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Supplemental material, sj-pdf-4-jcb-10.1177_0271678X221078616 for Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Michael A Levine, Joseph B Mandeville, Finnegan Calabro, David Izquierdo-Garcia, Daniel B Chonde, Kevin T Chen, Inki Hong, Julie C Price, Beatriz Luna and Ciprian Catana in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-6-jcb-10.1177_0271678X221078616 for Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Michael A Levine, Joseph B Mandeville, Finnegan Calabro, David Izquierdo-Garcia, Daniel B Chonde, Kevin T Chen, Inki Hong, Julie C Price, Beatriz Luna and Ciprian Catana in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-7-jcb-10.1177_0271678X221078616 for Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Michael A Levine, Joseph B Mandeville, Finnegan Calabro, David Izquierdo-Garcia, Daniel B Chonde, Kevin T Chen, Inki Hong, Julie C Price, Beatriz Luna and Ciprian Catana in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221078616 for Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Michael A Levine, Joseph B Mandeville, Finnegan Calabro, David Izquierdo-Garcia, Daniel B Chonde, Kevin T Chen, Inki Hong, Julie C Price, Beatriz Luna and Ciprian Catana in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-6-jcb-10.1177_0271678X221078616 for Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Michael A Levine, Joseph B Mandeville, Finnegan Calabro, David Izquierdo-Garcia, Daniel B Chonde, Kevin T Chen, Inki Hong, Julie C Price, Beatriz Luna and Ciprian Catana in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-5-jcb-10.1177_0271678X221078616 for Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Michael A Levine, Joseph B Mandeville, Finnegan Calabro, David Izquierdo-Garcia, Daniel B Chonde, Kevin T Chen, Inki Hong, Julie C Price, Beatriz Luna and Ciprian Catana in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-2-jcb-10.1177_0271678X221078616 for Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Michael A Levine, Joseph B Mandeville, Finnegan Calabro, David Izquierdo-Garcia, Daniel B Chonde, Kevin T Chen, Inki Hong, Julie C Price, Beatriz Luna and Ciprian Catana in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-7-jcb-10.1177_0271678X221078616 for Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Michael A Levine, Joseph B Mandeville, Finnegan Calabro, David Izquierdo-Garcia, Daniel B Chonde, Kevin T Chen, Inki Hong, Julie C Price, Beatriz Luna and Ciprian Catana in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-2-jcb-10.1177_0271678X221078616 for Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Michael A Levine, Joseph B Mandeville, Finnegan Calabro, David Izquierdo-Garcia, Daniel B Chonde, Kevin T Chen, Inki Hong, Julie C Price, Beatriz Luna and Ciprian Catana in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-3-jcb-10.1177_0271678X221078616 for Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Michael A Levine, Joseph B Mandeville, Finnegan Calabro, David Izquierdo-Garcia, Daniel B Chonde, Kevin T Chen, Inki Hong, Julie C Price, Beatriz Luna and Ciprian Catana in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221078616 for Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Michael A Levine, Joseph B Mandeville, Finnegan Calabro, David Izquierdo-Garcia, Daniel B Chonde, Kevin T Chen, Inki Hong, Julie C Price, Beatriz Luna and Ciprian Catana in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-3-jcb-10.1177_0271678X221078616 for Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Michael A Levine, Joseph B Mandeville, Finnegan Calabro, David Izquierdo-Garcia, Daniel B Chonde, Kevin T Chen, Inki Hong, Julie C Price, Beatriz Luna and Ciprian Catana in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-5-jcb-10.1177_0271678X221078616 for Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Michael A Levine, Joseph B Mandeville, Finnegan Calabro, David Izquierdo-Garcia, Daniel B Chonde, Kevin T Chen, Inki Hong, Julie C Price, Beatriz Luna and Ciprian Catana in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-4-jcb-10.1177_0271678X221078616 for Assessment of motion and model bias on the detection of dopamine response to behavioral challenge by Michael A Levine, Joseph B Mandeville, Finnegan Calabro, David Izquierdo-Garcia, Daniel B Chonde, Kevin T Chen, Inki Hong, Julie C Price, Beatriz Luna and Ciprian Catana in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, JCB905433 Supplemental Material2 for Guidelines for the content and format of PET brain data in publications and archives: A consensus paper by Gitte M Knudsen, Melanie Ganz, Stefan Appelhoff, Ronald Boellaard, Guy Bormans, Richard E Carson, Ciprian Catana, Doris Doudet, Antony D Gee, Douglas N Greve, Roger N Gunn, Christer Halldin, Peter Herscovitch, Henry Huang, Sune H Keller, Adriaan A Lammertsma, Rupert Lanzenberger, Jeih-San Liow, Talakad G Lohith, Mark Lubberink, Chul H Lyoo, J John Mann, Granville J Matheson, Thomas E Nichols, Martin Nørgaard, Todd Ogden, Ramin Parsey, Victor W Pike, Julie Price, Gaia Rizzo, Pedro Rosa-Neto, Martin Schain, Peter JH Scott, Graham Searle, Mark Slifstein, Tetsuya Suhara, Peter S Talbot, Adam Thomas, Mattia Veronese, Dean F Wong, Maqsood Yaqub, Francesca Zanderigo, Sami Zoghbi and Robert B Innis in Journal of Cerebral Blood Flow & Metabolism

Background: MR is an important imaging modality for evaluating musculoskeletal malignancies owing to its high soft tissue contrast and its ability to acquire multiparametric information. PET provides quantitative molecular and physiologic information and is a critical tool in the diagnosis and staging of several malignancies. PET/MR, which can take advantage of its constituent modalities, is uniquely suited for evaluating skeletal metastases. We reviewed the current evidence of PET/MR in assessing for skeletal metastases and provided recommendations for its use. Methods: We searched for the peer reviewed literature related to the usage of PET/MR in the settings of osseous metastases. In addition, expert opinions, practices, and protocols of major research institutions performing research on PET/MR of skeletal metastases were considered. Results: Peer-reviewed published literature was included. Nuclear medicine and radiology experts, including those from 13 major PET/MR centers, shared the gained expertise on PET/MR use for evaluating skeletal metastases and contributed to a consensus expert opinion statement. [18F]-FDG and non [18F]-FDG PET/MR may provide key advantages over PET/CT in the evaluation for osseous metastases in several primary malignancies. Conclusion: PET/MR should be considered for staging of malignancies where there is a high likelihood of osseous metastatic disease based on the characteristics of the primary malignancy, hight clinical suspicious and in case, where the presence of osseous metastases will have an impact on patient management. Appropriate choice of tumor-specific radiopharmaceuticals, as well as stringent adherence to PET and MR protocols, should be employed. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.

Understanding the neural basis of consciousness is fundamental to neuroscience research. Disruptions in cortico-cortical connectivity have been suggested as a primary mechanism of unconsciousness. By using a novel combination of positron emission tomography and functional magnetic resonance imaging, we studied anesthesia-induced unconsciousness and recovery using the α[subscript 2]-agonist dexmedetomidine. During unconsciousness, cerebral metabolic rate of glucose and cerebral blood flow were preferentially decreased in the thalamus, the Default Mode Network (DMN), and the bilateral Frontoparietal Networks (FPNs). Cortico-cortical functional connectivity within the DMN and FPNs was preserved. However, DMN thalamo-cortical functional connectivity was disrupted. Recovery from this state was associated with sustained reduction in cerebral blood flow and restored DMN thalamo-cortical functional connectivity. We report that loss of thalamo-cortical functional connectivity is sufficient to produce unconsciousness., National Institutes of Health (U.S.) (DP1-OD003646), National Institutes of Health (U.S.) (TR01-GM104948), National Institutes of Health (U.S.) (DP2-OD006454)