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Introduction: A solitary Peutz-Jeghers type hamartomatous polyp in the duodenum is rare. As compared with Peutz-Jeghers syndrome, Peutz-Jeghers type hamartomatous polyps are regarded as a different disorder. case report: We are reporting a case of a solitary hamartomatous polyp in the duodenum. A 24-year-old female was referred to our hospital with a diagnosis of duodenojejunal intussusception. We identified a polyp in the distal part of the duodenum. the patient underwent an endoscopic polypectomy. the polyp was confirmed to be a Peutz-Jeghers type of hamartomatous polyp. the patient underwent colonoscopy and small intestines follow-up with no evidence other polyps. conclusion: Previous reports have shown that solitary Peutz-Jeghers type hamartomatous polyps have malignant components in some cases. Patients with a duodenal solitary hamartomatous polyp should undergo treatment with complete removal of polyp and they need periodical follow- up examinations.