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Your search keyword '"Francesca Chiavarino"' showing total 2 results
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2 results on '"Francesca Chiavarino"'

1. Psychopathological and Organic Features of Atypical Anorexia Nervosa in Developmental Age: A Systematic Review

Author

Jacopo Pruccoli, Francesca Chiavarino, Beatrice Valeriani, Maria Letizia Petio, and Antonia Parmeggiani

Subjects
atypical anorexia nervosa, developmental age, BMI, feeding and eating disorders, weight loss, neurobiology, Medicine, Pediatrics, RJ1-570
Abstract

Purpose: This study aimed to comprehensively report the epidemiological and clinical features of atypical anorexia nervosa (AAN) in children and adolescents. Methods: In May 2024, a systematic review was performed using Medline, Cochrane Library, ClinicalTrials.gov, and relevant websites. Following PRISMA guidelines, 234 articles were screened for studies on DSM-5-defined AAN. A standardized checklist—the JBI critical appraisal tool—was adopted in assessing methodology, and 13 retained studies passed the screening and critical appraisal process for the final review. The Newcastle–Ottawa Scale was utilized to assess the risk of bias in cohort and case–control studies, ensuring a comprehensive evaluation of methodological quality. Results: AAN prevalence in young age groups is 2.8%, with a cumulative 2.8% incidence over 8 years. Incidence is 366 per 100,000 person-years, and the average episode duration is 11.6 months, with a 71% remission rate. Diagnostic persistence for AAN is less stable than other restrictive feeding and eating disorders (FEDs). AAN individuals exhibit higher EDE-Q scores, more severe distress, and distinct BMI differences compared to those with anorexia nervosa and controls. The diagnostic transition from the DSM-IV to the DSM-5 shows that AAN patients are predominantly female, slightly older, and with higher weight. Conclusions: This study yields concrete insights into the features of AAN in the developmental age, highlighting demographic variations, clinical presentations, and treatment outcomes. Recognizing the unique challenges faced by AAN individuals is vital for tailoring effective interventions and improving overall care within the FED spectrum.

Published
2024
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2. Prognostic factors in epileptic encephalopathies at onset in the first 2 years of life: The experience of a tertiary healthcare center in Italy

Author

Angelo Russo, Antonella Boni, Francesca Chiavarino, Elisa Fiumana, Giuditta Pellino, and Raffaella Faggioli

Subjects
Male, Pediatrics, medicine.medical_specialty, Drug Resistant Epilepsy, Palliative care, Autism Spectrum Disorder, Developmental Disabilities, early onset, Socio-culturale, Drug resistance, Cohort Studies, 03 medical and health sciences, Behavioral Neuroscience, Epilepsy, 0302 clinical medicine, Risk Factors, epileptic encephalopathies, Medicine, Humans, 030212 general & internal medicine, Retrospective Studies, Psychomotor learning, Neurologic Examination, business.industry, Retrospective cohort study, medicine.disease, epileptic encephalopathies , early onset, prognosis, Neurology, Italy, Autism spectrum disorder, Child, Preschool, Etiology, Anticonvulsants, Female, Neurology (clinical), prognosis, business, Neurocognitive, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

The aim of this retrospective cohort study was to identify some prognostic factors in anamnestic/clinical/instrumental data at the onset of epileptic encephalopathy (EE), for multiple outcome measures.We recruited patients diagnosed as affected by EE at Sant'Anna University Hospital, with onset in the first 24 months of life, with follow-up lasting longer than 3 years.At the end of the follow-up, 6 patients (14%) died within 2 years of age; 20 patient (49%) had a drug-resistant epilepsy (DRE); 9 patients (22%) had a language development delay (LDD); 12 patients (30%) had an autism spectrum disorder (ASD); 20 patients (49%) had a global psychomotor impairment (GPI); 9 patients (22%) needed palliative care; and nobody had a normal psychomotor development. Preexisting developmental delay predicts death (p = 0.009), and in survivors, it is associated with a GPI (p 0.001); patients with normal neurological examination at the onset of EE only develop a LDD (p = 0.020). Neuroimaging structural alterations are associated with DRE (p = 0.012) and with a GPI (p = 0.013). The history of perinatal risk factors predicts the worst prognosis (death: p = 0.035, GPI: p = 0.015, and access to palliative care: p = 0.007). The absence of early response to treatment is correlated to a poor long-term prognosis (GPI, p = 0.019; DRE, p = 0.001). The multivariate analysis confirms that a normal development at onset predicts the most favorable prognosis, both in terms of survival and cognitive outcome (OR [odds ratio] = 0.1). An early response to treatment is a protective factor for DRE (OR = 0.1). A perinatal pathology is confirmed as an independent prognostic factor of severe comorbidities (access to palliative care: OR = 10.4).This study was conducted to recognize possible prognostic factors among onset data of patients with EE, considering multiple outcome measures. This study design represents an innovative element compared to available papers, which were centered on isolated endpoints of prognosis, such as the prediction of neurocognitive development impairment or drug resistance. The data obtained from the study confirm that EEs prognosis is generally, but not universally, poor. Structural etiology and/or lack of response to antiepileptic drug (AED) within three months are main risk factors for DRE. Normal development at the onset of EEs and early response to treatment are the main positive prognostic factors.

Published
2019

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