Search

Your search keyword '"Jenifer Li"' showing total 4 results
Start Over Author "Jenifer Li" Topic medicine
4 results on '"Jenifer Li"'

2. Investigating colonization patterns of the infant gut microbiome during the introduction of solid food and weaning from breastmilk: A cohort study protocol.

Author

Sara Dizzell, Jennifer C Stearns, Jenifer Li, Niels van Best, Liene Bervoets, Monique Mommers, John Penders, Katherine M Morrison, Eileen K Hutton, and GI-MDH Consortium Partners

Subjects
Medicine, Science
Abstract

The first exposures to microbes occur during infancy and it is suggested that this initial colonization influences the adult microbiota composition. Despite the important role that the gut microbiome may have in health outcomes later in life, the factors that influence its development during infancy and early childhood have not been characterized fully. Guidelines about the introduction of solid foods and cessation of breastfeeding, which is thought to have a significant role in the transition to a more adult-like microbiota, are not based on microbiome research. There is even less understanding of approaches used to transition to solid food in the preterm population. The purpose of this study is to identify the impact of early life dietary events on gut microbiome community structures and function among infants born at term and pre-term. We plan to prospectively monitor the gut microbiome of infants during two critical timepoints in microbial development: the introduction of solid foods and cessation from breastmilk. A total of 35 participants from three primary observational birth cohorts (two full-term cohorts and one pre-term cohort) will be enrolled in this sub-study. Participants will be asked to collect stool samples and fill out a study diary before, during and after the introduction of solids and again during weaning from breastmilk. We will use frequent fecal sampling analyzed using 16S rRNA gene profiling, metagenomics, metabolomics, and targeted bacterial culturing to identify and characterize the microbial communities, as well as provide insight into the phenotypic characteristics and functional capabilities of the microbes present during these transitional periods of infancy. This study will provide a comprehensive approach to detailing the effects of dietary transition from breastmilk to a more adult-like solid food diet on the microbiome and in doing so will contribute to evidence-based infant nutrition guidance.

Published
2021
Full Text
View/download PDF

3. Obesity class versus the Edmonton Obesity Staging System for Pediatrics to define health risk in childhood obesity: results from the CANPWR cross-sectional study

Author

Jenifer Li, Annick Buchholz, Quazi Ibrahim, Jill Hamilton, Ian Zenlea, Lehana Thabane, Katherine M. Morrison, Geoff D.C. Ball, Josephine Ho, Anne-Marie Laberge, Mark S. Tremblay, Laurent Legault, and Stasia Hadjiyannakis

Subjects
Male, Canada, Pediatric Obesity, Pediatrics, medicine.medical_specialty, Adolescent, Cross-sectional study, Health Status, Child Welfare, Severity of Illness Index, Childhood obesity, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Class I obesity, 030225 pediatrics, Developmental and Educational Psychology, medicine, Humans, 030212 general & internal medicine, Child, Disease burden, business.industry, Class III obesity, Body Weight, Child Health, medicine.disease, Obesity, Mental health, Cross-Sectional Studies, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, business, Body mass index
Abstract

Summary Background Disease severity in paediatric obesity is usually defined using the body-mass index (BMI). Although informative at the population level, its usefulness on an individual level has limitations. The use of a clinical staging system—Edmonton Obesity Staging System for Pediatrics (EOSS-P)—in identifying health risk has been proposed. This study aimed to examine the association between BMI class and EOSS-P stage. Methods This cross-sectional study was done in children with obesity aged 5–17 years who enrolled in the Canadian Pediatric Weight Management Registry (CANPWR) between May 31, 2013, and Oct 27, 2017, involving ten multidisciplinary paediatric weight management clinics in Canada. We classified participants into WHO BMI classes (class I as 2–3 SD scores, class II as >3 SD scores, and class III as >4 SD scores above the WHO growth standard median), and applied the EOSS-P staging system (stages 0, 1, and 2/3) based on the clinical assessment of coexisting metabolic, mechanical, mental health, and social milieu issues. Clinical information was extracted from medical records and reported using standardised case report forms. Associations of BMI class with EOSS-P stage were examined in children with complete data. Findings Of the 847 children with complete data, 546 (64%) had severe obesity based on BMI class (ie, class II or III) and 678 (80%) were EOSS-P stage 2/3. Stage 2/3 obesity-related health issues were common; mental health concerns were most common (520 [61%] of 847 children), followed by metabolic (349 [41%] of 847 children), social milieu (179 [21%] of 847 children), and mechanical (86 [10%] of 847 children) health issues. Mental health issues (eg, anxiety and attention-deficit hyperactivity disorder) were equally distributed across BMI classes, metabolic health issues were slightly more common in higher BMI classes, and mechanical (eg, musculoskeletal issues and sleep apnoea) and social milieu (eg, bullying and low household income) issues increased with increasing BMI class. Of children with class I obesity, 206 (76%) of 270 had overall EOSS-P stage 2/3, compared with 195 (85%) of 229 with class III obesity. Interpretation Physical and mental health issues were highly prevalent among children with obesity irrespective of BMI class. Participants with class III obesity carried the greatest health risk across subcategories of the EOSS-P. As BMI class increased, a concomitant increased disease burden in mechanical and social milieu issues was observed, whereas metabolic and mental health risks were high across BMI classes. Funding Canadian Institutes of Health Research, Ontario Ministry of Health, McMaster University, and McMaster Children's Hospital.

Published
2019
Full Text
View/download PDF

4. Investigating colonization patterns of the infant gut microbiome during the introduction of solid food and weaning from breastmilk: A cohort study protocol

Author

Katherine M. Morrison, John Penders, Jennifer C. Stearns, Monique Mommers, Liene Bervoets, Niels van Best, Eileen K. Hutton, Jenifer Li, Sara Dizzell, RS: NUTRIM - R2 - Liver and digestive health, Med Microbiol, Infect Dis & Infect Prev, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, and RS: CAPHRI - R4 - Health Inequities and Societal Participation

Subjects
0301 basic medicine, Breastfeeding, DIVERSITY, Biochemistry, Cohort Studies, Families, Feces, Medicine and Health Sciences, Medicine, Early childhood, Children, education.field_of_study, Multidisciplinary, digestive, oral, and skin physiology, ASSOCIATION, Genomics, Nucleic acids, Ribosomal RNA, Medical Microbiology, Cohort, HEALTH, Infants, Cohort study, Cell biology, Cellular structures and organelles, Science, 030106 microbiology, Population, Microbial Genomics, Weaning, Microbiology, 03 medical and health sciences, DELIVERY, INTESTINAL MICROBIOTA, Environmental health, Registered Report Protocol, Genetics, Metabolomics, Humans, Microbiome, education, Non-coding RNA, Nutrition, Bacteria, business.industry, Gut Bacteria, Organisms, Biology and Life Sciences, Infant, LIBRARIES, Diet, Gastrointestinal Microbiome, 030104 developmental biology, Metabolism, Metagenomics, Food, Age Groups, People and Places, ESTABLISHMENT, ASTHMA, RNA, Population Groupings, business, COMMUNITIES, Ribosomes
Abstract

PLOS ONE 16(4), 0248924 (2021). doi:10.1371/journal.pone.0248924, Published by PLOS, San Francisco, California, US

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results