Male ,China ,Drug-Related Side Effects and Adverse Reactions ,Urban Population ,Satellite-based model ,Health, Toxicology and Mutagenesis ,0211 other engineering and technologies ,Context (language use) ,02 engineering and technology ,010501 environmental sciences ,Stroke mortality ,01 natural sciences ,complex mixtures ,Article ,Environmental pollution ,Cohort Studies ,Air Pollution ,Humans ,Medicine ,GE1-350 ,0105 earth and related environmental sciences ,Air Pollutants ,021110 strategic, defence & security studies ,business.industry ,Proportional hazards model ,Long-term exposure ,Hazard ratio ,Temperature ,Public Health, Environmental and Occupational Health ,Regression analysis ,Population-based cohort ,Environmental Exposure ,General Medicine ,Pollution ,Stroke ,Temperature variation ,Environmental sciences ,Individual risk factors ,TD172-193.5 ,Cohort ,Female ,Particulate Matter ,business ,Demography - Abstract
Evidence is still limited for the role of long-term PM2.5 exposure in cerebrovascular diseases among residents in high pollution regions. The study is aimed to investigate the long-term effects of PM2.5 exposure on stroke mortality, and further explore the effect modification of temperature variation on the PM2.5-mortality association in northern China. Based on a cohort data with an average follow-up of 9.8 years among 38,435 urban adults, high-resolution estimates of PM2.5 derived from a satellite-based model were assigned to each participant. A Cox regression model with time-varying exposures and strata of geographic regions was employed to assess the risks of stroke mortality associated with PM2.5, after adjusting for individual risk factors. The cross-product term of PM2.5 exposure and annual temperature range was further added into the regression model to test whether the long-term temperature variation would modify the association of PM2.5 with stroke mortality. Among the study participants, the annual mean level of PM2.5 concentration was 66.3 μg/m3 ranging from 39.0 μg/m3 to 100.6 μg/m3. For each 10 μg/m3 increment in PM2.5, the hazard ratio (HR) was 1.31 (95% CI: 1.04–1.65) for stroke mortality after multivariable adjustment. In addition, the HRs of PM2.5 decreased gradually as the increase of annual temperature range with the HRs of 1.95 (95% CI: 1.36–2.81), 1.53 (95% CI: 1.06–2.22), and 1.11 (95% CI: 0.75–1.63) in the low, middle, and high group of annual temperature range, respectively. The findings provided further evidence of long-term PM2.5 exposure on stroke mortality in high-exposure settings such as northern China, and also highlighted the view that assessing the adverse health effects of air pollution might not ignore the role of temperature variations in the context of climate change.
- Published
- 2021
4. Associations between the incidence and mortality rates of type 2 diabetes mellitus and long-term exposure to ambient air pollution: A 12-year cohort study in northern China
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Yu Zhang, Mengfan Yan, Xuejun Li, Anqi Shan, Hui Wu, Liwen Zhang, Baoxin Zhao, Yamin Liu, Ping Xian, Tong Wang, Xi Chen, Pengyi Guo, Naijun Tang, Chaokang Li, Guang-Hui Dong, Jie Chen, Yaoyan Li, and Zhao Ma
- Subjects
China ,010501 environmental sciences ,01 natural sciences ,Biochemistry ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Environmental health ,Air Pollution ,Medicine ,Humans ,030212 general & internal medicine ,Cities ,0105 earth and related environmental sciences ,General Environmental Science ,Retrospective Studies ,Air Pollutants ,Proportional hazards model ,business.industry ,Incidence (epidemiology) ,Mortality rate ,Incidence ,Hazard ratio ,Type 2 Diabetes Mellitus ,Retrospective cohort study ,Environmental Exposure ,Europe ,Diabetes Mellitus, Type 2 ,Cohort ,Particulate Matter ,business ,Cohort study - Abstract
Background Ambient air pollution has recently been related to type 2 diabetes mellitus (T2DM), a disease that has caused an economic and health burden worldwide. Evidence of an association between air pollution and T2DM was reported in the United States and Europe. However, few studies have focused on the association with high levels of air pollutants in a developing country. Objectives We conducted a 12-year cohort study to assess the incidence and mortality of T2DM associated with long-term exposure to PM10, SO2, and NO2. Methods A retrospective cohort with participants from four cities in northern China was conducted to assess mortality and incidence of T2DM from 1998 to 2009. Incidence of T2DM was self-reported, and incident intake of an antidiabetic drug or injection of insulin simultaneously and mortality of T2DM was obtained from a family member and double checked against death certificates provided from the local center for disease control and prevention. Individual pollution exposures were the mean concentrations of pollutants estimated from the local environmental monitoring centers over the survival years. Hazard ratios (HRs) were estimated using Cox regression models after adjusting for potential confounding factors. Results A total of 39 054 participants were recruited into the mortality cohort, among which 59 subjects died from T2DM; 38 529 participants were analyzed in the incidence cohort, and 1213 developed new cases of T2DM. For each 10 μg/m3 increase in PM10, SO2, and NO2, the adjusted HRs and 95% confidence interval (CI) for diabetic incidence were 1.831 (1.778, 1.886), 1.287 (1.256, 1.318), and 1.472 (1.419, 1.528), respectively. Similar results can be observed in the analysis of diabetic mortality with HRs (95% CI) up to 2.260 (1.732, 2.950), 1.130 (1.042, 1.225), and 1.525 (1.280, 1.816), respectively. Conclusions Our results suggested that long-term exposure to high levels of PM10, SO2, and NO2 increase risk of incident and mortality of T2DM in China.
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- 2019
5. The impact of chronic environmental metal and benzene exposure on human urinary metabolome among Chinese children and the elderly population
- Author
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Zhi Zhou, Baoxin Zhao, Ruiping Zhang, Xiaoyu Xu, Xia Zhou, Bingshu He, Zeper Abliz, Zhonghua Wang, Jinghua Guo, and Yanping Zhang
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Male ,China ,Azelaic acid ,Health, Toxicology and Mutagenesis ,0211 other engineering and technologies ,02 engineering and technology ,Urine ,010501 environmental sciences ,01 natural sciences ,chemistry.chemical_compound ,Metabolome ,medicine ,Humans ,Metabolomics ,Food science ,Benzene ,Child ,0105 earth and related environmental sciences ,Aged ,chemistry.chemical_classification ,021110 strategic, defence & security studies ,Public Health, Environmental and Occupational Health ,Lipid metabolism ,General Medicine ,Pollution ,Amino acid ,Oxidative Stress ,chemistry ,Metals ,Female ,Pyroglutamic acid ,Glucuronide ,medicine.drug ,Environmental Monitoring - Abstract
The health effects of metals and benzene exposure have been extensively investigated; however, information on the impact of chronic environmental metal and benzene exposure on human urinary metabolome is limited. In this study, a total of 566 participants, including 352 elderly and 214 children, were split into the “exposed” and “control” groups. The urine samples of all the participants were collected and stored at − 80 °C until analysis. The urinary levels of 17 metals and S-phenylmercapturic acid (S-PMA) were determined by the ICP–MS and LC–MS/MS methods to comprehensively assess the personal metal and benzene exposure levels, respectively. Then, the individual levels of metal and benzene exposure were correlated to the metabolic consequences of ambient pollutant exposure, which were previously observed in our metabolomics study. As a result, multiple metals, including Cd, Co, Cr, Cu, Fe, Hg, Li, Mo, Ni, Pb, Se, and Zn, exhibited a significant linear dose–dependent association with one or more urinary metabolites, including two amino acids (pyroglutamic acid and 3-methylhistidine), three organic acids (azelaic acid, decenedioic acid, and hydroxytetradecanedioic acid), ten medium-chainacylcarnitines (heptenedioylcarnitine, octenedioylcarnitine, nonenedioylcarnitine, decenedioylglucuronide, 3-hydroxydecanoylcarnitine, dodecanedioylcarnitine, nonanoylcarnitine, decadienylcarnitine, hydroxydodecenoylcarnitine, dodecadienylcarnitine, and dodecenoylcarnitine), and one glucuronide conjugate (decenedioylglucuronide). These observations indicate that the increased environmental metal exposure has caused various oxidative stress-related effects, including the depletion of antioxidants, accelerated muscle proteolysis, elevated activity of UGTs, increased lipid peroxidation, and the disorder of mitochondrial lipid metabolism among exposed children and the elderly. The current study provides new insights into the biological effects induced by metal exposure in the environment.
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- 2018
6. Human Metabolic Responses to Chronic Environmental Polycyclic Aromatic Hydrocarbon Exposure by a Metabolomic Approach
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Zeper Abliz, Jiuming He, Zhonghua Wang, Zhao Yang, Jing Xu, Baoxin Zhao, Zhe Liu, Huiqing Wang, Ruiping Zhang, Yanhua Chen, Ya-jie Zheng, Fenfen Wang, and Yanping Zhang
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Male ,Purine ,Population ,Polycyclic aromatic hydrocarbon ,Urine ,Pharmacology ,medicine.disease_cause ,Biochemistry ,Mass Spectrometry ,chemistry.chemical_compound ,Metabolomics ,polycyclic compounds ,medicine ,Humans ,Polycyclic Aromatic Hydrocarbons ,Child ,education ,Chromatography, High Pressure Liquid ,Carcinogen ,Aged ,chemistry.chemical_classification ,education.field_of_study ,Dose-Response Relationship, Drug ,Environmental Exposure ,General Chemistry ,Metabolism ,Middle Aged ,chemistry ,Environmental chemistry ,Female ,Oxidative stress - Abstract
The toxicities of polycyclic aromatic hydrocarbons (PAHs) have been extensively explored due to their carcinogenic and mutagenic potency; however, little is known about the metabolic responses to chronic environmental PAH exposure among the general population. In the present study, 566 healthy volunteers were dichotomized into exposed and control groups to investigate PAH-induced perturbations in the metabolic profiles. Nine urine PAH metabolites were measured by a sensitive LC-MS/MS method to comprehensively evaluate the PAH exposure level of each individual, and the metabolic profiles were characterized via a LC-MS-based metabolomic approach. PAH exposure was correlated to its metabolic outcomes by linear and logistic regression analyses. Metabolites related to amino acid, purine, lipid, and glucuronic acid metabolism were significantly changed in the exposed group. 1-Hydroxyphenanthrene and dodecadienylcarnitine have potential as sensitive and reliable biomarkers for PAH exposure and its metabolic outcomes, respectively, in the general population. These findings generally support the hypothesis that environmental PAH exposure causes oxidative stress-related effects in humans. The current study provides new insight into the early molecular events induced by PAH exposure in the actual environment.
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- 2015
7. Long-term exposure to high particulate matter pollution and cardiovascular mortality: A 12-year cohort study in four cities in northern China
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Zhipeng Bai, Bin Han, Xi Chen, Naijun Tang, Zengrong Sun, Peizhong Peter Wang, Min Sun, Jie Chen, Chang-ping Li, Hao Yu, Jing Ma, Yamin Liu, Xiao-dan Xue, Baoxin Zhao, Li-jun Zhao, and Liwen Zhang
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Adult ,Male ,China ,Time Factors ,Disease ,Cohort Studies ,Medicine ,Humans ,Cities ,Socioeconomic status ,lcsh:Environmental sciences ,General Environmental Science ,Retrospective Studies ,lcsh:GE1-350 ,Air Pollutants ,business.industry ,Confounding ,Retrospective cohort study ,Middle Aged ,Models, Theoretical ,medicine.disease ,Europe ,Cardiovascular Diseases ,Relative risk ,Heart failure ,Cohort ,Female ,Particulate Matter ,business ,Demography ,Cohort study ,Environmental Monitoring - Abstract
Epidemiologic studies have demonstrated that long-term exposure to relatively low levels of particulate air pollution is associated with adverse cardiovascular outcomes in Europe and North America. However, few studies have assessed the association with high level air pollutants. We aimed to assess the cardiovascular effects of long-term exposure to high level concentrations of inhalable particulate and to identify the characteristics of the Chinese population that are susceptible to the health effects. A retrospective cohort, containing 39,054 subjects from four cities in northern China, was followed for mortality of all cause and specific cardiovascular diseases from 1998 to 2009. Information on concentrations of PM10 (particulate matter
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- 2014
8. Study on the benefits of children’s health from air quality improved in XX city
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Jinliang Zhang, Baoxin Zhao, Tian Sang, Yanping Zhang, and Zhao Yang
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Outpatient visits ,business.industry ,Environmental health ,General Earth and Planetary Sciences ,Medicine ,business ,complex mixtures ,Air quality index ,respiratory tract diseases ,General Environmental Science - Abstract
Objective The aim of this study was to establish the concentration–response relationships between the levels of SO2 and PM10 and the daily numbers of pediatric outpatient visits and to estimate ben...
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- 2016
9. The Association Of Air Pollution With Outpatient Visits In A Hospital Taiyuan At Early 2013
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Baoxin Zhao, Yanping Zhang, Tian Sang, Jeremiah Liu, Tiansen Zou, Fenfen Wang, and Zhao Yang
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Outpatient visits ,Haze ,genetic structures ,business.industry ,Environmental health ,Air pollution ,medicine ,General Earth and Planetary Sciences ,medicine.disease_cause ,business ,eye diseases ,General Environmental Science - Abstract
Objective: To explore and descript the association of air pollution with outpatient visits in a hospital Taiyuan during 2013 haze episode. Methods: Data of outpatient visits were collected in a com...
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- 2015
10. Nonlinear Concentration-Response Function between Air Pollution and Childrens Hospital Admissions at High Concentration Levels: Evidence from Yangquan, China
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Yanping Zhang, Jinliang Zhang, Tian Sang, Jeremiah Liu, Baoxin Zhao, and Zhao Yang
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High concentration ,Concentration Response ,Environmental health ,Air pollution ,medicine ,General Earth and Planetary Sciences ,Environmental science ,medicine.disease_cause ,China ,General Environmental Science - Abstract
OBJECTIVE: To determine the shape of concentration-response function for air pollution related childrens hospital admissions across a high and wide range of air pollution in Yangquan, China (PM10:...
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- 2014
11. Population-based reference for birth weight for gestational age in northern China
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Fenfen Wang, Zhe Liu, lizhen Xu, Xiaoping Xue, Baoxin Zhao, Yanping Zhang, and Jinliang Zhang
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Male ,medicine.medical_specialty ,Pediatrics ,China ,Birth weight ,Gestational Age ,Sex Factors ,Epidemiology ,Medicine ,Birth Weight ,Humans ,Growth Charts ,Estimation ,business.industry ,Infant, Newborn ,Obstetrics and Gynecology ,Gestational age ,medicine.disease ,Cross-Sectional Studies ,Meta-analysis ,Pediatrics, Perinatology and Child Health ,Small for gestational age ,Gestation ,Female ,business ,Demography - Abstract
Background Localized birth weight references for gestational age serve as an essential tool in accurate evaluation of atypical birth outcomes (e.g. small for gestational age) in clinical diagnosis and region-specific epidemiological studies. Such standards are currently not available in Mainland China. Aims To construct up-to-date, sex- and parity-specific birth weight references based on 231,937 births in Taiyuan, China during years 2005–2011. Study design Population-based, cross-sectional. Subjects Hospital-registered, healthy infants with births dated between 11/01/2005 and 12/31/2011 within Taiyuan area. Outcome measures Birth weight in grams, and gestational age in complete weeks were calculated using a combination of last-menstrual-date-based estimation and ultrasound examination. Results Separate birth weight references are constructed for male and female infants born from primiparous and multiparous mothers. Male infants are found to weigh more than female infants in later gestational ages (appr. weeks 33–42), and infants born to multiparous mother are found to weigh more than infants born to primiparous mothers in later gestational ages (appr. weeks 36–42). Conclusions The Taiyuan birth weight reference curves display similar trends of growth as reference curves from other countries worldwide (Netherlands, Scotland, Australia, Canada, Hong Kong, Korea and Kuwait). However, growth of birth weight for Taiyuan infants tends to be slower compared to European and North American infants regardless of gender, but similar to infants from other Asian countries.
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- 2013
12. P-023
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Bao-qin Feng, Zhiqin Zhang, Xiao-ping Zhang, Hai-ping Li, Ligang Ma, Zhe Liu, Baoxin Zhao, and Yanping Zhang
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Epidemiology ,business.industry ,Environmental health ,Medicine ,China ,business - Published
- 2012
13. P-045
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Xiaoping Xue, lizhen Xu, Baoxin Zhao, Zhe Liu, Bing Su, and Yanping Zhang
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Epidemiology ,business.industry ,Air pollution exposure ,Environmental health ,medicine ,Small for gestational age ,medicine.disease ,business - Published
- 2012
14. P-349
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Xiaoping Xue, Li Liu, Jinfen Li, Ligang Ma, Yongchun Wu, Zhiqin Zhang, Baoxin Zhao, Yanping Zhang, and Zhe Liu
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medicine.medical_specialty ,Pediatrics ,Epidemiology ,business.industry ,Emergency medicine ,medicine ,Respiratory system ,business - Published
- 2012
15. P-024
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Yongchun Wu, Yanping Zhang, Zhe Liu, Baoxin Zhao, Zhiqin Zhang, Xiaoping Xue, Ligang Ma, Jinfen Li, and Li Liu
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Pediatrics ,medicine.medical_specialty ,Epidemiology ,business.industry ,Environmental health ,Air pollution ,medicine ,Respiratory system ,China ,medicine.disease_cause ,business - Published
- 2012
16. P-326
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Baoxin Zhao, Zhe Liu, Zhiqin Zhang, Yongchun Wu, Li Liu, Yanping Zhang, Ligang Ma, Jinfen Li, and Xiaoping Xue
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medicine.medical_specialty ,Epidemiology ,business.industry ,Emergency medicine ,Medicine ,Medical emergency ,business ,medicine.disease - Published
- 2012
17. P-350
- Author
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Ligang Ma, Zhiqin Zhang, Yongchun Wu, Zhe Liu, Li Liu, Baoxin Zhao, Xiaoping Xue, Yanping Zhang, and Jinfen Li
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medicine.medical_specialty ,Pediatrics ,Epidemiology ,business.industry ,Emergency medicine ,medicine ,Respiratory system ,business - Published
- 2012
18. E-021
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Ligang Ma, Baoxin Zhao, Yanping Zhang, Li Liu, Zhe Liu, Zhiqin Zhang, and Ruihong Gao
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Epidemiology ,business.industry ,Air pollution exposure ,Environmental health ,Medicine ,Respiratory system ,business - Published
- 2012
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