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O presente estudo teve como objetivo comparar as alteracoes no eletrocardiograma (ECG) e nos parâmetros cardiorrespiratorios da metadona ou morfina administrada pela via intravenosa (I.V.) em caes anestesiados com infusao intravenosa continua de propofol. Foram utilizados 16 cadelas, sem raca definida submetidos ao procedimento de ovario-histerectomia. Os animais foram distribuidos aleatoriamente em dois grupos, designados como GME (metadona 0,3 mg kg-1, I.V.) ou GMO (morfina 0,3 mg kg-1, I.V.). Os parâmetros avaliados foram frequencia cardiaca (FC), tempo e amplitude da onda P (Ps e PmV), intervalo entre as ondas P e R (PR), duracao do complexo QRS (QRS), amplitude da onda R (R), duracao do intervalo entre as ondas Q e T (QT), pressao arterial sistolica (PAS), temperatura retal (TR), frequencia respiratoria (f), tensao de dioxido de carbono no final da expiracao (ETCO2) e saturacao de oxigenio na hemoglobina (SpO2). A analgesia pos-operatoria foi verificada seguindo a proposta de Firth e Haldane (1999) e o regaste analgesico baseado na escala analoga visual. A FC foi menor no GME comparativamente ao GMO. Os valores de Ps, PmV, PR, QRS, R e QT mantiveram-se dentro da normalidade em ambos os grupos e sem significado clinico. Apneia e incremento da ETCO2 em ambos os grupos. Nao houve diferenca nos efeitos analgesicos entre os grupos. Podemos concluir que a metadona e a morfina promovem efeitos cardiovasculares similares quando administradas I.V. durante o procedimento cirurgico em caes anestesiados com propofol via infusao continua intravenosa, no entanto, quando a metadona e empregada, ventilacao assistida e necessaria. Alem disso, os dois opioides promoveram analgesia por 6h00 no pos-operatorio.

Made available in DSpace on 2015-11-03T15:30:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-01-01. Added 1 bitstream(s) on 2015-11-04T10:14:34Z : No. of bitstreams: 1 WOS000352019800028.pdf: 758039 bytes, checksum: 7906ad30b915c1ee5aa2510df253d0c4 (MD5) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) O objetivo deste estudo foi avaliar os efeitos oculares, a exequibilidade e qualidade do bloqueio retrobulbar pela técnica inferior temporal, em cães, com diferentes anestésicos locais empregando-se agulha epidural de Tuohy. Oito cães foram incluídos no experimento e cada um foi estudado quatro vezes, com intervalo de 15 dias entre os tratamentos: Lido - lidocaína a 2%; Ropi - ropivacaína a 0,5%, Bupi - bupivacaína racêmica a 0,5% e Levo - levobupivacaína a 0,75%. Com exceção da ropivacaína, todos os anestésicos continham epinefrina 1:200.000. Os bloqueios foram realizados nos olhos direitos dos animais imediatamente após a indução anestésica, e os olhos esquerdos, não bloqueados, foram utilizados como controle. Avaliou-se a pressão intraocular, a produção lacrimal e a sensibilidade corneal antes de qualquer procedimento (T0), 30 min após a medicação pré-anestésica (TMPA), 30 min após a indução anestésica (T30), após a recuperação da anestesia (TREC), a cada 60 min até 360 min e 12 e 24 h após o bloqueio. O diâmetro pupilar foi avaliado nos mesmos momentos, exceto no T0. A máxima dilatação pupilar foi observada no grupo Lido seguida pelos grupos Ropi, Bupi e Levo. Todos os anestésicos mantiveram a pressão ocular dentro dos níveis normais para cães e reduziram significativamente a produção lacrimal. A produção lacrimal retornou ao normal primeiramente no grupo Lido, seguida pelos grupos Bupi, Ropi e Levo. O retorno da sensibilidade corneal ocorreu primeiramente no grupo Lido, seguido pelos grupos Ropi, Bupi e Levo. O bloqueio retrobulbar pela técnica inferior temporal demonstrou ser exequível e seguro, embora o uso de lubrificantes oculares seja sugerido The objective of this study was to evaluate the ocular effects, the feasibility and the quality of retrobulbar block using the inferior temporal technique with different local anesthetics applied with the Tuohy epidural needle in dogs. Eight dogs were included in the experiment and each one was studied four times, with interval of 15 days between the treatments: Lido -2% lidocaine, Ropi - 0.75% ropivacaine, Bupi - 0.5% racemic bupivacaine and Levo - 0.75% levobupivacaine. Except for the ropivacaine, all of the local anesthetics contained epinephrine at 1: 200.000. The blocks were performed in the right eyes immediately after anesthetic induction, and the left eyes were not blocked and were used as controls. The intraocular pressure, tear production and corneal sensitivity were evaluated before any procedure (T0), 30 min after premedication (TMPA), 30 min after anesthetic induction (T30), after recovery from anesthesia (TREC), every 60 min up to 360 min and 12 and 24 h after the block. The pupil diameter was evaluated at the same time points, excepted at T0. The maximum pupillary dilatation was observed in Lido group at T120 followed by Ropi at TREC, and Bupi and Levo at T30. All of the anesthetics maintained eye pressure within acceptable levels for normal dogs and significantly reduced tear production. Tear production returned earliest in group Lido, followed by Bupi, Ropi and Levo. The corneal sensitivity returned earliest in group Lido, followed by Ropi, Bupi and Levo. The retrobulbar block using the temporal inferior technique proved to be feasible and safe, although lubrication of the ocular surface is suggested. Universidade de Franca, UNIFRAN, Franca, SP, Brasil. Universidade Federal de Goiás, UFG, Jataí, GO, Brasil. UNIFRAN, Franca, SP, Brasil. Faculdade de Ciências Sociais e Agrárias de Itapeva, Itapeva, SP, Brasil. Universidade de São Paulo, São Paulo, USP, SP, Brasil. Universidade Estadual Paulista “Júlio de Mesquita Filho”, Campus Jaboticabal, UNESP, Jaboticabal, SP, Brasil. FAPESP: 2007/03505-5 FAPESP: 2007/04586-9 FAPESP: 2007/08403-6

Objective To report the outcome of partial external mitral annuloplasty in dogs with congestive heart failure (CHF) due to mitral regurgitation caused by myxomatous mitral valve degeneration (MMVD). Animals, materials and methods Nine client-owned dogs with CHF due to mitral regurgitation caused by MMVD. Surgery consisted of a double row of pledget-butressed continuous suture lines placed into the left ventricle parallel and just ventral to the atrioventricular groove between the subsinuosal branch of the left circumflex coronary artery and the paraconal branch of the left coronary artery. Results Two dogs died during surgery because of severe hemorrhage. Two dogs died 12 and 36 h after surgery because of acute myocardial infarction. Three dogs were euthanized 2 and 4 weeks after surgery because of progression of CHF, 1 was euthanized 30 days after surgery for non-cardiac disease, and 1 survived for 48 months. In the 5 dogs that survived to discharge there was no significant change in the left atrium to aortic ratio with surgery (3.6 ± 0.56 before surgery; 3.1 ± 0.4 after surgery; p = 0.182), and no significant change in mitral regurgitant fraction in 4 dogs in which this measurement was made (78.7 ± 2.0% before surgery; 68.7 ± 7.5% after surgery; p = 0.09). Conclusions Partial external mitral annuloplasty in dogs with CHF due to MMVD was associated with high perioperative mortality and most dogs that survived to discharge failed to show clinically relevant palliation from this procedure. Consequently, partial external mitral annuloplasty is not a viable option for dogs with mitral regurgitation due to MMVD that has progressed to the stage of CHF.

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:41Z No. of bitstreams: 1 S0103-84782005000600018.pdf: 54202 bytes, checksum: 461115410d4554ba1528ef377c1991df (MD5) Made available in DSpace on 2013-08-22T18:59:41Z (GMT). No. of bitstreams: 1 S0103-84782005000600018.pdf: 54202 bytes, checksum: 461115410d4554ba1528ef377c1991df (MD5) Previous issue date: 2005-12-01 Made available in DSpace on 2013-09-30T19:56:48Z (GMT). No. of bitstreams: 2 S0103-84782005000600018.pdf: 54202 bytes, checksum: 461115410d4554ba1528ef377c1991df (MD5) S0103-84782005000600018.pdf.txt: 27577 bytes, checksum: 0b943cbbe8f98c35a17082fbcdafb7d5 (MD5) Previous issue date: 2005-12-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:14:46Z No. of bitstreams: 2 S0103-84782005000600018.pdf: 54202 bytes, checksum: 461115410d4554ba1528ef377c1991df (MD5) S0103-84782005000600018.pdf.txt: 27577 bytes, checksum: 0b943cbbe8f98c35a17082fbcdafb7d5 (MD5) Made available in DSpace on 2014-05-20T15:14:46Z (GMT). No. of bitstreams: 2 S0103-84782005000600018.pdf: 54202 bytes, checksum: 461115410d4554ba1528ef377c1991df (MD5) S0103-84782005000600018.pdf.txt: 27577 bytes, checksum: 0b943cbbe8f98c35a17082fbcdafb7d5 (MD5) Previous issue date: 2005-12-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Avaliaram-se os efeitos do propofol ou sevofluorano sobre variáveis hemodinâmicas, em cães submetidos à mielografia. Para tanto, utilizaram-se trinta animais distribuídos em dois grupos de igual número, denominados GP e GS. Os animais do GP receberam propofol (10mg kg-1) por via intravenosa para intubação orotraqueal, e imediatamente após, administrou-se continuamente, por meio de bomba de infusão, propofol (0,55 ± 0,15mg kg-1 min-1). Decorridos 30 minutos, foi colhido liquor na cisterna magna e o meio de contraste iohexol foi injetado. No GS empregou-se a mesma metodologia adotada para o GP, utilizando indução anestésica pela administração de sevofluorano a 2,5 CAM, com o uso de máscara naso-oral vedada e manutenção com 1,5 CAM. As variáveis estudadas foram freqüência cardíaca (FC), pressões arteriais sistólica, diastólica e média (PAS, PAD e PAM, respectivamente), débito cardíaco (DC), volume sistólico (VS), pressão venosa central (PVC), freqüência respiratória (f), concentração de dióxido de carbono ao final da expiração (ETCO2) e saturação de oxihemoglobina (SpO2). As mensurações das variáveis foram realizadas imediatamente após a colheita do liquor (M1), logo após a aplicação de iohexol (M2), seguida das demais em intervalos de 10 minutos, durante uma hora. Utilizazou-se a Análise de Variância (ANOVA) seguida pelo teste F como métodos estatísticos, considerando p

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:41Z No. of bitstreams: 1 S0103-84782005000600019.pdf: 53049 bytes, checksum: cace24a9ef47e7a0f17356ce18660ef2 (MD5) Made available in DSpace on 2013-08-22T18:59:41Z (GMT). No. of bitstreams: 1 S0103-84782005000600019.pdf: 53049 bytes, checksum: cace24a9ef47e7a0f17356ce18660ef2 (MD5) Previous issue date: 2005-12-01 Made available in DSpace on 2013-09-30T19:56:48Z (GMT). No. of bitstreams: 2 S0103-84782005000600019.pdf: 53049 bytes, checksum: cace24a9ef47e7a0f17356ce18660ef2 (MD5) S0103-84782005000600019.pdf.txt: 28008 bytes, checksum: f498f80b5c201817f8a5a7e821df584f (MD5) Previous issue date: 2005-12-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:14:46Z No. of bitstreams: 2 S0103-84782005000600019.pdf: 53049 bytes, checksum: cace24a9ef47e7a0f17356ce18660ef2 (MD5) S0103-84782005000600019.pdf.txt: 28008 bytes, checksum: f498f80b5c201817f8a5a7e821df584f (MD5) Made available in DSpace on 2014-05-20T15:14:46Z (GMT). No. of bitstreams: 2 S0103-84782005000600019.pdf: 53049 bytes, checksum: cace24a9ef47e7a0f17356ce18660ef2 (MD5) S0103-84782005000600019.pdf.txt: 28008 bytes, checksum: f498f80b5c201817f8a5a7e821df584f (MD5) Previous issue date: 2005-12-01 Avaliaram-se os efeitos da hipovolemia aguda em cães anestesiados pelo isofluorano sobre a eletrocardiografia com a duração e amplitude da onda P (Pms e PmV, respectivamente); intervalo entre as ondas P e R (P-R); duração do complexo QRS (QRS); amplitude da onda R (RmV); intervalo entre as ondas Q e T (Q-T) e intervalo entre as duas ondas (R-R), freqüência cardíaca (FC), índice cardíaco (IC), índice sistólico (IS) e pressões arteriais sistólica (PAS), diastólica (PAD) e média (PAM). Verificou-se também a possível influência do anestésico sobre a resposta compensatória à hipovolemia aguda. Para tal, foram utilizados 20 cães hígidos, sem raça definida, adultos, machos e fêmeas. Induziu-se a anestesia geral com isofluorano por meio de máscara naso-oral a 2,5 CAM e, após a intubação orotraqueal, o vaporizador foi ajustado em 1,5 CAM. Induziu-se a hipovolemia nos animais retirando-se volume total de 35 mlkg-1 de sangue. As mensurações foram realizadas antes da hipovolemia (M0), imediatamente após a retirada do volume total de sangue calculado (M1), e aos dez (M2), trinta (M3) e sessenta (M4) minutos. A avaliação estatística das variáveis foi efetuada por meio de Análise de Variância (ANOVA), seguida pelo teste de Tukey, considerando nível de significância de 5% (P

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:36Z No. of bitstreams: 1 S0103-84782005000300016.pdf: 101592 bytes, checksum: 0ce731105813ba8cc3ba86a662daa6ef (MD5) Made available in DSpace on 2013-08-22T18:59:36Z (GMT). No. of bitstreams: 1 S0103-84782005000300016.pdf: 101592 bytes, checksum: 0ce731105813ba8cc3ba86a662daa6ef (MD5) Previous issue date: 2005-06-01 Made available in DSpace on 2013-09-30T19:56:39Z (GMT). No. of bitstreams: 2 S0103-84782005000300016.pdf: 101592 bytes, checksum: 0ce731105813ba8cc3ba86a662daa6ef (MD5) S0103-84782005000300016.pdf.txt: 25796 bytes, checksum: 256ad3405af307ec081fb630df4cbe5a (MD5) Previous issue date: 2005-06-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:14:04Z No. of bitstreams: 2 S0103-84782005000300016.pdf: 101592 bytes, checksum: 0ce731105813ba8cc3ba86a662daa6ef (MD5) S0103-84782005000300016.pdf.txt: 25796 bytes, checksum: 256ad3405af307ec081fb630df4cbe5a (MD5) Made available in DSpace on 2014-05-20T13:14:04Z (GMT). No. of bitstreams: 2 S0103-84782005000300016.pdf: 101592 bytes, checksum: 0ce731105813ba8cc3ba86a662daa6ef (MD5) S0103-84782005000300016.pdf.txt: 25796 bytes, checksum: 256ad3405af307ec081fb630df4cbe5a (MD5) Previous issue date: 2005-06-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) O líquido cerebrospinal é útil no diagnóstico, acompanhamento e prognóstico de enfermidades neurológicas caninas. Dentre elas, a cinomose é considerada a encefalite mais comum nos cães e inúmeras alterações podem ocorrer neste fluido frente a esta enfermidade. Sendo assim, diante da possível verificação de anormalidades precoces relacionadas com esta virose, amostras liquóricas de cães portadores do vírus da cinomose, na fase neurológica e não neurológica foram avaliadas quanto à coloração, aspecto, pH, densidade, glicose, proteínas totais, celularidade e comparadas com amostras liquóricas de cães hígidos. Os parâmetros coloração, aspecto, pH, densidade e glicose mostraram-se semelhantes entre animais acometidos pela cinomose, independentemente da fase evolutiva da doença, e animais normais. A concentração liquórica de proteínas totais mostrou-se mais elevada nos animais portadores de sinais neurológicos, bem como a celularidade total, cuja pleocitose foi observada em 50% dos cães deste mesmo grupo, com predominância de mononucleares. The cerebrospinal fluid is useful to diagnosis, monitoring and prognosis canine neurological diseases. Among them distemper is considered the most common encephalitis in dogs and several alterations can be observed in this fluid with this disease. Since the early abnormalities related to this virus were possibly verified, CSF samples of dogs infected by distemper virus, with or without neurological signs were collected. The samples were evaluated according to colour, turbidity, pH, specific gravity, glucose, total proteins, and cytological examination, and then were compared to CSF samples of healthy dogs. The parameters related to colour, turbidity, pH, specific gravity, glucose showed to be similar between all animals studied in this attempt. The CSF total protein concentration revealed higher values in animals with neurological signs of distemper, as the celularity, whose pleocytosis with predominance of mononuclear cells was observed in 50% of dogs among this group. Universidade Estadual Paulista Departamento de Clínica e Cirurgia Centro Universitário Moura Lacerda Univeersidade Estadual de São Paulo Departamento de Clínica e Cirurgia Veterinária Universidade Estadual Paulista Departamento de Clínica e Cirurgia

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:00:24Z No. of bitstreams: 1 S0034-737X2012000400004.pdf: 458107 bytes, checksum: f14e6bdf77b0ef76583fa611bc94e885 (MD5) Made available in DSpace on 2013-08-22T19:00:24Z (GMT). No. of bitstreams: 1 S0034-737X2012000400004.pdf: 458107 bytes, checksum: f14e6bdf77b0ef76583fa611bc94e885 (MD5) Previous issue date: 2012-08-01 Made available in DSpace on 2013-09-30T19:58:53Z (GMT). No. of bitstreams: 2 S0034-737X2012000400004.pdf: 458107 bytes, checksum: f14e6bdf77b0ef76583fa611bc94e885 (MD5) S0034-737X2012000400004.pdf.txt: 24608 bytes, checksum: 7c06ab0b2b5180e43e9c8b0b17818c2a (MD5) Previous issue date: 2012-08-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:15:09Z No. of bitstreams: 2 S0034-737X2012000400004.pdf: 458107 bytes, checksum: f14e6bdf77b0ef76583fa611bc94e885 (MD5) S0034-737X2012000400004.pdf.txt: 24608 bytes, checksum: 7c06ab0b2b5180e43e9c8b0b17818c2a (MD5) Made available in DSpace on 2014-05-20T15:15:09Z (GMT). No. of bitstreams: 2 S0034-737X2012000400004.pdf: 458107 bytes, checksum: f14e6bdf77b0ef76583fa611bc94e885 (MD5) S0034-737X2012000400004.pdf.txt: 24608 bytes, checksum: 7c06ab0b2b5180e43e9c8b0b17818c2a (MD5) Previous issue date: 2012-08-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Após a remoção do volume ocular ou de seu conteúdo, o implante de esferas de diferentes tipos de materiais previne a concentração da cavidade orbital. O objetivo deste estudo foi avaliar a esfera de polimetilmetacrilato (PMMA), utilizado como implante intraocular em coelhos submetidos evisceração. Doze coelhos da raça Nova Zelândia foram submetidos evisceração unilateral do olho esquerdo, com posterior implantação da esfera de PMMA com 12 mm de diâmetro. A avaliação clínica foi realizada diariamente nos primeiros 15 dias após a cirurgia e em intervalos de 15 dias até o final do período de estudo (180 dias). Para análise histopatológica, três animais por período experimental foram submetidos enucleação aos 15, 45, 90 e 180 dias após a evisceração. Não foi observada deiscência da ferida, sinais de infecção ou extrusão do implante em nenhum dos animais durante todo o período do estudo. O exame histológico revelou a formação de tecido fibrovascular ao redor dos implantes. O PMMA comportou-se como material inerte e não- integrável. Spheres of different types of material are used for the replacement of lost volume after removal of the eye bulb or its content to prevent contraction of the orbital cavity. The aim of this study was to evaluate the scope of polymethylmethacrylate (PMMA) used as intraocular implant in eviscerated rabbit eye. Twelve New Zealand rabbits underwent unilateral evisceration of the left eye, with subsequent implantation of PMMA sphere 12 mm in diameter. Clinical evaluation was performed daily during the first 15 days after surgery and every 15 days until the end of the study period (180 days). For the histopathological analysis, three animals per trial underwent enucleation at 15, 45, 90 and 180 days after evisceration. There was no wound dehiscence, signs of infection or implant extrusion in any animal throughout the study period. Histological examination revealed the formation of fibrovascular tissue around the implants. The PMMA behaved as inert and non-integrable. Universidade Federal da Bahia (UFBA) Departamento de Patologia e Clínicas União Metropolitana de Educação e Cultura Universidade Federal do Rio Grande do Sul (UFRGS) Departamento de Materiais IPEV Universidade Federal de Goiás (UFG) Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Ciências Agrárias e Veterinárias

Objective To evaluate the influence of different inspired oxygen fractions (FiO 2 ) on pulmonary oxygen exchange and Tei‐index of myocardial performance in propofol‐anesthetized dogs. Study design Prospective crossover, randomized, experimental trial. Animals Eight adult dogs weighing 8.6 ± 1.8 kg. Methods The animals were anesthetized on five occasions, receiving either an FiO 2 = 1.0 (F100), 0.8 (F80), 0.6 (F60), 0.4 (F40) or 0.21 (F21). Propofol was used for induction (6.45 ± 0.69 mgkg −1 IV) followed by a continuous rate infusion (CRI, 0.7 mgkg −1 minute −1 ). The dogs breathed spontaneously. The initial measurements of arterial partial pressures of oxygen (PaO 2 ) and carbon dioxide (PaCO 2 ), arterial hemoglobin saturation (SaO 2 ), heart rate (HR), mean arterial pressure (MAP), cardiac index (CI), stroke index (SI), pre‐ejection period (PEP) and left ventricular ejection time (LVET) were performed 30 minutes after beginning the CRI (T0) and then, at 15‐minute intervals (T15–T60). From these measurements the following were calculated; alveolar oxygen partial pressure (PAO 2 ), alveolar‐arterial oxygen gradient (AaDO 2 ), arterial oxygen partial pressure/inspired oxygen fraction ratio (PaO 2 /FiO 2 ), arterial‐to‐alveolar oxygen tension ratio (PaO 2 /PAO 2 ), respiratory index (RI), oxygen delivery ( D ˙ O 2 ), PEP/LVET ratio, isovolumic relaxation time (IVRT) and Tei‐index. Results At T30, PaCO 2 in F100 was higher than in F21. The AaDO 2 mean in F100 was greater than in other treatments. PaO 2 /FiO 2 in F21 was lower than F100 and F80 at T0 and than in F80 and F60 at T15. At T15, PaO 2 /PAO 2 and RI in F100 were higher than in F80, F60 and F21. At T30, PaO 2 /PAO 2 in F21 was lower than in F100 and F60. At T30, PEP/LVET in F100 was higher than F80, F40 and F21, which was lower than F80 and F40. Conclusion The Tei‐index and cardiovascular parameters are not affected by different FiO 2 . Clinical Relevance An FiO 2 of 1.0 and 0.21 impaired respiratory efficiency.

Objective To evaluate the effects of butorphanol on cardiopulmonary parameters in dogs anesthetized with desflurane and breathing spontaneously. Study design Prospective, randomized experimental trial. Animals Twenty dogs weighing 12 ± 3 kg. Methods Animals were distributed into two groups: a control group (CG) and butorphanol group (BG). Propofol was used for induction and anesthesia was maintained with desflurane (10%). Forty minutes after induction, the dogs in the CG received sodium chloride 0.9% (0.05 mL kg −1 IM), and dogs in the BG received butorphanol (0.4 mg kg −1 IM). The first measurements of body temperature (BT), heart rate (HR), arterial pressures (AP), cardiac output (CO), cardiac index (CI), central venous pressure (CVP), stroke volume index (SVI), pulmonary arterial occlusion pressure (PAOP), mean pulmonary arterial pressure (mPAP), left ventricular stroke work (LVSW), systemic (SVR) and pulmonary (PVR) vascular resistances, respiratory rate (f R ), and arterial oxygen (PaO 2 ) and carbon dioxide (PaCO 2 ) partial pressures were taken immediately before the administration of butorphanol or sodium chloride solution (T0) and then at 15-minute intervals (T15–T75). Results In the BG, HR, AP, mPAP and SVR decreased significantly from T15 to T75 compared to baseline. f R was lower at T30 than at T0 in the BG. AP and f R were significantly lower than in the CG from T15 to T75. PVR was lower in the BG than in the CG at T30, while PaCO 2 was higher compared with T0 from T30 to T75 in the BG and significantly higher than in the CG at T30 to T75. Conclusions and clinical relevance At the studied dose, butorphanol caused hypotension and decreased ventilation during desflurane anesthesia in dogs. The hypotension (from 86 ± 10 to 64 ± 10 mmHg) is clinically relevant, despite the maintenance of cardiac index.

Objective To compare cardiac output (CO) measured by Doppler echocardiography and thermodilution techniques in spontaneously breathing dogs during continuous infusion of propofol. To do so, CO was obtained using the thermodilution method (CO TD ) and Doppler evaluation of pulmonary flow (CO DP ) and aortic flow (CO DA ). Study design Prospective cohort study. Animals Eight adult dogs weighing 8.3 ± 2.0 kg. Methods Propofol was used for induction (7.5 ± 1.9 mg kg −1 IV) followed by a continuous rate infusion at 0.7 mg kg −1 minute −1 . The animals were positioned in left lateral recumbency on an echocardiography table that allowed for positioning of the transducer at the 3rd and 5th intercostal spaces of the left hemithorax for Doppler evaluation of pulmonary and aortic valves, respectively. CO DP and CO DA were calculated from pulmonary and aortic velocity spectra, respectively. A pulmonary artery catheter was inserted via the jugular vein and positioned inside the lumen of the pulmonary artery in order to evaluate CO TD . The first measurement of CO TD , CO DP and CO DA was performed 30 minutes after beginning continuous infusion (T0) and then at 15‐minute intervals (T15, T30, T45 and T60). Numeric data were submitted to two‐way anova for repeated measurements, Pearson’s correlation coefficient and Bland & Altman analysis. Data are presented as mean ± SD. Results At T0, CO TD was lower than CO DA . CO DA was higher than CO TD and CO DP at T30, T45 and T60. The difference between the CO TD and CO DP , when all data were included, was −0.04 ± 0.22 L minute −1 and Pearson’s correlation coefficient ( r ) was 0.86. The difference between the CO TD and CO DA was −0.87 ± 0.54 L minute −1 and r = 0.69. For CO TD and CO DP , the difference was −0.82 ± 0.59 L minute −1 and r = 0.61. Conclusion Doppler evaluation of pulmonary flow was a clinically acceptable method for assessing the CO in propofol‐anesthetized dogs.

Objective The aim of the present study was to evaluate the effects of nitrous oxide on IOP and pupillary diameter (PD) of dogs anesthetized with varying desflurane concentrations. Animals studied Twenty adult Mongrel dogs were used. Methods They were anesthetized with propofol (10 mg/kg, IV) and maintained with varying concentrations of desflurane (1.6, 1.4, and 1.2 MAC) diluted in 100% oxygen (G1) or in 70% nitrous oxide and 30% oxygen (G2) (30 mL/kg/min). IOP was measured by applanation tonometry and horizontal PD was taken with a caliper adjacent to the cornea. Mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR), and end-tidal CO2 (etCO2) were also measured. All parameters were measured at T0, T30, T45, and T60 time points. One-way repeated measures anova and the t-test were used to assess statistical differences (P

Objective To establish the correlation between the bispectral index (BIS) and different rates of infusion of propofol in dogs. Study design Prospective experimental trial. Animals Eight adult dogs weighing 6–20 kg. Methods Eight animals underwent three treatments at intervals of 20 days. Propofol was used for induction of anesthesia (10 mg kg −1 IV), followed by a continuous rate infusion (CRI) at 0.2 mg kg −1 minute −1 (P2), 0.4 mg kg −1 minute −1 (P4) or 0.8 mg kg −1 minute −1 (P8) for 55 minutes. The BIS values were measured at 10, 20, 30, 40, and 50 minutes (T10, T20, T30, T40, and T50, respectively) after the CRI of propofol was started. Numeric data were submitted to analysis of variance followed by Tukey test ( p Results The BIS differed significantly among groups at T40, when P8 was lower than P2 and P4. At T50, P8 was lower than P2. The electromyographic activity (EMG) in P2 and P4 was higher than P8 at T40 and T50. Conclusions An increase in propofol infusion rates decreases the BIS values and EMG.

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:49Z No. of bitstreams: 1 S0103-84782007000200020.pdf: 60700 bytes, checksum: 536c2832e259f234f406fa9b4246c56d (MD5) Made available in DSpace on 2013-08-22T18:59:49Z (GMT). No. of bitstreams: 1 S0103-84782007000200020.pdf: 60700 bytes, checksum: 536c2832e259f234f406fa9b4246c56d (MD5) Previous issue date: 2007-04-01 Made available in DSpace on 2013-09-30T19:57:12Z (GMT). No. of bitstreams: 2 S0103-84782007000200020.pdf: 60700 bytes, checksum: 536c2832e259f234f406fa9b4246c56d (MD5) S0103-84782007000200020.pdf.txt: 34338 bytes, checksum: 3a859f493f519e940fc17e03b7c828ad (MD5) Previous issue date: 2007-04-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:14:00Z No. of bitstreams: 2 S0103-84782007000200020.pdf: 60700 bytes, checksum: 536c2832e259f234f406fa9b4246c56d (MD5) S0103-84782007000200020.pdf.txt: 34338 bytes, checksum: 3a859f493f519e940fc17e03b7c828ad (MD5) Made available in DSpace on 2014-05-20T13:14:00Z (GMT). No. of bitstreams: 2 S0103-84782007000200020.pdf: 60700 bytes, checksum: 536c2832e259f234f406fa9b4246c56d (MD5) S0103-84782007000200020.pdf.txt: 34338 bytes, checksum: 3a859f493f519e940fc17e03b7c828ad (MD5) Previous issue date: 2007-04-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Este experimento teve por objetivos avaliar as possíveis alterações cardiopulmonares e hemogasométricas decorrentes do uso do butorfanol em cães submetidos à anestesia pelo desfluorano sob ventilação espontânea. Para tal, foram utilizados vinte cães adultos, clinicamente saudáveis, pesando 12±3kg. Os animais foram distribuídos igualmente em dois grupos, GS e GB, e induzidos à anestesia com propofol (8,4±0,8mg kg-1, IV), intubados e submetidos à anestesia inalatória pelo desfluorano (10V%). Decorridos 40 minutos da indução, foi administrado aos animais do GS 0,05mL kg-1 de solução fisiológica a 0,9% (salina), enquanto que, no GB, foi aplicado butorfanol na dose de 0,4mg kg-1, ambos pela via intramuscular. As observações das variáveis freqüências cardíaca (FC) e respiratória (f), pressões arteriais sistólica (PAS), diastólica (PAD) e média (PAM), pH arterial (pH), pressão parcial de oxigênio no sangue arterial (PaO2), pressão parcial de dióxido de carbono no sangue arterial (PaCO2), déficit de base (DB), bicarbonato (HCO3) e saturação de oxigênio na hemoglobina (SatO2) tiveram início imediatamente antes da aplicação do opióide ou salina (M0). Novas mensurações foram realizadas 15 minutos após a administração do butorfanol ou salina (M15) e as demais colheitas foram realizadas a intervalos de 15 minutos, por um período de 60 minutos (M30, M45, M60 e M75). Os dados numéricos dessas variáveis foram submetidos à Análise de Perfil (P

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:45Z No. of bitstreams: 1 S0103-84782006000500013.pdf: 59798 bytes, checksum: 4dca94318759efdbe7b5ff68bc28c658 (MD5) Made available in DSpace on 2013-08-22T18:59:45Z (GMT). No. of bitstreams: 1 S0103-84782006000500013.pdf: 59798 bytes, checksum: 4dca94318759efdbe7b5ff68bc28c658 (MD5) Previous issue date: 2006-10-01 Made available in DSpace on 2013-09-30T19:57:01Z (GMT). No. of bitstreams: 2 S0103-84782006000500013.pdf: 59798 bytes, checksum: 4dca94318759efdbe7b5ff68bc28c658 (MD5) S0103-84782006000500013.pdf.txt: 34240 bytes, checksum: b1e1faabc855dd32fbd74e8ade2cf033 (MD5) Previous issue date: 2006-10-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:14:49Z No. of bitstreams: 2 S0103-84782006000500013.pdf: 59798 bytes, checksum: 4dca94318759efdbe7b5ff68bc28c658 (MD5) S0103-84782006000500013.pdf.txt: 34240 bytes, checksum: b1e1faabc855dd32fbd74e8ade2cf033 (MD5) Made available in DSpace on 2014-05-20T15:14:49Z (GMT). No. of bitstreams: 2 S0103-84782006000500013.pdf: 59798 bytes, checksum: 4dca94318759efdbe7b5ff68bc28c658 (MD5) S0103-84782006000500013.pdf.txt: 34240 bytes, checksum: b1e1faabc855dd32fbd74e8ade2cf033 (MD5) Previous issue date: 2006-10-01 Objetivou-se com este experimento avaliar os efeitos do butorfanol precedido ou não pela levomepromazina sobre a freqüência cardíaca (FC), as pressões arteriais sistólica, diastólica e média (PAS, PAD e PAM, respectivamente), a freqüência respiratória (f), a concentração de dióxido de carbono ao final da expiração (ETCO2), a saturação da oxihemoglobina (SpO2), o volume corrente (VC) e o volume minuto (VM), em cães. Para tal, foram empregados vinte animais adultos, clinicamente saudáveis, distribuídos igualmente em dois grupos (GC e GL). Ao GC administrou-se solução salina a 0,9% (Controle), no volume de 0,2mL kg-1, pela via intravenosa (IV). Decorridos 15 minutos, administrou-se butorfanol na dose de 0,3mg kg-1 pela mesma via. Aos animais do GL foi adotada a mesma metodologia, porém substituindo-se a solução salina pela levomepromazina na dose de 1mg kg-1. As medidas das variáveis cardiorrespiratórias iniciaram-se imediatamente antes da aplicação dos fármacos (M1). Novas mensurações foram realizadas 15 minutos após a administração da solução salina a 0,9% ou levomepromazina (M2) e 10 minutos após a administração de butorfanol (M3). As demais colheitas foram realizadas a intervalos de 10 minutos, durante 30 minutos (M4, M5 e M6, respectivamente). Os dados numéricos colhidos foram submetidos à Análise de Variância (ANOVA), seguida pelo teste de Tukey (p

PURPOSE To evaluate the macroscopy, microstructure, and tissue reaction of a double-setting alpha-tricalcium phosphate bone cement used as an intraocular implant in rabbits. METHODS The internal and external surface of the double-setting alpha-tricalcium phosphate implant was analyzed macroscopically and by scanning electron microscopy. Twelve New Zealand rabbits received 12-mm implants made of double-setting alpha-tricalcium phosphate cement after unilateral evisceration. Clinical evaluation was performed daily for the first 15 days after surgery and at 15-day intervals until the end of the study period. For histopathologic analysis, 3 animals per experimental period were submitted to enucleation at 15, 45, 90, and 180 days. RESULTS On gross inspection, the external surface of the implant was solid, smooth, and compact. The microarchitecture was characterized by the formation of columns of hexagonal crystals with interconnecting channels forming micropores. No wound dehiscence, signs of infection, or implant extrusion were observed in any animal throughout the study period. Histologic examination revealed the formation of fibrovascular tissue surrounding the implants, and there were signs of minimal integration of the surface limiting the fibrocellular cap with the space previously occupied by the implant. CONCLUSIONS The double-setting alpha-tricalcium phosphate implant behaved as an inert and non-integratable material. The lack of incorporation of this material by fibrovascular tissue is related to its characteristics of compactness and high resistance.

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:40Z No. of bitstreams: 1 S0103-84782005000600017.pdf: 46213 bytes, checksum: fbd6fae37139393662fb969117564ae7 (MD5) Made available in DSpace on 2013-08-22T18:59:40Z (GMT). No. of bitstreams: 1 S0103-84782005000600017.pdf: 46213 bytes, checksum: fbd6fae37139393662fb969117564ae7 (MD5) Previous issue date: 2005-12-01 Made available in DSpace on 2013-09-30T19:56:48Z (GMT). No. of bitstreams: 2 S0103-84782005000600017.pdf: 46213 bytes, checksum: fbd6fae37139393662fb969117564ae7 (MD5) S0103-84782005000600017.pdf.txt: 28924 bytes, checksum: 98c33bb0dbfecb3ee28e5f53e97850fd (MD5) Previous issue date: 2005-12-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:14:00Z No. of bitstreams: 2 S0103-84782005000600017.pdf: 46213 bytes, checksum: fbd6fae37139393662fb969117564ae7 (MD5) S0103-84782005000600017.pdf.txt: 28924 bytes, checksum: 98c33bb0dbfecb3ee28e5f53e97850fd (MD5) Made available in DSpace on 2014-05-20T13:14:00Z (GMT). No. of bitstreams: 2 S0103-84782005000600017.pdf: 46213 bytes, checksum: fbd6fae37139393662fb969117564ae7 (MD5) S0103-84782005000600017.pdf.txt: 28924 bytes, checksum: 98c33bb0dbfecb3ee28e5f53e97850fd (MD5) Previous issue date: 2005-12-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Objetivou-se, com este estudo, avaliar os efeitos da buprenorfina sobre variáveis cardiovasculares e respiratórias em cães durante anestesia com desfluorano. Para tanto, foram utilizados 20 cães adultos, distribuídos em dois grupos (GB e GC). A anestesia foi induzida com propofol (8mg kg-1 IV) e em seguida os animais foram intubados com sonda de Magill, a qual foi conectada ao aparelho de anestesia para administração de desfluorano (1,5 CAM). Após 30 minutos, foi aplicado no GB buprenorfina (0,02mg kg-1) e no GC solução de NaCl à 0,9% (0,05ml kg-1). Avaliaram-se: freqüências cardíaca e respiratória (FC e ¦); pressões arteriais sistólica, diastólica e média (PAS, PAD e PAM); débito cardíaco (DC); pressão venosa central (PVC); e as variáveis hemogasométricas pH, PaCO2, PaO2, HCO3, SatO2 e DB. As colheitas dos dados foram feitas aos 30 minutos após o início da administração do desfluorano (MO), 15 minutos após a administração do opióide ou placebo (M15), e a cada 15 minutos após Ml5 (M30, M45, M60 e M75). A avaliação estatística dos dados foi efetuada por meio de Análise de Perfil (P

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:28Z No. of bitstreams: 1 S0103-84782004000400022.pdf: 50705 bytes, checksum: 2ec72c03aabded2f079295c772475269 (MD5) Made available in DSpace on 2013-08-22T18:59:28Z (GMT). No. of bitstreams: 1 S0103-84782004000400022.pdf: 50705 bytes, checksum: 2ec72c03aabded2f079295c772475269 (MD5) Previous issue date: 2004-08-01 Made available in DSpace on 2013-09-30T19:56:26Z (GMT). No. of bitstreams: 2 S0103-84782004000400022.pdf: 50705 bytes, checksum: 2ec72c03aabded2f079295c772475269 (MD5) S0103-84782004000400022.pdf.txt: 30289 bytes, checksum: 4b1cacd62cc615637a5f2f0d5027c1e0 (MD5) Previous issue date: 2004-08-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:14:40Z No. of bitstreams: 2 S0103-84782004000400022.pdf: 50705 bytes, checksum: 2ec72c03aabded2f079295c772475269 (MD5) S0103-84782004000400022.pdf.txt: 30289 bytes, checksum: 4b1cacd62cc615637a5f2f0d5027c1e0 (MD5) Made available in DSpace on 2014-05-20T15:14:40Z (GMT). No. of bitstreams: 2 S0103-84782004000400022.pdf: 50705 bytes, checksum: 2ec72c03aabded2f079295c772475269 (MD5) S0103-84782004000400022.pdf.txt: 30289 bytes, checksum: 4b1cacd62cc615637a5f2f0d5027c1e0 (MD5) Previous issue date: 2004-08-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Objetivou-se com este experimento avaliar as possíveis alterações eletrocardiográficas decorrentes do uso do butorfanol em cães, durante anestesia geral inalatória com desfluorano. Para tal, foram utilizados vinte cães adultos, clinicamente saudáveis, distribuídos em dois grupos (n=10) denominados de GS e GB. Os animais foram induzidos à anestesia com propofol (8,4 ± 0,8mg kg-1, IV) intubados com sonda orotraqueal de Magill e submetidos à anestesia inalatória pelo desfluorano (10V%). Decorridos 40 minutos da indução, foi administrado aos animais do GS, por via intramuscular, 0,05mL kg-1 de solução fisiológica a 0,9% (salina), enquanto que no GB, foi aplicado butorfanol na dose de 0,4mg kg-1 pela mesma via e em volume equivalente ao empregado no grupo anterior. As observações das variáveis freqüência cardíaca (FC), duração e amplitude da onda P (Ps e PmV), intervalo entre as ondas P e R (PR), duração do complexo QRS (QRSs), amplitude da onda R (RmV), duração do intervalo entre as ondas Q e T (QT) e intervalo entre duas ondas R (RR) tiveram início imediatamente antes da aplicação do opióide ou salina (M0). Novas mensurações foram realizadas 15 minutos após a administração do butorfanol ou salina (M15) e as demais colheitas foram realizadas à intervalos de 15 minutos, por um período de 60 minutos (M30, M45, M60 e M75). Os dados numéricos destas variáveis foram submetidos à Análise de Perfil (p

The cardiopulmonary effects of desflurane and sevoflurane anesthesia were compared in cats breathing spontaneously. Heart (HR) and respiratory (RR) rates; systolic (SAP), diastolic (DAP) and mean arterial (MAP) pressures; partial pressure of end tidal carbon dioxide (PETCO2), arterial blood pH (pH), arterial partial pressure of oxygen (PaO2) and carbon dioxide (PaCO2); base deficit (BD), arterial oxygen saturation (SaO2) and bicarbonate ion concentration (HCO3) were measured. Anesthesia was induced with propofol (8±2.3 mg/kg IV) and maintained with desflurane (GD) or sevoflurane (GS), both at 1.3 MAC. Data were analyzed by analysis of variance (ANOVA), followed by the Tukey test ( P2 increased with time. Both anesthetics caused acidemia and hypercapnia, but BD stayed within normal limits. Therefore, despite reducing HR and SAP (GD) when compared to the basal values, desflurane and sevoflurane provide good stability of the cardiovascular parameters during a short period of inhalant anesthesia (T20–T60). However, both volatile anesthetics cause acute respiratory acidosis in cats breathing spontaneously.

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:26Z No. of bitstreams: 1 S0103-84782004000300024.pdf: 37242 bytes, checksum: fc31c20bca3efd2b1382f28975f63a8f (MD5) Made available in DSpace on 2013-08-22T18:59:26Z (GMT). No. of bitstreams: 1 S0103-84782004000300024.pdf: 37242 bytes, checksum: fc31c20bca3efd2b1382f28975f63a8f (MD5) Previous issue date: 2004-06-01 Made available in DSpace on 2013-09-30T19:56:22Z (GMT). No. of bitstreams: 2 S0103-84782004000300024.pdf: 37242 bytes, checksum: fc31c20bca3efd2b1382f28975f63a8f (MD5) S0103-84782004000300024.pdf.txt: 26205 bytes, checksum: 05c53b4e319c63ca1372ce88649dca7b (MD5) Previous issue date: 2004-06-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:14:39Z No. of bitstreams: 2 S0103-84782004000300024.pdf: 37242 bytes, checksum: fc31c20bca3efd2b1382f28975f63a8f (MD5) S0103-84782004000300024.pdf.txt: 26205 bytes, checksum: 05c53b4e319c63ca1372ce88649dca7b (MD5) Made available in DSpace on 2014-05-20T15:14:39Z (GMT). No. of bitstreams: 2 S0103-84782004000300024.pdf: 37242 bytes, checksum: fc31c20bca3efd2b1382f28975f63a8f (MD5) S0103-84782004000300024.pdf.txt: 26205 bytes, checksum: 05c53b4e319c63ca1372ce88649dca7b (MD5) Previous issue date: 2004-06-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Objetivou-se avaliar comparativamente os efeitos da buprenorfina, administrada pelas vias intramuscular(IM) ou intravenosa (IV), sobre variáveis cardiovasculares, em cães anestesiados com desfluorano. Para tanto, foram utilizados dezesseis cães adultos, clinicamente saudáveis, distribuídos em dois grupos (n=8) denominados de GI e GII. em ambos os grupos, a anestesia foi induzida com propofol (8 mg/kg, IV) e em seguida os animais foram intubados com sonda orotraqueal de Magill, a qual foi conectada ao aparelho de anestesia volátil para administração de desfluorano (1,5 CAM). Após 30 minutos do início da anestesia inalatória, foi aplicado no GI buprenorfina na dose de 0,02 mg/kg pela via IV, enquanto no GII administrou-se o opióide na mesma dose porém pela via IM. Avaliaram-se: freqüência cardíaca (FC); pressões arteriais sistólica, diastólica e média (PAS, PAD e PAM); débito cardíaco (DC); pressão venosa central (PVC) e pressão da artéria pulmonar (PAP). As colheitas foram feitas nos seguintes momentos: M1 - 30 minutos após o início da anestesia inalatória antes da aplicação do opióide; M2 - 15 minutos após a administração da buprenorfina; M3, M4 e M5 - de 15 em 15 minutos após M2. A avaliação estatística dos dados foi efetuada por meio de Análise de Perfil (p

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:26Z No. of bitstreams: 1 S0103-84782004000300025.pdf: 37316 bytes, checksum: a87fa5050f88e1aab81cf309970bbc49 (MD5) Made available in DSpace on 2013-08-22T18:59:26Z (GMT). No. of bitstreams: 1 S0103-84782004000300025.pdf: 37316 bytes, checksum: a87fa5050f88e1aab81cf309970bbc49 (MD5) Previous issue date: 2004-06-01 Made available in DSpace on 2013-09-30T19:56:22Z (GMT). No. of bitstreams: 2 S0103-84782004000300025.pdf: 37316 bytes, checksum: a87fa5050f88e1aab81cf309970bbc49 (MD5) S0103-84782004000300025.pdf.txt: 28082 bytes, checksum: c1779701dad74101a6c64afd0e3ac455 (MD5) Previous issue date: 2004-06-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:14:39Z No. of bitstreams: 2 S0103-84782004000300025.pdf: 37316 bytes, checksum: a87fa5050f88e1aab81cf309970bbc49 (MD5) S0103-84782004000300025.pdf.txt: 28082 bytes, checksum: c1779701dad74101a6c64afd0e3ac455 (MD5) Made available in DSpace on 2014-05-20T15:14:39Z (GMT). No. of bitstreams: 2 S0103-84782004000300025.pdf: 37316 bytes, checksum: a87fa5050f88e1aab81cf309970bbc49 (MD5) S0103-84782004000300025.pdf.txt: 28082 bytes, checksum: c1779701dad74101a6c64afd0e3ac455 (MD5) Previous issue date: 2004-06-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Objetivou-se com a realização deste experimento, estudar possíveis alterações nas variáveis cardiovasculares e intracranianas promovidas pela buprenorfina, em cães anestesiados com desflurano. Para tanto, foram utilizados oito cães adultos, clinicamente saudáveis. A anestesia foi induzida com propofol (8 mg/kg IV) e em seguida os animais foram intubados com sonda orotraqueal de Magill, a qual foi conectada ao aparelho de anestesia volátil para administração de desflurano (1,5 CAM). Os animais foram mantidos sob ventilação controlada durante todo o período experimental. Após 20 minutos do posicionamento do cateter de pressão intracraniana (PIC), administrou-se buprenorfina (0,02 mg/kg IV). Foram avaliados: PIC; pressão de perfusão cerebral (PPC); FC; PAS, PAM e PAD; débito cardíaco (DC); pressão venosa central (PVC); e pressão da artéria pulmonar (PAP). As colheitas foram feitas nos seguintes momentos: M1 - 20 minutos após o posicionamento do cateter de PIC; M2 - 15 minutos após a administração do opióide; M3, M4 e M5 - de 15 em 15 minutos após M2. A avaliação estatística dos dados foi efetuada por meio de ANOVA seguida do Teste de Tukey (p