1. Coronavirus Disease 2019-Associated PICU Admissions: A Report From the Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study Registry
- Author
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Sandeep, Tripathi, Katja M, Gist, Erica C, Bjornstad, Rahul, Kashyap, Karen, Boman, Kathleen, Chiotos, Varsha P, Gharpure, Heda, Dapul, Imran A, Sayed, Joshua, Kuehne, Julia A, Heneghan, Manoj, Gupta, Paras B, Khandhar, Shina, Menon, Neha, Gupta, Vishakha K, Kumar, Lynn, Retford, Jerry, Zimmerman, Utpal S, Bhalala, and Kathleen, Johnson
- Subjects
medicine.medical_specialty ,Abdominal pain ,Adolescent ,Critical Care ,Critical Illness ,030204 cardiovascular system & hematology ,Intensive Care Units, Pediatric ,outcomes ,Critical Care and Intensive Care Medicine ,intensive care unit ,Viral infection ,Coronavirus Disease 2019 ,PICU ,children ,coronavirus disease 2019 ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Internal medicine ,medicine ,Humans ,Registries ,Child ,multisystem inflammatory syndrome in children ,Retrospective Studies ,Study Registry ,SARS-CoV-2 ,business.industry ,COVID-19 ,030208 emergency & critical care medicine ,Retrospective cohort study ,Odds ratio ,medicine.disease ,Feature Articles ,Systemic Inflammatory Response Syndrome ,Hospitalization ,Systemic inflammatory response syndrome ,Pediatrics, Perinatology and Child Health ,Cohort ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,medicine.symptom ,business ,severe acute respiratory syndrome coronavirus 2 - Abstract
Supplemental Digital Content is available in the text., OBJECTIVES: To compare clinical characteristics and outcomes of children admitted to the PICU for severe acute respiratory syndrome coronavirus 2–related illness with or without multisystem inflammatory syndrome in children. The secondary objective was to identify explanatory factors associated with outcome of critical illness defined by a composite index of in-hospital mortality and organ system support requirement. DESIGN: Retrospective cohort study. SETTING: Thirty-eight PICUs within the Viral Infection and Respiratory Illness Universal Study registry from March 2020 to January 2021. PATIENTS: Children less than 18 years with severe acute respiratory syndrome coronavirus 2–related illness with or without multisystem inflammatory syndrome in children. MEASUREMENTS AND MAIN RESULTS: Of 394 patients, 171 (43.4%) had multisystem inflammatory syndrome in children. Children with multisystem inflammatory syndrome in children were more likely younger (2–12 yr vs adolescents; p < 0.01), Black (35.6% vs 21.9%; p < 0.01), present with fever/abdominal pain than cough/dyspnea (p < 0.01), and less likely to have comorbidities (33.3% vs 61.9%; p < 0.01) compared with those without multisystem inflammatory syndrome in children. Inflammatory marker levels, use of inotropes/vasopressors, corticosteroids, and anticoagulants were higher in multisystem inflammatory syndrome in children patients (p < 0.01). Overall mortality was 3.8% (15/394), with no difference in the two groups. Diagnosis of multisystem inflammatory syndrome in children was associated with longer duration of hospitalization as compared to nonmultisystem inflammatory syndrome in children (7.5 d[interquartile range, 5–11] vs 5.3 d [interquartile range, 3–11 d]; p < 0.01). Critical illness occurred in 164 patients (41.6%) and was more common in patients with multisystem inflammatory syndrome in children compared with those without (55.6% vs 30.9%; p < 0.01). Multivariable analysis failed to show an association between critical illness and age, race, sex, greater than or equal to three signs and symptoms, or greater than or equal to two comorbidities among the multisystem inflammatory syndrome in children cohort. Among nonmultisystem inflammatory syndrome in children patients, the presence of greater than or equal to two comorbidities was associated with greater odds of critical illness (odds ratio 2.95 [95% CI, 1.61–5.40]; p < 0.01). CONCLUSIONS: This study delineates significant clinically relevant differences in presentation, explanatory factors, and outcomes among children admitted to PICU with severe acute respiratory syndrome coronavirus 2–related illness stratified by multisystem inflammatory syndrome in children.
- Published
- 2021