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2 results on '"Getulio Capello Tominc"'

1. Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions

Author

Mariana Dalmagro, Mariana Moraes Pinc, Guilherme Donadel, Getulio Capello Tominc, Ezilda Jacomassi, Emerson Luiz Botelho Lourenço, Arquimedes Gasparotto Junior, André Giarola Boscarato, Salviano Tramontin Belettini, Odair Alberton, Inara Staub Prochnau, Reinaldo Aparecido Bariccatti, Rafael Menck de Almeida, Kelen Menezes Flores Rossi de Aguiar, and Jaqueline Hoscheid

Subjects
polyvinyl alcohol, chaguinha, checkerboard, pitanga, polyvinylpyrrolidone, Medicine, Pharmacy and materia medica, RS1-441
Abstract

Natural products can be used as complements or as alternatives to synthetic drugs. Eugenia uniflora and Tropaeolum majus are natives of Brazil and have antimicrobial, anti-inflammatory, and antioxidant activities. This study aimed to develop a film-forming system (FFS) loaded with plant extracts with the potential for treating microbial infections. E. uniflora and T. majus leaf extracts were prepared and characterized, and the individual and combined antioxidant and antimicrobial activities were evaluated. The FFS was developed with different concentrations of polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) and analyzed for physicochemical characteristics. The combination of extracts showed a superior antioxidant effect compared to the individual extracts, justifying the use of the blend. FFS prepared with 4.5% PVA, 4.5% PVP, 7.81% E. uniflora extract, and 3.90% T. majus extract was adhesive, lacked scale formation, presented good malleability, and had a suitable pH for topical application. In addition, the viscosity at rest was satisfactory for maintaining stability; water solubility was adequate; skin permeation was low; and the antimicrobial effect was superior to that of the individual extracts. Therefore, the developed FFS is promising for the differentiated treatment of skin lesions through topical application.

Published
2023
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2. Sericin Biofilm Endowed with Silver Sulfadiazine for Treatment of Burns

Author

Jaqueline Hoscheid, Marcelino Luiz Gimenes, Ana Paula Sone, Getulio Capello Tominc, Eduardo Borges Lied, Mariana Dalmagro, Tatiana Shioji Tiuman, and Camilo Freddy Mendoza Morejon

Subjects
Active ingredient, Moisture, Chemistry, Biofilm, Pharmaceutical Science, Context (language use), Absorption (skin), Silver sulfadiazine, Sericin, Dressing change, Drug Discovery, medicine, Food science, medicine.drug
Abstract

Ointments and creams used in burn treatments have limitations that compromise their effectiveness since they dry on the skin, their removal/replacement is traumatic and the half-life of the active ingredient is short requiring more applications during treatment. In this context, the objective was to develop a biofilm with potential biotherapeutics for differential treatment of burns. The methodology involved prospecting, method development, and synthesis of biofilm with biotherapeutic potential, its characterization and also assessment of its pharmacological and microbiological properties. The resulting biofilm with potential biotherapeutic showed a water solubility of 37.82%, moisture vapour permeability of 1.887 g (10 cm2 24 h)−1, water vapour permeability of 0.743 g (10 cm2 24 h)−1, silver amount of 9608.377 mg L−1, low silver release rate and microbiological inhibition capacity. This new biofilm with potential biotherapeutic shows better absorption/release of the active ingredient, longer half-life, increased inhibition of microorganism proliferation, greater moisture-holding capacity and better hydration of the skin. These features facilitate dressing change without traumatizing the injured tissue. In short, the new biofilm should provide efficient and less traumatic treatment of burns.

Published
2021
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