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Your search keyword '"I. M., Heid"' showing total 3 results
Start Over Author "I. M., Heid" Topic medicine
3 results on '"I. M., Heid"'

1. The ATGL gene is associated with free fatty acids, triglycerides and type 2 diabetes

Author

Robert Zimmermann, I. M. Heid, Florian Kronenberg, Thomas Illig, Ted D. Adams, A. Lingenhel, Rudolf Zechner, Veit Schoenborn, Steven C. Hunt, Caren Vollmert, and Paul N. Hopkins

Subjects
medicine.medical_specialty, Nutrition and Dietetics, Endocrinology, Biochemistry, Chemistry, Internal medicine, medicine, Medicine (miscellaneous), Type 2 diabetes, medicine.disease, Gene
Published
2006
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2. A common genetic variant is associated with adult and childhood obesity

Author

Kerstin Koberwitz, Joel N. Hirschhorn, Johannes Hebebrand, Marc E. Lenburg, Michael F. Christman, Frank B. Hu, David J. Hunter, Anke Hinney, Nan M. Laird, Helen N. Lyon, Arne Pfeufer, Thomas Illig, Norman P. Gerry, Thomas Meitinger, Richard S. Cooper, Xiaofeng Zhu, Matthew B. McQueen, Graham A. Colditz, Christoph Lange, Alan Herbert, I. M. Heid, Kristin G. Ardlie, and H.-Erich Wichmann

Subjects
Adult, Male, Genotype, Medizin, Genes, Recessive, Type 2 diabetes, Polymorphism, Single Nucleotide, Childhood obesity, Genetic determinism, Linkage Disequilibrium, White People, Body Mass Index, Cohort Studies, Framingham Heart Study, Gene Frequency, medicine, Humans, Genetic Predisposition to Disease, Obesity, Risk factor, Child, Alleles, Oligonucleotide Array Sequence Analysis, Genetics, Multidisciplinary, Models, Genetic, business.industry, INSIG2, Intracellular Signaling Peptides and Proteins, Genetic Variation, Membrane Proteins, medicine.disease, Black or African American, Europe, Haplotypes, Case-Control Studies, Female, business
Abstract

Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.

Published
2006

3. Response to Comments on 'A Common Genetic Variant Is Associated with Adult and Childhood Obesity'

Author

Arne Pfeufer, Thomas Meitinger, Graham A. Colditz, Alan Herbert, Kristin G. Ardlie, I. M. Heid, Kerstin Koberwitz, Richard S. Cooper, Thomas Illig, H.-Erich Wichmann, Marc E. Lenburg, Xiaofeng Zhu, Nan M. Laird, Matthew B. McQueen, Christoph Lange, Norman P. Gerry, Michael F. Christman, Helen N. Lyon, Anke Hinney, Joel N. Hirschhorn, Frank B. Hu, David G. Hunter, and Johannes Hebebrand

Subjects
Genetics, False positive finding, Multidisciplinary, Medizin, medicine, Genetic variants, Identification (biology), Biology, Association (psychology), medicine.disease, Body mass index, Obesity, Childhood obesity
Abstract

Identification of genetic variants affecting complex traits such as obesity is confounded by many types of bias, especially when effect sizes are small. Given our findings of a positive association between rs7566605 and body mass index in four out of five separate samples, a false positive finding cannot be ruled out with certainty but seems unlikely. Meta-analyses of multiple large studies will help refine the estimate of the effects of rs7566605 on body mass index.

Published
2007
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