28 results on '"Cazzaniga, S"'
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2. Hidradenitis suppurativa epidemiology. From the first Italian registry in 2009 to the most recent epidemiology updates - Italian Registry Hidradenitis Suppurativa project 2
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Bettoli, V., Cazzaniga, S., Scuderi, V., Zedde, P., Di Landro, A., Naldi, L., Cannavò, S., Fabbrocini, G., Marzano, A. V., Mazzanti, C., Offidani, A., Patrizi, A., Pellacani, G., Pimpinelli, N., Potenza, C., Romanelli, M., Rongioletti, F., Bettoli, V., Cazzaniga, S., Scuderi, V., Zedde, P., Di Landro, A., Naldi, L., Cannavo, S., Fabbrocini, G., Marzano, A. V., Mazzanti, C., Offidani, A., Patrizi, A., Pellacani, G., Pimpinelli, N., Potenza, C., Romanelli, M., Rongioletti, F., Bettoli V., Cazzaniga S., Scuderi V., Zedde P., Di Landro A., Naldi L., Cannavo S., Fabbrocini G., Marzano A.V., Mazzanti C., Offidani A., Patrizi A., Pellacani G., Pimpinelli N., Potenza C., Romanelli M., and Rongioletti F.
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Adult ,Male ,Registrie ,medicine.medical_specialty ,MEDLINE ,Dermatology ,Body Mass Index ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Age Distribution ,Epidemiology ,medicine ,Prevalence ,Humans ,Hidradenitis suppurativa ,Registries ,Young adult ,Age of Onset ,Sex Distribution ,business.industry ,Incidence (epidemiology) ,Incidence ,Smoking ,hidradenitis suppurativa ,medicine.disease ,Infectious Diseases ,Italy ,030220 oncology & carcinogenesis ,Age distribution ,Female ,Age of onset ,business ,Body mass index ,Demography ,Human - Abstract
BACKGROUND The incidence of hidradenitis suppurativa (HS) is still not fully established with only a few studies reporting its estimates. Prevalence estimates range from 5:10 000 to 4:100. These extremely large variations could be explained by a combination of factors, including different selection procedures, different diagnostic criteria, and variations in the sex and age distribution of the examined samples. OBJECTIVES To analyze variations between two consecutive Italian Registries on HS. METHODS Data obtained from the second Italian Registry on HS, named 'Italian Registry Hidradenitis Suppurativa (IRHIS) Project 2', are compared to the previous first Italian registry on HS. RESULTS Data on 944 patients are reported. The more relevant aspects that characterize IRHIS 2 project, in comparison with the previous first Italian Registry on HS, are as follows: (i) the total number of patients, about fourfold higher; (ii) a more uniform national geographic distribution of the patient population; (iii) a larger number of dermatology units involved; (iv) a larger number of items considered in the data collection; (v) 6 years of difference between the onset of the two registries (2009-2013 vs. 2015-2019). Comparing data of the two registries, there are no statistically significant differences in terms of age at the time of the visit, gender, BMI, smoking habits, age at onset and age at first diagnosis by physician. Interestingly, the mean Sartorius score in the IRHIS project 2 (58.8) was significantly lower compared to the first Italian Registry (78.4). CONCLUSIONS The importance of the registries, at both national and international levels, in collecting useful real-life data is confirmed by these two Italian projects.
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- 2019
3. Pruritus characteristics in a large Italian cohort of psoriatic patients
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Damiani, G., Cazzaniga, S., Conic, R. R. Z., Naldi, L., Griseta, V., Miracapillo, A., Azzini, M., Mocci, L., Michelini, M., Offidani, A., Bernardini, L., Campanati, A., Ricotti, G., Giacchetti, A., Norat, M., Gualco, F., Castelli, A., Cuccia, A., Diana, A., Roncarolo, G., Belli, M. A., Baldassarre, M. A., Santoro, G., Vena, G. A., Lo Console, F., Filotico, R., Mastrandrea, V., Brunetti, B., Musumeci, F., Carrabba, E., Dal Mas, P., Annicchiarico, F., Benvegnu, B., Spaziani, G., Cusano, F., Saletta Iannazzone, S., Galluccio, A., Pezza, M., Marchesi, L., Imberti, G., Reseghetti, A., Barbera, C., Reggiani, M., Lanzoni, A., Patrizi, A., Bardazzi, F., Antonucci, A., De Tommaso, S., Wallnofer, W., Ingannamorte, F., Calzavara-Pinton, P., Iannazzi, S., Zane, C., Capezzera, R., Bassisi, S., Rossi, M. T., Altamura, V., Vigl, W., Nobile, C., Aste, N., Murgia, S., Mugheddu, C., Scuderi, G., Baglieri, F., Di Dio, C., Cilioni Grilli, E., Mastronardi, C., Agnusdei, C. P., Antrilli, A., Aulisa, L., Raimondo, U., Scotto di Luzio, G., Battarra, V. C., Farro, P., Plaitano, R., Micali, G., Musumeci, M. L., Massimino, D., Li Calzi, M., La Greca, S., Pettinato, M., Sapienza, G., Valenti, G., De Giacomo, P. F., Amico, Arcangeli, F., Brunelli, D., Ghetti, E., Tulli, A., Assi, G., Amerio, P., Laria, G., Prestinari, F., Spadafora, S., Coppola, M., Caresana, G., Pezzarossa, E., Felisi, C., Donato, L., Bertero, M., Musso, L., Pa lazzini, S., Bruscino, P., Agozzino, U. C., Ottaviani, M., Simoncini, C., Virgili, A., Osti, F., Fabbri, P., Volpi, W., Caproni, M., Lotti, T., Prignano, F., Buggiani, G., Troiano, M., Fenizi, G., Altobella, A., Amoruso, A., Condello, M., Goffredo, A., Righini, M. G., Alessandrini, F., Satolli, F., Zampetti, M., Bertani, E., Fossati, S., Parodi, A., Burlando, M., Fiorucci, C., Nigro, A., Ghigliotti, G., Massone, L., Moise, G. M., Serrai, M., Cannata, G., Campagnoli, A. M., Daly, M., Leporati, C., Peila, R., Filosa, G., Bugatti, L., Nicolini, M., Nazzari, G., Cestari, R., Anastasio, F., Larussa, F. M., Pollice, N., De Francesco, F., Mazzocchetti, G., Peris, K., Fargnoli, M. C., Di Cesare, A., De Angelis, L., Flati, G., Biamonte, A. S., Quarta, G., Congedo, M., Carcaterra, A., Strippoli, D., Fideli, D., Marsili, F., Celli, M., Ceccarini, M., Bachini, L., D'Oria, M., Schirripa, V., De Filippi, C., Martini, P., Lapucci, E., Mazzatenta, C., Ghilardi, A., Simonacci, M., Bettacchi, A., Gasco, R., Zanca, A., Battistini, S., Dattola, S., Vernaci, R., Postorino, F., Zampieri, P. F., Padovan, C., Gonzalez Intchaurraga, M. A., Ladurner, J., Guarneri, B., Cannavo, S., Manfre, C., Borgia, F., Puglisi Guerra, A., Cattaneo, A., Carrera, C., Fracchiolla, C., Mozzanica, N., Prezzemolo, L., Menni, S., Lodi, A., Martino, P., Monti, M., Mancini, L., Sacrini, F., Altomare, G. F., Taglioni, M., Lovati, C., Mercuri, S. R., Schiesari, G., Giannetti, A., Conti, A., Lasagni, C., Greco, M., Ronsini, G., Schianchi, S., Fiorentini, C., Niglietta, S., Maglietta, R., Padalino, C., Crippa, D., Pini, M., Rossi, E., Tosi, D., Armas, M., Ruocco, V., Ayala, F., Balato, N., Gaudiello, F., Cimmino, G. F., Monfrecola, G., Gallo, L., Argenziano, G., Fulgione, E., Berruti, G., Ceparano, S., De Michele, I., Giorgiano, D., Leigheb, G., Deledda, S., Peserico, A., Alaibac, M., Piaserico, S., Schiesari, L., Dan, G., Mattei, I., Oro, E., Arico, M., Bongiorno, M. R., Angileri, R., Amato, S., Todaro, F., Milioto, M., Bellastro, R., Di Nuzzo, S., De Panfilis, G., Zanni, M., Borroni, G., Cananzi, R., Brazzelli, V., Lisi, P., Stingeni, L., Hansel, K., Pierfelice, V., Donelli, S., Rastelli, D., Gasperini, M., Barachini, P., Cecchi, R., Bartoli, L., Pavesi, M., De Paola, S., Corradin, M. T., Ricciuti, F., Piccirillo, A., Viola, L., Tataranni, M., Mautone, M. G., Lo Scocco, G., Niccoli, M. C., Brunasso Vernetti, A. M. G., Gaddoni, G., Resta, F., Casadio, M. C., Arcidiaco, M. C., Luvara, M. C., Albertini, G., Di Lernia, V., Guareschi, E., Catrani, S., Morri, M., De Simone, C., D'Agostino, M., Agostino, I., Calvieri, S., Cantoresi, F., Richetta, A., Sorgi, P., Carnevale, C., Nicolucci, F., Berardesca, E., Ardigo, M., De Felice, C., Gubinelli, E., Talamonti, M., Camplone, G., Cruciani, G., Riccardi, F., Barbati, R., Zumiani, G., Pagani, W., Malagoli, P. G., Pellicano, R., Donadio, D., Di Vito, C., Cottoni, F., Montesu, M. A., Pirodda, C., Addis, G., Marongiu, P., Farris, A., Cacciapuoti, M., Verrini, A., Desirello, G., Gnone, M., Fimiani, M., Pellegrino, M., Castelli, G., Zappala, L., Sesana, G., Ingordo, V., Vozza, E., Di Giuseppe, D., Fasciocco, D., Nespoli, P., Papini, M., Cicoletti, M., Bernengo, M. G., Ortoncelli, M., Bonvicino, A., Capella, G., Doveil, G. C., Forte, M., Peroni, A., Salomone, B., Savoia, P., Pippione, M., Zichichi, L., Frazzitta, M., De Luca, G., Tasin, L., Simonetto, D., Ros, S., Trevisan, G., Patamia, M., Miertusova, S., Patrone, P., Frattasio, A., Piccirillo, F., La Spina, S., Di Gaetano, L., Marzocchi, V., Motolese, A., Venturi, C., Gai, F., Pasquinucci, S., Bellazzi, R. M., Silvestri, T., Girolomoni, G., Gisondi, P., Veller Fornasa, C., Trevisan, G. P., Damiani G., Cazzaniga S., Conic R.R.Z., Naldi L., Griseta V., Miracapillo A., Azzini M., Mocci L., Michelini M., Offidani A., Bernardini L., Campanati A., Ricotti G., Giacchetti A., Norat M., Gualco F., Castelli A., Cuccia A., Diana A., Roncarolo G., Belli M.A., Baldassarre M.A., Santoro G., Vena G.A., Lo Console F., Filotico R., Mastrandrea V., Brunetti B., Musumeci F., Carrabba E., Dal Mas P., Annicchiarico F., Benvegnu B., Spaziani G., Cusano F., Saletta Iannazzone S., Galluccio A., Pezza M., Marchesi L., Imberti G., Reseghetti A., Barbera C., Reggiani M., Lanzoni A., Patrizi A., Bardazzi F., Antonucci A., De Tommaso S., Wallnofer W., Ingannamorte F., Calzavara-Pinton P., Iannazzi S., Zane C., Capezzera R., Bassisi S., Rossi M.T., Altamura V., Vigl W., Nobile C., Aste N., Murgia S., Mugheddu C., Scuderi G., Baglieri F., Di Dio C., Cilioni Grilli E., Mastronardi C., Agnusdei C.P., Antrilli A., Aulisa L., Raimondo U., Scotto di Luzio G., Battarra V.C., Farro P., Plaitano R., Micali G., Musumeci M.L., Massimino D., Li Calzi M., La Greca S., Pettinato M., Sapienza G., Valenti G., De Giacomo P.F., Amico, Arcangeli F., Brunelli D., Ghetti E., Tulli A., Assi G., Amerio P., Laria G., Prestinari F., Spadafora S., Coppola M., Caresana G., Pezzarossa E., Felisi C., Donato L., Bertero M., Musso L., Pa lazzini S., Bruscino P., Agozzino U.C., Ottaviani M., Simoncini C., Virgili A., Osti F., Fabbri P., Volpi W., Caproni M., Lotti T., Prignano F., Buggiani G., Troiano M., Fenizi G., Altobella A., Amoruso A., Condello M., Goffredo A., Righini M.G., Alessandrini F., Satolli F., Zampetti M., Bertani E., Fossati S., Parodi A., Burlando M., Fiorucci C., Nigro A., Ghigliotti G., Massone L., Moise G.M., Serrai M., Cannata G., Campagnoli A.M., Daly M., Leporati C., Peila R., Filosa G., Bugatti L., Nicolini M., Nazzari G., Cestari R., Anastasio F., Larussa F.M., Pollice N., De Francesco F., Mazzocchetti G., Peris K., Fargnoli M.C., Di Cesare A., De Angelis L., Flati G., Biamonte A.S., Quarta G., Congedo M., Carcaterra A., Strippoli D., Fideli D., Marsili F., Celli M., Ceccarini M., Bachini L., D'Oria M., Schirripa V., De Filippi C., Martini P., Lapucci E., Mazzatenta C., Ghilardi A., Simonacci M., Bettacchi A., Gasco R., Zanca A., Battistini S., Dattola S., Vernaci R., Postorino F., Zampieri P.F., Padovan C., Gonzalez Intchaurraga M.A., Ladurner J., Guarneri B., Cannavo S., Manfre C., Borgia F., Puglisi Guerra A., Cattaneo A., Carrera C., Fracchiolla C., Mozzanica N., Prezzemolo L., Menni S., Lodi A., Martino P., Monti M., Mancini L., Sacrini F., Altomare G.F., Taglioni M., Lovati C., Mercuri S.R., Schiesari G., Giannetti A., Conti A., Lasagni C., Greco M., Ronsini G., Schianchi S., Fiorentini C., Niglietta S., Maglietta R., Padalino C., Crippa D., Pini M., Rossi E., Tosi D., Armas M., Ruocco V., Ayala F., Balato N., Gaudiello F., Cimmino G.F., Monfrecola G., Gallo L., Argenziano G., Fulgione E., Berruti G., Ceparano S., De Michele I., Giorgiano D., Leigheb G., Deledda S., Peserico A., Alaibac M., Piaserico S., Schiesari L., Dan G., Mattei I., Oro E., Arico M., Bongiorno M.R., Angileri R., Amato S., Todaro F., Milioto M., Bellastro R., Di Nuzzo S., De Panfilis G., Zanni M., Borroni G., Cananzi R., Brazzelli V., Lisi P., Stingeni L., Hansel K., Pierfelice V., Donelli S., Rastelli D., Gasperini M., Barachini P., Cecchi R., Bartoli L., Pavesi M., De Paola S., Corradin M.T., Ricciuti F., Piccirillo A., Viola L., Tataranni M., Mautone M.G., Lo Scocco G., Niccoli M.C., Brunasso Vernetti A.M.G., Gaddoni G., Resta F., Casadio M.C., Arcidiaco M.C., Luvara M.C., Albertini G., Di Lernia V., Guareschi E., Catrani S., Morri M., De Simone C., D'Agostino M., Agostino I., Calvieri S., Cantoresi F., Richetta A., Sorgi P., Carnevale C., Nicolucci F., Berardesca E., Ardigo M., De Felice C., Gubinelli E., Talamonti M., Camplone G., Cruciani G., Riccardi F., Barbati R., Zumiani G., Pagani W., Malagoli P.G., Pellicano R., Donadio D., Di Vito C., Cottoni F., Montesu M.A., Pirodda C., Addis G., Marongiu P., Farris A., Cacciapuoti M., Verrini A., Desirello G., Gnone M., Fimiani M., Pellegrino M., Castelli G., Zappala L., Sesana G., Ingordo V., Vozza E., Di Giuseppe D., Fasciocco D., Nespoli P., Papini M., Cicoletti M., Bernengo M.G., Ortoncelli M., Bonvicino A., Capella G., Doveil G.C., Forte M., Peroni A., Salomone B., Savoia P., Pippione M., Zichichi L., Frazzitta M., De Luca G., Tasin L., Simonetto D., Ros S., Trevisan G., Patamia M., Miertusova S., Patrone P., Frattasio A., Piccirillo F., La Spina S., Di Gaetano L., Marzocchi V., Motolese A., Venturi C., Gai F., Pasquinucci S., Bellazzi R.M., Silvestri T., Girolomoni G., Gisondi P., Veller Fornasa C., and Trevisan G.P.
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Male ,Cross-sectional study ,Severity of Illness Index ,Cohort Studies ,030207 dermatology & venereal diseases ,0302 clinical medicine ,Risk Factors ,education ,itch ,pruritus ,psoriasis ,pustular psoriasis ,treatment ,Adolescent ,Adult ,Cross-Sectional Studies ,Educational Status ,Facial Dermatoses ,Female ,Foot Dermatoses ,Genitalia ,Hand Dermatoses ,Humans ,Italy ,Middle Aged ,Pruritus ,Psoriasis ,Registries ,Sex Factors ,Young Adult ,Epidemiology ,Young adult ,skin and connective tissue diseases ,Settore MED/33 - MALATTIE APPARATO LOCOMOTORE ,Infectious Diseases ,030220 oncology & carcinogenesis ,Cohort ,PRURITIS EPIDEMIOLOGY ,Settore MED/35 - MALATTIE CUTANEE E VENEREE ,Cohort study ,medicine.medical_specialty ,PSORIAS ,Dermatology ,Article ,03 medical and health sciences ,Pharmacotherapy ,Settore MED/35 ,Severity of illness ,medicine ,business.industry ,medicine.disease ,Pruritus,Itch sensation ,business - Abstract
Background: Psoriasis (Ps) is a chronic systemic autoimmune disease associated with pruritus in 64–98% of patients. However, few modestly sized studies assess factors associated with psoriatic pruritus. Objective: To investigate factors associated with Ps pruritus intensity. Methods: Psoriasis patients 18years or older seen in one of 155 centres in Italy between September 2005 and 2009 were identified from the Italian PsoCare registry. Patients without cutaneous psoriasis and those with missed information on pruritus were excluded. Results: We identified 10802 patients, with a mean age 48.8±14.3years. Mild itch was present in 33.2% of patients, moderate in 34.4%, severe in 18.7% and very severe in 13.7%. Higher itch intensity was associated with female gender, lower educational attainment compared to university degree, pustular psoriasis, psoriasis on the head, face, palmoplantar areas, folds and genitalia, more severe disease, disease duration
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- 2019
4. Gender differences in genital lichen sclerosus: Data from a multicenter Italian study on 729 consecutive cases
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Virgili, A., Borghi, A., Cazzaniga, S., Dilandro, A., Naldi, L., Minghetti, S., Fierro, M. T., Verrone, A., Caproni, M., Micali, G., Gaspari, V., Papini, M., Dilernia, V., Germi, L., Girolomoni, G., Bellonifortina, A., Cannavò, S. P., Bilenchi, R., Corazza, M., Battarra, V. C., D'Antuono, A., Ficarelli, E., Fontana, E., Guarneri, F., Ingordo, V., Nasca, M. R., Natalini, Y., Schena, D., Stroppiana, E., Vassilopoulou, A., Venturini, M., and Verdelli, A.
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Adult ,Male ,medicine.medical_specialty ,Referral ,Dermatology ,Disease ,Therapeutics ,Pallor ,NO ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Squamous cell carcinoma ,Carcinoma ,medicine ,Sex characteristics ,Humans ,Sex organ ,Sex Distribution ,Vulvar Lichen Sclerosus ,Vulvar lichen sclerosus ,business.industry ,medicine.disease ,Cross-Sectional Studies ,Lichen Sclerosus et Atrophicus ,Italy ,Genital Diseases ,Itching ,Female ,medicine.symptom ,Genital Diseases, Male ,business ,Genital Diseases, Female - Abstract
BACKGROUND Studies specifically conducted to assess gender differences in genital lichen sclerosus (GLS) are not available. This multicenter study aimed to identify possible gender-related differences on GLS clinical features, history and course, through collecting data from a large mixed-sex sample of patients. METHODS This was a cross-sectional study on 729 subjects (53.8% females, 46.2% males) affected with GLS, consecutively observed within a network of 15 Italian dermatology units. The following information was specifically collected: clinical features and severity of symptoms related to GLS, extragenital involvement, previous therapies, diagnostic suspicion at referral, type of referring physicians, development of genital squamous-cell carcinoma (SCC). RESULTS Females complained of symptoms more frequent and severe than men; pallor and scarring-sclerosis-atrophy were the most frequent features without gender differences; itching- related signs were more frequent in females than in males as well as extragenital involvement; prior to receiving a definitive diagnosis, females received treatment more frequently than males; 40% of patients were referred with a misdiagnosis; the highest rate of correct suspected diagnosis at referral came from dermatologists than from other physicians; duration of the disease was found to predispose to SCC development. CONCLUSIONS Our findings highlighted several gender differences on clinical presentation and symptom profile of GLS. In spite of some characteristic features, misdiagnosis at referrals was frequent.
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- 2020
5. An original exploration of genital lichen sclerosus: the semantic connectivity map
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Cazzaniga, S, Naldi, L, Virgili, A, Di Landro, A, Simon, D, Corazza, M, Borghi, A, Minghetti, S, Fierro, Mt, Verrone, A, Stroppiana, E, Caproni, M, Verdelli, A, Micali, G, Nasca, Mr, D'Antuono, A, Gaspari, V, Papini, M, Natalini, Y, Di Lernia, V, Ficarelli, E, Germi, L, Vassilopoulou, A, Girolomoni, G, Schena, D, Fortina, Ab, Fontana, E, Cannavo, Sp, Guarneri, F, Bilenchi, R, Venturini, M, Battarra, Vc, and Ingordo, V
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Socio-culturale ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,genital lichen sclerosus ,gender ,Medicine ,Humans ,Aged ,spanning tree ,business.industry ,Female ,Genital Diseases, Female ,Genital Diseases, Male ,Lichen Sclerosus et Atrophicus ,Middle Aged ,Semantics ,Genital lichen sclerosus ,Infectious Diseases ,Genital Diseases ,030220 oncology & carcinogenesis ,semantic connectivity map ,symptoms ,business ,genital lichen sclerosus, semantic connectivity map, spanning tree, symptoms, gender - Published
- 2019
6. New insights into potential risk factors and associations in genital lichen sclerosus: Data from a multicentre Italian study on 729 consecutive cases
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Virgili, A., Borghi, A, Cazzaniga, S., DI LANDRO, Alessio, Naldi, L., Minghetti, S., Verrone, A., Stroppiana, E., Caproni, M., Nasca, MARIA RITA, D'Antuono, A., Papini, M., Di Lernia, V., Corazza, M., Fierro, Maria Teresa, Verdelli, Alice, Micali, Giuseppe, Gaspari, Valeria, Natalini, Ylenia, Ficarelli, Elena, Germi, Lerica, Vassilopoulou, Angela, Schena, Donatella, Girolomoni, Giampiero, Fortina, Anna Belloni, Fontana, Elena, Guarneri, Fabrizio, Cannavã², Serafinella Patrizia, Bilenchi, Roberta, Venturini, Marina, Battarra, Vincenzo C., Ingordo, Vito, Virgili, A., Borghi, A, Cazzaniga, S., Di Landro, A., Naldi, L., Minghetti, S., Verrone, A., Stroppiana, E., Caproni, M., Nasca, M.R., D'Antuono, A., Papini, M., Di Lernia, V., Corazza, M., Fierro, Maria Teresa, Verdelli, Alice, Micali, Giuseppe, Gaspari, Valeria, Natalini, Ylenia, Ficarelli, Elena, Germi, Lerica, Vassilopoulou, Angela, Schena, Donatella, Girolomoni, Giampiero, Fortina, Anna Belloni, Fontana, Elena, Guarneri, Fabrizio, Cannavò, Serafinella Patrizia, Bilenchi, Roberta, Venturini, Marina, Battarra, Vincenzo C., and Ingordo, Vito
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Male ,Pediatrics ,Adolescent ,Adult ,Age of Onset ,Aged ,Aged, 80 and over ,Child ,Comorbidity ,Cross-Sectional Studies ,Diabetes Mellitus, Type 2 ,Educational Status ,Female ,Humans ,Hypertension ,Hypothyroidism ,Italy ,Lichen Sclerosus et Atrophicus ,Middle Aged ,Obesity ,Penile Diseases ,Risk Factors ,Sedentary Lifestyle ,Sex Factors ,Vulvar Lichen Sclerosus ,Young Adult ,Cross-sectional study ,Overweight ,Lichen sclerosus ,80 and over Child Comorbidity Cross-Sectional Studies Diabetes Mellitus ,030207 dermatology & venereal diseases ,0302 clinical medicine ,genital lichen sclerosus ,gender ,80 and over ,Medicine ,Family history ,610 Medicine & health ,education.field_of_study ,Infectious Diseases ,030220 oncology & carcinogenesis ,genital lichen sclerosus, risk factors, gender ,Type 2 Educational Status Female Humans Hypertension Hypothyroidism Italy Lichen Sclerosus et Atrophicus Male Middle Aged Obesity Penile Diseases Risk Factors Sedentary Lifestyle Sex Factors Vulvar Lichen Sclerosus Young Adult ,medicine.symptom ,Sedentary Behavior ,2708 ,Type 2 ,medicine.medical_specialty ,Population ,Adolescent Adult Age of Onset Aged Aged ,Socio-culturale ,Dermatology ,03 medical and health sciences ,Diabetes Mellitus ,education ,Sedentary lifestyle ,business.industry ,medicine.disease ,Adolescent Adult Age of Onset Aged Aged, 80 and over Child Comorbidity Cross-Sectional Studies Diabetes Mellitus, Type 2 Educational Status Female Humans Hypertension Hypothyroidism Italy Lichen Sclerosus et Atrophicus Male Middle Aged Obesity Penile Diseases Risk Factors Sedentary Lifestyle Sex Factors Vulvar Lichen Sclerosus Young Adult ,Age of onset ,business ,Demography - Abstract
BACKGROUND Limited data are available on risk factors associated with lichen sclerosus and no data are available on gender differences in genital lichen sclerosus (GLS). OBJECTIVE This multicentre study aimed at identifying potential risk factors for GLS, through data collection from a large, mixed-sex sample of patients comparing gender-related differences in relation to data from the general population. METHODS This was a cross-sectional study on 729 subjects (53.8% females, 46.2% males) affected with GLS, consecutively observed within a network of 15 Italian dermatology units. The following information was collected: demographic data, anthropometric measures, comorbidities, family history of LS, clinical features and symptoms related to GLS. RESULTS Overweight and obesity, blood hypertension, hypothyroidism and an educational attainment equal or above upper secondary school level were more frequent among the study patients than among the general Italian population. Moreover, a family history of GLS was reported more frequently than expected among GLS patients. These factors were similar in males and females. The disease tended to occur later in females than in males. CONCLUSIONS Our findings suggest that metabolic factors, and possibly a sedentary lifestyle, may play a role in GLS pathogenesis in genetically predisposed patients, and that risk profile is similar in males and females despite some difference in the onset of symptoms.
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- 2017
7. Latent tubercolosis infection in patients with cronic plaque psoriasis: evidence from the Italian Psocare Registry
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Gisondi, P, Cazzaniga, S, Chimenti, S, Maccarone, M, Picardo, M, Girolomoni, G, Naldi, L, Griseta V, Psocare Study Group., Miracapillo, A, Azzini, M, Mocci, L, Michelini, M, Offidani, A, Bernardini, L, Campanati, A, Ricotti, G, Giacchetti, Alessandro, Norat, M, Gualco, F, Castelli, A, Cuccia, A, Diana, A, Roncarolo, G, Belli, Ma, Baldassarre, Ma, Santoro, G, Vena, Ga, Lo Console, F, Filotico, R, Mastrandrea, V, Brunetti, B, Musumeci, F, Carrabba, E, Dal Mas, P, Annicchiarico, F, Benvegnù, B, Spaziani, G, Cusano, F, Saletta Iannazzone, S, Galluccio, A, Pezza, M, Marchesi, L, Imberti, G, Reseghetti, A, Barbera, Claudia, Reggiani, Matteo, Lanzoni, A, Patrizi, A, Bardazzi, F, Antonucci, A, De Tommaso, S, Balestri, R, Wallnofer, W, Ingannamorte, F, Calzavara-Pinton, P, Iannazzi, S, Zane, C, Capezzera, R, Bassisi, S, Rossi, Mt, Altamura, V, Vigl, W, SCHETTINO NOBILE, Carla, Aste, N, Murgia, S, Mugheddu, C, Scuderi, G, Baglieri, F, Di Dio, C, Cilioni Grilli, E, Mastronardi, C, Agnusdei, Cp, Antrilli, A, Aulisa, L, Raimondo, U, Scotto di Luzio, G, Battarra, Vc, Farro, P, Plaitano, R, Micali, G, Musumeci, Ml, D'Armiento, Massimino, Li Calzi, M, LA GRECA, SEBASTIANO VITTORIO, Pettinato, Cristiana Maria, Sapienza, G, Valenti, G, De Giacomo PF, D'Amico, D, Arcangeli, Federica, Brunelli, D, Ghetti, E, Tulli, Augusta, Assi, G, Amerio, P, Laria, G, Prestinari, F, Spadafora, S, Coppola, M, Caresana, G, Pezzarossa, E, Domaneschi, E, Felisi, C, Donato, L, Bertero, M, Musso, L, Pa Lazzini, S, Bruscino, P, Agozzino, Uc, Ottaviani, M, Simoncini, Cristiana, Virgili, A, Osti, F, Fabbri, P, Volpi, Walter, Caproni, M, Lotti, T, Prignano, F, Buggiani, G, Troiano, M, Fenizi, G, Altobella, A, Amoruso, A, Condello, M, Goffredo, A, Righini, Mg, Alessandrini, F, Satolli, F, Zampetti, M, Bertani, E, Fossati, S, Parodi, A, Burlando, M, Fiorucci, C, Nigro, A, Ghigliotti, G, Massone, L, Moise, Gm, Serrai, M, Cannata, G, Campagnoli, Am, Daly, M, Leporati, C, Peila, R, Filosa, Giovanna, Bugatti, L, Nicolini, M, Nazzari, G, Cestari, R, Anastasio, Fabio, Larussa, Fm, Pollice, N, De Francesco, F, Mazzocchetti, G, Peris, K, Fargnoli, Mc, Di Cesare, A, De Angelis, L, Flati, G, Biamonte, As, Quarta, Giovanni, Congedo, M, Carcaterra, A, Strippoli, D, Fideli, D, Marsili, Filippo, Celli, M, Ceccarini, M, Bachini, L, D ORIA, MARIA FEDERICA, Schirripa, V, De Filippi, C, Martini, P, Lapucci, E, Mazzatenta, C, Ghilardi, A, Simonacci, M, Bettacchi, A, Gasco, R, Zanca, A, Battistini, Simone, Dattola, S, Vernaci, R, Postorino, F, Zampieri, Pf, Padovan, MARIA CRISTINA, González Intchaurraga MA, Ladurner, J, Guarneri, B, Cannavo', Serena, Manfrè, C, Borgia, F, Puglisi Guerra, A, Sedona, P, Cattaneo, A, Carrera, C, Fracchiolla, C, Mozzanica, N, Prezzemolo, L, Menni, S, Lodi, A, Martino, P, Monti, M, Mancini, L, Sacrini, F, Altomare, Gf, Taglioni, M, Lovati, C, Mercuri, Sr, Schiesari, G, Giannetti, A, Conti, A, Lasagni, C, Greco, M, Ronsini, G, Schianchi, S, Fiorentini, C, Niglietta, S, Miglietta, R, Padalino, C, Crippa, D, Pini, M, Rossi, E, Tosi, D, Armas, M, Ruocco, V, Ayala, F, Balato, N, Gaudiello, F, Cimmino, Gf, Monfrecola, G, Gallo, L, Argenziano, G, Fulgione, E, Berruti, G, Mozzillo, R, Ceparano, S, De Michele, I, Giorgiano, D, Leigheb, G, Deledda, S, Peserico, A, Alaibac, M, Piaserico, S, Schiesari, L, Dan, G, Mattei, I, Oro, E, Aricò, M, Bongiorno, Mr, Angileri, Rosalia, Amato, S, Todaro, F, Milioto, M, Bellastro, R, Di Nuzzo, S, De Panfilis, G, Zanni, M, Borroni, G, Cananzi, R, Brazzelli, V, Lisi, P, Stingeni, L, Hansel, K, Pierfelice, V, Donelli, S, Rastelli, D, Gasperini, M, Barachini, P, Cecchi, R, Bartoli, L, Pavesi, Maria Gabriella, De Paola, S, Corradin, Mt, Ricciuti, F, Piccirillo, Alessandro, Viola, L, Tataranni, M, Mautone, Mg, Lo Scocco, G, Niccoli, Mc, Brunasso Vernetti AM, Gaddoni, G, DI RESTA, Fabio, Casadio, Mc, Arcidiaco, Mc, Luvarà, Mc, ALBERTINI PETRONI, Guglielmo, DI LERNIA, Valerio, Guareschi, E, Catrani, S, Morri, M, De Simone, C, D'Agostino, M, Agostino, I, Calvieri, S, Cantoresi, F, Richetta, A, Sorgi, Paola, Carnevale, C, Nicolucci, F, Berardesca, E, Ardigò, M, De Felice, C, Gubinelli, E, Talamonti, Marina, Camplone, G, Cruciani, Giulio, Riccardi, F, Barbati, R, Zumiani, G, Pagani, W, Malagoli, Pg, Pellicano, R, Donadio, Diego, Di Vito, C, Cottoni, F, Montesu, Ma, Pirodda, C, Addis, G, Marongiu, P, Farris, A, Cacciapuoti, Anna Maria, Verrini, A, Desirello, G, Gnone, M, Fimiani, M, Pellegrino, M, Castelli, G, Zappalà, L, Sesana, G, Ingordo, V, Vozza, E, Di Giuseppe, D, Fasciocco, D, Nespoli, P, Papini, M, Cicoletti, M, Bernengo, Mg, Ortoncelli, M, Bonvicino, A, Capella, G, Doveil, Gc, Forte, M, Peroni, A, Salomone, B, Savoia, P, Pippione, M, Zichichi, Ludovica, Frazzitta, M, De Luca, G, Tasin, L, Simonetto, D, Ros, S, Trevisan, G, Patamia, M, Miertusova, S, Patrone, Pietro, Frattasio, A, Piccirillo, Fabiola, La Spina, S, Di Gaetano, L, Marzocchi, V, Motolese, A, Venturi, Caterina, Gai, Francesco, Pasquinucci, S, Bellazzi, Rm, Silvestri, Tommaso, Veller Fornasa, C, Trevisan, Gp., Gisondi, P, Cazzaniga, S, Chimenti, S, Maccarone, M, Picardo, M, Girolomoni, G, Naldi, L, the Psocare Study Group [.., Annalisa Patrizi, ], Trevisan, Giusto, Girolomoni, G., Maccarone, Sergio, Naldi, L., Gisondi, P., Cazzaniga, S., Chimenti, S., Maccarone, M., Picardo, M., Griseta, V., Miracapillo, A., Azzini, M., Mocci, L., Michelini, M., Offidani, A., Bernardini, L., Campanati, A., Ricotti, G., Giacchetti, A., Norat, M., Gualco, F., Castelli, A., Cuccia, A., Diana, A., Roncarolo, G., Belli, M.A., Baldassarre, M.A., Santoro, G., Vena, G.A., Lo Console, F., Filotico, R., Mastrandrea, V., Brunetti, B., Musumeci, F., Carrabba, E., Dal Mas, P., Annicchiarico, F., Benvegnù, B., Spaziani, G., Cusano, F., Saletta Iannazzone, S., Galluccio, A., Pezza, M., Marchesi, L., Imberti, G., Reseghetti, A., Barbera, C., Reggiani, M., Lanzoni, A., Patrizi, A., Bardazzi, F., Antonucci, A., De Tommaso, S., Balestri, R., Wallnofer, W., Ingannamorte, F., Calzavara-Pinton, P., Iannazzi, S., Zane, C., Capezzera, R., Bassisi, S., Rossi, M.T., Altamura, V., Vigl, W., Nobile, C., Aste, N., Murgia, S., Mugheddu, C., Scuderi, G., Baglieri, F., Di Dio, C., Cilioni Grilli, E., Mastronardi, C., Agnusdei, C.P., Antrilli, A., Aulisa, L., Raimondo, U., Scotto Di Luzio, G., Battarra, V.C., Farro, P., Plaitano, R., Micali, G., Musumeci, M.L., Massimino, D., Li Calzi, M., La Greca, S., Pettinato, M., Sapienza, G., Valenti, G., De Giacomo, P.F., D'Amico, D., Arcangeli, F., Brunelli, D., Ghetti, E., Tulli, A., Assi, G., Amerio, P., Laria, G., Prestinari, F., Spadafora, S., Coppola, M., Caresana, G., Pezzarossa, E., Domaneschi, E., Felisi, C., Donato, L., Bertero, M., Musso, L., Pa Lazzini, S., Bruscino, P., Agozzino, U.C., Ottaviani, M., Simoncini, C., Virgili, A., Osti, F., Fabbri, P., Volpi, W., Caproni, M., Lotti, T., Prignano, F., Buggiani, G., Troiano, M., Fenizi, G., Altobella, A., Amoruso, A., Condello, M., Goffredo, A., Righini, M.G., Alessandrini, F., Satolli, F., Zampetti, M., Bertani, E., Fossati, S., Parodi, A., Burlando, M., Fiorucci, C., Nigro, A., Ghigliotti, G., Massone, L., Moise, G.M., Serrai, M., Cannata, G., Campagnoli, A.M., Daly, M., Leporati, C., Peila, R., Filosa, G., Bugatti, L., Nicolini, M., Nazzari, G., Cestari, R., Anastasio, F., Larussa, F.M., Pollice, N., De Francesco, F., Mazzocchetti, G., Peris, K., Fargnoli, M.C., Di Cesare, A., De Angelis, L., Flati, G., Biamonte, A.S., Quarta, G., Congedo, M., Carcaterra, A., Strippoli, D., Fideli, D., Marsili, F., Celli, M., Ceccarini, M., Bachini, L., D'Oria, M., Schirripa, V., De Filippi, C., Martini, P., Lapucci, E., Mazzatenta, C., Ghilardi, A., Simonacci, M., Bettacchi, A., Gasco, R., Zanca, A., Battistini, S., Dattola, S., Vernaci, R., Postorino, F., Zampieri, P.F., Padovan, C., González Intchaurraga, M.A., Ladurner, J., Guarneri, B., Cannavò, S.P., Manfrè, C., Borgia, F., Puglisi Guerra, A., Sedona, P., Cattaneo, A., Carrera, C., Fracchiolla, C., Mozzanica, N., Prezzemolo, L., Menni, S., Lodi, A., Martino, P., Monti, M., Mancini, L., Sacrini, F., Altomare, G.F., Taglioni, M., Lovati, C., Mercuri, S.R., Schiesari, G., Giannetti, A., Conti, A., Lasagni, C., Greco, M., Ronsini, G., Schianchi, S., Fiorentini, C., Niglietta, S., Maglietta, R., Padalino, C., Crippa, D., Pini, M., Rossi, E., Tosi, D., Armas, M., Ruocco, V., Ayala, F., Balato, N., Gaudiello, F., Cimmino, G.F., Monfrecola, G., Gallo, L., Argenziano, G., Fulgione, E., Berruti, G., Mozzillo, R., Ceparano, S., De Michele, I., Giorgiano, D., Leigheb, G., Deledda, S., Peserico, A., Alaibac, M., Piaserico, S., Schiesari, L., Dan, G., Mattei, I., Oro, E., Aricò, M., Bongiorno, M.R., Angileri, R., Amato, S., Todaro, F., Milioto, M., Bellastro, R., Di Nuzzo, S., De Panfilis, G., Zanni, M., Borroni, G., Cananzi, R., Brazzelli, V., Lisi, P., Stingeni, L., Hansel, K., Pierfelice, V., Donelli, S., Rastelli, D., Gasperini, M., Barachini, P., Cecchi, R., Bartoli, L., Pavesi, M., De Paola, S., Corradin, M.T., Ricciuti, F., Piccirillo, A., Viola, L., Tataranni, M., Mautone, M.G., Lo Scocco, G., Niccoli, M.C., Brunasso Vernetti, A.M.G., Gaddoni, G., Resta, F., Casadio, M.C., Arcidiaco, M.C., Luvarà, M.C., Albertini, G., Di Lernia, V., Guareschi, E., Catrani, S., Morri, M., De Simone, C., D'Agostino, M., Agostino, I., Calvieri, S., Cantoresi, F., Richetta, A., Sorgi, P., Carnevale, C., Nicolucci, F., Berardesca, E., Ardigò, M., De Felice, C., Gubinelli, E., Talamonti, M., Camplone, G., Cruciani, G., Riccardi, F., Barbati, R., Zumiani, G., Pagani, W., Malagoli, P.G., Pellicano, R., Donadio, D., Di Vito, C., Cottoni, F., Montesu, M.A., Pirodda, C., Addis, G., Marongiu, P., Farris, A., Cacciapuoti, M., Verrini, A., Desirello, G., Gnone, M., Fimiani, M., Pellegrino, M., Castelli, G., Zappalà, L., Sesana, G., Ingordo, V., Vozza, E., Di Giuseppe, D., Fasciocco, D., Nespoli, P., Papini, M., Cicoletti, M., Bernengo, M.G., Ortoncelli, M., Bonvicino, A., Capella, G., Doveil, G.C., Forte, M., Peroni, A., Salomone, B., Savoia, P., Pippione, M., Zichichi, L., Frazzitta, M., De Luca, G., Tasin, L., Simonetto, D., Ros, S., Trevisan, G., Patamia, M., Miertusova, S., Patrone, P., Frattasio, A., Piccirillo, F., La Spina, S., Di Gaetano, L., Marzocchi, V., Motolese, A., Venturi, C., Gai, F., Pasquinucci, S., Bellazzi, R.M., Silvestri, T., Veller Fornasa, C., and Trevisan, G.P.
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Registrie ,Male ,taiwan ,Antitubercular Agents ,Biological Factor ,quantiferon-tb-gold ,Antitubercular Agent ,Biological Factors ,experience ,Residence Characteristics ,80 and over ,Prevalence ,Registries ,Young adult ,risk ,Aged, 80 and over ,Latent Tuberculosi ,Latent tuberculosis ,psoriasis ,Middle Aged ,Italy ,Female ,tubercolosis ,tubercolosi ,Adolescent ,Adult ,Age Distribution ,Aged ,Chronic Disease ,Humans ,Latent Tuberculosis ,PUVA Therapy ,Psoriasis ,Sex Distribution ,Tuberculin Test ,Young Adult ,2708 ,Human ,medicine.drug ,medicine.medical_specialty ,chronic plaque psoriasis ,Tuberculin ,consensus statement ,Dermatology ,tuberculosis infection ,Settore MED/35 ,Internal medicine ,medicine ,Adalimumab ,factor antagonists ,necrosis-factor blockers ,systemic treatment ,therapy ,assay ,Psoriasi ,History of tuberculosis ,tuberculosis infection, chronic plaque psoriasis,Italian Psocare Registry ,business.industry ,Odds ratio ,medicine.disease ,bacterial infections and mycoses ,Confidence interval ,Surgery ,Residence Characteristic ,Italian Psocare Registry ,business - Abstract
SummaryBackground The nationwide prevalence of latent tuberculosis infection (LTBI) in Italian patients with psoriasis has never been investigated. Objectives To estimate the nationwide prevalence of LTBI in Italian patients with psoriasis who are candidates for systemic treatment. Methods Data were obtained from the Psocare Registry on those patients (n = 4946) with age > 18 years, systemic treatment at entry specified and tuberculin skin test (TST) performed according to the Mantoux method. LTBI diagnosis was based on a positive TST result in the absence of any clinical, radiological or microbiological evidence of active tuberculosis. Results Latent tuberculosis infection was diagnosed in 8·3% of patients with psoriasis (409 of 4946). The prevalence of LTBI was lower in patients on biologics than in those on conventional systemic treatments, ranging from 4·3% (19 of 444) of patients on adalimumab to 31% (eight of 26) of those on psoralen–ultraviolet A (P
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- 2015
8. Family history, body mass index, selected dietary factors, menstrual history, and risk of moderate to severe acne in adolescents and young adults
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Di Landro A, Cazzaniga S, Parazzini F, Ingordo V, Cusano F, Atzori L, Cutrì FT, Musumeci ML, Zinetti C, Pezzarossa E, Bettoli V, Caproni M, Lo Scocco G, Bonci A, Bencini P, Naldi L, Assunta E, Lanzoni A, Micali G, Virgili A, Antiga E, Volpi W, Fabbri P, Barbareschi M, Licci N., FABBROCINI, GABRIELLA, Di Landro, A, Cazzaniga, S, Parazzini, F, Ingordo, V, Cusano, F, Atzori, L, Cutrì, Ft, Musumeci, Ml, Zinetti, C, Pezzarossa, E, Bettoli, V, Caproni, M, Lo Scocco, G, Bonci, A, Bencini, P, Naldi, L, Assunta, E, Lanzoni, A, Micali, G, Virgili, A, Antiga, E, Volpi, W, Fabbri, P, Barbareschi, M, Fabbrocini, Gabriella, and Licci, N.
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Male ,medicine.medical_specialty ,Pediatrics ,Adolescent ,Dermatology ,Severity of Illness Index ,smoking ,Body Mass Index ,Young Adult ,Acne Vulgari ,Risk Factors ,Acne Vulgaris ,medicine ,Humans ,Outpatient clinic ,Mass index ,Family history ,Young adult ,Acne ,fish ,menstrual history ,milk ,business.industry ,skim milk ,Risk Factor ,moderate to severe acne ,Odds ratio ,medicine.disease ,Confidence interval ,Diet ,Menstruation ,Surgery ,Case-Control Studies ,Female ,Case-Control Studie ,business ,body mass index ,contraceptive pill ,diet ,risk factors ,Body mass index ,Human - Abstract
Background: Genetic and environmental components may contribute to acne causation. Objective: We sought to assess the impact of family history, personal habits, dietary factors, and menstrual history on a new diagnosis of moderate to severe acne. Methods: We conducted a case-control study in dermatologic outpatient clinics in Italy. Cases (205) were consecutive those receiving a new diagnosis of moderate to severe acne. Control subjects (358) were people with no or mild acne, coming for a dermatologic consultation other than for acne. Results: Moderate to severe acne was strongly associated with a family history of acne in first-degree relatives (odds ratio 3.41, 95% confidence interval 2.31-5.05). The risk was reduced in people with lower body mass index with a more pronounced effect in male compared with female individuals. No association with smoking emerged. The risk increased with increased milk consumption (odds ratio 1.78, 95% confidence interval 1.22-2.59) in those consuming more than 3 portions per week. The association was more marked for skim than for whole milk. Consumption of fish was associated with a protective effect (odds ratio 0.68, 95% confidence interval 0.47-0.99). No association emerged between menstrual variables and acne risk. Limitations: Some degree of overmatching may arise from choosing dermatologic control subjects and from inclusion of mild acne in the control group. Conclusions: Family history, body mass index, and diet may influence the risk of moderate to severe acne. The influence of environmental and dietetic factors in acne should be further explored.
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- 2012
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9. Adjuvant concurrent docetaxel, epirubicin and cyclophosphamide chemotherapy in breast cancer: The TEC regimen. A retrospective analysis
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Cazzaniga S, Zenoni D, Mauri Cm, Galdy S, and Galmozzi A
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Oncology ,TEC regimen ,Chemotherapy ,medicine.medical_specialty ,Cyclophosphamide ,business.industry ,medicine.medical_treatment ,lcsh:R ,lcsh:Medicine ,medicine.disease ,epirubicin ,Docetaxel/epirubicin ,Breast cancer ,breast cancer ,adjuvant ,Internal medicine ,medicine ,Retrospective analysis ,docetaxel ,cyclophosphamide ,business ,Adjuvant ,medicine.drug - Abstract
Background: The use of taxanes and anthracyclines in the adjuvant treatment of primary breast cancer is well established, with benefit in both disease free survival (DFS) and overall survival (OS). Several studies demonstrated that the addition of taxanes to anthracycline-based chemotherapy improves the outcome in either concurrent or sequential schedule. Nowadays, the TAC regimen (docetaxel, doxorubicin and cyclophosphamide) is a standard treatment in both node-positive and high-risk node-negative early breast cancer. Doxorubicin and epirubicin are equivalent, but at similar doses epirubicin appears to have a better side effects profile than doxorubicin in terms of myelosuppression and cardiotoxicity. We conducted a retrospective study to establish the role of TEC (epirubicin) regimen in adjuvant setting. Methods: Pre- or post-menopausal women, with stage I-III breast cancer, PS ECOG 0-2 and normal left ventricular ejection fraction, were eligible. TEC chemotherapy at median doses of docetaxel 75 mg/m2, epirubicin 60 mg/m2 and cyclophosphamide 500 mg/m2 was administered IV on day 1 every three weeks for 6 cycles. The primary endpoint was toxicity; secondary endpoints were DFS and OS. Results: Thirty-three consecutive female patients were retrospectively enrolled. The median age was 57 years old. Eighty eight percentage of patients completed the treatment plan. In 21.2% of cases a dose reduction was performed and these patients needed a chemotherapy interval prolongation. The main side effects were neutropenia G3-4 (21.2%; 95% CI, 9.8-37.5), allergic reaction G3 to docetaxel (6.1%; 95% CI, 1.0-18.6) and febrile neutropenia (3.0%; 95% CI, 0.1-14.0), while cardiotoxicity was absent (95% CI, 0-8.7%). Globally, the percentage of any other severe side effect was very low and no one toxic death was seen. The 3-year DFS and OS were 89.9% (95% CI, 79.0-100) and 93.8% (95% CI, 85.6-100), respectively. Conclusions: As compared to TAC treatment, TEC regimen with epirubicin 60 mg/m2 is feasible and well tolerated adjuvant chemotherapy in breast cancer, with acceptable and manageable toxicity.
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- 2014
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10. Diet and physical exercise in psoriasis: a randomized controlled trial
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Naldi, L, Conti, A, Cazzaniga, S, Patrizi, A, Pazzaglia, M, Lanzoni, A, Veneziano, L, Pellacani, G, Psoriasis Emilia Romagna Study Group: Miglietta, R, Padalino, C, Giannetti, A, Santoro, S, Satolli, F, Donelli, S, Savoia, F, Di Lernia, V, Virgili, Anna, Borghi, Alessandro, Alessandrini, F, Di Crecchio, R., Naldi L, Conti A, Cazzaniga S, Patrizi A, Pazzaglia M, Lanzoni A, Veneziano L, and Pellacani G and the Psoriasis Emilia Romagna Study Group
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Diet, Reducing ,Population ,Physical exercise ,body mass index ,Dermatology ,Overweight ,psoriasis ,PASI ,diet ,Young Adult ,Psoriasis Area and Severity Index ,Weight loss ,Internal medicine ,Psoriasis ,Humans ,Medicine ,Obesity ,education ,Aged ,Caloric Restriction ,Aged, 80 and over ,education.field_of_study ,business.industry ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Exercise Therapy ,Treatment Outcome ,Physical therapy ,Female ,medicine.symptom ,business ,Body mass index ,Weight gain - Abstract
BACKGROUND: Increased body mass index and weight gain are risk factors for psoriasis, and the prevalence of obesity in patients with psoriasis is higher than in the general population. Limited data exist regarding the role of diet in psoriasis. Here we assessed the impact of a dietary intervention combined with physical exercise for weight loss on improving psoriasis in overweight or obese patients. METHODS: This study included 303 overweight or obese patients with moderate-to-severe chronic plaque psoriasis not achieving clearance after 4 weeks of continuous systemic treatment. They were randomized to receive a 20-week quantitative and qualitative dietary plan associated with physical exercise for weight loss, or simple informative counseling at baseline about the utility of weight loss for clinical control of psoriatic disease. The main outcome was any reduction of the Psoriasis Area and Severity Index (PASI) from baseline to week 20. RESULTS: Intention-to-treat analysis showed a median PASI reduction of 48% (95% confidence interval, 33.3 to 58.3%) in the dietary intervention arm and 25.5% (95% confidence interval, 18.2 to 33.3%) in the information-only arm (P=0.02). Among secondary outcomes, PASI50 significantly differed between study arms (49.7% with dietary intervention vs. 34.2% with information only, P=0.006). The weight-loss target (a ≥5% reduction from baseline) was reached by 29.8% of patients in the dietary intervention arm compared to 14.5% in the information-only arm (P=0.001). CONCLUSIONS: A 20-week dietetic intervention associated with increased physical exercise reduced psoriasis severity in systemically treated overweight or obese patients with active psoriasis. This article is protected by copyright. All rights reserved.
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- 2014
11. Adult female acne and associated risk factors: Results of a multicenter case-control study in Italy
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Di Landro A, Cazzaniga S, Cusano F, Bonci A, Carla C, Ml, Musumeci, Patrizi A, Bettoli V, Pezzarossa E, Caproni M, Anna Belloni Fortina, Campione E, Ingordo V, Naldi L, Group for Epidemiologic Research in Dermatology Acne Study Group, Di Landro, Anna, Cazzaniga, Simone, Cusano, Francesco, Bonci, Angela, Carla, Cardinali, Musumeci, Maria Letizia, Patrizi, Annalisa, Bettoli, Vincenzo, Pezzarossa, Enrico, Caproni, Marzia, Fortina, Anna Belloni, Campione, Elena, Ingordo, Vito, and Naldi, Luigi
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Adult ,Hirsutism ,medicine.medical_specialty ,Pediatrics ,Multivariate analysis ,Adolescent ,case-control study ,Gravidity ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,stress ,0302 clinical medicine ,Recurrence ,Acne Vulgaris ,Vegetables ,medicine ,Humans ,risk factors ,030212 general & internal medicine ,Occupations ,Family history ,adult female acne ,diet ,family history ,610 Medicine & health ,Prospective cohort study ,hirsutism ,Acne ,Gynecology ,Adult female ,business.industry ,Case-control study ,Odds ratio ,medicine.disease ,Italy ,Seafood ,risk factor ,Unemployment ,Case-Control Studies ,Fruit ,Female ,business ,Stress, Psychological - Abstract
BACKGROUND: The reasons for the appearance of acne in adulthood are largely unknown. OBJECTIVE: We explored the role of personal and environmental factors in adult female acne. METHODS: We conducted a multicenter case-control study in the outpatient departments of 12 Italian cities. Cases (n = 248) were consecutive women ≥25 years of age with newly diagnosed acne of any grade. Controls (n = 270) were females diagnosed with conditions other than acne. RESULTS: In multivariate analysis, a history of acne in parents (odds ratio [OR] = 3.02) or siblings (OR = 2.40), history of acne during adolescence (OR = 5.44), having no previous pregnancies (OR = 1.71), having hirsutism (OR = 3.50), being an office worker versus being unemployed or being a housewife (OR = 2.24), and having a high level of reported psychological stress (OR = 2.95) were all associated with acne. A low weekly intake of fruits or vegetables (OR = 2.33) and low consumption of fresh fish (OR = 2.76) were also associated with acne. LIMITATIONS: We did not establish an onset date for acne. Some of our associations may reflect consequences of established acne. CONCLUSION: Lifestyle factors may play an important role for acne development in adulthood, but their role should be further assessed in prospective studies.
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- 2016
12. Efficacy of switching between tumor necrosis factor-alfa inhibitors in psoriasis: results from the Italian Psocare registry
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Piaserico, Stefano, Cazzaniga, Simone, Chimenti, Sergio, Giannetti, Alberto, Maccarone, Mara, Picardo, Mauro, Peserico, Andrea, Naldi, Luigi, Griseta, V., Miracapillo, A., Azzini, M., Mocci, L., Michelini, M., Offidani, A., Bernardini, L., Campanati, A., Ricotti, G., Giacchetti, A., Norat, M., Gualco, F., Castelli, A., Cuccia, A., Diana, A., Roncarolo, G., Belli, M. A., Baldassarre, M. A., Santoro, G., Vena, G. A., Lo Console, F., Filotico, R., Mastrandrea, V., Brunetti, B., Musumeci, F., Carrabba, E., Dal Mas, P., Annicchiarico, F., Benvegnã¹, B., Spaziani, G., Cusano, F., Saletta Iannazzone, S., Galluccio, A., Pezza, M., Marchesi, L., Imberti, G., Reseghetti, A., Barbera, C., Reggiani, M., Lanzoni, A., Patrizi, A., Bardazzi, F., Antonucci, A., De Tommaso, S., Balestri, R., Wallnofer, W., Ingannamorte, F., Calzavara-Pinton, P., Iannazzi, S., Zane, C., Capezzera, R., Bassisi, S., Rossi, M. T., Altamura, V., Vigl, W., Nobile, C., Aste, N., Murgia, S., Mugheddu, C., Scuderi, G., Baglieri, F., Di Dio, C., Cilioni Grilli, E., Mastronardi, C., Agnusdei, C. P., Antrilli, A., Aulisa, L., Raimondo, U., Scotto di Luzio, G., Battarra, V. C., Farro, P., Plaitano, R., Micali, G., Musumeci, M. L., Massimino, D., Li Calzi, M., La Greca, S., Pettinato, M., Sapienza, G., Valenti, G., De Giacomo, P. F., D’amico, D., Arcangeli, F., Brunelli, D., Ghetti, E., Tulli, A., Assi, G., Amerio, P., Laria, G., Prestinari, F., Spadafora, S., Coppola, M., Caresana, G., Pezzarossa, E., Domaneschi, E., Felisi, C., Donato, L., Bertero, M., Musso, L., Pa lazzini, S., Bruscino, P., Agozzino, U. C., Ottaviani, M., Simoncini, C., Virgili, A., Osti, F., Fabbri, P., Volpi, W., Caproni, M., Lotti, T., Prignano, F., Buggiani, G., Troiano, M., Fenizi, G., Altobella, A., Amoruso, A., Condello, M., Goffredo, A., Righini, M. G., Alessandrini, F., Satolli, F., Zampetti, M., Bertani, E., Fossati, S., Parodi, A., Burlando, M., Fiorucci, C., Nigro, A., Ghigliotti, G., Massone, L., Moise, G. M., Serrai, M., Cannata, G., Campagnoli, A. M., Daly, M., Leporati, C., Peila, R., Filosa, G., Bugatti, L., Nicolini, M., Nazzari, G., Cestari, R., Anastasio, F., Larussa, F. M., Pollice, N., De Francesco, F., Mazzocchetti, G., Peris, K., Fargnoli, M. C., Di Cesare, A., De Angelis, L., Flati, G., Biamonte, A. S., Quarta, G., Congedo, M., Carcaterra, A., Strippoli, D., Fideli, D., Marsili, F., Celli, M., Ceccarini, M., Bachini, L., D’oria, M., Schirripa, V., De Filippi, C., Martini, P., Lapucci, E., Mazzatenta, C., Ghilardi, A., Simonacci, M., Bettacchi, A., Gasco, R., Zanca, A., Battistini, S., Dattola, S., Vernaci, R., Postorino, F., Zampieri, P. F., Padovan, C., González Intchaurraga, M. A., Ladurner, J., Guarneri, B., Cannavo', S., Manfrã, C., Borgia, F., Puglisi Guerra, A., Sedona, P., Cattaneo, A., Carrera, C., Fracchiolla, C., Mozzanica, N., Prezzemolo, L., Menni, S., Lodi, A., Martino, P., Monti, M., Mancini, L., Sacrini, F., Altomare, G. F., Taglioni, M., Lovati, C., Mercuri, S. R., Schiesari, G., Giannetti, A., Conti, A., Lasagni, C., Greco, M., Ronsini, G., Schianchi, S., Fiorentini, C., Niglietta, S., Maglietta, R., Padalino, C., Crippa, D., Pini, M., Rossi, E., Tosi, D., Armas, M., Ruocco, V., Ayala, F., Balato, N., Gaudiello, F., Cimmino, G. F., Monfrecola, G., Gallo, L., Argenziano, G., Fulgione, E., Berruti, G., Ceparano, S., De Michele, I., Giorgiano, D., Leigheb, G., Deledda, S., Peserico, A., Alaibac, M., Piaserico, S., Schiesari, L., Dan, G., Mattei, I., Oro, E., Aricã², M., Bongiorno, M. R., Angileri, R., Amato, S., Todaro, F., Milioto, M., Bellastro, R., Di Nuzzo, S., De Panfilis, G., Zanni, M., Borroni, G., Cananzi, R., Brazzelli, V., Lisi, P., Stingeni, L., Hansel, K., Pierfelice, V., Donelli, S., Rastelli, D., Gasperini, M., Barachini, P., Cecchi, R., Bartoli, L., Pavesi, M., De Paola, S., Corradin, M. T., Ricciuti, F., Piccirillo, A., Viola, L., Tataranni, M., Mautone, M. G., Lo Scocco, G., Niccoli, M. C., Brunasso Vernetti, A. M. G., Gaddoni, G., Resta, F., Casadio, M. C., Arcidiaco, M. C., Luvarã , M. C., Albertini, G., Di Lernia, V., Guareschi, E., Catrani, S., Morri, M., De Simone, C., D’agostino, M., Agostino, I., Calvieri, S., Cantoresi, F., Richetta, A., Sorgi, P., Carnevale, C., Nicolucci, F., Berardesca, E., Ardigã², M., De Felice, C., Gubinelli, E., Chimenti, S., Talamonti, M., Camplone, G., Cruciani, G., Riccardi, F., Barbati, R., Zumiani, G., Pagani, W., Malagoli, P. G., Pellicano, R., Donadio, D., Di Vito, C., Cottoni, F., Montesu, M. A., Pirodda, C., Addis, G., Marongiu, P., Farris, A., Cacciapuoti, M., Verrini, A., Desirello, G., Gnone, M., Fimiani, M., Pellegrino, M., Castelli, G., Zappalã , L., Sesana, G., Ingordo, V., Vozza, E., Di Giuseppe, D., Fasciocco, D., Nespoli, P., Papini, M., Cicoletti, M., Bernengo, M. G., Ortoncelli, M., Bonvicino, A., Capella, G., Doveil, G. C., Forte, M., Peroni, A., Salomone, B., Savoia, P., Pippione, M., Zichichi, L., Frazzitta, M., De Luca, G., Tasin, L., Simonetto, D., Ros, S., Trevisan, G., Patamia, M., Miertusova, S., Patrone, P., Frattasio, A., Piccirillo, F., La Spina, S., Di Gaetano, L., Marzocchi, V., Motolese, A., Venturi, C., Gai, F., Pasquinucci, S., Bellazzi, R. M., Silvestri, T., Girolomoni, G., Gisondi, P., Veller Fornasa, C., Trevisan, G. P., Piaserico S, Cazzaniga S, Chimenti S, Giannetti A, Maccarone M, Picardo M, Peserico A, Naldi L, Psocare Study Group [.., Patrizi A, ], Piaserico, S, Cazzaniga, S, Chimenti, S, Giannetti, A, Maccarone, M, Picardo, M, Peserico, A, Naldi, L, Bongiorno, MR, Psocare Study Group, Monfrecola, Giuseppe, and Trevisan, Giusto
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Male ,primary inefficacy ,75% improvement in the Psoriasis Area Severity Index score ,PASI ,PASI 75 ,Psoriasis Area Severity Index ,TNF ,biologics ,efficacy ,psoriasis ,secondary loss of efficacy ,switching ,tumor necrosis factor ,tumor necrosis factor-alfa inhibitors ,Adult ,Analysis of Variance ,Antibodies, Monoclonal ,Antibodies, Monoclonal, Humanized ,Cohort Studies ,Confidence Intervals ,Dose-Response Relationship, Drug ,Drug Administration Schedule ,Female ,Follow-Up Studies ,Humans ,Immunoglobulin G ,Italy ,Middle Aged ,Multivariate Analysis ,Predictive Value of Tests ,Proportional Hazards Models ,Psoriasis ,Receptors, Tumor Necrosis Factor ,Registries ,Retrospective Studies ,Risk Assessment ,Severity of Illness Index ,Treatment Outcome ,Tumor Necrosis Factor-alpha ,Young Adult ,SWITHCES ,psoriasis arthritis ,pharmachological treatment ,Etanercept ,Monoclonal ,Receptors ,Settore MED/35 - Malattie Cutanee E Veneree ,Humanized ,Hazard ratio ,Predictive value of tests ,Drug ,biologic ,TNF-alpha ,medicine.medical_specialty ,Dermatology ,Antibodies ,Dose-Response Relationship ,Settore MED/35 ,Internal medicine ,Severity of illness ,medicine ,Adverse effect ,psoriasi ,Adalimumab ,Infliximab ,2708 ,Proportional hazards model ,business.industry ,tumor necrosis factor-alfa inhibitor ,Retrospective cohort study ,medicine.disease ,Confidence interval ,Surgery ,ANTI-TNFA ,business - Abstract
Background: Some studies have shown that switching patients from one tumor necrosis factor (TNF)-alfa inhibitor to another may be beneficial when they have an inadequate response or an adverse event. Objective: We sought to assess the variables predicting the efficacy of the second TNF-alfa inhibitor in patients discontinuing the first TNF-alfa inhibitor. Methods: Data from all 5423 consecutive patients starting TNF-alfa inhibitor therapy for psoriasis between September 2005 and September 2010 who were included in the Italian Psocare registry were analyzed. Results: In 105 patients who switched to a second TNF-alfa inhibitor who had complete follow-up data, 75% improvement in the Psoriasis Area Severity Index score (PASI 75) was reached by 29% after 16 weeks and by 45.6% after 24 weeks. Patients who switched because of secondary loss of efficacy (loss of initial PASI 75 response) or adverse events/intolerance were more likely to reach PASI 75 than those who switched as a result of primary inefficacy (PASI 75 never achieved) (hazard ratio 2.7, 95% confidence interval 1.3-5.5 vs hazard ratio 2.0, 95% confidence interval 1.0-3.9 and 1, respectively). Limitations: There was a small number of patients with complete follow-up data. Conclusion: PASI 75 response in patients who switched from one antie-TNF-alfa agent to another was significantly reduced in patients who showed primary inefficacy of the first antie-TNF-alfa.
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- 2014
13. Characterization of Hidradenitis Suppurativa Phenotypes: A Multidimensional Latent Class Analysis of the National Italian Registry IRHIS
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Gabriella Fabbrocini, Angelo V. Marzano, Marzia Caproni, Claudia Lasagni, Elena Pezzolo, Valentina Dini, Serafinella P. Cannavò, Simone Cazzaniga, Annamaria Offidani, Laura Atzori, Vincenzo Bettoli, Damiano Abeni, Annalisa Patrizi, Luigi Naldi, Cazzaniga, S., Pezzolo, E., Bettoli, V., Abeni, D., Marzano, A. V., Patrizi, A., Atzori, L., Fabbrocini, G., Offidani, A., Lasagni, C., Dini, V., Caproni, M., Cannavo, S. P., and Naldi, L.
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0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Cross-sectional study ,Dermatology ,Biochemistry ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Hidradenitis suppurativa ,Registries ,Molecular Biology ,business.industry ,Cell Biology ,Odds ratio ,Dermatology Life Quality Index ,Middle Aged ,medicine.disease ,Hidradenitis Suppurativa ,body regions ,030104 developmental biology ,Cross-Sectional Studies ,Phenotype ,Italy ,Latent Class Analysis ,030220 oncology & carcinogenesis ,Cohort ,Female ,business ,Body mass index ,Acne conglobata ,Cohort study - Abstract
In spite of the large heterogeneity, limited data exist on hidradenitis suppurativa (HS) phenotypes. To identify the HS phenotypes that best explain the disease heterogeneity, a cross-sectional study using latent class (LC) analysis was conducted on a cohort of patients examined at 17 dermatological centers participating in the Italian Registry of Hidradenitis Suppurativa and being enrolled between January 2015 and January 2020. Overall, 965 patients aged 32.0 ± 12.4 years (mean ± SD) were evaluated. A three-class model in LC analysis best fitted the data. Patients in LC1 (20.1%) were females, mostly obese, with a high probability of axillary‒groin (0.85) and mammary (0.59) lesions and the highest HS severity. Patients in LC2 (29.6%) were nonobese males, with moderate disease severity; with a high probability of gluteal (0.50) and genital (0.17) lesions, besides axillary‒groin involvement; and with acne and pilonidal cysts. Patients in LC3 (50%) were nonobese females with a milder disease mostly limited to axillary (0.52) and groin (0.66) areas. The stratification of patients with HS into a severe axillary‒mammary‒groin phenotype with predominantly anterior body involvement in females, an axillary‒gluteal‒groin phenotype of intermediate severity mainly affecting males in the posterior body areas, and an axillary‒groin phenotype with mildest clinical symptoms and limited skin involvement may help in optimizing HS management.
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- 2021
14. Validation of a visual‐aided questionnaire for the self‐assessment of hidradenitits suppurativa
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Simone Cazzaniga, Giulia Guidarelli, Laura Atzori, Vincenzo Bettoli, Giovanni Damiani, Luigi Naldi, F. Patta, Cazzaniga, S., Naldi, L., Damiani, G., Atzori, L., Patta, F., Guidarelli, G., and Bettoli, V.
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Adult ,Male ,Self-assessment ,Self-Assessment ,medicine.medical_specialty ,Population ,Dermatology ,Risk Assessment ,Sensitivity and Specificity ,Severity of Illness Index ,Statistics, Nonparametric ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Quality of life ,Reference Values ,Sickness Impact Profile ,Surveys and Questionnaires ,Confidence Intervals ,medicine ,Humans ,Hidradenitis suppurativa ,610 Medicine & health ,education ,education.field_of_study ,business.industry ,Age Factors ,Middle Aged ,medicine.disease ,Confidence interval ,Hidradenitis Suppurativa ,Critical appraisal ,Infectious Diseases ,Italy ,Case-Control Studies ,030220 oncology & carcinogenesis ,Quality of Life ,Physical therapy ,Female ,Observational study ,business ,Kappa - Abstract
BACKGROUND Hidradenitis Suppurativa (HS) is a chronic, highly debilitating disease. Few questionnaires have been developed to identify potential HS cases based on simple questions. A visual representation may help in characterising these lesions. OBJECTIVE To develop and validate a visually assisted questionnaire for HS detection. METHODS This was an observational diagnostic study on a series of patients with a first diagnosis of HS and a corresponding series of age and gender-matched controls consecutively observed in two Italian centres. The questionnaire was developed based on a critical appraisal of the relevant literature and on expert consensus. Measures of accuracy and reproducibility were assessed. RESULTS 57 patients with HS and 57 controls were included in the study (mean age 32.9 ± 12.3 years). Based on at least one affirmative answer to the proposed questionnaire items, the accuracy was 95.6%, with a sensitivity of 98.2% and a specificity of 93.0%. Reproducibility was almost perfect on all the tested items (Cohen's kappa ≥ 0.85). LIMITATIONS The questionnaire was tested only in experimental conditions. CONCLUSION The questionnaire could be a useful tool for HS screening in the general population. Further studies are needed to confirm its performance in a real-world setting.
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- 2018
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15. Linkage between patients' characteristics and prescribed systemic treatments for psoriasis: a semantic connectivity map analysis of the Swiss Dermatology Network for Targeted Therapies registry
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Peter Häusermann, Julia-Tatjana Maul, Wolf-Henning Boehncke, Stephan Jeff Rustenbach, Simone Cazzaniga, Lars E. French, Nikhil Yawalkar, Luca Borradori, Dagmar Simon, Florian Anzengruber, Matthias Augustin, Alexander A. Navarini, C. Sorbe, Luigi Naldi, Markus Streit, Curdin Conrad, Peter Itin, Carlo Mainetti, Antonios G.A. Kolios, Emmanuel Laffitte, Kristine Heidemeyer, Michel Gilliet, Vahid Djamei, Antonio Cozzio, University of Zurich, and Cazzaniga, S
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Adult ,Male ,medicine.medical_specialty ,610 Medicine & health ,Dermatology ,Etanercept ,2708 Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Psoriatic arthritis ,0302 clinical medicine ,Quality of life ,Psoriasis ,Ustekinumab ,Adalimumab ,Medicine ,Humans ,Registries ,Dermatologic Agents/therapeutic use ,ddc:616 ,Psoriasis/drug therapy/physiopathology ,business.industry ,10177 Dermatology Clinic ,2725 Infectious Diseases ,Middle Aged ,medicine.disease ,Infliximab ,Infectious Diseases ,030220 oncology & carcinogenesis ,10033 Clinic for Immunology ,Secukinumab ,Female ,Dermatologic Agents ,business ,Algorithms ,Switzerland ,medicine.drug - Abstract
BACKGROUND Several treatment options are currently available for the treatment of psoriasis. OBJECTIVE To explore the main associations between patients' characteristics and systemic treatments prescribed for psoriasis in a large group of patients observed in real-life clinical practice. METHODS This was a retrospective analysis of baseline data collected within the Swiss Dermatology Network for Targeted Therapies registry in Switzerland between March 2011 and December 2017. Semantic map analysis was used in order to capture the best associations between variables taking into account other covariates in the system. RESULTS A total of 549 patients (mean age 46.7 ± 14.7 years) were included in the analysis. Conventional therapies such as retinoids and methotrexate were associated with no previous systemic therapies for psoriasis, a moderate quality of life (QoL) at therapy onset and older age (≥60 years). Fumaric acid derivatives were associated with mild psoriasis (psoriasis area severity index
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- 2019
16. Variability by country in the European Neuroanaesthesia and Critical Care Interest Group subarachnoid haemorrhage survey
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Ferdinando Luca Lorini, Federico Bilotta, L. Velly, Carlo Alberto Castioni, Paolo Gritti, Simone Cazzaniga, Gritti, P, Cazzaniga, S, Castioni, C, Lorini, F, Velly, L, and Bilotta, F
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medicine.medical_specialty ,Consensus ,Subarachnoid hemorrhage ,Critical Care ,subarachnoid haemorrhage ,Neurosurgical Procedures ,Perioperative Care ,03 medical and health sciences ,0302 clinical medicine ,Health care ,medicine ,Humans ,Anesthesia ,030212 general & internal medicine ,Healthcare Disparities ,Practice Patterns, Physicians' ,610 Medicine & health ,Intensive care medicine ,Letter to the Editor ,business.industry ,030208 emergency & critical care medicine ,Subarachnoid Hemorrhage ,medicine.disease ,Europe ,Neuroanaesthesia ,Anesthesiology and Pain Medicine ,Health Care Surveys ,Perioperative care ,Interest group ,Subarachnoid haemorrhage ,business - Published
- 2016
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17. Female Patients with Dermatitis Herpetiformis Show a Reduced Diagnostic Delay and Have Higher Sensitivity Rates at Autoantibody Testing for Celiac Disease
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Emiliano Antiga, Veronica Bonciolini, Simone Cazzaniga, Mauro Alaibac, Antonino Salvatore Calabrò, Carla Cardinali, Emanuele Cozzani, Angelo Valerio Marzano, Giuseppe Micali, Tarcisio Not, Pietro Quaglino, Camilla Vassallo, Luigi Naldi, Marzia Caproni, the GISED Group and the Italian Group for Cutaneous Immunopathology, Antiga, E., Bonciolini, V., Cazzaniga, S., Alaibac, M., Calabro, A. S., Cardinali, C., Cozzani, E., Marzano, A. V., Micali, G., Not, T., Quaglino, P., Vassallo, C., Naldi, L., and Caproni, M.
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Male ,Delayed Diagnosis ,Biopsy ,lcsh:Medicine ,Disease ,Gastroenterology ,Thyroiditis ,Serology ,030207 dermatology & venereal diseases ,0302 clinical medicine ,Child ,biology ,General Medicine ,Middle Aged ,030220 oncology & carcinogenesis ,Child, Preschool ,Female ,Antibody ,Research Article ,Adult ,medicine.medical_specialty ,Article Subject ,Adolescent ,General Biochemistry, Genetics and Molecular Biology ,Autoimmune thyroiditis ,03 medical and health sciences ,Young Adult ,Sex Factors ,Dermatitis herpetiformis ,Internal medicine ,medicine ,Humans ,Serologic Tests ,Direct fluorescent antibody ,Aged ,Autoantibodies ,General Immunology and Microbiology ,business.industry ,lcsh:R ,Autoantibody ,Infant, Newborn ,Thyroiditis, Autoimmune ,Infant ,medicine.disease ,Celiac Disease ,Cross-Sectional Studies ,biology.protein ,Atrophy ,business ,dermatitis herpetiformis ,diagnosis ,serology - Abstract
Objective. Our objective was to characterize the demographic information, clinical features, and laboratory data of patients with dermatitis herpetiformis (DH). Methods. In this multicentre cross-sectional study, consecutive patients with a new diagnosis of DH that referred to nine different Italian centers between 2011 and 2016 were characterized assessing demographic, clinical and laboratory findings, and evaluating gender and age differences across selected variables. Results. A total of 151 patients were included. Among them, 81 (53.6%) were males and 70 (46.4%) were females, with a male to female ratio of 1.2 : 1. The median age at the time of diagnosis was 41 years (range 0–85). Males had a significant longer diagnostic delay if compared to females (9 vs. 3 months, respectively; p=0.01). Direct immunofluorescence was positive in 94.7% of the patients, while duodenal biopsy showed partial to total villous atrophy in 70.1% of patients. All the females resulted positive to at least one of the antibodies tested, while a total of 12 male patients (10.5%) tested negative to celiac-specific antibodies. Female patients had a high rate (14.1%) of autoimmune thyroiditis. Conclusions. Our study confirmed some of the most relevant data regarding DH that have been previously reported in the literature. In addition, we found a reduced diagnostic delay in females with respect to males, possibly related to the higher sensitivity of serologic testing in females with DH compared to males. Finally, we demonstrated that intestinal involvement could be severe in patients with DH and that females should be tested for thyroiditis.
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- 2019
18. Sunburn-related variables, secular trends of improved sun protection and short-term impact on sun attitude behavior in Italian primary schoolchildren
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Giuseppe Palmieri, Ignazio Stanganelli, Marco Simonacci, Paola Queirolo, Simone Cazzaniga, Sara Gandini, Simone Ribero, Pietro Quaglino, Maria Antonietta Pizzichetta, Serena Magi, Francesco Spagnolo, Luigi Naldi, Stanganelli, I., Naldi, L., Cazzaniga, S., Gandini, S., Magi, S., Quaglino, P., Ribero, S., Simonacci, M., Pizzichetta, M. A., Spagnolo, F., Palmieri, G., and Queirolo, P.
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Male ,Parents ,Health Knowledge, Attitudes, Practice ,Skin Neoplasms ,Sun protection ,primary prevention ,Sunburn ,03 medical and health sciences ,medical education ,melanoma ,sun protection ,Child ,Female ,Humans ,Italy ,Program Evaluation ,Students ,Sunscreening Agents ,Surveys and Questionnaires ,0302 clinical medicine ,Primary prevention ,Medicine ,Skin Neoplasm ,030212 general & internal medicine ,skin and connective tissue diseases ,Sunscreening Agent ,Practice ,integumentary system ,business.industry ,Health Knowledge ,Behavior change ,General Medicine ,medicine.disease ,Secular variation ,Parent ,Attitudes ,030220 oncology & carcinogenesis ,Skin color ,Observational study ,Sun exposure ,Student ,business ,Human ,Demography - Abstract
Sun protection early in life is an essential issue for primary prevention of skin cancers. The Il Sole per Amico was an educational campaign among 66 Italian primary schools. A total of 12,188 questionnaires were completed at baseline. Overall, 9.4% children reported >1 sunburn during the last year and 44.7% parents a use of sunlamps. Independent factors associated with sunburns were: age, lower level of parents' education, light eye and skin color, freckles, nevi on arms, intense sun exposure during the last year, sporadic use of sunscreens, and parental use of sunlamps. A total of 7280 (59.7%) questionnaires were completed at the end of the educational intervention. No significant difference was documented about behavior between the pre- and post-intervention periods. A significant reduction was instead found in both prevalence of recent sunburns and total number of sunburn episodes after comparison with the data obtained by identical questionnaire in the same geographic areas in the "Sole Si Sole No" project in 2001.
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- 2020
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19. The constellation of dietary factors in adolescent acne: a semantic connectivity map approach
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E, Grossi, S, Cazzaniga, S, Crotti, L, Naldi, A, Di Landro, V, Ingordo, F, Cusano, L, Atzori, F, Tripodi Cutrì, M L, Musumeci, E, Pezzarossa, V, Bettoli, M, Caproni, A, Bonci, Nicola, Licci, Grossi, E., Cazzaniga, S., Crotti, S., Naldi, L., Di Landro, A., Ingordo, V., Cusano, F., Atzori, L., Tripodi Cutrì, F., Musumeci, M. L., Pezzarossa, E., Bettoli, V., Caproni, M., Bonci, A., and Fabbrocini, Gabriella
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0301 basic medicine ,Adolescent ,Dermatology ,Severity of Illness Index ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Environmental health ,Acne Vulgaris ,Severity of illness ,medicine ,Humans ,Young adult ,Family history ,First-degree relatives ,Child ,610 Medicine & health ,Acne ,030109 nutrition & dietetics ,Anthropometry ,business.industry ,Case-control study ,medicine.disease ,Obesity ,Diet ,Semantics ,Infectious Diseases ,Case-Control Studies ,business - Abstract
BACKGROUND: Different lifestyle and dietetic factors have been linked with the onset and severity of acne. OBJECTIVE: To assess the complex interconnection between dietetic variables and acne. METHODS: This was a reanalysis of data from a case-control study by using a semantic connectivity map approach. 563 subjects, aged 10-24 years, involved in a case-control study of acne between March 2009 and February 2010, were considered in this study. The analysis evaluated the link between a moderate to severe acne and anthropometric variables, family history and dietetic factors. Analyses were conducted by relying on an artificial adaptive system, the Auto Semantic Connectivity Map (AutoCM). RESULTS: The AutoCM map showed that moderate-severe acne was closely associated with family history of acne in first degree relatives, obesity (BMI ≥ 30), and high consumption of milk, in particular skim milk, cheese/yogurt, sweets/cakes, chocolate, and a low consumption of fish, and limited intake of fruits/vegetables. CONCLUSION: Our analyses confirm the link between several dietetic items and acne. When providing care, dermatologists should also be aware of the complex interconnection between dietetic factors and acne.
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- 2014
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20. 'Familial venoms': a thallium intoxication cluster
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Silvia Francesconi, Valeria Margherita Petrolini, Sara Cazzaniga, Alberto Facchini, Roberto Colombo, Eduardo Beck, Giuseppe Citerio, Gabriella Ciceri, Alessandro Terrani, Maurizio Saini, Francesco Ratti, Cecilia Tedesco, Ratti, F, Facchini, A, Beck, E, Cazzaniga, S, Francesconi, S, Tedesco, C, Terrani, A, Ciceri, G, Colombo, R, Saini, M, Petrolini, V, and Citerio, G
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0301 basic medicine ,medicine.medical_specialty ,Chemical toxicity ,business.industry ,030111 toxicology ,Water pollutants ,Pain medicine ,Treatment outcome ,030232 urology & nephrology ,MEDLINE ,chemistry.chemical_element ,Critical Care and Intensive Care Medicine ,Disease cluster ,03 medical and health sciences ,0302 clinical medicine ,chemistry ,Thallium intoxication ,Anesthesiology ,Emergency medicine ,Medicine ,Thallium ,business - Published
- 2018
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21. Overweight, diabetes and disease duration influence clinical severity in hidradenitis suppurativa–acne inversa: evidence from the national Italian registry
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Vincenzo Bettoli, Luigi Naldi, Marzia Caproni, Stefania Zauli, Annarosa Virgili, Gabriella Fabbrocini, Beatrice Raone, M. Ricci, Simone Cazzaniga, Laura Atzori, C. Cardinali, Alessandro Borghi, Annalisa Patrizi, Riccardo Balestri, S. Pasquinucci, Al Pinna, R. Capezzera, V. Devita, Massimo Donini, A. Gimma, Bettoli, V., Naldi, L., Cazzaniga, S., Zauli, S., Atzori, L., Borghi, A., Capezzera, R., Caproni, M., Cardinali, C., Devita, V., Donini, M., Fabbrocini, Gabriella, Gimma, A., Pasquinucci, S., Patrizi, A., Pinna, A. L., Raone, B., Ricci, M., Virgili, A., Balestri, R., Fabbrocini, G., and Pinna, A.L.
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Adult ,Male ,obesity ,skin ,medicine.medical_specialty ,Adolescent ,Demographics ,Disease duration ,Socio-culturale ,Dermatology ,Overweight ,smoking ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Acne Vulgaris ,Diabetes Mellitus ,Prevalence ,medicine ,Humans ,Hidradenitis suppurativa ,Clinical severity ,Registries ,030212 general & internal medicine ,Age of Onset ,Child ,610 Medicine & health ,Acne ,Aged ,Aged, 80 and over ,business.industry ,association ,hidradenitis suppurativa ,Middle Aged ,medicine.disease ,Cross-Sectional Studies ,Italy ,diabete ,clinical severity ,Female ,medicine.symptom ,business ,association, obesity, smoking, skin - Abstract
Hidradenitis suppurativa–acne inversa (HS-AI) is a chronic inflammatory skin condition that involves the folliculopilosebaceous units. Histopathological studies have suggested that the occlusion of the follicular infundibulum and both innate and adaptive immunity play central roles.1,2 Limited data regarding the clinical aspects and prognosis of HS-AI are available. Patients affected by HS-AI may benefit from early dietary interventions aimed at the metabolic comorbidities that may predispose the patient to HS-AI, reducing weight as a secondary benefit. The rationalization of preventive and therapeutic approaches among centres may help to harmonize the clinical management of HS-AI internationally, with a lasting benefit to patients.
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- 2015
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22. Circulating Autoantibodies and Autoimmune Comorbidities in Vitiligo Patients: A Multicenter Italian Study
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Maria Donata Digiuseppe, Dario Fai, Vito Ingordo, Enrico Pezzarossa, Maria Letizia Musumeci, Vincenzo Claudio Battarra, Michele Pellegrino, Simone Cazzaniga, Annalisa Patrizi, Vito Di Lernia, Luigi Naldi, Riccardo Sirna, Beatrice Raone, Ingordo, V., Cazzaniga, S., Raone, B., Digiuseppe, M. D., Musumeci, M. L., Fai, D., Pellegrino, M., Pezzarossa, E., Di Lernia, V., Battarra, V. C., Sirna, R., Patrizi, A., and Naldi, L.
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Male ,Comorbidity ,Vitiligo ,Severity of Illness Index ,Cohort Studies ,Prevalence ,Child ,skin and connective tissue diseases ,Aged, 80 and over ,integumentary system ,medicine.diagnostic_test ,Middle Aged ,Prognosis ,Italy ,Child, Preschool ,Female ,Thyroid function ,multicenter italian study ,Cohort study ,Adult ,medicine.medical_specialty ,Adolescent ,Dermatology ,Risk Assessment ,Autoimmune Diseases ,circulating autoantibodie ,Young Adult ,Age Distribution ,Severity of illness ,Confidence Intervals ,medicine ,Humans ,Blood test ,Sex Distribution ,Aged ,Autoantibodies ,Retrospective Studies ,Analysis of Variance ,autoimmune comorbiditie ,business.industry ,Autoantibody ,Retrospective cohort study ,medicine.disease ,Logistic Models ,Multivariate Analysis ,Immunology ,business - Abstract
Background: Autoimmune comorbidities and circulating autoantibodies have been observed in vitiligo patients, but differences in rate are present according to countries in which the studies were performed, perhaps owing to ethnic diversities or different trigger factors. Objective: To estimate the prevalence of circulating autoantibodies and overt autoimmune diseases in a fairly large sample of Italian vitiligo patients. Methods: 175 outpatients affected by vitiligo and referred to nine dermatological centers were included in the study. Patients were offered routine blood test, serological testing for thyroid function and search for autoantibodies. Results: At least one circulating autoantibody was detected in 61 (41.8%) of 146 subjects who underwent laboratory tests. Anti-thyroperoxidase (25.6%), anti-thyroglobulin (23.4%), antinuclear antibodies (16.8%) and anti-gastric parietal cell antibodies (7.8%) were the most noticed autoantibodies. 74 (41.5%) autoimmune comorbidities, mainly autoimmune thyroiditis (37%), were reported. Conclusion: The prevalence of autoimmune comorbidities and circulating autoantibodies in this study was in agreement with other surveys conducted on Caucasian patients.
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- 2014
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23. Postoperative complications in cirrhotic pediatric deceased donor liver transplantation: Focus on transfusion therapy
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Oliviero Fochi, Davide Corbella, G. Colombo, Francesco Fazzi, M. Zambelli, C. Gattoni, Mirco Nacoti, Simone Cazzaniga, Michele Colledan, Ezio Bonanomi, Nacoti, M, Cazzaniga, S, Colombo, G, Corbella, D, Fazzi, F, Fochi, O, Gattoni, C, Zambelli, M, Colledan, M, and Bonanomi, E
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Liver Cirrhosis ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,complication ,Kaplan-Meier Estimate ,Platelet Transfusion ,030230 surgery ,Liver transplantation ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Risk Factors ,medicine ,Humans ,Major complication ,Child ,Propensity Score ,Proportional Hazards Models ,Retrospective Studies ,Transplantation ,Deceased donor ,Intraoperative Care ,business.industry ,Graft Survival ,Infant ,Stepwise regression ,Tissue Donors ,Surgery ,Liver Transplantation ,Death ,pediatric liver transplantation ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Cohort ,Propensity score matching ,030211 gastroenterology & hepatology ,Transfusion therapy ,Female ,Risk Adjustment ,transfusion therapy ,business ,Erythrocyte Transfusion ,Follow-Up Studies - Abstract
Intraoperative transfusions seem associated with patient death and graft failure after PLTx. A retrospective analysis of recipients' and donors' characteristics and transplantation data in a cohort of patients undergoing PLTx from 2002 to 2009 at the Bergamo General Hospital was performed. A two-stage hierarchical Cox proportional hazard regression with forward stepwise selection was used to identify the main risk factors for major complications. In addition, propensity score analysis was used to adjust risk estimates for possible selection biases in the use of blood products. Over the 12-year period, 232 pediatric cirrhotic patients underwent PLTx. One-year patient and graft survival rates were 92.3% and 83.7%, respectively. The Kaplan-Meier shows that the main decrease in both graft and patient survival occurs during the first months post-transplantation. At the same time, it appears that most of the complications occur during the first month post-transplantation. One-month and 1-year patient complication-free survival rates were 24.8% and 12.1%, respectively. Our study shows that intraoperative red blood cells and platelet transfusions are independent risk factors for developing one or more major complications in the first year after PLTx. Decreasing major complications will improve the health status and overall long-term patient survival after pediatric PLTx.
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- 2017
24. To what extent is quality of life impaired in vitiligo? A multicenter study on Italian patients using the dermatology life quality index
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Maria Donata Digiuseppe, Vincenzo Claudio Battarra, Enrico Pezzarossa, Matelda Medri, Riccardo Sirna, Francesca Peccerillo, Dario Fai, Vito Di Lernia, Ivana Romano, Beatrice Raone, Luigi Naldi, Annalisa Patrizi, Vito Ingordo, Michele Pellegrino, Maria Letizia Musumeci, Simone Cazzaniga, Ingordo V, Cazzaniga S, Medri M, Raone B, Digiuseppe MD, Musumeci ML, Romano I, Fai D, Pellegrino M, Pezzarossa E, Di Lernia V, Peccerillo F, Battarra VC, Sirna R, Patrizi A, and Naldi L.
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Adult ,Male ,medicine.medical_specialty ,genetic structures ,Adolescent ,Vitiligo ,Dermatology ,Risk Assessment ,Severity of Illness Index ,Young Adult ,Sex Factors ,Quality of life ,Sickness Impact Profile ,Surveys and Questionnaires ,Severity of illness ,Adaptation, Psychological ,Odds Ratio ,Medicine ,Humans ,Young adult ,skin and connective tissue diseases ,Aged ,Retrospective Studies ,Aged, 80 and over ,integumentary system ,business.industry ,Age Factors ,Retrospective cohort study ,Odds ratio ,Dermatology Life Quality Index ,Middle Aged ,medicine.disease ,Prognosis ,humanities ,Italy ,Multivariate Analysis ,Quality of Life ,Observational study ,Female ,business ,Italian vitiligo patients - Abstract
Background: It is believed that vitiligo has an impact on the overall patient quality of life (QoL). Objective: To estimate QoL in a fairly large sample of Italian vitiligo patients by using the Dermatology Life Quality Index (DLQI) questionnaire. Methods: One hundred and sixty-one vitiligo patients referred to 9 dermatological centers were offered to participate by filling in the Italian version of the DLQI questionnaire. Results: The mean total DLQI score was 4.3 (SD ±4.9; range: 0-22). In multivariate analysis, DLQI >5 was associated with female gender, stability of the disease over time and involvement of the face at disease onset. Conclusions: The impairment of QoL is overall limited in Italian vitiligo patients, especially if it is compared with results from other available studies. This could be due to cultural and ethnic characteristics of the sample.
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- 2014
25. Clinical evaluation of hyponatremia and hypovolemia in critically ill adult neurologic patients: contribution of the use of cumulative balance of sodium
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Carlo Brembilla, Lidia Rotasperti, Simone Cazzaniga, Matteo Filippini, Paolo Gritti, Luigi A. Lanterna, Tatyana Sarnecki, Ferdinando Luca Lorini, Gritti, P, Lanterna, L, Rotasperti, L, Filippini, M, Cazzaniga, S, Brembilla, C, Sarnecki, T, and Lorini, F
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Adult ,Male ,inorganic chemicals ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Cerebral salt-wasting syndrome ,Critical Illness ,Hypovolemia ,Inappropriate ADH Syndrome ,Young Adult ,Intensive care ,Anesthesiology ,medicine ,Humans ,Young adult ,Intensive care medicine ,Aged ,Retrospective Studies ,Syndrome of inappropriate antidiuretic hormone secretion ,business.industry ,organic chemicals ,Sodium ,nutritional and metabolic diseases ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Anesthesiology and Pain Medicine ,Female ,medicine.symptom ,Hyponatremia ,business ,Cumulative balance of sodium - Abstract
Knowledge of the cumulative balance of sodium (CBS) is important for the diagnosis of salt disorders and water homeostasis and has the potential to predict hypovolemic status in acute neurological patients. However, an extensive application of the use of CBS is still lacking in the intensive care setting, where salt and water homeostasis represents a priority.Records of consecutive series of acute neurological patients admitted to a neurointensive care unit over a 6-month period were retrospectively reviewed. CBS was calculated at the admission to the Emergency Department. Discrimination between cerebral salt-wasting syndrome (CSWS) and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) was performed on the basis of the classical criteria. Additionally, we used the findings of a negative CBS exceeding 2 mEq/kg for the diagnosis of CSWS. Two independent clinicians who were blinded to the CBS results performed diagnosis of the causes of hyponatremia and estimated the daily volemic status of the patients on the basis of clinical parameters. Logistic regression analysis was used to determine the independent prognostic factors of hypovolemia.Thirty-five patients were studied for a total of 418 days. Four patients (11.4%) fitted the criteria of CSWS and three patients (8.5%) had SIADH. The unavailability of the CBS led to a wrong diagnosis in three of the eight hyponatremic patients (37.5%). The risk of developing hypovolemia in patients with negative CBS was 7.1 times higher (CI 3.86-13.06; p0.001). Multivariate analysis revealed that negative cumulative fluid balance, negative CBS2 mEq/kg, and CVP ≤5 cmH2O were independent prognostic factors for hypovolemia.CBS is likely to be a useful parameter in the diagnosis of CSWS and a surrogate parameter for estimating hypovolemia in acute neurological patients.
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- 2014
26. A rapid method for the purification of wild-type and V804M mutant ret catalytic domain: A tool to study thyroid cancer
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Sara Cazzaniga, Luca Mologni, Elisa Sala, Elena Papinutto, Carlo Gambacorti-Passerini, Sala, E, Mologni, L, Cazzaniga, S, Papinutto, E, and GAMBACORTI PASSERINI, C
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endocrine system diseases ,Mutant ,Spodoptera ,Biology ,Biochemistry ,Cell Line ,RET, V804M, purification ,Thyroid carcinoma ,Piperidines ,Structural Biology ,Glial cell line-derived neurotrophic factor ,medicine ,Animals ,Humans ,Point Mutation ,Thyroid Neoplasms ,Enzyme Inhibitors ,Molecular Biology ,Thyroid cancer ,Kinase ,Proto-Oncogene Proteins c-ret ,Wild type ,General Medicine ,medicine.disease ,Molecular biology ,Recombinant Proteins ,Protein Structure, Tertiary ,Pyrimidines ,Amino Acid Substitution ,Protein kinase domain ,Drug Resistance, Neoplasm ,Quinazolines ,biology.protein ,Pyrazoles ,Tyrosine kinase - Abstract
RET (rearranged during transfection) is a transmembrane tyrosine kinase and acts as co-receptor of glial-derived neurotrophic factor (GDNF) family neurothrofic factors in complex with GFRalpha family proteins; RET is important for development of enteric nervous system and renal organogenesis during embryonal life. Alterations in Ret gene are related to several neoplasias: point mutations are identified in medullary thyroid carcinoma (MTC) and multiple endocrine neoplasias 2A and B (MEN2A and B), while translocations and chromosomal inversions cause papillary thyroid carcinoma (PTC). We expressed recombinant RET kinase domain (rRET) containing the active site, the ATP binding pocket, and the activation loop with regulatory activity, with the Baculovirus expression system. RET was purified by a two-step procedure consisting of an anion exchange chromatography followed by nickel affinity chromatography. Moreover a biochemical characterization of the recombinant product was performed in order to verify its activity (by ELISA) and physical state (dynamic light scattering). We used rRET to validate an ELISA-based kinase assay, by testing inhibitors reported in literature such as PP1 and PP2. This method represents an easy system to screen potential inhibitors found by computational methods. We also produced V804M mutants to identify inhibitors that can overcome resistance to PP1 and ZD6474. The catalytic domain of RET can be used also for X-ray diffraction to obtain information about the three-dimensional structure, necessary for a rational design of selective inhibitors: it represents an important tool to understand the molecular mechanisms causing thyroid cancer and to care it.
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- 2006
27. Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence
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Luigi Naldini, Simona Cavalieri, Sabrina Cazzaniga, Chiara Bonini, Claudio Bordignon, Massimo Geuna, Zulma Magnani, Cavalieri, S, Cazzaniga, S, Geuna, M, Magnani, Z, Bordignon, Claudio, Naldini, Luigi, and Bonini, MARIA CHIARA
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Cytotoxic ,T-Lymphocytes ,Cytomegalovirus ,Kidney ,Lymphocyte Activation ,Biochemistry ,Receptor, Nerve Growth Factor ,Genes, Reporter ,T-Lymphocyte Subsets ,Transduction, Genetic ,Nerve Growth Factor ,Receptors ,Viral ,Antigens, Viral ,Interleukin-15 ,Cell Cycle ,Hematology ,Donor Lymphocytes ,Interleukin 15 ,Antigen ,Immunocompetence ,Receptor ,medicine.drug ,Interleukin 2 ,Immunology ,Genetic Vectors ,Receptors, Antigen, T-Cell ,Biology ,Viral vector ,Cell Line ,Transduction ,Interferon-gamma ,Immune system ,Genetic ,medicine ,Humans ,Antigens ,Reporter ,Interleukin-7 ,Lentivirus ,Cell Biology ,Suicide gene ,T-Cell ,Genes ,HeLa Cells ,Interleukin-2 ,T-Lymphocytes, Cytotoxic ,CD8 - Abstract
Gene transfer into T lymphocytes is currently being tested for the treatment of lymphohematologic disorders. We previously showed that suicide gene transfer into donor lymphocytes infused to treat leukemic relapse after allogeneic hematopoietic stem cell transplantation allowed control of graft-versus-host disease. However, the T-cell receptor (TCR) activation and sustained proliferation required for retroviral vector transduction may impair the half-life and immune competence of transduced cells and reduce graft-versus-leukemia activity. Thus, we tested lentiviral vectors (LVs) and stimulation with cytokines involved in antigen-independent T-cell homeostasis, such as interleukin 7 (IL-7), IL-2, and IL-15. Late-generation LVs transduced efficiently nonproliferating T cells that had progressed from G0 to the G1 phase of the cell cycle on cytokine treatment. Importantly, IL-2 and IL-7, but not IL-15, stimulation preserved physiologic CD4/CD8 and naive-memory ratios in transduced cells with only minor induction of some activation markers. Functional analysis of immune response to cytomegalovirus (CMV) showed that, although CMV-specific T cells were preserved by all conditions of transduction, proliferation and specific killing of autologous cells presenting a CMV epitope were higher for IL-2 and IL-7 than for IL-15. Thus, LV transduction of IL-2 or IL-7 prestimulated cells overcomes the limitations of retroviral vectors and may significantly improve the efficacy of T-cell–based gene therapy.
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- 2003
28. Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation
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Zulma Magnani, Sarah Marktel, Fabio Ciceri, Catia Traversari, Claudio Bordignon, Stanley R. Riddell, Sabrina Cazzaniga, Chiara Bonini, Marktel, S, Magnani, Z, Ciceri, Fabio, Cazzaniga, S, Riddell, Sr, Traversari, C, Bordignon, Claudio, and Bonini, MARIA CHIARA
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Herpesvirus 4, Human ,Isoantigens ,T-Lymphocytes ,medicine.medical_treatment ,T cell ,Immunology ,Cytomegalovirus ,Graft vs Host Disease ,Blood Donors ,Graft vs Leukemia Effect ,Biology ,Transfection ,Thymidine Kinase ,Biochemistry ,Lymphocyte Depletion ,Immunophenotyping ,Interferon-gamma ,Immune system ,Antigen ,immune system diseases ,medicine ,Humans ,Simplexvirus ,Lymphocytes ,Antigens, Viral ,Cells, Cultured ,Cell Biology ,Hematology ,Immunotherapy ,Donor Lymphocytes ,medicine.disease ,Lymphocyte Subsets ,Retroviridae ,surgical procedures, operative ,medicine.anatomical_structure ,Graft-versus-host disease ,Lymphocyte Transfusion ,Interleukin-2 ,Leukocyte Common Antigens ,Cytokine secretion ,Stem cell ,Stem Cell Transplantation ,T-Lymphocytes, Cytotoxic - Abstract
We have previously shown that the infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase (HSV-tk) gene is an efficient tool for controlling graft-versus-host disease (GVHD) while preserving the graft-versus-leukemia (GVL) effect. In addition to the GVL effect, the administration of donor HSV-tk(+) cells could have a clinical impact in promoting immune reconstitution after T-cell-depleted stem cell transplantation (SCT). To explore this hypothesis, we have investigated whether in vitro polyclonal activation, retroviral transduction, immunoselection, and expansion affect the immune competence of donor T cells. We have observed that, after appropriate in vitro manipulation, T cells specific for antigens relevant in the context of SCT are preserved in terms of frequency, expression of T-cell receptor, proliferation, cytokine secretion, and lytic activity. A reduction in the frequency of allospecific T-cell precursors is observed after prolonged T-cell culture, suggesting that cell manipulation protocols involving a short culture time and high transduction efficiency are needed. Finally, the long-term persistence of HSV-tk(+) cells was observed in a patient treated in the GVL clinical trial, and a reversion of the phenotype of HSV-tk(+) cells from CD45RO(+) to CD45RA(+) was documented more than 2 years after the infusion. Based on all this evidence, we propose a clinical study of preemptive infusions of donor HSV-tk(+) T cells after SCT from haploidentical donors to provide early immune reconstitution against infection and potential immune protection against disease recurrence. (C) 2003 by The American Society of Hematology. We have previously shown that the infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase (HSV-tk) gene is an efficient tool for controlling graft-versus-host disease (GVHD) while preserving the graft-versus-leukemia (GVL) effect. In addition to the GVL effect, the administration of donor HSV-tk(+) cells could have a clinical impact in promoting immune reconstitution after T-cell-depleted stem cell transplantation (SCT). To explore this hypothesis, we have investigated whether in vitro polyclonal activation, retroviral transduction, immunoselection, and expansion affect the immune competence of donor T cells. We have observed that, after appropriate in vitro manipulation, T cells specific for antigens relevant in the context of SCT are preserved in terms of frequency, expression of T-cell receptor, proliferation, cytokine secretion, and lytic activity. A reduction in the frequency of allospecific T-cell precursors is observed after prolonged T-cell culture, suggesting that cell manipulation protocols involving a short culture time and high transduction efficiency are needed. Finally, the long-term persistence of HSV-tk(+) cells was observed in a patient treated in the GVL clinical trial, and a reversion of the phenotype of HSV-tk(+) cells from CD45RO(+) to CD45RA(+) was documented more than 2 years after the infusion. Based on all this evidence, we propose a clinical study of preemptive infusions of donor HSV-tk(+) T cells after SCT from haploidentical donors to provide early immune reconstitution against infection and potential immune protection against disease recurrence. (C) 2003 by The American Society of Hematology.
- Published
- 2003
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