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The purpose of the research is to study the acute oral toxicity of the medicinal product for veterinary use Iverbutan, intended for the treatment and prevention of arachnoentomoses and nematodoses of poultry.Materials and methods. The studies were carried out on 30 outbred male rats weighing 210-240 g and 60 mice weighing 18–21 g. The animals were divided into experimental and control groups. The drug was administered once without dilution in the form of the provided solution using an intragastric tube. Doses of 2000, 4000, 6000, 8000 and 10 000 mg/kg were tested on mice, and on rats – 10 000, 8000, 5000, 4000 mg/kg. The animals of the control groups were injected with drinking water. Within 14 days after a single dose of the drug, the physiological state and behavior of animals, possible death, as well as the manifestation of symptoms of intoxication were monitored. The control of the body weight of the animals of the experimental and control groups was carried out on the day of the experiment (before drug administration), as well as on the 1st, 3rd, 7th, 9th and 14th days.Results and discussion. It was found that after oral administration of iverbutan to experimental animals, the average lethal dose, calculated by the Kerber method, was 5600 mg/kg of body weight in mice and 7000 mg/kg of body weight in rats (hazard class 4 according to GOST 12.1.007-76). The average lethal dose, calculated by the Miller and Tainter method, was 5292.0±1058.6 (4233.4÷6350.6) mg/kg of body weight in mice and 6463.2±1496.9 (4966.3÷7960.1) mg/kg of body weight of rats (hazard class 3 according to GOST 12.1.007-76), which indicates species sensitivity.

The purpose of the research is to study efficiency of drugs for veterinary use "Inspector Quadro C” and "Inspector Quadro K” in the case of dogs’ and cats’ dirofilariosis. Materials and methods . Study was conducted on 24 animals of different breeds, which were naturally infected by Dirofilaria immitis and D. repens, including 12 dogs at the age from 7 weeks to four years with the body weight of 6–20 kg, and 12 cats at the age from 7 weeks to two years with the body weight of 0.7–5 kg. Diagnosis as well as drug efficiency was confirmed in its entirety based on clinical signs and laboratory studies (microscopic evaluation of animals’ blood films). V. B. Yastreb concentration method were used as the method of study. The drug was administered to the animals from experimental group by applying on dry, uninjured skin on places inaccessible for licking off in the dose range of 0.1 ml per 1 kg of animal body weight twice at intervals of 10–14 days which corresponds to the dose for cats 1 mg/kg, for dogs 2.5 mg/kg for moxidectin. Results and discussion . It has been established that drugs "Inspector Quadro C” and "Inspector Quadro K” had demonstrated 100 % efficiency at dirofilariosis disease in dogs and cats. Negative influence of drugs on animals’ organisms was not established.

The authors study the efficacy of pharmaceutical drug “Inspector Mini” for external cutaneous use (spot-on), developed for the treatment and prevention of arachnoses, entomoses and nematodoses in small breeds dogs and cats, puppies and kittens weighing under 1 kg since the use of many drugs is limited for the small weight of the animal. It was found that in 14 days after 2-4 times treatments of animals with demodecosis, sarcoptosis, notoedrosis and otodectosis, microscopy in tick scrapings was not found; when observing experimental animals within 30 days, live larvae, adults of ixodid ticks, fleas, lice, and chewing lice were not observed; in 10 days after treatments of animals with intestinal nematodoses were not observed with a coprooscopic examination of nematodes eggs (Toxocara canis/mystax, Toxascaris leonina). Within 30 days observing dogs and cats using the drug no side effects were detected.