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Your search keyword '"Chiara Scorziello"' showing total 3 results
Start Over Author "Chiara Scorziello" Topic medicine
3 results on '"Chiara Scorziello"'

1. Laterocervical lymph node metastases from suspected thyroidal primary site that turned out to be metastases of lung cancer: A case report

Author

Chiara Scorziello, Maria Carola Borcea, Marco Biffoni, Angelina Pernazza, Francesca Arienzo, Rossella Melcarne, Luca Ventrone, Angelo Laca, Giorgio Grani, Cosimo Durante, Fabrizio Consorti, and Laura Giacomelli

Subjects
case report, lung adenocarcinoma, lung cancer, non‐thyroidal cervical lymph node metastases, thyroid cancer, Medicine, Medicine (General), R5-920
Abstract

Key Clinical Message Incidental sonographic discovery of thyroid nodules is an increasingly common event in clinical practice. Less frequently, patients with cytological benign thyroid nodules have suspicious cervical lymph nodes detected by ultrasound examination or by cytological exam. Here, we discuss an intriguing case of cervical lymph node metastasis with a probable thyroid origin in a 65‐year‐old asymptomatic male smoker. He underwent thyroidectomy and unilateral cervical lymphadenectomy. Despite a negative chest X‐ray, the postoperative histological examination revealed that the lymph node metastasis was actually from a lung carcinoma. Metastatic lesions in cervical lymph nodes from non‐thyroidal origins must be excluded when evaluating lesions in the region, especially when thyroid nodules subjected to fine needle aspiration biopsy yield negative results, or lymph node cytological evaluations are inconsistent with thyroid cytological findings and sonographic features. Thyroid and lung adenocarcinomas share some epithelial and mesenchymal markers. Thyroglobulin helps differentiate primary thyroid tumors from lung ones, but in cases of poor differentiation, distinguishing metastatic lesions in the thyroid gland can be challenging. Lung cancer (LC) is the leading cause of cancer mortality worldwide, and survival rates have only marginally improved over the last several decades. The ongoing clinical challenge is detecting LC at earlier stages of the disease.

Published
2023
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2. Preoperative Ultrasonography in the Evaluation of Suspected Familial Non-Medullary Thyroid Cancer: Are We Able to Predict Multifocality and Extrathyroidal Extension?

Author

Giorgio Grani, Piernatale Lucia, Cira Di Gioia, Giovanni Conzo, Maria Carola Borcea, Alessio Metere, Cosimo Durante, Gianluca Cera, Valeria Del Gatto, Marco Biffoni, Rosa Menditto, Laura Giacomelli, Rossella Melcarne, Marianna Maranghi, Chiara Scorziello, Marco Summa, and Vito Cantisani

Subjects
Thyroid nodules, medicine.medical_specialty, endocrine system, endocrine system diseases, multifocality, thyroid cancer, thyroid nodules, TIRADS, Article, medicine, Family history, Thyroid cancer, business.industry, Thyroid, Medullary thyroid cancer, Cancer, Retrospective cohort study, General Medicine, medicine.disease, medicine.anatomical_structure, Medicine, Histopathology, Radiology, business
Abstract

Family history of thyroid cancer increases the risk of harboring thyroid malignancies that end up having extrathyroidal extension (ETE) and multifocality on histology, some authors suggest a more aggressive surgical approach. Their pre-operative identification could allow more conservative surgical procedures if none of these features are suspected. Our aim was to assess if neck ultrasonography could identify or exclude multifocality or ETE in these patients to tailor the extent of surgery. This retrospective study included patients with previous thyroid surgery, ≥1 first-grade relative with thyroid cancer, and who had undergone pre-surgical ultrasound. ETE was suspected in the case of thyroid border interruption or gross invasion of perithyroidal tissues. Multiple suspicious nodules were defined as suspicion of multifocal cancer. The cohort consisted of 45 patients (median age 49 years, 40 with thyroid cancer, 30 females). The positive predictive value of ultrasonography in predicting multifocality and ETE was 57.14% (25.25–84.03) and 41.67% (21.5–65.1%), respectively, while the negative predictive values were 63.2% (56.4–69.4%) and 72.7% (63.3–80.5%). Pre-operative ultrasound examination is unable to reliably identify or exclude multifocal disease or extrathyroidal extension. In patients scheduled for surgery and with a first-degree relative affected by DTC, a “negative” pre-operative US report does not exclude the potential finding of multifocality and ETE at final histopathology.

Published
2021

3. Poorly differentiated thyroid carcinoma: single centre experience and review of the literature

Author

Rossella Melcarne, Laura Giacomelli, Maria Irene Bellini, Maria Carola Borcea, Tiziana Garritano, Chiara Scorziello, Vito D'Andrea, Luca Ventrone, Rosa Menditto, Marco Biffoni, Maria Ludovica Costanzo, Alessio Metere, Renato Patrone, and Marco Summa

Subjects
Total thyroidectomy, Pathology, medicine.medical_specialty, business.industry, General Medicine, Review, poorly differentiated thyroid cancer, total thyroidectomy, fine-needle aspiration cytology, medicine.disease, Thyroid carcinoma, Single centre, Poorly Differentiated Thyroid Carcinoma, Fine needle aspiration cytology, Epidemiology, Medicine, Limited evidence, business
Abstract

There is controversy in the literature regarding a distinct subset of thyroid carcinoma whose histologically classification falls between well-differentiated and anaplastic carcinomas, previously identified as ‘poorly differentiated thyroid carcinoma’ (PDTC), or ‘insular carcinoma’, in view of the peculiar morphological characteristics of the cell groupings. The correct diagnosis and treatment of this entity have important prognostic and therapeutic significance. In this review, we describe the epidemiology, diagnosis, and management of PDTC and report our single centre experience to add to the limited evidence existing in the literature.

Published
2021

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